iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000024083.15	ENSMUST00000172818.7	ENSMUSP00000134380.1
ENSMUSG00000024083.15	ENSMUST00000172733.1	ENSMUSP00000133730.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	microRNA	TRANSFAC	RepTar
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
PHOSIDA	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	16247473

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	4.60e-06	28.2	633	674

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf..kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iC++++  +d    lpC H+fh+ C+  w       +k+ +CP+Cr
   Q: 633  CPICCSEYikDDIATELPCHHFFHKPCVSIW------LQKSGTCPVCR 674
           ******99753324449**************......**********8 PP

Organism

Mus musculus

Functional Description
(View)

Has E2-dependent E3 ubiquitin-protein ligase activity. Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA-mediated long-term memory processes (By similarity).

Protein Sequence
(Fasta)

MSQYTEKEPS VMDQESSKAA WPKPAGGYQT ITGRRYGRRH AYVSFKPCMT RHERSLGRAG 60
DDYEVLELDD VPKENTSGSS SLDQVHPALP NEPTVEKSET EISTCGPALN QSTESSPSIA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGCCGCCGCC GCTGCAGCCG CTGCGCGTTC GGCGGGGGAG GAGTCGGAGG CGGAGAAGAA 60
GGCGGTGGTG GCGGGTGGAG GATCGAGCGC TGTTCTCGCT CTGGAGCCGC TGCACATCTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0965--Cell junction
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0472--Membrane
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0628--Postsynaptic cell membrane
KW-1185--Reference proteome
KW-0770--Synapse
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR030639--Praja-2
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF13639--zf-RING_2

SMART

SM00184--RING

Gene Ontology

GO:0030054--C:cell junction
GO:0005737--C:cytoplasm
GO:0005789--C:endoplasmic reticulum membrane
GO:0000139--C:Golgi membrane
GO:0045111--C:intermediate filament cytoskeleton
GO:0005886--C:plasma membrane
GO:0014069--C:postsynaptic density
GO:0045211--C:postsynaptic membrane
GO:0034236--F:protein kinase A catalytic subunit binding
GO:0034237--F:protein kinase A regulatory subunit binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0035329--P:hippo signaling
GO:0007616--P:long-term memory
GO:0016567--P:protein ubiquitination
GO:0010738--P:regulation of protein kinase A signaling

KEGG

mmu:224938

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001388	Ailuropoda melanoleuca	79.21	0.00e+00	1100.00
IUUC-Aca-004858	Anolis carolinensis	45.77	2.00e-144	505.00
IUUC-Ago-007872	Ashbya gossypii	41.54	5.00e-09	53.50
IUUC-Ame-010842	Astyanax mexicanus	60.00	8.00e-63	234.00
IUUC-Bta-013122	Bos taurus	79.18	0.00e+00	1103.00
IUUC-Cja-019345	Callithrix jacchus	76.87	0.00e+00	808.00
IUUC-Cfa-021193	Canis familiaris	82.53	0.00e+00	1099.00
IUUC-Cpo-021991	Cavia porcellus	79.35	0.00e+00	1092.00
IUUC-Csa-024052	Chlorocebus sabaeus	83.73	0.00e+00	1096.00
IUUC-Cho-024680	Choloepus hoffmanni	80.03	0.00e+00	1097.00
IUUC-Dre-027662	Danio rerio	46.15	3.00e-63	236.00
IUUC-Dno-028851	Dasypus novemcinctus	81.14	0.00e+00	1108.00
IUUC-Dor-031005	Dipodomys ordii	76.77	0.00e+00	867.00
IUUC-Ete-032637	Echinops telfairi	66.37	2.00e-121	429.00
IUUC-Eca-034011	Equus caballus	81.05	0.00e+00	920.00
IUUC-Eeu-034596	Erinaceus europaeus	77.37	0.00e+00	998.00
IUUC-Fca-036523	Felis catus	81.36	0.00e+00	1080.00
IUUC-Fal-037255	Ficedula albicollis	40.81	2.00e-108	386.00
IUUC-Gga-040434	Gallus gallus	45.19	2.00e-129	456.00
IUUC-Hsa-046514	Homo sapiens	83.26	0.00e+00	1108.00
IUUC-Itr-047883	Ictidomys tridecemlineatus	82.70	0.00e+00	1087.00
IUUC-Lch-050133	Latimeria chalumnae	32.48	2.00e-48	187.00
IUUC-Loc-051901	Lepisosteus oculatus	39.11	2.00e-106	379.00
IUUC-Laf-054289	Loxodonta africana	80.20	0.00e+00	1067.00
IUUC-Mcc-055552	Macaca mulatta	83.85	0.00e+00	1120.00
IUUC-Meu-056394	Macropus eugenii	74.73	6.00e-108	385.00
IUUC-Mga-059909	Meleagris gallopavo	75.51	2.00e-23	100.00
IUUC-Mmr-060712	Microcebus murinus	80.75	0.00e+00	1048.00
IUUC-Mdo-062457	Monodelphis domestica	54.19	0.00e+00	672.00
IUUC-Mpu-065994	Mustela putorius furo	82.88	0.00e+00	1127.00
IUUC-Mlu-067843	Myotis lucifugus	78.49	0.00e+00	1055.00
IUUC-Nle-069787	Nomascus leucogenys	83.11	0.00e+00	1103.00
IUUC-Opr-071190	Ochotona princeps	67.06	8.00e-118	417.00
IUUC-Oan-072728	Ornithorhynchus anatinus	30.40	4.00e-59	223.00
IUUC-Ocu-074152	Oryctolagus cuniculus	82.99	0.00e+00	1082.00
IUUC-Oga-088608	Otolemur garnettii	81.63	0.00e+00	1080.00
IUUC-Oar-090415	Ovis aries	77.16	0.00e+00	1033.00
IUUC-Ptr-091211	Pan troglodytes	83.11	0.00e+00	1102.00
IUUC-Pan-091698	Papio anubis	78.71	0.00e+00	1023.00
IUUC-Psi-093139	Pelodiscus sinensis	49.78	3.00e-138	485.00
IUUC-Pab-097745	Pongo abelii	82.97	0.00e+00	1102.00
IUUC-Pca-100681	Procavia capensis	74.16	0.00e+00	955.00
IUUC-Pva-102525	Pteropus vampyrus	81.13	0.00e+00	1107.00
IUUC-Rno-105620	Rattus norvegicus	92.08	0.00e+00	1287.00
IUUC-Sce-106223	Saccharomyces cerevisiae	48.89	9.00e-09	53.10
IUUC-Sha-106812	Sarcophilus harrisii	49.75	2.00e-120	426.00
IUUC-Sar-113270	Sorex araneus	84.73	1.00e-162	566.00
IUUC-Ssc-115913	Sus scrofa	72.49	2.00e-178	618.00
IUUC-Tgu-117101	Taeniopygia guttata	58.63	2.00e-68	252.00
IUUC-Tsy-119078	Tarsius syrichta	78.98	0.00e+00	899.00
IUUC-Tbe-127715	Tupaia belangeri	77.49	0.00e+00	1023.00
IUUC-Ttr-129003	Tursiops truncatus	83.12	0.00e+00	1161.00
IUUC-Vpa-130373	Vicugna pacos	83.11	0.00e+00	1120.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence