iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
TRANSFAC
Protein-protein Interaction
IID
Protein Expression/Proteomics

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box	F-box	19074476

Reviewed

Classification

Family	Identity	E-value	Score	Source Orthology
E3 adaptor/Cullin RING/SCF/F-box	95.49	0.00e+00	702.00	IUUC-Hsa-046173

Organism

Rattus norvegicus

Functional Description
(View)

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1 (By similarity).

Protein Sequence
(Fasta)

MPFLGQDWRS PGQSWVKTAD GWKRFLDEKS GTFVSDLSSY CNKENLFNSL NYDVAAKKRK 60
KDIQNSKTKT QYFHQEKWIY VHKGSTKERH GYCTLGEAFN RLDFSTAILD SRRFNYVVRL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCCTGATCCC CTGCCAGTGC AAGGACCCTC GCGCCCACCC AGGACCCGCA ACCCTCCACA 60
TCAGTTCCCC GACTCTTGTT CCAGTTGCCG CCTGCGTTCC CTAGCGTCTT CCCAGAGCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR001810--F-box_dom

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0000151--C:ubiquitin ligase complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0014889--P:muscle atrophy
GO:0010614--P:negative regulation of cardiac muscle hypertrophy
GO:0010666--P:positive regulation of cardiac muscle cell apoptotic process
GO:0016567--P:protein ubiquitination
GO:0014894--P:response to denervation involved in regulation of muscle adaptation
GO:0014878--P:response to electrical stimulus involved in regulation of muscle adaptation
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

rno:171043

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001986	Ailuropoda melanoleuca	94.93	0.00e+00	701.00
IUUC-Apl-003973	Anas platyrhynchos	89.34	3.00e-172	597.00
IUUC-Aca-004945	Anolis carolinensis	86.48	0.00e+00	630.00
IUUC-Aor-009979	Aspergillus oryzae	46.15	1.30e+00	28.50
IUUC-Ame-011383	Astyanax mexicanus	73.52	1.00e-158	551.00
IUUC-Bta-013522	Bos taurus	94.37	0.00e+00	697.00
IUUC-Bci-013735	Botrytis cinerea	27.94	1.70e+00	28.50
IUUC-Bdi-014435	Brachypodium distachyon	37.50	2.00e-04	39.70
IUUC-Bol-015763	Brassica oleracea	28.81	4.20e-02	31.60
IUUC-Cja-019893	Callithrix jacchus	95.49	0.00e+00	703.00
IUUC-Cfa-021053	Canis familiaris	94.65	0.00e+00	697.00
IUUC-Cpo-021330	Cavia porcellus	94.93	0.00e+00	697.00
IUUC-Csa-023160	Chlorocebus sabaeus	95.77	0.00e+00	704.00
IUUC-Cho-024993	Choloepus hoffmanni	74.66	7.00e-123	433.00
IUUC-Cin-025462	Ciona intestinalis	29.91	2.00e-25	108.00
IUUC-Csv-025908	Ciona savignyi	29.33	7.00e-41	160.00
IUUC-Dre-028707	Danio rerio	74.72	7.00e-158	549.00
IUUC-Dno-029334	Dasypus novemcinctus	94.08	0.00e+00	696.00
IUUC-Dor-030350	Dipodomys ordii	94.72	0.00e+00	659.00
IUUC-Dme-031699	Drosophila melanogaster	27.73	1.00e-31	130.00
IUUC-Ete-033123	Echinops telfairi	75.32	7.00e-128	449.00
IUUC-Eca-033246	Equus caballus	95.21	0.00e+00	699.00
IUUC-Eeu-035339	Erinaceus europaeus	95.24	5.00e-130	457.00
IUUC-Fca-035805	Felis catus	95.16	0.00e+00	692.00
IUUC-Fal-037424	Ficedula albicollis	89.30	0.00e+00	669.00
IUUC-Gga-040478	Gallus gallus	90.14	0.00e+00	671.00
IUUC-Gac-042238	Gasterosteus aculeatus	73.41	5.00e-156	543.00
IUUC-Ggo-045515	Gorilla gorilla	95.77	0.00e+00	704.00
IUUC-Hsa-046173	Homo sapiens	95.49	0.00e+00	702.00
IUUC-Itr-048038	Ictidomys tridecemlineatus	95.21	0.00e+00	700.00
IUUC-Lch-049820	Latimeria chalumnae	79.94	9.00e-172	595.00
IUUC-Loc-051732	Lepisosteus oculatus	76.90	7.00e-165	572.00
IUUC-Laf-053789	Loxodonta africana	93.56	0.00e+00	667.00
IUUC-Mcc-055119	Macaca mulatta	95.77	0.00e+00	704.00
IUUC-Meu-056262	Macropus eugenii	78.80	9.00e-94	336.00
IUUC-Mga-059869	Meleagris gallopavo	82.58	2.00e-170	591.00
IUUC-Mmr-061443	Microcebus murinus	95.77	0.00e+00	704.00
IUUC-Mdo-062355	Monodelphis domestica	92.68	0.00e+00	688.00
IUUC-Mmu-064306	Mus musculus	98.03	0.00e+00	717.00
IUUC-Mpu-066902	Mustela putorius furo	95.09	2.00e-177	614.00
IUUC-Mlu-067076	Myotis lucifugus	94.08	0.00e+00	689.00
IUUC-Nle-069716	Nomascus leucogenys	95.77	0.00e+00	704.00
IUUC-Ont-072007	Oreochromis niloticus	73.46	1.00e-154	539.00
IUUC-Oan-073321	Ornithorhynchus anatinus	92.81	7.00e-157	546.00
IUUC-Ocu-074320	Oryctolagus cuniculus	95.49	0.00e+00	674.00
IUUC-Obr-076772	Oryza brachyantha	39.13	2.00e-03	33.90
IUUC-Ogu-078178	Oryza glumaepatula	29.73	1.00e-02	34.30
IUUC-Oin-079543	Oryza indica	29.73	1.10e-02	33.90
IUUC-Oni-082751	Oryza nivara	29.73	1.10e-02	33.90
IUUC-Oru-084545	Oryza rufipogon	29.73	1.10e-02	33.90
IUUC-Osa-085485	Oryza sativa	29.73	1.10e-02	33.90
IUUC-Ola-087193	Oryzias latipes	72.63	2.00e-156	544.00
IUUC-Oga-088558	Otolemur garnettii	95.21	0.00e+00	702.00
IUUC-Oar-090092	Ovis aries	94.08	0.00e+00	696.00
IUUC-Ptr-091443	Pan troglodytes	95.21	0.00e+00	698.00
IUUC-Pan-092207	Papio anubis	95.77	0.00e+00	704.00
IUUC-Psi-093282	Pelodiscus sinensis	87.99	0.00e+00	657.00
IUUC-Pma-094448	Petromyzon marinus	65.83	2.00e-141	495.00
IUUC-Ppa-096011	Physcomitrella patens	27.85	3.50e-02	32.30
IUUC-Pfo-096873	Poecilia formosa	73.67	2.00e-158	551.00
IUUC-Pca-101124	Procavia capensis	92.96	0.00e+00	681.00
IUUC-Pva-102791	Pteropus vampyrus	94.65	0.00e+00	696.00
IUUC-Sha-106684	Sarcophilus harrisii	93.24	0.00e+00	690.00
IUUC-Smo-109491	Selaginella moellendorffii	20.88	2.50e-02	33.50
IUUC-Sar-113077	Sorex araneus	86.73	2.00e-157	548.00
IUUC-Ssc-115993	Sus scrofa	92.11	0.00e+00	669.00
IUUC-Tgu-117376	Taeniopygia guttata	88.71	1.00e-171	595.00
IUUC-Tru-118690	Takifugu rubripes	72.63	1.00e-156	545.00
IUUC-Tni-120740	Tetraodon nigroviridis	72.47	2.00e-156	545.00
IUUC-Tae-124742	Triticum aestivum	32.58	9.00e-05	40.00
IUUC-Tbe-127713	Tupaia belangeri	86.41	3.00e-155	540.00
IUUC-Ttr-128339	Tursiops truncatus	95.49	0.00e+00	703.00
IUUC-Vpa-130070	Vicugna pacos	94.20	3.00e-78	285.00
IUUC-Xtr-132470	Xenopus tropicalis	82.77	6.00e-179	619.00
IUUC-Xma-133649	Xiphophorus maculatus	72.63	9.00e-158	549.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence