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Tag Content
UUCD2 ID IUUC-Bta-013132
UUCD1 version UUC-BoT-01109
Ensembl Protein ID ENSBTAP00000027667.5
UniProt Accession A6QNM7; UBP33_BOVIN
Genbank Protein ID AAI48906.1
Protein Name Ubiquitin carboxyl-terminal hydrolase 33; Deubiquitinating enzyme 33; Ubiquitin thioesterase 33; Ubiquitin-specific-processing protease 33
Genbank Nucleotide ID BC148905
Gene Name USP33
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSBTAG00000020761.5 ENSBTAT00000027667.5 ENSBTAP00000027667.5
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/USP 2.20e-114 382.3 154 684
Active Site
Position(s) Description Evidence
163 Nucleophile ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
643 Proton acceptor ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
Domain Profile

   DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgye 88
    tGlkN+gNtCYmN++LQ+Lsn+p+l++++l+ + +++++k +++ks+ kl++elw ks+ ++v p++l++ +k++++ f+gy+
   Q: 154 TGLKNIGNTCYMNAALQALSNCPPLTQFFLD-----CGGLARTDKKPAICKSYLKLMTELWhKSRPGSVVPTTLFQGIKTVNPTFRGYS 237
    7******************************.....999999*******************99************************** PP
   S: 89 qqDaqEflaflldqleeelkk........eknkpkeeeeeedkselsde........................................ 129
    qqDaqEfl++l+d l+eelk+ ++ +ee++eedks+++ +
   Q: 238 QQDAQEFLRCLMDLLHEELKEqvmeveedPQTIMTEETMEEDKSQSDVDfqscescsssdkaenengsrsfsednnettmliqddenns 326
    *******************8889988866666666666666666666669*************************************** PP
   S: 130 ......................................................................................... 129
   
   Q: 327 emskdwqkekmcnkinkvhsegeldkdrdsvsetadlnnqetvkvqihsraseyitdvhlndlstpqilpsnegvnprlsasppksgnl 415
    ***************************************************************************************** PP
   S: 130 .................aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke................ 185
    +++k++kk++s+isd+F+g++ s+++cl+cd+vs++ e+f+dlslp+pgke+ +k+
   Q: 416 wpglppthkkvqsalspKRKKQHKKYRSVISDIFDGTIISSVQCLTCDRVSVTLETFQDLSLPIPGKEDLAKLhssshptsivkagscg 504
    ********************************************************************99888**************** PP
   S: 186 .................................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfse 241
    +lqdcL++f++++el+g+n+y+cekckk+++ +k +k++k+Pe+L++hLkRf ++
   Q: 505 eayapqgwiaffmeyvkrfvvscvpswfwgpvvTLQDCLAAFFARDELKGDNMYSCEKCKKLRNGVKFCKVQKFPEILCIHLKRF--RH 591
    *************************************************************************************..99 PP
   S: 242 eqksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetgs 328
    e ++++ki+++v+fple Ldl+pf+++++ q ++Y+L++v++H+G++ssGHY+ay++n+ ++ W++fdD++Vtev+e++v++ +
   Q: 592 ELMFSTKISTHVSFPLEgLDLQPFLAKDSPVQ--IVTYDLLSVICHHGTASSGHYIAYCRNNLNNlWYEFDDQSVTEVSESTVQN---A 675
    99*************************77776..9**************************88889*******************...* PP
   S: 329 taYvlfYkr 337
    +aYvlfY++
   Q: 676 EAYVLFYRK 684
    *******98 PP
   

Organism Bos taurus
Functional Description
(View)

Functional Description



     Deubiquitinating enzyme involved in various processes such as centrosome duplication, cellular migration and beta-2 adrenergic receptor/ADRB2 recycling. Involved in regulation of centrosome duplication by mediating deubiquitination of CCP110 in S and G2/M phase, leading to stabilize CCP110 during the period which centrioles duplicate and elongate. Involved in cell migration via its interaction with intracellular domain of ROBO1, leading to regulate the Slit signaling. Plays a role in commissural axon guidance cross the ventral midline of the neural tube in a Slit-dependent manner, possibly by mediating the deubiquitination of ROBO1. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination of beta-arrestins (ARRB1 and ARRB2) and beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).
Deubiquitinating enzyme involved in various processes such as centrosome duplication, cellular migration and beta-2 adrenergic receptor/ADRB2 recycling. Involved in regulation of centrosome duplication by mediating deubiquitination of CCP110 in S and G2/M phase, leading to stabilize CCP110 during the period which centrioles duplicate and elongate. Involved in cell migration via its interaction with intracellular domain of ROBO1, leading to regulate the Slit signaling. Plays a role in commissural axon guidance cross the ventral midline of the neural tube in a Slit-dependent manner, possibly by mediating the deubiquitination of ROBO1. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination of beta-arrestins (ARRB1 and ARRB2) and beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).
Protein Sequence
(Fasta)
MSSFRSHCPH LDSVGEITKE DLIQKSHGSC QDCKVRGPNL WACLENRCSY VGCGESQVDH 60
STIHSQETKH YLTVNLTTLR VWCYACSKEV FLDRKLGTQP SLPHVKPLHQ IQENGVQDFK 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Bta-013132|DUB,USP|Bos taurus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGAAGGAGCG GTAGCTGCTG CGGGAAGTGG CGGGTGCGGG AGGCGGGGAG CCCGCGGGCT 60
AAGCTGCGGA GCTGTTTTCC GGCGCCCAGG ACGCGAAGCC TCCCGTCTCC TAGGGCAGGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Bta-013132|DUB,USP|Bos taurus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0254--Endocytosis
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0677--Repeat
KW-0788--Thiol protease
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS51283--DUSP
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF06337--DUSP
PF00443--UCH
PF02148--zf-UBP

SMART

SM00695--DUSP
SM00290--ZnF_UBP

Gene Ontology

GO:0005776--C:autophagosome
GO:0044297--C:cell body
GO:0005813--C:centrosome
GO:0005925--C:focal adhesion
GO:0005794--C:Golgi apparatus
GO:0005654--C:nucleoplasm
GO:0048471--C:perinuclear region of cytoplasm
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0007411--P:axon guidance
GO:0016477--P:cell migration
GO:0009267--P:cellular response to starvation
GO:0051298--P:centrosome duplication
GO:0006897--P:endocytosis
GO:0032091--P:negative regulation of protein binding
GO:0032092--P:positive regulation of protein binding
GO:0016579--P:protein deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0050821--P:protein stabilization
GO:0010506--P:regulation of autophagy
GO:0008277--P:regulation of G-protein coupled receptor protein signaling pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG bta:531706
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001742 Ailuropoda melanoleuca 97.27 0.00e+00 1805.00
IUUC-Apl-003987 Anas platyrhynchos 82.82 0.00e+00 1489.00
IUUC-Aca-004713 Anolis carolinensis 76.70 0.00e+00 1419.00
IUUC-Cja-018811 Callithrix jacchus 96.60 0.00e+00 1794.00
IUUC-Cfa-021158 Canis familiaris 96.94 0.00e+00 1798.00
IUUC-Cpo-021910 Cavia porcellus 88.84 0.00e+00 1582.00
IUUC-Csa-023130 Chlorocebus sabaeus 97.04 0.00e+00 1797.00
IUUC-Cho-024383 Choloepus hoffmanni 79.09 0.00e+00 668.00
IUUC-Csv-025889 Ciona savignyi 43.87 1.00e-35 142.00
IUUC-Dre-028639 Danio rerio 70.20 0.00e+00 1253.00
IUUC-Dno-029416 Dasypus novemcinctus 94.74 0.00e+00 1720.00
IUUC-Ete-032994 Echinops telfairi 80.32 0.00e+00 870.00
IUUC-Eca-034248 Equus caballus 96.49 0.00e+00 1793.00
IUUC-Eeu-035357 Erinaceus europaeus 76.75 0.00e+00 1306.00
IUUC-Fca-036013 Felis catus 94.75 0.00e+00 1737.00
IUUC-Fal-037509 Ficedula albicollis 81.93 0.00e+00 1489.00
IUUC-Gmo-038944 Gadus morhua 65.63 0.00e+00 1193.00
IUUC-Gga-040647 Gallus gallus 82.17 0.00e+00 1480.00
IUUC-Gac-041752 Gasterosteus aculeatus 69.82 0.00e+00 1271.00
IUUC-Hsa-045694 Homo sapiens 96.60 0.00e+00 1785.00
IUUC-Itr-049041 Ictidomys tridecemlineatus 96.06 0.00e+00 1749.00
IUUC-Lch-050400 Latimeria chalumnae 71.24 0.00e+00 1287.00
IUUC-Loc-052616 Lepisosteus oculatus 72.89 0.00e+00 1333.00
IUUC-Laf-053493 Loxodonta africana 94.97 0.00e+00 1765.00
IUUC-Mcc-055542 Macaca mulatta 97.26 0.00e+00 1800.00
IUUC-Meu-056645 Macropus eugenii 74.18 0.00e+00 1302.00
IUUC-Mga-060019 Meleagris gallopavo 82.75 0.00e+00 1269.00
IUUC-Mmr-061241 Microcebus murinus 92.87 0.00e+00 1734.00
IUUC-Mmu-063786 Mus musculus 92.00 0.00e+00 1681.00
IUUC-Mpu-065772 Mustela putorius furo 97.19 0.00e+00 1498.00
IUUC-Mlu-067732 Myotis lucifugus 95.20 0.00e+00 1770.00
IUUC-Nle-069528 Nomascus leucogenys 95.83 0.00e+00 1790.00
IUUC-Opr-070606 Ochotona princeps 90.46 0.00e+00 1580.00
IUUC-Ont-071495 Oreochromis niloticus 71.13 0.00e+00 1282.00
IUUC-Oan-073695 Ornithorhynchus anatinus 85.51 0.00e+00 1054.00
IUUC-Ocu-074457 Oryctolagus cuniculus 92.93 0.00e+00 1734.00
IUUC-Ola-086739 Oryzias latipes 70.10 0.00e+00 1315.00
IUUC-Oga-088720 Otolemur garnettii 95.40 0.00e+00 1775.00
IUUC-Oar-089921 Ovis aries 99.56 0.00e+00 1844.00
IUUC-Ptr-090526 Pan troglodytes 96.71 0.00e+00 1789.00
IUUC-Pan-092396 Papio anubis 97.05 0.00e+00 1792.00
IUUC-Psi-092971 Pelodiscus sinensis 83.06 0.00e+00 1557.00
IUUC-Pfo-097415 Poecilia formosa 70.26 0.00e+00 1285.00
IUUC-Pab-098740 Pongo abelii 96.71 0.00e+00 1814.00
IUUC-Pca-100598 Procavia capensis 83.68 0.00e+00 903.00
IUUC-Pva-102820 Pteropus vampyrus 93.15 0.00e+00 1518.00
IUUC-Rno-104894 Rattus norvegicus 92.22 0.00e+00 1703.00
IUUC-Sce-106176 Saccharomyces cerevisiae 32.35 2.00e-25 111.00
IUUC-Sha-107244 Sarcophilus harrisii 77.91 0.00e+00 1405.00
IUUC-Sar-113665 Sorex araneus 93.31 0.00e+00 1760.00
IUUC-Ssc-115793 Sus scrofa 94.63 0.00e+00 1724.00
IUUC-Tgu-117487 Taeniopygia guttata 83.39 0.00e+00 1467.00
IUUC-Tru-117694 Takifugu rubripes 68.68 0.00e+00 1289.00
IUUC-Tsy-119598 Tarsius syrichta 83.95 0.00e+00 1457.00
IUUC-Tni-120189 Tetraodon nigroviridis 67.14 0.00e+00 1219.00
IUUC-Tbe-128125 Tupaia belangeri 84.94 8.00e-111 394.00
IUUC-Ttr-128269 Tursiops truncatus 93.64 0.00e+00 1665.00
IUUC-Vpa-130598 Vicugna pacos 94.63 0.00e+00 1750.00
IUUC-Xtr-132044 Xenopus tropicalis 75.63 0.00e+00 1343.00
Created Date 25-Jun-2017

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