iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	TRANSFAC	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.90e-42	141.2	341	376
UBD/Beta-Prp	9.40e-46	156.7	246	412

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf...sdtllvsGsdDgtikvWDlrtgv 34
           Ht++vt++++   +d  l+sGs D+ +k+WD+r+++
   Q: 341  HTGWVTSVKWsptHDQQLISGSLDNMVKLWDTRSCK 376
           ***********755588**************99876 PP

UBD/Beta-Prp

   S: 83   tgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdl..ktg 169
           t+++++tl+gh++ + s+ +s   d + s+s+d t+rvwd+e+g   + tl+g++ v nc++++p ++ l+sGs+Dr +rlWd   k g
   Q: 246  TRTPLVTLSGHTEAISSVLWSD-ADEVCSASWDHTVRVWDVESGGLKS-TLTGNK-VFNCISYSPLCKRLASGSTDRHIRLWDPrtKDG 331
           67899****************9.9***********************9.***987.99**************************54456 PP
   S: 170  kllrtl.tgghtdsvyslsfdsng.kelvsgsldgtvklwdlq.tgecvrtlnghtdnvksvrfspnderlvsgssDgsiriW 249
           +l+    t+ ht+ v+s++++++  ++l+sgsld+ vklwd +  +  ++ l +h+d v+sv+ + ++ +l+sg++D+ ++ +
   Q: 332  SLVSLSlTS-HTGWVTSVKWSPTHdQQLISGSLDNMVKLWDTRsCKAPLYDLAAHEDKVLSVDWT-DTGLLLSGGADNKLYSY 412
           666644366.************999******************54566****************9.999********998765 PP

Organism

Rattus norvegicus

Functional Description
(View)

Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.

Protein Sequence
(Fasta)

MAQLQARFYT ENKKYAVDDV PFSIPATSEV ADLSNIINKL LETKNELHKH VEFDFLIKGQ 60
FLRMPLVKHM ELEDISSEEV VELEYVEKYT APQPEQCMFH DDWISSIKGA EEWILSGSYD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTAGAAACCC GAGGAAGATA ACTGAAGCCT GTCTTCTACT GCGCTCGAGG TGCAGTCTAC 60
CTTAGAGCTA CTTGATTATC GGCGCATACA TTTTTGTGGA GAAGCCTCGT TGTATACTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0690--Ribosome biogenesis
KW-0698--rRNA processing
KW-0832--Ubl conjugation
KW-0853--WD repeat

Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR012972--NLE
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR028599--WDR12/Ytm1

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08154--NLE
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0070545--C:PeBoW complex
GO:0030687--C:preribosome, large subunit precursor
GO:0008283--P:cell proliferation
GO:0000460--P:maturation of 5.8S rRNA
GO:0000466--P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000470--P:maturation of LSU-rRNA
GO:0000463--P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0007219--P:Notch signaling pathway

KEGG

rno:363237

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000532	Aegilops tauschii	32.38	5.00e-57	215.00
IUUC-Aml-001997	Ailuropoda melanoleuca	93.17	0.00e+00	750.00
IUUC-Atr-002544	Amborella trichopoda	32.14	3.00e-56	212.00
IUUC-Apl-003981	Anas platyrhynchos	85.11	0.00e+00	658.00
IUUC-Aca-004370	Anolis carolinensis	83.53	0.00e+00	719.00
IUUC-Aly-006455	Arabidopsis lyrata	34.13	8.00e-60	224.00
IUUC-Ath-006669	Arabidopsis thaliana	34.40	2.00e-55	210.00
IUUC-Ago-007864	Ashbya gossypii	29.32	4.00e-38	152.00
IUUC-Acl-008177	Aspergillus clavatus	28.47	1.00e-36	147.00
IUUC-Afl-008617	Aspergillus flavus	29.23	2.00e-36	146.00
IUUC-Afu-008752	Aspergillus fumigatus	28.05	4.00e-34	139.00
IUUC-Ani-009136	Aspergillus nidulans	29.74	5.00e-37	148.00
IUUC-Ang-009701	Aspergillus niger	28.97	9.00e-35	141.00
IUUC-Aor-009884	Aspergillus oryzae	29.23	5.00e-36	145.00
IUUC-Ate-010472	Aspergillus terreus	29.88	7.00e-23	101.00
IUUC-Ame-011432	Astyanax mexicanus	77.07	0.00e+00	672.00
IUUC-Bgr-012218	Blumeria graminis	28.11	1.00e-32	134.00
IUUC-Bta-012829	Bos taurus	92.91	0.00e+00	775.00
IUUC-Bci-013953	Botrytis cinerea	29.54	2.00e-35	143.00
IUUC-Bdi-014351	Brachypodium distachyon	34.83	5.00e-55	208.00
IUUC-Bol-016190	Brassica oleracea	34.81	3.00e-56	212.00
IUUC-Bra-018095	Brassica rapa	33.77	8.00e-56	211.00
IUUC-Cel-018569	Caenorhabditis elegans	31.64	6.00e-49	188.00
IUUC-Cja-019468	Callithrix jacchus	93.14	0.00e+00	762.00
IUUC-Cfa-020471	Canis familiaris	92.20	0.00e+00	745.00
IUUC-Cpo-022260	Cavia porcellus	92.67	0.00e+00	761.00
IUUC-Cre-022614	Chlamydomonas reinhardtii	31.98	9.00e-41	160.00
IUUC-Csa-023989	Chlorocebus sabaeus	93.14	0.00e+00	764.00
IUUC-Cho-024426	Choloepus hoffmanni	89.84	1.00e-162	565.00
IUUC-Cin-025789	Ciona intestinalis	43.44	2.00e-99	355.00
IUUC-Cne-027063	Cryptococcus neoformans	24.27	5.00e-22	99.00
IUUC-Dre-027907	Danio rerio	78.25	0.00e+00	682.00
IUUC-Dno-029225	Dasypus novemcinctus	91.49	0.00e+00	766.00
IUUC-Dor-031082	Dipodomys ordii	77.78	7.00e-173	599.00
IUUC-Dse-031308	Dothistroma septosporum	28.76	2.00e-38	153.00
IUUC-Dme-032189	Drosophila melanogaster	41.02	1.00e-93	336.00
IUUC-Ete-032247	Echinops telfairi	86.52	0.00e+00	714.00
IUUC-Eca-034285	Equus caballus	93.14	0.00e+00	776.00
IUUC-Eeu-035322	Erinaceus europaeus	83.67	0.00e+00	655.00
IUUC-Fca-036114	Felis catus	92.91	0.00e+00	775.00
IUUC-Fal-036891	Ficedula albicollis	83.33	5.00e-176	610.00
IUUC-Fox-037965	Fusarium oxysporum	26.01	3.00e-35	142.00
IUUC-Fso-038244	Fusarium solani	26.64	2.00e-35	143.00
IUUC-Gmo-039040	Gadus morhua	76.36	0.00e+00	686.00
IUUC-Ggr-040093	Gaeumannomyces graminis	24.09	3.00e-11	63.20
IUUC-Gga-040610	Gallus gallus	82.03	0.00e+00	722.00
IUUC-Gac-042117	Gasterosteus aculeatus	75.41	0.00e+00	655.00
IUUC-Gma-043146	Glycine max	36.67	9.00e-67	247.00
IUUC-Ggo-045179	Gorilla gorilla	92.67	0.00e+00	755.00
IUUC-Hsa-046114	Homo sapiens	93.38	0.00e+00	761.00
IUUC-Hvu-047331	Hordeum vulgare	33.16	1.00e-52	200.00
IUUC-Itr-048275	Ictidomys tridecemlineatus	93.85	0.00e+00	781.00
IUUC-Kpa-049304	Komagataella pastoris	30.00	2.00e-43	170.00
IUUC-Lch-050655	Latimeria chalumnae	76.72	3.00e-149	520.00
IUUC-Lpe-051675	Leersia perrieri	34.52	2.00e-58	220.00
IUUC-Loc-052868	Lepisosteus oculatus	79.91	0.00e+00	679.00
IUUC-Lma-053258	Leptosphaeria maculans	26.11	2.00e-31	131.00
IUUC-Laf-053993	Loxodonta africana	92.43	0.00e+00	773.00
IUUC-Mcc-055128	Macaca mulatta	76.60	2.00e-174	604.00
IUUC-Meu-056501	Macropus eugenii	76.14	5.00e-164	570.00
IUUC-Mor-057114	Magnaporthe oryzae	25.56	3.00e-26	112.00
IUUC-Mtr-058367	Medicago truncatula	35.65	6.00e-61	228.00
IUUC-Mla-059107	Melampsora laricipopulina	27.37	2.00e-29	123.00
IUUC-Mga-059745	Meleagris gallopavo	79.76	0.00e+00	694.00
IUUC-Mvi-060362	Microbotryum violaceum	29.78	7.00e-35	141.00
IUUC-Mdo-062257	Monodelphis domestica	83.05	0.00e+00	726.00
IUUC-Mmu-063546	Mus musculus	95.51	0.00e+00	790.00
IUUC-Mac-065540	Musa acuminata	34.04	3.00e-55	209.00
IUUC-Mpu-066284	Mustela putorius furo	93.38	0.00e+00	778.00
IUUC-Mlu-067241	Myotis lucifugus	92.91	0.00e+00	773.00
IUUC-Nfi-068260	Neosartorya fischeri	29.02	1.00e-35	144.00
IUUC-Ncr-068719	Neurospora crassa	26.11	7.00e-28	118.00
IUUC-Nle-068981	Nomascus leucogenys	93.38	0.00e+00	743.00
IUUC-Opr-071218	Ochotona princeps	85.18	0.00e+00	676.00
IUUC-Ont-071646	Oreochromis niloticus	77.83	0.00e+00	686.00
IUUC-Oan-073453	Ornithorhynchus anatinus	87.47	0.00e+00	765.00
IUUC-Ocu-074008	Oryctolagus cuniculus	93.85	0.00e+00	781.00
IUUC-Oba-075712	Oryza barthii	30.12	2.00e-42	166.00
IUUC-Obr-076721	Oryza brachyantha	34.36	8.00e-58	217.00
IUUC-Ogl-077229	Oryza glaberrima	33.73	2.00e-57	216.00
IUUC-Ogu-078977	Oryza glumaepatula	30.12	1.00e-42	167.00
IUUC-Oin-079683	Oryza indica	33.73	1.00e-57	217.00
IUUC-Olo-080291	Oryza longistaminata	29.73	7.00e-29	120.00
IUUC-Ome-081834	Oryza meridionalis	33.97	2.00e-58	220.00
IUUC-Oni-082507	Oryza nivara	32.85	3.00e-54	205.00
IUUC-Opu-083396	Oryza punctata	33.97	3.00e-58	219.00
IUUC-Oru-085220	Oryza rufipogon	33.09	1.00e-53	203.00
IUUC-Osa-085767	Oryza sativa	33.73	1.00e-57	217.00
IUUC-Ola-087420	Oryzias latipes	77.30	0.00e+00	678.00
IUUC-Olu-087740	Ostreococcus lucimarinus	27.87	1.00e-37	150.00
IUUC-Oga-088264	Otolemur garnettii	92.20	0.00e+00	755.00
IUUC-Oar-089335	Ovis aries	92.43	0.00e+00	770.00
IUUC-Ptr-091320	Pan troglodytes	93.38	0.00e+00	761.00
IUUC-Pan-092833	Papio anubis	92.67	0.00e+00	760.00
IUUC-Psi-093504	Pelodiscus sinensis	85.34	0.00e+00	727.00
IUUC-Pma-094189	Petromyzon marinus	68.87	3.00e-176	611.00
IUUC-Pno-094929	Phaeosphaeria nodorum	27.16	9.00e-34	137.00
IUUC-Ppa-095429	Physcomitrella patens	36.07	2.00e-66	246.00
IUUC-Pfo-096337	Poecilia formosa	74.94	0.00e+00	680.00
IUUC-Pab-097571	Pongo abelii	93.14	0.00e+00	760.00
IUUC-Pop-099977	Populus trichocarpa	35.34	1.00e-64	240.00
IUUC-Pca-100394	Procavia capensis	87.29	0.00e+00	677.00
IUUC-Ppe-101848	Prunus persica	34.62	4.00e-61	228.00
IUUC-Pva-102921	Pteropus vampyrus	92.31	6.00e-118	417.00
IUUC-Pgr-103637	Puccinia graminis	28.11	7.00e-35	141.00
IUUC-Ptt-103781	Puccinia triticina	28.82	4.00e-35	142.00
IUUC-Pte-104135	Pyrenophora teres	25.83	5.00e-32	133.00
IUUC-Pyt-104609	Pyrenophora triticirepentis	25.49	3.00e-31	129.00
IUUC-Sce-106401	Saccharomyces cerevisiae	30.26	3.00e-42	166.00
IUUC-Sha-107122	Sarcophilus harrisii	83.70	0.00e+00	697.00
IUUC-Sja-107766	Schizosaccharomyces japonicus	32.48	6.00e-50	191.00
IUUC-Spo-108134	Schizosaccharomyces pombe	29.98	6.00e-41	161.00
IUUC-Ssl-108398	Sclerotinia sclerotiorum	28.37	4.00e-37	149.00
IUUC-Smo-108720	Selaginella moellendorffii	33.57	3.00e-58	219.00
IUUC-Sit-110311	Setaria italica	35.13	4.00e-56	212.00
IUUC-Sly-111023	Solanum lycopersicum	31.19	3.00e-53	202.00
IUUC-Stu-112778	Solanum tuberosum	33.89	1.00e-59	223.00
IUUC-Sar-113596	Sorex araneus	76.60	7.00e-173	599.00
IUUC-Sbi-114193	Sorghum bicolor	35.73	6.00e-59	221.00
IUUC-Sre-115002	Sporisorium reilianum	25.33	3.00e-12	66.60
IUUC-Ssc-116066	Sus scrofa	92.67	0.00e+00	771.00
IUUC-Tgu-117048	Taeniopygia guttata	82.45	0.00e+00	645.00
IUUC-Tsy-119573	Tarsius syrichta	60.77	6.00e-134	470.00
IUUC-Tni-119820	Tetraodon nigroviridis	76.25	0.00e+00	680.00
IUUC-Tca-121605	Theobroma cacao	35.58	1.00e-62	233.00
IUUC-Tre-121947	Trichoderma reesei	27.02	8.00e-35	141.00
IUUC-Tvi-122481	Trichoderma virens	27.45	1.00e-36	147.00
IUUC-Tae-123847	Triticum aestivum	32.38	5.00e-57	215.00
IUUC-Tur-126586	Triticum urartu	33.16	1.00e-54	207.00
IUUC-Tme-126900	Tuber melanosporum	32.39	2.00e-51	196.00
IUUC-Tbe-127736	Tupaia belangeri	71.11	3.00e-150	524.00
IUUC-Ttr-129041	Tursiops truncatus	80.85	0.00e+00	662.00
IUUC-Uma-129628	Ustilago maydis	24.07	8.00e-13	68.60
IUUC-Vpa-130260	Vicugna pacos	93.62	0.00e+00	780.00
IUUC-Vvi-131009	Vitis vinifera	34.76	1.00e-60	227.00
IUUC-Xtr-132083	Xenopus tropicalis	80.38	0.00e+00	694.00
IUUC-Xma-133094	Xiphophorus maculatus	74.70	0.00e+00	679.00
IUUC-Yli-134531	Yarrowia lipolytica	24.59	3.00e-20	93.20
IUUC-Zma-135509	Zea mays	34.29	1.00e-59	223.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence