iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
microRNA	TRANSFAC	RepTar	miRNAMap
RAID2
Protein-protein Interaction
IID	HINT	Mentha
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.70e-17	63.3	197	227

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWD 29
           gHt++vt+l++ +  + l sGs D+++ +WD
   Q: 197  GHTGGVTALCWdPVqRVLFSGSSDHSVIMWD 227
           8**********855689************** PP

Organism

Mus musculus

Functional Description
(View)

Acts in an adapter protein-like fashion to mediate the interaction between the kinase PRKCZ and its substrate VAMP2 and increases the PRKCZ-dependent phosphorylation of VAMP2 (By similarity). Positively regulates adipocyte differentiation, by facilitating the phosphorylation and thus inactivation of the anti-adipogenetic transcription factor FOXO1 by the kinase AKT1 (PubMed:18388859). Plays a role in endosomal control of AKT2 signaling; required for insulin-stimulated AKT2 phosphorylation and glucose uptake and insulin-stimulated phosphorylation of AKT2 substrates (PubMed:20189988). Participates in transferrin receptor endocytosis (By similarity).

Protein Sequence
(Fasta)

MAAEIQPQPL TRKPILLQRV EGSQEVVNMA VIVPKEEGVI SVSEDRTVRV WLKRDSGQYW 60
PSIYHAMPSP CSCMSFNPET RRLSIGLDNG TISEFILSED YNKMTPVKNY QAHQSRVTMV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTGCTCCCCG CCCCCTACTC TCTTAGGTGG CGCCGGCTTG CGGCTAGTGT GGCGGCGGTG 60
TTGGTTTTGG AAGCCAGAGC GGGCACATTC CCTGGACAGG CGGCAGGGCT ATGGTCGCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0967--Endosome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR000306--Znf_FYVE
IPR017455--Znf_FYVE-rel
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
PS50178--ZF_FYVE

Pfam

PF01363--FYVE
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00064--FYVE
SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005769--C:early endosome
GO:0031982--C:vesicle
GO:0046872--F:metal ion binding
GO:0045600--P:positive regulation of fat cell differentiation
GO:0001934--P:positive regulation of protein phosphorylation

KEGG

mmu:268752

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002074	Ailuropoda melanoleuca	97.75	0.00e+00	822.00
IUUC-Apl-003892	Anas platyrhynchos	86.16	0.00e+00	649.00
IUUC-Aca-004902	Anolis carolinensis	87.78	0.00e+00	749.00
IUUC-Ame-010837	Astyanax mexicanus	83.25	0.00e+00	727.00
IUUC-Cel-018382	Caenorhabditis elegans	41.84	7.00e-100	357.00
IUUC-Cja-019949	Callithrix jacchus	98.00	0.00e+00	823.00
IUUC-Cfa-020057	Canis familiaris	96.62	0.00e+00	724.00
IUUC-Cpo-022446	Cavia porcellus	98.25	0.00e+00	827.00
IUUC-Csa-023138	Chlorocebus sabaeus	98.50	0.00e+00	827.00
IUUC-Cho-024545	Choloepus hoffmanni	83.63	0.00e+00	673.00
IUUC-Cin-025573	Ciona intestinalis	53.12	4.00e-137	481.00
IUUC-Csv-026091	Ciona savignyi	53.00	5.00e-138	484.00
IUUC-Dre-027501	Danio rerio	84.00	0.00e+00	734.00
IUUC-Dno-029611	Dasypus novemcinctus	96.25	0.00e+00	811.00
IUUC-Dor-030240	Dipodomys ordii	84.91	0.00e+00	665.00
IUUC-Dme-031869	Drosophila melanogaster	50.49	3.00e-132	464.00
IUUC-Ete-032680	Echinops telfairi	72.25	1.00e-161	562.00
IUUC-Eca-033811	Equus caballus	98.50	0.00e+00	827.00
IUUC-Eeu-034637	Erinaceus europaeus	85.50	0.00e+00	704.00
IUUC-Fca-036536	Felis catus	98.50	0.00e+00	693.00
IUUC-Fal-037221	Ficedula albicollis	93.80	0.00e+00	713.00
IUUC-Gmo-039257	Gadus morhua	80.25	0.00e+00	703.00
IUUC-Gga-040902	Gallus gallus	92.75	0.00e+00	788.00
IUUC-Gac-042268	Gasterosteus aculeatus	78.50	0.00e+00	687.00
IUUC-Ggo-044590	Gorilla gorilla	98.50	0.00e+00	828.00
IUUC-Hsa-045692	Homo sapiens	98.25	0.00e+00	828.00
IUUC-Itr-049053	Ictidomys tridecemlineatus	99.00	0.00e+00	830.00
IUUC-Loc-052370	Lepisosteus oculatus	84.46	0.00e+00	743.00
IUUC-Laf-054594	Loxodonta africana	97.75	0.00e+00	820.00
IUUC-Mcc-055882	Macaca mulatta	98.43	0.00e+00	661.00
IUUC-Meu-056323	Macropus eugenii	92.58	0.00e+00	768.00
IUUC-Mga-060043	Meleagris gallopavo	93.24	0.00e+00	704.00
IUUC-Mmr-060574	Microcebus murinus	98.75	0.00e+00	662.00
IUUC-Mdo-062455	Monodelphis domestica	93.00	0.00e+00	788.00
IUUC-Mpu-066482	Mustela putorius furo	97.56	0.00e+00	670.00
IUUC-Mlu-067061	Myotis lucifugus	92.52	2.00e-164	571.00
IUUC-Nle-069796	Nomascus leucogenys	98.50	0.00e+00	829.00
IUUC-Opr-071092	Ochotona princeps	98.25	0.00e+00	822.00
IUUC-Ont-072372	Oreochromis niloticus	82.50	0.00e+00	716.00
IUUC-Oan-073463	Ornithorhynchus anatinus	91.32	0.00e+00	654.00
IUUC-Ocu-074804	Oryctolagus cuniculus	99.00	0.00e+00	831.00
IUUC-Oga-088615	Otolemur garnettii	89.12	2.00e-175	608.00
IUUC-Oar-089827	Ovis aries	97.23	0.00e+00	809.00
IUUC-Ptr-091426	Pan troglodytes	98.75	0.00e+00	829.00
IUUC-Pan-092239	Papio anubis	98.65	4.00e-178	616.00
IUUC-Psi-093305	Pelodiscus sinensis	92.91	0.00e+00	753.00
IUUC-Pfo-096834	Poecilia formosa	81.00	0.00e+00	709.00
IUUC-Pab-098398	Pongo abelii	98.75	0.00e+00	829.00
IUUC-Pca-100650	Procavia capensis	72.00	2.00e-163	568.00
IUUC-Pva-102773	Pteropus vampyrus	98.50	0.00e+00	827.00
IUUC-Rno-104983	Rattus norvegicus	99.50	0.00e+00	832.00
IUUC-Sha-107407	Sarcophilus harrisii	94.00	0.00e+00	795.00
IUUC-Sar-113400	Sorex araneus	76.60	1.00e-114	405.00
IUUC-Tgu-116478	Taeniopygia guttata	93.00	0.00e+00	788.00
IUUC-Tru-118438	Takifugu rubripes	81.25	0.00e+00	711.00
IUUC-Tsy-119319	Tarsius syrichta	97.00	0.00e+00	812.00
IUUC-Tni-120051	Tetraodon nigroviridis	79.50	0.00e+00	697.00
IUUC-Ttr-129137	Tursiops truncatus	92.25	0.00e+00	765.00
IUUC-Vpa-130398	Vicugna pacos	85.51	2.00e-175	608.00
IUUC-Xtr-132445	Xenopus tropicalis	86.00	0.00e+00	751.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence