iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000230230.7	ENST00000438908.5	ENSP00000409182.1
ENSG00000230230.7	ENST00000451189.1	ENSP00000393753.1

Annotation

Cancer Mutation
TCGA	COSMIC	CGAP	IntOGen
mRNA Expression
ArrayExpress	TCGA	ICGC	COSMIC
THPA	HPM	SZDB
DNA & RNA Element
UTRdb	circRNADb	CircNet	RepTar
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	PINA	Mentha
Disease-associated Information
GWASdb
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	18248090

Classification

Family	E-value	Score	Start	End
E3 activity/RING/U-box	7.70e-05	24.3	12	72
E3 activity/RING/RING	6.20e-07	31.5	16	57

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 4    eeflCpIslelMrdPvvlpsGitydrssIekwl..asggktcPvtrqplteedlvPnltlr 62
           ee  C+I l+  rdPv++ +G+++ rs+       + ++  cP++++p+++e++ P   l 
   Q: 12   EEVTCSICLDYLRDPVTIDCGHVFCRSCTTDVRpiSGSRPVCPLCKKPFKKENIRPVWQLA 72
           7899************************998765366666*************99987665 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iCl+ ++d p++ +CgHvf+++C   +      s  +  CPlC+
   Q: 16   CSICLDYLRD-PVTIDCGHVFCRSCTTDV---RPISGSRPVCPLCK 57
           **********.999***********9666...333777889****6 PP

Organism

Homo sapiens

Protein Sequence
(Fasta)

MATSAPLRSL EEEVTCSICL DYLRDPVTID CGHVFCRSCT TDVRPISGSR PVCPLCKKPF 60
KKENIRPVWQ LASLVENIER LKVDKGRQPG EVTREQQDAK LCERHREKLH YYCEDDGKLL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGAGATTAC GGGGCGGGGA CGAGCTGTCG CGCTGGTTGC TCGTGCAGGA GCGGGACCCG 60
GAACAGACCG CCGTGAGAGA GGAGGGGCGC CGGCCGGGAT TCGCGGCCCG GAGCTCGGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR006574--PRY
IPR003877--SPRY_dom
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS50089--ZF_RING_2

Pfam

PF13765--PRY
PF00622--SPRY
PF00643--zf-B_box

PRINTS

PR01407--BUTYPHLNCDUF

SMART

SM00336--BBOX
SM00589--PRY
SM00184--RING
SM00449--SPRY

Gene Ontology

GO:0005829--C:cytosol
GO:0003677--F:DNA binding
GO:0046872--F:metal ion binding
GO:0008270--F:zinc ion binding
GO:0045087--P:innate immune response
GO:0060333--P:interferon-gamma-mediated signaling pathway
GO:0046597--P:negative regulation of viral entry into host cell
GO:1902187--P:negative regulation of viral release from host cell
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity

KEGG

hsa:7726

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002296	Ailuropoda melanoleuca	88.86	0.00e+00	693.00
IUUC-Acl-008377	Aspergillus clavatus	32.65	1.00e-08	55.10
IUUC-Bta-012463	Bos taurus	91.76	0.00e+00	707.00
IUUC-Cja-018768	Callithrix jacchus	99.19	0.00e+00	710.00
IUUC-Cfa-020619	Canis familiaris	94.79	1.00e-92	333.00
IUUC-Csa-024036	Chlorocebus sabaeus	100.00	0.00e+00	705.00
IUUC-Cho-024784	Choloepus hoffmanni	85.63	1.00e-72	266.00
IUUC-Dno-029308	Dasypus novemcinctus	80.45	8.00e-138	483.00
IUUC-Dor-030812	Dipodomys ordii	90.11	0.00e+00	675.00
IUUC-Ete-032424	Echinops telfairi	69.10	3.00e-90	325.00
IUUC-Eca-033331	Equus caballus	94.05	0.00e+00	695.00
IUUC-Fca-036166	Felis catus	90.27	0.00e+00	697.00
IUUC-Ggo-044614	Gorilla gorilla	99.73	0.00e+00	703.00
IUUC-Itr-047952	Ictidomys tridecemlineatus	90.77	0.00e+00	685.00
IUUC-Laf-054420	Loxodonta africana	88.83	0.00e+00	668.00
IUUC-Mcc-055692	Macaca mulatta	97.59	0.00e+00	681.00
IUUC-Meu-056070	Macropus eugenii	76.15	6.00e-156	544.00
IUUC-Mdo-062024	Monodelphis domestica	73.44	3.00e-156	545.00
IUUC-Mmu-063867	Mus musculus	86.51	0.00e+00	652.00
IUUC-Mpu-066285	Mustela putorius furo	90.27	0.00e+00	667.00
IUUC-Mlu-066931	Myotis lucifugus	83.02	0.00e+00	629.00
IUUC-Nle-069433	Nomascus leucogenys	100.00	0.00e+00	705.00
IUUC-Opr-070804	Ochotona princeps	91.35	0.00e+00	705.00
IUUC-Ocu-074288	Oryctolagus cuniculus	93.51	0.00e+00	666.00
IUUC-Oga-088525	Otolemur garnettii	95.14	0.00e+00	729.00
IUUC-Oar-089671	Ovis aries	81.84	2.00e-170	592.00
IUUC-Ptr-090593	Pan troglodytes	100.00	0.00e+00	705.00
IUUC-Pan-092128	Papio anubis	100.00	0.00e+00	705.00
IUUC-Ppa-095647	Physcomitrella patens	27.10	9.00e-08	51.20
IUUC-Pab-098693	Pongo abelii	100.00	0.00e+00	705.00
IUUC-Pva-102332	Pteropus vampyrus	92.21	0.00e+00	905.00
IUUC-Rno-104867	Rattus norvegicus	86.24	0.00e+00	652.00
IUUC-Sha-107080	Sarcophilus harrisii	75.40	2.00e-157	549.00
IUUC-Sar-112969	Sorex araneus	74.63	0.00e+00	723.00
IUUC-Ssc-115426	Sus scrofa	91.89	0.00e+00	711.00
IUUC-Tsy-118963	Tarsius syrichta	94.83	0.00e+00	638.00
IUUC-Tbe-127732	Tupaia belangeri	93.22	0.00e+00	718.00
IUUC-Ttr-128856	Tursiops truncatus	93.26	1.00e-98	353.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence