iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Aca-004357

Ensembl Protein ID

ENSACAP00000011257.2

UniProt Accession

H9GHP3; H9GHP3_ANOCA

Protein Name

Tyrosine-protein kinase

Gene Name

BLK

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSACAG00000011166.2	ENSACAT00000011493.2	ENSACAP00000011257.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	6.50e-12	45.2	2	58

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 4    ekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           + v++++d+ ++++ +L l++G+  +v+   + +++W+ +++ +++k G +P+nFv++ +
   Q: 2    HCVIAQHDFVPSSERDLPLTAGERFEVL---CSNGDWWLAKSLTTKKIGYIPSNFVVRFN 58
           7799************************...*************************9875 PP

Organism

Anolis carolinensis

Protein Sequence
(Fasta)

KHCVIAQHDF VPSSERDLPL TAGERFEVLC SNGDWWLAKS LTTKKIGYIP SNFVVRFNSL 60
EEEKWFFKGL SRKETERFLM APRNAVGSFL IRESETTPDA FSLSIRDSTS QGDVIKHYKI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAACACTGTG TAATTGCACA ACATGATTTT GTACCATCAA GTGAACGGGA TCTGCCATTG 60
ACAGCAGGTG AAAGATTTGA AGTCCTTTGC AGGTAAGCAT CTATGTTCAG ATTATTATTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0050853--P:B cell receptor signaling pathway
GO:0030154--P:cell differentiation
GO:0016477--P:cell migration
GO:0045087--P:innate immune response
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0032024--P:positive regulation of insulin secretion
GO:0042127--P:regulation of cell proliferation
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000140	Aegilops tauschii	28.73	5.00e-22	99.80
IUUC-Aml-002133	Ailuropoda melanoleuca	69.28	0.00e+00	672.00
IUUC-Apl-003307	Anas platyrhynchos	76.98	0.00e+00	731.00
IUUC-Ame-010642	Astyanax mexicanus	70.65	0.00e+00	671.00
IUUC-Bta-012400	Bos taurus	68.54	0.00e+00	669.00
IUUC-Cfa-021056	Canis familiaris	69.53	0.00e+00	669.00
IUUC-Cpo-021779	Cavia porcellus	69.66	0.00e+00	677.00
IUUC-Csa-023557	Chlorocebus sabaeus	69.28	0.00e+00	673.00
IUUC-Dre-027517	Danio rerio	71.33	0.00e+00	673.00
IUUC-Eca-034218	Equus caballus	69.51	0.00e+00	678.00
IUUC-Eeu-035095	Erinaceus europaeus	51.35	2.00e-132	465.00
IUUC-Fca-036015	Felis catus	67.94	0.00e+00	660.00
IUUC-Fal-036946	Ficedula albicollis	76.30	0.00e+00	724.00
IUUC-Gmo-038861	Gadus morhua	66.59	1.00e-175	608.00
IUUC-Gga-040822	Gallus gallus	75.68	0.00e+00	724.00
IUUC-Gac-041860	Gasterosteus aculeatus	65.46	2.00e-177	615.00
IUUC-Ggo-044608	Gorilla gorilla	68.94	0.00e+00	639.00
IUUC-Hsa-046719	Homo sapiens	68.83	0.00e+00	667.00
IUUC-Itr-048323	Ictidomys tridecemlineatus	69.07	0.00e+00	663.00
IUUC-Lch-050114	Latimeria chalumnae	70.14	0.00e+00	676.00
IUUC-Laf-053387	Loxodonta africana	69.73	0.00e+00	674.00
IUUC-Mcc-055026	Macaca mulatta	69.51	0.00e+00	676.00
IUUC-Mga-059427	Meleagris gallopavo	75.23	0.00e+00	715.00
IUUC-Mmr-061660	Microcebus murinus	70.43	0.00e+00	679.00
IUUC-Mdo-062318	Monodelphis domestica	68.09	0.00e+00	664.00
IUUC-Mmu-063325	Mus musculus	69.30	0.00e+00	667.00
IUUC-Mpu-066582	Mustela putorius furo	69.06	0.00e+00	672.00
IUUC-Nle-069624	Nomascus leucogenys	69.44	0.00e+00	675.00
IUUC-Ont-072266	Oreochromis niloticus	67.19	0.00e+00	639.00
IUUC-Ocu-073907	Oryctolagus cuniculus	70.11	0.00e+00	674.00
IUUC-Oga-088057	Otolemur garnettii	69.89	0.00e+00	675.00
IUUC-Ptr-091551	Pan troglodytes	68.94	0.00e+00	638.00
IUUC-Pan-092173	Papio anubis	69.98	0.00e+00	675.00
IUUC-Psi-093895	Pelodiscus sinensis	75.34	0.00e+00	721.00
IUUC-Pab-097598	Pongo abelii	69.30	0.00e+00	671.00
IUUC-Pva-102135	Pteropus vampyrus	68.61	0.00e+00	664.00
IUUC-Rno-104891	Rattus norvegicus	69.30	0.00e+00	669.00
IUUC-Sha-107192	Sarcophilus harrisii	70.11	0.00e+00	677.00
IUUC-Ssc-115696	Sus scrofa	69.28	0.00e+00	673.00
IUUC-Tgu-117056	Taeniopygia guttata	74.94	0.00e+00	716.00
IUUC-Tru-117621	Takifugu rubripes	66.74	0.00e+00	634.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence