iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGALG00000006824.6	ENSGALT00000047599.1	ENSGALP00000044856.1
ENSGALG00000006824.6	ENSGALT00000059261.1	ENSGALP00000052320.1
ENSGALG00000006824.6	ENSGALT00000066090.1	ENSGALP00000053018.1
ENSGALG00000006824.6	ENSGALT00000011032.6	ENSGALP00000011018.6

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.30e-115	386.6	593	1328

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsg 86
           tGl NlgNtC+mNSv+Q+Lsn++elr+++++ ++++++n +np ++ g+l+  ++ l+++lwk++++a++p++l+++++++a++f+g
   Q: 593  TGLVNLGNTCFMNSVIQSLSNTRELRDYFHDrSFESEINYNNPLGTGGRLAIGFAMLLRALWKGTHHAFQPSKLKAIVASKASQFTG 679
           7******************************99****************************************************** PP
   S: 87   yeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde.....aeekkkkknkslisdlFqgqlksqikclecdnvssreep 168
           y+q+DaqEf+aflld+l+e+l++ +nkp++e+ ++d   ++de     a++++k++n+s+i+dlFqgq+ks+++c+ c +vs +++p
   Q: 680  YAQHDAQEFMAFLLDGLHEDLNRIQNKPYTETVDSD--GRPDEvvaeeAWQRHKMRNDSFIVDLFQGQYKSKLVCPVCSKVSITFDP 764
           ********************************9999..6666666777*************************************** PP
   S: 169  fldlslpvpgkeetkke...................................................................... 185
           fl+l++p+p+k++  +                                                                       
   Q: 765  FLYLPVPLPQKQKVLTVyyfakephkkpikflvsiskenssamevldsvahsvhvkpdnlrlaeviknrfqrmflpsqsldtvsptd 851
           ************87555********************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 852  lllcfevlspelakervvelqvqqrpqvpsvpvakcaacqkkqlseeeklrrctrcyrvgycnvtcqkthwpdhkalcrpenigfpf 938
           *************************************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 939  lisvpesrltyarlaqllegyarysvsvfqppfqlgrmspeqglqpllldkleplakgscaaatsapelgdgdrasgllqepplspa 1025
           *************************************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 1026 vpelypemsdtgtvrskvlaarssllsldsgfsehmdlqgdsccekepsyeralkpeaaipgyqhtpdslsaratqfyinkidaank 1112
           *************************************************************************************** PP
   S: 186  ...........................................................slqdcLesftkeeelegenkyycekckk 213
                                                                      +l++cL+ ftk+e l  e+++yc+kck+
   Q: 1113 eykledkgdtpleltddcslalvwknnerlkefvlveskelecvedpssaseaaraghfTLEQCLNLFTKPEVLAPEEAWYCPKCKQ 1199
           *************************************************************************************** PP
   S: 214  kqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayv 299
           ++ea+k+l+l++lP+vLi++LkRfsf++  +++ kin+ v+fp + Ldls+fc+ ++ +q +   Y+L+av++H+G++ +GHY+ay+
   Q: 1200 HREASKQLMLWRLPNVLIIQLKRFSFRSFIWRD-KINDMVDFPVRsLDLSKFCIGRKGEQ-QLPMYDLYAVINHYGGMIGGHYTAYA 1284
           *****************************8886.*********************88776.5************************* PP
   S: 300  knekgk........WllfdDskVtevkeeevleetgstaYvlfYkrr 338
           +  ++k        W lfdDs+Vt+v+e++v++   + aYvlfY+rr
   Q: 1285 RLPNDKnsqrsdvgWRLFDDSTVTTVDESQVVT---RYAYVLFYRRR 1328
           *9554455677888*******************...********996 PP

Organism

Gallus gallus

Protein Sequence
(Fasta)

MSSSTNAPGQ RRVSRGLDDA TNKKKQKDRA NQESKEVSRP ELEQAETSQE RDLEEELLLD 60
WKQNADEIIV KLNLGSGSLK VEDVDTFFTD TDCVIKLPDG RQWSCQFYEE IEGSCSKIQC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CATGAGGACG CCCCGAGCGG GGAGCGGACA AGAGCGGGGG CCGAACCAGC GGCCGGGCCC 60
GGCTCGCGTC ACGTGACCTA ACCACGCTCC CGCGTCACGT GGGCCCGTCC GCCGGCTTCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR007052--CS_dom
IPR008978--HSP20-like_chaperone
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR002893--Znf_MYND

PROSITE

PS51203--CS
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS01360--ZF_MYND_1
PS50865--ZF_MYND_2

Pfam

PF04969--CS
PF00443--UCH
PF01753--zf-MYND

Gene Ontology

GO:0005829--C:cytosol
GO:0005789--C:endoplasmic reticulum membrane
GO:0016021--C:integral component of membrane
GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0046872--F:metal ion binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:1901799--P:negative regulation of proteasomal protein catabolic process
GO:0048642--P:negative regulation of skeletal muscle tissue development
GO:0050821--P:protein stabilization
GO:1900037--P:regulation of cellular response to hypoxia
GO:1904292--P:regulation of ERAD pathway
GO:0030433--P:ubiquitin-dependent ERAD pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001999	Ailuropoda melanoleuca	77.25	0.00e+00	1545.00
IUUC-Apl-003368	Anas platyrhynchos	89.07	0.00e+00	2255.00
IUUC-Aca-004267	Anolis carolinensis	76.03	0.00e+00	1956.00
IUUC-Ame-010970	Astyanax mexicanus	59.02	0.00e+00	1491.00
IUUC-Bta-012905	Bos taurus	77.27	0.00e+00	1518.00
IUUC-Cel-018257	Caenorhabditis elegans	44.30	2.00e-90	327.00
IUUC-Cja-018789	Callithrix jacchus	71.95	0.00e+00	1581.00
IUUC-Cfa-021004	Canis familiaris	77.15	0.00e+00	1522.00
IUUC-Cpo-021529	Cavia porcellus	65.59	0.00e+00	1702.00
IUUC-Csa-024035	Chlorocebus sabaeus	73.71	0.00e+00	1546.00
IUUC-Cho-025036	Choloepus hoffmanni	59.57	0.00e+00	885.00
IUUC-Cin-025451	Ciona intestinalis	42.48	8.00e-85	308.00
IUUC-Dre-028556	Danio rerio	60.25	0.00e+00	1482.00
IUUC-Dno-029240	Dasypus novemcinctus	64.16	0.00e+00	1557.00
IUUC-Dor-030495	Dipodomys ordii	72.14	0.00e+00	984.00
IUUC-Ete-032741	Echinops telfairi	75.81	0.00e+00	1486.00
IUUC-Eca-033661	Equus caballus	66.37	0.00e+00	1730.00
IUUC-Eeu-034648	Erinaceus europaeus	73.24	0.00e+00	659.00
IUUC-Fca-035646	Felis catus	76.76	0.00e+00	1518.00
IUUC-Fal-037094	Ficedula albicollis	89.05	0.00e+00	2449.00
IUUC-Gmo-038869	Gadus morhua	70.17	0.00e+00	859.00
IUUC-Gac-041901	Gasterosteus aculeatus	63.43	0.00e+00	1346.00
IUUC-Ggo-044708	Gorilla gorilla	71.74	0.00e+00	1583.00
IUUC-Hsa-046791	Homo sapiens	73.26	0.00e+00	1569.00
IUUC-Itr-048892	Ictidomys tridecemlineatus	63.92	0.00e+00	1639.00
IUUC-Lch-050456	Latimeria chalumnae	65.38	0.00e+00	1201.00
IUUC-Loc-052861	Lepisosteus oculatus	63.03	0.00e+00	1214.00
IUUC-Laf-053788	Loxodonta africana	74.07	0.00e+00	1546.00
IUUC-Mcc-055693	Macaca mulatta	66.64	0.00e+00	1623.00
IUUC-Meu-055921	Macropus eugenii	80.14	0.00e+00	1367.00
IUUC-Mga-059879	Meleagris gallopavo	93.64	0.00e+00	2484.00
IUUC-Mmr-060802	Microcebus murinus	67.12	0.00e+00	1682.00
IUUC-Mdo-061856	Monodelphis domestica	77.28	0.00e+00	1565.00
IUUC-Mmu-063874	Mus musculus	65.93	0.00e+00	1731.00
IUUC-Mpu-066166	Mustela putorius furo	76.57	0.00e+00	1520.00
IUUC-Nle-070161	Nomascus leucogenys	65.76	0.00e+00	1687.00
IUUC-Opr-071015	Ochotona princeps	77.37	0.00e+00	1505.00
IUUC-Ont-072308	Oreochromis niloticus	71.22	0.00e+00	1420.00
IUUC-Oan-072723	Ornithorhynchus anatinus	65.47	0.00e+00	1677.00
IUUC-Ocu-073938	Oryctolagus cuniculus	76.35	0.00e+00	1515.00
IUUC-Ola-086375	Oryzias latipes	71.25	0.00e+00	1382.00
IUUC-Oga-088297	Otolemur garnettii	73.66	0.00e+00	1531.00
IUUC-Oar-089675	Ovis aries	77.16	0.00e+00	1360.00
IUUC-Ptr-091621	Pan troglodytes	73.17	0.00e+00	1566.00
IUUC-Pan-092118	Papio anubis	73.71	0.00e+00	1546.00
IUUC-Pma-094154	Petromyzon marinus	51.67	4.00e-114	405.00
IUUC-Pfo-097246	Poecilia formosa	61.77	0.00e+00	1489.00
IUUC-Pab-098551	Pongo abelii	69.75	0.00e+00	1545.00
IUUC-Pca-100158	Procavia capensis	63.40	0.00e+00	1630.00
IUUC-Pva-103160	Pteropus vampyrus	66.34	0.00e+00	1667.00
IUUC-Rno-105355	Rattus norvegicus	66.14	0.00e+00	1699.00
IUUC-Sha-107057	Sarcophilus harrisii	78.48	0.00e+00	1545.00
IUUC-Sar-113011	Sorex araneus	72.36	0.00e+00	1127.00
IUUC-Ssc-115761	Sus scrofa	77.54	0.00e+00	1526.00
IUUC-Tgu-116956	Taeniopygia guttata	77.99	0.00e+00	1085.00
IUUC-Tru-118739	Takifugu rubripes	66.25	0.00e+00	1415.00
IUUC-Tsy-118827	Tarsius syrichta	80.36	0.00e+00	769.00
IUUC-Tni-119921	Tetraodon nigroviridis	65.54	0.00e+00	1354.00
IUUC-Tbe-128017	Tupaia belangeri	71.79	0.00e+00	1511.00
IUUC-Ttr-128869	Tursiops truncatus	65.81	0.00e+00	1673.00
IUUC-Vpa-130427	Vicugna pacos	71.75	0.00e+00	699.00
IUUC-Xtr-132734	Xenopus tropicalis	76.88	0.00e+00	1512.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence