iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Dre-028691

Ensembl Protein ID

ENSDARP00000140869.1

UniProt Accession

Q7ZV43; Q6NYL4; TOLIP_DANRE

Genbank Protein ID

AAH46009.1; AAH66544.1

Protein Name

Toll-interacting protein

Genbank Nucleotide ID

BC046009; BC066544

Gene Name

tollip; zgc:76985

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000098486.1	ENSDART00000172021.1	ENSDARP00000140869.1

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Other/Other	UBD/Other/Other	26110841
UBD/Alpha-Helix/CUE	CUE	26110841

Classification

Family	E-value	Score	Start	End
UBD/Alpha-Helix/CUE	1.90e-15	57.3	232	274

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/CUE

   S: 2    letaleqLkeiFPnldysviqvvLeantgsleaavnnLLegse 44
            e++l++L+++FPnld++vi+ vLea++g+ +aa+n+LL+++e
   Q: 232  SEEDLKALQDMFPNLDKEVIRTVLEAQQGNKDAAINSLLQMAE 274
           699**************************************75 PP

Organism

Danio rerio

Functional Description
(View)

Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (By similarity).

Protein Sequence
(Fasta)

MATTISTQRG QVYIGELPQD FLRIMPTQQQ QQVQLDAQAA RQLQYGGSLG TAGRLSITVV 60
QAKLAKNYGM TRMDPYCRIR LGYAVYETPT AHNGAKNPRW NKVIQCTVPP GVDSFYLEIF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGATCCAGGA CACAAGCTTG AGAGGAAACT CATGAGTAAA CACAGTCCGA CACTCACAAC 60
ACACTGGAAG AAGGTGATGA AGACCGGCGC GTCGAGCTCC TTGCTGTCTA ACAGGTAATT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0072--Autophagy
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0391--Immunity
KW-0395--Inflammatory response
KW-0399--Innate immunity
KW-1185--Reference proteome
KW-0677--Repeat

Interpro

IPR000008--C2_dom
IPR003892--CUE
IPR009060--UBA-like

PROSITE

PS51140--CUE

Pfam

PF00168--C2
PF02845--CUE

SMART

SM00239--C2
SM00546--CUE

Gene Ontology

GO:0005737--C:cytoplasm
GO:0043130--F:ubiquitin binding
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0006914--P:autophagy
GO:0006954--P:inflammatory response
GO:0045087--P:innate immune response
GO:0030178--P:negative regulation of Wnt signaling pathway
GO:0016310--P:phosphorylation
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001566	Ailuropoda melanoleuca	81.51	2.00e-101	362.00
IUUC-Apl-003706	Anas platyrhynchos	81.51	2.00e-108	385.00
IUUC-Aca-004943	Anolis carolinensis	73.09	7.00e-97	346.00
IUUC-Ago-007813	Ashbya gossypii	27.46	7.00e-05	42.00
IUUC-Ame-011082	Astyanax mexicanus	93.12	7.00e-134	469.00
IUUC-Bta-013259	Bos taurus	82.55	2.00e-107	381.00
IUUC-Bci-013731	Botrytis cinerea	38.89	2.00e-01	30.80
IUUC-Cel-018399	Caenorhabditis elegans	37.17	3.00e-46	178.00
IUUC-Cja-018753	Callithrix jacchus	81.32	6.00e-113	400.00
IUUC-Cfa-020087	Canis familiaris	82.33	1.00e-99	355.00
IUUC-Cpo-021735	Cavia porcellus	76.52	1.00e-104	372.00
IUUC-Csa-023623	Chlorocebus sabaeus	82.25	5.00e-111	393.00
IUUC-Cin-025139	Ciona intestinalis	40.11	2.00e-38	152.00
IUUC-Csv-025877	Ciona savignyi	38.70	1.00e-49	190.00
IUUC-Cme-027282	Cyanidioschyzon merolae	35.00	6.70e-01	28.10
IUUC-Dno-029753	Dasypus novemcinctus	78.83	5.00e-102	363.00
IUUC-Dor-030201	Dipodomys ordii	72.16	4.00e-83	301.00
IUUC-Ete-032378	Echinops telfairi	75.89	1.00e-84	306.00
IUUC-Eca-034156	Equus caballus	81.82	1.00e-107	382.00
IUUC-Fca-035386	Felis catus	79.70	2.00e-103	369.00
IUUC-Fal-036799	Ficedula albicollis	78.67	7.00e-114	403.00
IUUC-Gmo-038999	Gadus morhua	85.71	2.00e-123	435.00
IUUC-Gga-041068	Gallus gallus	82.18	3.00e-117	414.00
IUUC-Ggo-044809	Gorilla gorilla	68.25	1.00e-79	290.00
IUUC-Hsa-046654	Homo sapiens	82.25	5.00e-111	393.00
IUUC-Itr-048912	Ictidomys tridecemlineatus	83.02	2.00e-107	381.00
IUUC-Lch-049986	Latimeria chalumnae	80.73	1.00e-125	442.00
IUUC-Loc-052419	Lepisosteus oculatus	50.87	1.00e-59	222.00
IUUC-Lma-053222	Leptosphaeria maculans	41.67	1.30e-01	31.20
IUUC-Laf-053390	Loxodonta africana	83.02	3.00e-106	377.00
IUUC-Mcc-054649	Macaca mulatta	82.26	7.00e-106	376.00
IUUC-Meu-056690	Macropus eugenii	90.07	1.00e-68	252.00
IUUC-Mor-057041	Magnaporthe oryzae	50.00	2.00e-03	37.40
IUUC-Mga-059674	Meleagris gallopavo	78.91	2.00e-108	385.00
IUUC-Mmr-060744	Microcebus murinus	79.70	2.00e-104	372.00
IUUC-Mdo-062591	Monodelphis domestica	81.82	5.00e-119	420.00
IUUC-Mmu-063685	Mus musculus	82.91	3.00e-112	397.00
IUUC-Mac-064554	Musa acuminata	25.83	4.00e-06	45.40
IUUC-Mpu-066005	Mustela putorius furo	82.26	2.00e-103	368.00
IUUC-Nle-069520	Nomascus leucogenys	82.25	5.00e-111	393.00
IUUC-Opr-071036	Ochotona princeps	88.54	1.00e-81	295.00
IUUC-Ont-071379	Oreochromis niloticus	85.92	7.00e-128	449.00
IUUC-Oan-073508	Ornithorhynchus anatinus	94.17	3.00e-57	213.00
IUUC-Ocu-074753	Oryctolagus cuniculus	80.00	1.00e-106	379.00
IUUC-Ola-086417	Oryzias latipes	87.05	4.00e-131	460.00
IUUC-Olu-087609	Ostreococcus lucimarinus	45.00	9.00e-05	40.80
IUUC-Oga-088770	Otolemur garnettii	77.49	1.00e-106	379.00
IUUC-Oar-089598	Ovis aries	93.75	1.00e-34	137.00
IUUC-Pan-091998	Papio anubis	82.25	5.00e-111	393.00
IUUC-Psi-093365	Pelodiscus sinensis	81.72	2.00e-108	385.00
IUUC-Pma-094505	Petromyzon marinus	52.00	5.00e-72	264.00
IUUC-Pno-094817	Phaeosphaeria nodorum	41.67	1.50e-01	30.80
IUUC-Pfo-096152	Poecilia formosa	87.41	4.00e-135	473.00
IUUC-Pab-097752	Pongo abelii	82.25	5.00e-111	393.00
IUUC-Pop-099461	Populus trichocarpa	41.18	1.90e-01	29.60
IUUC-Pca-100823	Procavia capensis	69.60	4.00e-104	371.00
IUUC-Pva-102815	Pteropus vampyrus	77.25	9.00e-96	342.00
IUUC-Rno-105011	Rattus norvegicus	82.91	4.00e-112	397.00
IUUC-Sce-106317	Saccharomyces cerevisiae	38.00	4.90e-02	32.30
IUUC-Sha-107028	Sarcophilus harrisii	74.36	6.00e-59	219.00
IUUC-Ssl-108621	Sclerotinia sclerotiorum	38.89	1.80e-01	30.80
IUUC-Smo-109303	Selaginella moellendorffii	26.92	1.00e-08	51.60
IUUC-Stu-112916	Solanum tuberosum	31.15	3.00e-10	57.40
IUUC-Sar-113252	Sorex araneus	58.13	1.00e-37	149.00
IUUC-Sre-115062	Sporisorium reilianum	50.00	1.00e-04	42.00
IUUC-Ssc-116217	Sus scrofa	55.39	3.00e-59	221.00
IUUC-Tgu-116503	Taeniopygia guttata	82.18	1.00e-113	402.00
IUUC-Tru-118257	Takifugu rubripes	87.36	7.00e-133	466.00
IUUC-Tni-120576	Tetraodon nigroviridis	82.01	8.00e-122	429.00
IUUC-Tca-121166	Theobroma cacao	27.50	8.00e-06	44.30
IUUC-Tvi-122320	Trichoderma virens	43.75	1.90e-01	30.40
IUUC-Tbe-128094	Tupaia belangeri	80.17	9.00e-93	333.00
IUUC-Ttr-128957	Tursiops truncatus	93.44	1.00e-50	193.00
IUUC-Uma-129647	Ustilago maydis	52.78	1.00e-05	45.10
IUUC-Vda-129734	Verticillium dahliae	47.22	2.00e-03	37.40
IUUC-Xtr-132846	Xenopus tropicalis	76.28	2.00e-108	385.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence