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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063997
Ensembl Protein ID ENSMUSP00000085985.5
UniProt Accession Q9QXL2; Q6P5H1; Q6ZPJ8; Q8BWZ9; Q8BXF1; KI21A_MOUSE
Genbank Protein ID AAF17083.1; AAH60698.1; AAH62896.1; BAC98236.1; BAC33669.1; BAC33031.1
Protein Name Kinesin-like protein KIF21A
Genbank Nucleotide ID AF202892; BC060698; BC062896; AK129426; AK049303; AK047350
Gene Name Kif21a; Kiaa1708
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000022629.16 ENSMUST00000088614.11 ENSMUSP00000085985.5
ENSMUSG00000022629.16 ENSMUST00000100304.10 ENSMUSP00000097877.4
ENSMUSG00000022629.16 ENSMUST00000067205.14 ENSMUSP00000066911.8
ENSMUSG00000022629.16 ENSMUST00000109288.8 ENSMUSP00000104911.2
ENSMUSG00000022629.16 ENSMUST00000109287.2 ENSMUSP00000104910.2
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarRAID2
Protein-protein Interaction
IIDMentha
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMPhospho.ELM
UniProtPHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 6.80e-29 99.8 1343 1377
UBD/Beta-Prp 1.80e-41 143.4 1447 1660
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclafsdtllvsGsdDgtikvWDlrtgvl 35
           gHt  v c++ +d+ll +Gs D t+kvW+l tg  
   Q: 1343 GHTKAVLCVDSTDDLLFTGSKDRTCKVWNLVTGQE 1377
           899*****99767*****************99976 PP
   

   UBD/Beta-Prp
   S: 50   gheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfsp..sg.dklvsGshdrtirvwdletgqclee.. 131
           + e++++++ ++p+g +++ +++ ++++ wdl+ ++ + +l+gh   v++l++++  +g d +++Gs+d +i+++d+ +g       
   Q: 1447 SGESQINQIALNPTG-TFLYAASGNAVRMWDLKRFQSTGKLTGHLGPVMCLTVDQisNGqDLIITGSKDHYIKMFDVTEGALGTVsp 1532
           45678*********9.999*************************************9888*****************9998765466 PP
   S: 132  ...tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecv 215
              ++ +h + +  +++++  + l+sGs D+ ++ Wdl+++ ll++   +h+d v  l + +  + l+sg + g +klw++ t   v
   Q: 1533 thnFEPPHYDGIEALAIQG--DNLFSGSRDNGIKKWDLAQKGLLQQVPNAHKDWVCALGLVPGHPVLLSGCRGGILKLWNVDTFVPV 1617
           7889999999999999999..7799**********************999************************************* PP
   S: 216  rtlnghtdnvksvrfspnderlvsgssDgsiriW...dlrsgdll 257
            +++gh+++++ + +   ++++ ++++D+++riW   +l+ g+l 
   Q: 1618 GEMRGHDSPINAICVN--STHVFTAADDRTVRIWkahNLQDGQLS 1660
           ***********99888..****************99999999876 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Microtubule-binding motor protein probably involved in neuronal axonal transport. In vitro, has a plus-end directed motor activity.
 Microtubule-binding motor protein probably involved in neuronal axonal transport. In vitro, has a plus-end directed motor activity.
Protein Sequence
(Fasta)
MLGAADESSV RVAVRIRPQL AKEKIEGCHI CTSVTPGEPQ VFLGKDKAFT FDYVFDIDSQ 60
QEQIYTQCIE KLIEGCFEGY NATVFAYGQT GAGKTYTMGT GFDVNIMEEE QGIISRAVRH 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063997|E3,WD_repeat;UBD,Beta-Prp|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGACCGGCCA CGGCTGACGC AGGGCAGCGC GGAGCCTGGC GAGTGGGGGC AAGGGGCGGC 60
GCCGCCCTGA GTCACCGCCC CCTCCCGCGC CTCCGCGCCG CCACCTTTCC ATTCAGTCGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063997|E3,WD_repeat;UBD,Beta-Prp|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0966--Cell projection
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0493--Microtubule
KW-0505--Motor protein
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR019821--Kinesin_motor_CS
IPR001752--Kinesin_motor_dom
IPR027417--P-loop_NTPase
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00411--KINESIN_MOTOR_1
PS50067--KINESIN_MOTOR_2
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00225--Kinesin
PF00400--WD40
PRINTS

PR00380--KINESINHEAVY
SMART

SM00129--KISc
SM00320--WD40
Gene Ontology

GO:0030424--C:axon
GO:0005737--C:cytoplasm
GO:0030425--C:dendrite
GO:0005871--C:kinesin complex
GO:0005874--C:microtubule
GO:0005524--F:ATP binding
GO:0016887--F:ATPase activity
GO:0003777--F:microtubule motor activity
GO:0007018--P:microtubule-based movement
KEGG mmu:16564
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001391 Ailuropoda melanoleuca 93.01 0.00e+00 2963.00
IUUC-Apl-003353 Anas platyrhynchos 83.59 0.00e+00 2594.00
IUUC-Aca-004467 Anolis carolinensis 82.87 0.00e+00 2685.00
IUUC-Ame-011430 Astyanax mexicanus 65.93 0.00e+00 1276.00
IUUC-Bta-013485 Bos taurus 91.92 0.00e+00 2848.00
IUUC-Cja-019385 Callithrix jacchus 91.01 0.00e+00 2862.00
IUUC-Cfa-020986 Canis familiaris 92.19 0.00e+00 2914.00
IUUC-Cpo-022297 Cavia porcellus 91.03 0.00e+00 2814.00
IUUC-Csa-023685 Chlorocebus sabaeus 92.49 0.00e+00 2915.00
IUUC-Cho-024531 Choloepus hoffmanni 89.76 0.00e+00 1070.00
IUUC-Cin-025160 Ciona intestinalis 48.29 6.00e-88 318.00
IUUC-Dno-029972 Dasypus novemcinctus 89.15 0.00e+00 2706.00
IUUC-Ete-032872 Echinops telfairi 76.88 0.00e+00 1003.00
IUUC-Eca-033518 Equus caballus 93.09 0.00e+00 2917.00
IUUC-Fca-036197 Felis catus 92.17 0.00e+00 2911.00
IUUC-Fal-037534 Ficedula albicollis 83.05 0.00e+00 2618.00
IUUC-Gga-040687 Gallus gallus 82.43 0.00e+00 2560.00
IUUC-Gac-041626 Gasterosteus aculeatus 67.39 0.00e+00 2160.00
IUUC-Ggo-044457 Gorilla gorilla 92.68 0.00e+00 2897.00
IUUC-Hsa-046372 Homo sapiens 93.02 0.00e+00 2928.00
IUUC-Lch-049786 Latimeria chalumnae 59.54 0.00e+00 1858.00
IUUC-Loc-052689 Lepisosteus oculatus 73.82 0.00e+00 2334.00
IUUC-Laf-054018 Loxodonta africana 88.02 0.00e+00 2695.00
IUUC-Mcc-055558 Macaca mulatta 93.02 0.00e+00 2930.00
IUUC-Meu-056080 Macropus eugenii 87.43 0.00e+00 966.00
IUUC-Mga-059283 Meleagris gallopavo 81.73 0.00e+00 2515.00
IUUC-Mmr-060773 Microcebus murinus 91.81 0.00e+00 2846.00
IUUC-Mdo-062688 Monodelphis domestica 87.69 0.00e+00 2547.00
IUUC-Mpu-066354 Mustela putorius furo 91.41 0.00e+00 2907.00
IUUC-Mlu-067599 Myotis lucifugus 91.91 0.00e+00 2870.00
IUUC-Nle-069477 Nomascus leucogenys 93.14 0.00e+00 2933.00
IUUC-Opr-070188 Ochotona princeps 83.83 0.00e+00 1606.00
IUUC-Ont-071938 Oreochromis niloticus 66.38 0.00e+00 1316.00
IUUC-Oan-073055 Ornithorhynchus anatinus 86.58 0.00e+00 2586.00
IUUC-Ocu-074302 Oryctolagus cuniculus 89.95 0.00e+00 2874.00
IUUC-Ola-086604 Oryzias latipes 64.84 0.00e+00 1271.00
IUUC-Oga-088799 Otolemur garnettii 92.01 0.00e+00 2597.00
IUUC-Oar-089629 Ovis aries 90.69 0.00e+00 2834.00
IUUC-Pan-092214 Papio anubis 91.41 0.00e+00 2904.00
IUUC-Psi-093757 Pelodiscus sinensis 81.16 0.00e+00 2485.00
IUUC-Pfo-096978 Poecilia formosa 65.48 0.00e+00 1316.00
IUUC-Pab-097984 Pongo abelii 93.26 0.00e+00 2902.00
IUUC-Pca-101061 Procavia capensis 75.98 0.00e+00 1679.00
IUUC-Pva-102306 Pteropus vampyrus 90.15 0.00e+00 2812.00
IUUC-Rno-105354 Rattus norvegicus 95.90 0.00e+00 2913.00
IUUC-Sha-106938 Sarcophilus harrisii 85.55 0.00e+00 2702.00
IUUC-Ssc-115810 Sus scrofa 91.60 0.00e+00 2850.00
IUUC-Tgu-117076 Taeniopygia guttata 80.79 0.00e+00 2477.00
IUUC-Tru-118091 Takifugu rubripes 64.85 0.00e+00 1256.00
IUUC-Tsy-119020 Tarsius syrichta 91.33 0.00e+00 2877.00
IUUC-Tni-120813 Tetraodon nigroviridis 68.27 0.00e+00 2133.00
IUUC-Tbe-127494 Tupaia belangeri 78.50 0.00e+00 981.00
IUUC-Ttr-128393 Tursiops truncatus 84.78 0.00e+00 2630.00
IUUC-Vpa-130675 Vicugna pacos 79.88 0.00e+00 745.00
IUUC-Xtr-132829 Xenopus tropicalis 77.95 0.00e+00 2489.00
Created Date 25-Jun-2017

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