iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
TRANSFAC	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	7.80e-11	42.6	30	129

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmelees.................................ksklmveikdvqpevfral 56
           +Dv+l+ g+++f+ah++vLaasS++F+  +l   +                                    +    e+ +v + +f+++
   Q: 30   CDVTLIAGDTKFPAHRSVLAASSPFFREALLASAPLPlppvtggsapspatttaasssssppppasphssSPPRVLELPGVPAAAFSDV 118
           9*****************************998885569*****************************976566778889********* PP
   S: 57   lkFlYtgklde 67
           l+F+Y+ +l +
   Q: 119  LNFIYSARLAL 129
           ******99975 PP

Organism

Rattus norvegicus

Functional Description
(View)

Transcriptional repressor with bimodal DNA-binding specificity. Represses transcription in a methyl-CpG-dependent manner. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3' also known as the consensus kaiso binding site (KBS). Can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA.

Protein Sequence
(Fasta)

MPPPAEVTDP SHAPAVLRQL NEQRLRGLFC DVTLIAGDTK FPAHRSVLAA SSPFFREALL 60
ASAPLPLPPV TGGSAPSPAT TTAASSSSSP PPPASPHSSS PPRVLELPGV PAAAFSDVLN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGGAAAAGGC CAGACTGGAG GGACTTGCTG AGCCACTACA CTGCTCCATG TTGGCTATGC 60
TCTCAGGTGA GAAAGTGTGG GGAAGACAGC AAAGGCAGCT ACCTTGTTCA CCCCCTGACC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0158--Chromosome
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000210--BTB/POZ_dom
IPR000877--Prot_inh_BBI
IPR011333--SKP1/BTB/POZ
IPR013087--Znf_C2H2_type
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50097--BTB
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2

Pfam

PF00651--BTB

SMART

SM00225--BTB
SM00355--ZnF_C2H2

Gene Ontology

GO:0005694--C:chromosome
GO:0005829--C:cytosol
GO:0016604--C:nuclear body
GO:0046872--F:metal ion binding
GO:0008327--F:methyl-CpG binding
GO:0010428--F:methyl-CpNpG binding
GO:0000977--F:RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001227--F:transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0006351--P:transcription, DNA-templated

KEGG

rno:287441

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aca-004385	Anolis carolinensis	42.16	1.00e-167	583.00
IUUC-Bta-012689	Bos taurus	79.70	0.00e+00	974.00
IUUC-Cja-019922	Callithrix jacchus	77.33	0.00e+00	817.00
IUUC-Cfa-020348	Canis familiaris	81.61	0.00e+00	949.00
IUUC-Cpo-021824	Cavia porcellus	77.86	0.00e+00	1003.00
IUUC-Csa-024023	Chlorocebus sabaeus	81.03	0.00e+00	902.00
IUUC-Dno-029721	Dasypus novemcinctus	80.78	0.00e+00	981.00
IUUC-Dor-030987	Dipodomys ordii	84.37	2.00e-165	576.00
IUUC-Ete-032788	Echinops telfairi	79.97	4.00e-174	604.00
IUUC-Eca-034199	Equus caballus	84.40	0.00e+00	910.00
IUUC-Eeu-034887	Erinaceus europaeus	79.86	2.00e-118	420.00
IUUC-Fca-036123	Felis catus	89.53	8.00e-163	567.00
IUUC-Ggo-044792	Gorilla gorilla	82.94	0.00e+00	931.00
IUUC-Hsa-045806	Homo sapiens	82.17	0.00e+00	928.00
IUUC-Itr-048293	Ictidomys tridecemlineatus	84.98	0.00e+00	1051.00
IUUC-Lch-049633	Latimeria chalumnae	39.42	4.00e-151	528.00
IUUC-Laf-053666	Loxodonta africana	79.80	0.00e+00	972.00
IUUC-Mcc-055380	Macaca mulatta	82.27	0.00e+00	902.00
IUUC-Meu-056434	Macropus eugenii	63.49	0.00e+00	706.00
IUUC-Mdo-062151	Monodelphis domestica	70.71	6.00e-107	381.00
IUUC-Mmu-064025	Mus musculus	93.82	0.00e+00	1162.00
IUUC-Mpu-065808	Mustela putorius furo	81.69	0.00e+00	968.00
IUUC-Mlu-068025	Myotis lucifugus	82.15	0.00e+00	1037.00
IUUC-Opr-070749	Ochotona princeps	75.95	0.00e+00	808.00
IUUC-Ocu-074809	Oryctolagus cuniculus	81.15	0.00e+00	972.00
IUUC-Oga-088975	Otolemur garnettii	80.99	0.00e+00	1008.00
IUUC-Oar-090000	Ovis aries	80.42	1.00e-137	483.00
IUUC-Ptr-090835	Pan troglodytes	80.70	0.00e+00	907.00
IUUC-Pan-092409	Papio anubis	82.15	0.00e+00	906.00
IUUC-Pab-097964	Pongo abelii	80.81	0.00e+00	873.00
IUUC-Pca-100651	Procavia capensis	74.75	0.00e+00	893.00
IUUC-Pva-102379	Pteropus vampyrus	78.03	0.00e+00	911.00
IUUC-Sha-106756	Sarcophilus harrisii	62.65	0.00e+00	770.00
IUUC-Sar-113009	Sorex araneus	79.17	0.00e+00	874.00
IUUC-Ssc-115587	Sus scrofa	81.39	0.00e+00	945.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence