iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ptr-091258

Ensembl Protein ID

ENSPTRP00000024020.6

UniProt Accession

H2QL37; H2QL37_PANTR

Genbank Protein ID

JAA05950.1; JAA18718.1; JAA32701.1; JAA44702.1

Protein Name

Salt-inducible kinase 1

Genbank Nucleotide ID

BS000236; GABF01003427; GABD01000399; GABE01000037

Gene Name

SIK1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000013954.6	ENSPTRT00000026037.6	ENSPTRP00000024020.6

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/Alpha-Helix/UBA	99.62	0.00e+00	1370.00	IUUC-Hsa-046775

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Pan troglodytes

Protein Sequence
(Fasta)

MVIMSEFSAD PAGQGQGQQK PLRVGFYDIE RTLGKGNFAV VKLARHRVTK TQVAIKIIDK 60
TRLDSSNLEK IYREVQLMKL LNHPHIIKLY QVMETKDMLY IVTEFAKNGE MFDYLTSNGH 120

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Nucleotide Sequence
(Fasta)

ATGCGGCGCG GCCCCGGAGG CAGCAGCAGC GGCGGCCGCA GCCGGAGCAG TAGGCACCCG 60
AGCAGCGCCA GCGGCCGAGC GGGCGGCTTC CTGGCCTGGG CGCTCCGGGG GCGGCGGAGG 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0418--Kinase
KW-1185--Reference proteome
KW-0808--Transferase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR008271--Ser/Thr_kinase_AS
IPR017090--Ser/Thr_kinase_SIK1/2
IPR034672--SIK
IPR015940--UBA

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
PS50030--UBA

Pfam

PF00069--Pkinase

SMART

SM00220--S_TKc

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0005524--F:ATP binding
GO:0000287--F:magnesium ion binding
GO:0004674--F:protein serine/threonine kinase activity
GO:0043276--P:anoikis
GO:0055007--P:cardiac muscle cell differentiation
GO:0032870--P:cellular response to hormone stimulus
GO:0043153--P:entrainment of circadian clock by photoperiod
GO:0035556--P:intracellular signal transduction
GO:0032792--P:negative regulation of CREB transcription factor activity
GO:0045721--P:negative regulation of gluconeogenesis
GO:0010868--P:negative regulation of triglyceride biosynthetic process
GO:0006468--P:protein phosphorylation
GO:0007346--P:regulation of mitotic cell cycle
GO:0010830--P:regulation of myotube differentiation

KEGG

ptr:474029

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001538	Ailuropoda melanoleuca	46.80	3.00e-125	442.00
IUUC-Aca-004739	Anolis carolinensis	65.38	0.00e+00	927.00
IUUC-Ame-011603	Astyanax mexicanus	66.17	0.00e+00	768.00
IUUC-Cja-019873	Callithrix jacchus	93.27	0.00e+00	1325.00
IUUC-Cfa-020801	Canis familiaris	74.18	0.00e+00	983.00
IUUC-Cpo-022296	Cavia porcellus	78.14	0.00e+00	1006.00
IUUC-Csa-023676	Chlorocebus sabaeus	95.54	0.00e+00	1317.00
IUUC-Cho-025021	Choloepus hoffmanni	76.80	3.00e-159	555.00
IUUC-Cin-025762	Ciona intestinalis	61.90	7.00e-125	441.00
IUUC-Dre-028021	Danio rerio	64.45	0.00e+00	749.00
IUUC-Dno-029103	Dasypus novemcinctus	76.52	0.00e+00	800.00
IUUC-Dme-031957	Drosophila melanogaster	63.80	2.00e-130	460.00
IUUC-Ete-033190	Echinops telfairi	83.79	0.00e+00	732.00
IUUC-Gmo-039423	Gadus morhua	61.95	0.00e+00	747.00
IUUC-Gga-040174	Gallus gallus	65.50	0.00e+00	898.00
IUUC-Gac-041875	Gasterosteus aculeatus	50.52	7.00e-170	591.00
IUUC-Ggo-045090	Gorilla gorilla	98.73	0.00e+00	1395.00
IUUC-Hsa-046775	Homo sapiens	99.62	0.00e+00	1369.00
IUUC-Itr-048715	Ictidomys tridecemlineatus	81.93	0.00e+00	1106.00
IUUC-Lch-049933	Latimeria chalumnae	58.01	0.00e+00	803.00
IUUC-Loc-052048	Lepisosteus oculatus	58.70	0.00e+00	791.00
IUUC-Laf-054466	Loxodonta africana	78.70	0.00e+00	1097.00
IUUC-Mcc-054655	Macaca mulatta	96.82	0.00e+00	1333.00
IUUC-Meu-056705	Macropus eugenii	75.00	0.00e+00	806.00
IUUC-Mmr-061419	Microcebus murinus	83.99	0.00e+00	1121.00
IUUC-Mdo-062854	Monodelphis domestica	69.15	0.00e+00	893.00
IUUC-Mmu-064252	Mus musculus	78.73	0.00e+00	1184.00
IUUC-Nle-069329	Nomascus leucogenys	93.62	0.00e+00	1302.00
IUUC-Opr-071101	Ochotona princeps	64.47	0.00e+00	676.00
IUUC-Ont-071887	Oreochromis niloticus	61.09	0.00e+00	703.00
IUUC-Oan-073050	Ornithorhynchus anatinus	75.23	0.00e+00	892.00
IUUC-Oga-088220	Otolemur garnettii	83.93	0.00e+00	1152.00
IUUC-Oar-089420	Ovis aries	74.25	0.00e+00	927.00
IUUC-Pan-092031	Papio anubis	96.56	0.00e+00	1331.00
IUUC-Pfo-097451	Poecilia formosa	63.86	0.00e+00	705.00
IUUC-Pab-097806	Pongo abelii	98.72	0.00e+00	1355.00
IUUC-Pva-102182	Pteropus vampyrus	76.74	0.00e+00	760.00
IUUC-Sha-107262	Sarcophilus harrisii	68.27	0.00e+00	972.00
IUUC-Ssc-115584	Sus scrofa	95.97	4.00e-145	506.00
IUUC-Tgu-116973	Taeniopygia guttata	64.98	0.00e+00	914.00
IUUC-Tsy-119567	Tarsius syrichta	44.96	1.00e-116	413.00
IUUC-Ttr-128365	Tursiops truncatus	81.82	0.00e+00	856.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence