iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000006398.15	ENSMUST00000006565.12	ENSMUSP00000006565.6
ENSMUSG00000006398.15	ENSMUST00000183942.1	ENSMUSP00000139345.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
microRNA	TRANSFAC	RepTar	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/APC_C/CDC20	CDC20	19900895

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.60e-29	101.1	307	336
E3 adaptor/Cullin RING/APC_C/CDC20	7.90e-147	489.5	172	478

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvW 28
           gH+ +v++l++ +d ++l+sG++D+ + vW
   Q: 307  GHSQEVCGLRWaPDgRHLASGGNDNIVNVW 336
           8***********999*************** PP

E3 adaptor/Cullin RING/APC_C/CDC20

   S: 1    pekvldapelrddfylnLldWssknvlavaLgssvylwsaktgdvskladl.eekdlvtsvswieegtllavGtkkgeveiyDveekkk 88
           p+++ldape+r+d+ylnL+dWss nvlavaL++svylw+a +gd+ +l ++ +++d+++sv+wi+eg++lavGt+++ev+++Dv+++k+
   Q: 172  PDRILDAPEIRNDYYLNLVDWSSGNVLAVALDNSVYLWNAGSGDILQLLQMeQPGDYISSVAWIKEGNYLAVGTSNAEVQLWDVQQQKR 260
           689************************************************899*********************************** PP
   S: 89   vrtltghsarvgaLsWnaevlssGsrdgeilhrdvrvkelklstlqahaqevCGlkwnedaklLasGGnDnsvsvwdassse....Plk 173
           +r++t+hsarv++LsWn+++lssGsr+g+i+h+dvrv+e++++tl++h+qevCGl+w+ d+++LasGGnDn v+vw +   e    Pl+
   Q: 261  LRNMTSHSARVSSLSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNIVNVWPSGPGEsgwaPLQ 349
           *****************************************************************************999888999*** PP
   S: 174  kfkehkaavkaiawsPwqkslLasGGGtaDrcikfwntltgalleeidtgsqvcsllwskkskelvsthGfaenkitlwkypslskvae 262
           +f++h++avka+aw+Pwq+++La+GGGt+Dr+i++wn+++ga+l+++d++sqvcs+lws+++kel+s+hGfa+n++++wkyp+++kvae
   Q: 350  TFTQHQGAVKAVAWCPWQSNILATGGGTSDRHIRIWNVCSGACLSAVDVHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAE 438
           ***************************************************************************************** PP
   S: 263  lkgheaRvlslalspdgeaivtaagDetlrfwklfdkkka 302
           lkgh+aRvl l++spdg+++++aa+Detlr+w++f++++a
   Q: 439  LKGHTARVLGLTMSPDGATVASAAADETLRLWRCFEMDPA 478
           ************************************9875 PP

Organism

Mus musculus

Functional Description
(View)

Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation.

Protein Sequence
(Fasta)

MAQFVFESDL HSLLQLDAPI PNAPVARWQR KAKEATGPAP SPMRAANRSH SAGRTPGRTP 60
GKSSSKVQTT PSKPGGDRFI PQRSASQMEV ASFLLSKENQ PEDRGTPTKK EHQKAWSLNL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCCAATGAAC GCTAGCAGCG GAGAGTTTAA GAACAACAGT CCGGCGTGTC CTTAGCTTGT 60
CTGGAAAAGA ACGCGTTCGG CAGGCGCACT GACGCGCTGC GAGGAGCTGG GGGTTTGTGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0221--Differentiation
KW-0903--Direct protein sequencing
KW-1017--Isopeptide bond
KW-0498--Mitosis
KW-0524--Neurogenesis
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR024977--Apc4_WD40_dom
IPR033187--CDC20
IPR033010--Cdc20/Fizzy
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12894--ANAPC4_WD40
PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0005680--C:anaphase-promoting complex
GO:0005813--C:centrosome
GO:0048471--C:perinuclear region of cytoplasm
GO:0043234--C:protein complex
GO:0000922--C:spindle pole
GO:0019899--F:enzyme binding
GO:0008022--F:protein C-terminus binding
GO:0097027--F:ubiquitin-protein transferase activator activity
GO:0031145--P:anaphase-promoting complex-dependent catabolic process
GO:0051301--P:cell division
GO:0007064--P:mitotic sister chromatid cohesion
GO:0090307--P:mitotic spindle assembly
GO:0008284--P:positive regulation of cell proliferation
GO:0090129--P:positive regulation of synapse maturation
GO:0031915--P:positive regulation of synaptic plasticity
GO:1904668--P:positive regulation of ubiquitin protein ligase activity
GO:0016567--P:protein ubiquitination
GO:0050773--P:regulation of dendrite development
GO:0040020--P:regulation of meiotic nuclear division

KEGG

mmu:107995

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000638	Aegilops tauschii	44.51	7.00e-109	387.00
IUUC-Aml-001545	Ailuropoda melanoleuca	94.99	0.00e+00	929.00
IUUC-Atr-003103	Amborella trichopoda	46.68	5.00e-109	388.00
IUUC-Apl-003255	Anas platyrhynchos	80.45	0.00e+00	752.00
IUUC-Aca-004920	Anolis carolinensis	75.64	0.00e+00	768.00
IUUC-Aly-006303	Arabidopsis lyrata	49.02	3.00e-109	388.00
IUUC-Ath-006795	Arabidopsis thaliana	46.71	7.00e-108	384.00
IUUC-Ate-010479	Aspergillus terreus	40.78	1.00e-91	330.00
IUUC-Ame-010850	Astyanax mexicanus	60.70	3.00e-91	328.00
IUUC-Bgr-012059	Blumeria graminis	48.87	3.00e-93	335.00
IUUC-Bta-012625	Bos taurus	94.19	0.00e+00	924.00
IUUC-Bci-013607	Botrytis cinerea	46.49	3.00e-96	345.00
IUUC-Bdi-014344	Brachypodium distachyon	46.62	1.00e-107	383.00
IUUC-Bol-015368	Brassica oleracea	46.12	7.00e-107	382.00
IUUC-Bra-016738	Brassica rapa	46.86	2.00e-106	380.00
IUUC-Cja-019132	Callithrix jacchus	93.99	0.00e+00	928.00
IUUC-Cfa-020780	Canis familiaris	94.39	0.00e+00	923.00
IUUC-Cpo-022223	Cavia porcellus	95.19	0.00e+00	886.00
IUUC-Cre-022701	Chlamydomonas reinhardtii	50.82	8.00e-120	424.00
IUUC-Csa-023666	Chlorocebus sabaeus	94.59	0.00e+00	927.00
IUUC-Cho-024920	Choloepus hoffmanni	93.26	6.00e-155	540.00
IUUC-Cin-025675	Ciona intestinalis	51.00	5.00e-136	478.00
IUUC-Csv-026019	Ciona savignyi	51.04	1.00e-131	463.00
IUUC-Cgl-026465	Colletotrichum gloeosporioides	40.56	2.00e-95	343.00
IUUC-Cme-027234	Cyanidioschyzon merolae	51.91	1.00e-105	377.00
IUUC-Dre-028026	Danio rerio	60.36	0.00e+00	634.00
IUUC-Dno-028865	Dasypus novemcinctus	93.20	0.00e+00	908.00
IUUC-Dor-030958	Dipodomys ordii	94.79	0.00e+00	929.00
IUUC-Dse-031391	Dothistroma septosporum	39.60	5.00e-97	348.00
IUUC-Dme-031905	Drosophila melanogaster	49.63	1.00e-143	503.00
IUUC-Ete-032387	Echinops telfairi	88.38	0.00e+00	874.00
IUUC-Eca-033522	Equus caballus	85.77	0.00e+00	837.00
IUUC-Eeu-035059	Erinaceus europaeus	83.20	0.00e+00	782.00
IUUC-Fca-036346	Felis catus	94.78	0.00e+00	842.00
IUUC-Fal-037558	Ficedula albicollis	79.37	0.00e+00	788.00
IUUC-Fox-037850	Fusarium oxysporum	44.65	8.00e-96	344.00
IUUC-Fso-038375	Fusarium solani	44.56	2.00e-96	346.00
IUUC-Gmo-039284	Gadus morhua	63.04	0.00e+00	633.00
IUUC-Ggr-039864	Gaeumannomyces graminis	47.97	4.00e-98	352.00
IUUC-Gga-040790	Gallus gallus	79.13	0.00e+00	810.00
IUUC-Gac-041431	Gasterosteus aculeatus	62.43	0.00e+00	627.00
IUUC-Gma-043489	Glycine max	46.99	2.00e-107	382.00
IUUC-Ggo-045052	Gorilla gorilla	94.79	0.00e+00	927.00
IUUC-Hsa-046305	Homo sapiens	94.79	0.00e+00	927.00
IUUC-Hvu-047476	Hordeum vulgare	44.90	1.00e-108	386.00
IUUC-Itr-048461	Ictidomys tridecemlineatus	95.79	0.00e+00	892.00
IUUC-Lch-050174	Latimeria chalumnae	60.23	1.00e-171	595.00
IUUC-Lpe-050954	Leersia perrieri	46.97	3.00e-99	355.00
IUUC-Loc-052638	Lepisosteus oculatus	62.52	0.00e+00	627.00
IUUC-Lma-052998	Leptosphaeria maculans	43.11	2.00e-99	356.00
IUUC-Laf-053742	Loxodonta africana	93.79	0.00e+00	917.00
IUUC-Mcc-054948	Macaca mulatta	94.59	0.00e+00	927.00
IUUC-Meu-056013	Macropus eugenii	85.51	2.00e-140	492.00
IUUC-Mor-057277	Magnaporthe oryzae	41.78	4.00e-96	345.00
IUUC-Mpo-057624	Magnaporthe poae	50.81	4.00e-96	345.00
IUUC-Mtr-057725	Medicago truncatula	46.38	4.00e-100	358.00
IUUC-Mga-060102	Meleagris gallopavo	79.37	0.00e+00	811.00
IUUC-Mmr-061615	Microcebus murinus	93.69	0.00e+00	923.00
IUUC-Mdo-061982	Monodelphis domestica	87.76	0.00e+00	766.00
IUUC-Mac-064861	Musa acuminata	47.10	6.00e-109	387.00
IUUC-Mpu-066502	Mustela putorius furo	94.79	0.00e+00	917.00
IUUC-Mlu-067277	Myotis lucifugus	86.63	0.00e+00	855.00
IUUC-Ncr-068951	Neurospora crassa	44.56	2.00e-93	336.00
IUUC-Nle-070149	Nomascus leucogenys	94.39	0.00e+00	920.00
IUUC-Opr-070778	Ochotona princeps	93.59	0.00e+00	675.00
IUUC-Ont-071660	Oreochromis niloticus	61.35	3.00e-178	618.00
IUUC-Oan-073677	Ornithorhynchus anatinus	75.70	0.00e+00	696.00
IUUC-Ocu-073797	Oryctolagus cuniculus	94.57	0.00e+00	924.00
IUUC-Oba-075946	Oryza barthii	47.10	4.00e-106	378.00
IUUC-Obr-076018	Oryza brachyantha	45.62	9.00e-107	380.00
IUUC-Ogl-077254	Oryza glaberrima	46.97	3.00e-99	355.00
IUUC-Ogu-078521	Oryza glumaepatula	47.32	3.00e-106	379.00
IUUC-Oin-080094	Oryza indica	46.97	3.00e-99	355.00
IUUC-Olo-080449	Oryza longistaminata	47.19	2.00e-99	356.00
IUUC-Ome-081186	Oryza meridionalis	47.07	2.00e-106	380.00
IUUC-Oni-082243	Oryza nivara	46.97	3.00e-99	355.00
IUUC-Opu-084007	Oryza punctata	46.97	5.00e-99	354.00
IUUC-Oru-084562	Oryza rufipogon	47.32	6.00e-106	378.00
IUUC-Osa-086094	Oryza sativa	46.97	4.00e-99	355.00
IUUC-Ola-086907	Oryzias latipes	60.87	7.00e-166	577.00
IUUC-Olu-087647	Ostreococcus lucimarinus	50.49	3.00e-118	418.00
IUUC-Oga-088184	Otolemur garnettii	93.40	0.00e+00	914.00
IUUC-Oar-090023	Ovis aries	88.71	0.00e+00	814.00
IUUC-Ptr-090935	Pan troglodytes	93.87	0.00e+00	864.00
IUUC-Pan-091845	Papio anubis	94.59	0.00e+00	927.00
IUUC-Psi-093188	Pelodiscus sinensis	80.54	0.00e+00	841.00
IUUC-Pma-094187	Petromyzon marinus	54.77	4.00e-149	521.00
IUUC-Pno-094809	Phaeosphaeria nodorum	41.94	6.00e-101	361.00
IUUC-Ppa-095457	Physcomitrella patens	49.41	3.00e-111	395.00
IUUC-Pfo-097429	Poecilia formosa	59.36	2.00e-162	565.00
IUUC-Pab-098603	Pongo abelii	94.59	0.00e+00	927.00
IUUC-Pop-099654	Populus trichocarpa	46.38	3.00e-103	368.00
IUUC-Pca-101062	Procavia capensis	92.79	0.00e+00	894.00
IUUC-Ppe-101865	Prunus persica	46.40	3.00e-96	345.00
IUUC-Pva-102925	Pteropus vampyrus	93.59	0.00e+00	944.00
IUUC-Pte-104142	Pyrenophora teres	42.60	3.00e-98	352.00
IUUC-Pyt-104693	Pyrenophora triticirepentis	42.44	3.00e-98	352.00
IUUC-Rno-106005	Rattus norvegicus	97.60	0.00e+00	958.00
IUUC-Sha-107472	Sarcophilus harrisii	87.80	0.00e+00	877.00
IUUC-Sja-107919	Schizosaccharomyces japonicus	42.36	4.00e-94	338.00
IUUC-Spo-108075	Schizosaccharomyces pombe	51.74	1.00e-95	343.00
IUUC-Ssl-108507	Sclerotinia sclerotiorum	47.80	1.00e-95	343.00
IUUC-Smo-108922	Selaginella moellendorffii	49.03	4.00e-123	434.00
IUUC-Sit-110732	Setaria italica	45.81	2.00e-107	382.00
IUUC-Sly-111202	Solanum lycopersicum	43.48	3.00e-105	375.00
IUUC-Stu-112024	Solanum tuberosum	42.12	1.00e-105	377.00
IUUC-Sar-113092	Sorex araneus	89.78	0.00e+00	862.00
IUUC-Sbi-114558	Sorghum bicolor	44.84	2.00e-107	382.00
IUUC-Ssc-115710	Sus scrofa	94.59	0.00e+00	926.00
IUUC-Tgu-117100	Taeniopygia guttata	78.77	0.00e+00	788.00
IUUC-Tru-118184	Takifugu rubripes	59.62	2.00e-138	485.00
IUUC-Tsy-118892	Tarsius syrichta	95.74	2.00e-160	557.00
IUUC-Tni-120474	Tetraodon nigroviridis	59.24	9.00e-168	583.00
IUUC-Tca-120949	Theobroma cacao	46.15	2.00e-105	375.00
IUUC-Tre-122211	Trichoderma reesei	39.96	3.00e-96	345.00
IUUC-Tvi-122531	Trichoderma virens	40.75	3.00e-97	349.00
IUUC-Tae-123017	Triticum aestivum	44.03	6.00e-109	387.00
IUUC-Tur-126018	Triticum urartu	45.43	6.00e-102	364.00
IUUC-Tbe-127384	Tupaia belangeri	95.96	2.00e-173	602.00
IUUC-Ttr-128511	Tursiops truncatus	94.39	0.00e+00	919.00
IUUC-Vda-129993	Verticillium dahliae	40.26	2.00e-96	347.00
IUUC-Vvi-131245	Vitis vinifera	45.57	9.00e-94	337.00
IUUC-Xtr-131993	Xenopus tropicalis	73.68	0.00e+00	760.00
IUUC-Xma-133332	Xiphophorus maculatus	62.57	3.00e-178	618.00
IUUC-Zma-135135	Zea mays	46.23	1.00e-105	377.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence