iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
miRTarBase	microRNA	TRANSFAC	RepTar
RAID2
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/Josephin	6.60e-100	333.4	1	201

Active Site

Position(s)	Description	Evidence
36	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU00331}
139	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU00331}

Domain Profile

DUB/Josephin

   S: 1    msqvpg............aqaapesiyhekqrrelCalhalnnvlqd.elfsreeldeiakrldeeerlqPs.kslldtGnydvnvisa 75
           ms+vp+            +qaap++iyhekqrrelCalhalnnv+qd ++f+re+l+ei++rl+++++++P+ ks+l++Gnydvnvi+a
   Q: 1    MSCVPWkgdkakaessdlPQAAPPQIYHEKQRRELCALHALNNVFQDsNAFTRETLQEIFQRLSPNTMVTPHkKSMLGNGNYDVNVIMA 89
           8**********************************************9************************99*************** PP
   S: 76   alkvlGleavwfdkrrelqklaldnvlgfilnlpsslslgllklplkkqhWvtvrkvgkayynldsklkaPeligdetelrkflakllq 164
           al+++G+eavw+dkrr+++++al+nv+gfi+nlpssl++g+lklplk+qhW++vr+vg+ayynldsklk+Pe+ig+e+elrkfl+ +l+
   Q: 90   ALQTKGYEAVWWDKRRDVGVIALTNVMGFIMNLPSSLCWGPLKLPLKRQHWICVREVGGAYYNLDSKLKMPEWIGGESELRKFLKYHLR 178
           ***************************************************************************************** PP
   S: 165  qkyselllvvkeevedkesdqrld 188
           +k++elllvv+eeve+++s+ r d
   Q: 179  GKNCELLLVVPEEVEAHQSW-RAD 201
           ********************.665 PP

Organism

Mus musculus

Functional Description
(View)

Deubiquitinates monoubiquitinated probes (in vitro). When ubiquitinated, cleaves 'Lys-63'-linked and 'Lys-48'-linked poly-ubiquitin chains (in vitro), hence may act as a deubiquitinating enzyme. May increase macropinocytosis and suppress clathrin- and caveolae-mediated endocytosis. May enhance membrane dynamics and cell motility independently of its catalytic activity (By similarity).

Protein Sequence
(Fasta)

MSCVPWKGDK AKAESSDLPQ AAPPQIYHEK QRRELCALHA LNNVFQDSNA FTRETLQEIF 60
QRLSPNTMVT PHKKSMLGNG NYDVNVIMAA LQTKGYEAVW WDKRRDVGVI ALTNVMGFIM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGAGTGAACG CCGCTGACGT CGGGCTCAGG TGCGCGTGCC CGCCCGCTCC GCCGCCTGCT 60
TGTCCGCGCG TGGGCCAGGT GGCGGCCCGC AAGCTCCAGG TGGCGGCGTC GGGGAGACGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0378--Hydrolase
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway

Interpro

IPR006155--Josephin

PROSITE

PS50957--JOSEPHIN

Pfam

PF02099--Josephin

SMART

SM01246--Josephin

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005886--C:plasma membrane
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination

KEGG

mmu:100043771; mmu:74158

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002429	Ailuropoda melanoleuca	96.53	4.00e-109	386.00
IUUC-Apl-003240	Anas platyrhynchos	89.16	4.00e-96	343.00
IUUC-Aca-004262	Anolis carolinensis	89.60	2.00e-102	364.00
IUUC-Afl-008651	Aspergillus flavus	31.88	1.20e-01	28.90
IUUC-Ame-011040	Astyanax mexicanus	69.59	1.00e-80	292.00
IUUC-Bta-012440	Bos taurus	96.53	1.00e-109	388.00
IUUC-Cja-019461	Callithrix jacchus	96.04	8.00e-109	385.00
IUUC-Cfa-021002	Canis familiaris	96.53	4.00e-109	386.00
IUUC-Cpo-021309	Cavia porcellus	97.52	2.00e-110	391.00
IUUC-Csa-023194	Chlorocebus sabaeus	96.53	8.00e-110	389.00
IUUC-Cho-025019	Choloepus hoffmanni	95.54	5.00e-109	386.00
IUUC-Cin-025666	Ciona intestinalis	60.37	2.00e-54	205.00
IUUC-Csv-026011	Ciona savignyi	57.00	1.00e-58	219.00
IUUC-Dre-028692	Danio rerio	68.98	9.00e-80	289.00
IUUC-Dno-029803	Dasypus novemcinctus	95.54	9.00e-109	385.00
IUUC-Dor-030619	Dipodomys ordii	99.29	3.00e-73	267.00
IUUC-Ete-032777	Echinops telfairi	95.19	8.00e-106	375.00
IUUC-Eca-034395	Equus caballus	95.05	2.00e-108	384.00
IUUC-Eeu-035075	Erinaceus europaeus	74.26	2.00e-76	278.00
IUUC-Fca-035819	Felis catus	97.03	4.00e-110	390.00
IUUC-Fal-037330	Ficedula albicollis	91.09	1.00e-99	355.00
IUUC-Gmo-038979	Gadus morhua	79.77	2.00e-75	275.00
IUUC-Gga-040456	Gallus gallus	93.60	8.00e-100	355.00
IUUC-Gac-041797	Gasterosteus aculeatus	73.63	9.00e-81	292.00
IUUC-Ggo-045586	Gorilla gorilla	97.03	3.00e-110	390.00
IUUC-Hsa-047008	Homo sapiens	97.03	3.00e-110	390.00
IUUC-Itr-048432	Ictidomys tridecemlineatus	97.03	5.00e-110	389.00
IUUC-Lch-049682	Latimeria chalumnae	78.71	7.00e-85	306.00
IUUC-Loc-051775	Lepisosteus oculatus	80.23	9.00e-77	279.00
IUUC-Laf-054283	Loxodonta africana	96.08	5.00e-108	382.00
IUUC-Mcc-055073	Macaca mulatta	96.88	2.00e-111	394.00
IUUC-Meu-056650	Macropus eugenii	92.08	6.00e-104	369.00
IUUC-Mga-059703	Meleagris gallopavo	93.56	4.00e-101	360.00
IUUC-Mdo-062114	Monodelphis domestica	93.07	8.00e-106	375.00
IUUC-Mpu-065845	Mustela putorius furo	96.04	9.00e-109	385.00
IUUC-Mlu-067564	Myotis lucifugus	93.07	4.00e-99	353.00
IUUC-Nfi-068472	Neosartorya fischeri	30.00	2.00e-01	29.30
IUUC-Nle-069516	Nomascus leucogenys	96.53	1.00e-109	388.00
IUUC-Opr-070945	Ochotona princeps	79.70	7.00e-85	306.00
IUUC-Ont-071439	Oreochromis niloticus	69.59	7.00e-78	283.00
IUUC-Oan-073122	Ornithorhynchus anatinus	90.91	1.00e-68	251.00
IUUC-Ocu-074128	Oryctolagus cuniculus	85.12	3.00e-55	206.00
IUUC-Ola-086972	Oryzias latipes	66.99	2.00e-70	258.00
IUUC-Oga-088786	Otolemur garnettii	96.04	5.00e-116	409.00
IUUC-Oar-089212	Ovis aries	96.06	3.00e-108	384.00
IUUC-Ptr-090936	Pan troglodytes	97.03	3.00e-110	390.00
IUUC-Pan-092234	Papio anubis	97.03	3.00e-110	390.00
IUUC-Psi-093448	Pelodiscus sinensis	93.07	1.00e-104	372.00
IUUC-Pfo-096711	Poecilia formosa	81.25	2.00e-78	285.00
IUUC-Pab-097628	Pongo abelii	96.53	2.00e-108	384.00
IUUC-Pop-099793	Populus trichocarpa	36.14	4.00e-23	100.00
IUUC-Pca-100555	Procavia capensis	94.90	3.00e-85	306.00
IUUC-Pva-102259	Pteropus vampyrus	96.53	2.00e-109	388.00
IUUC-Rno-105045	Rattus norvegicus	97.03	3.00e-110	390.00
IUUC-Sha-107606	Sarcophilus harrisii	93.56	2.00e-106	377.00
IUUC-Ssc-115663	Sus scrofa	97.52	2.00e-110	391.00
IUUC-Tgu-117374	Taeniopygia guttata	90.59	1.00e-101	361.00
IUUC-Tru-118030	Takifugu rubripes	80.11	8.00e-77	279.00
IUUC-Tsy-119298	Tarsius syrichta	96.04	2.00e-108	384.00
IUUC-Tni-119797	Tetraodon nigroviridis	79.55	1.00e-76	278.00
IUUC-Tca-121220	Theobroma cacao	38.64	3.00e-29	122.00
IUUC-Tbe-127896	Tupaia belangeri	97.52	1.00e-110	391.00
IUUC-Ttr-128523	Tursiops truncatus	96.04	1.00e-108	384.00
IUUC-Vpa-130184	Vicugna pacos	93.56	2.00e-111	394.00
IUUC-Xtr-131903	Xenopus tropicalis	84.16	8.00e-94	335.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence