iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000168395.15	ENST00000636051.1	ENSP00000490767.1
ENSG00000168395.15	ENST00000313552.10	ENSP00000322142.6
ENSG00000168395.15	ENST00000445620.5	ENSP00000416878.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Variation
OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	8.60e-09	37.1	187	234

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedekslveCek..Cr.ewfHpaClklsveeelpnsekwiCpkCrs 53
           ++C +C++ + +e  ++ C++  C  ewfH+aC+ l+   ++p+ + w+Cp+C +
   Q: 187  TYC-LCHQVSYGE--MIGCDNpdCPiEWFHFACVDLT---TKPKGK-WFCPRCVQ 234
           69*.*******99..*********99***********...999997.******87 PP

Organism

Homo sapiens

Functional Description
(View)

Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Through chromatin acetylation it may regulate DNA replication and may function as a transcriptional coactivator.

Protein Sequence
(Fasta)

MATAMYLEHY LDSIENLPCE LQRNFQLMRE LDQRTEDKKA EIDILAAEYI STVKTLSPDQ 60
RVERLQKIQN AYSKCKEYSD DKVQLAMQTY EMVDKHIRRL DADLARFEAD LKDKMEGSDF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCGCGGGCT GGACGGCCGG AGACGCGGGG TCAGGGCGCG GACGAGGGGA GCGCAGGGTC 60
GGAGGGGCTC CCGGACGCTG CCCGCCCAGC GTCGGCTCTC GTTGGCCCCT GGCTGCGCGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0010--Activator
KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0488--Methylation
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR028638--ING5
IPR028651--ING_fam
IPR024610--ING_N_histone_binding
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS01359--ZF_PHD_1
PS50016--ZF_PHD_2

Pfam

PF12998--ING

SMART

SM01408--ING
SM00249--PHD

Gene Ontology

GO:0070776--C:MOZ/MORF histone acetyltransferase complex
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0035064--F:methylated histone binding
GO:0008270--F:zinc ion binding
GO:0006260--P:DNA replication
GO:0043966--P:histone H3 acetylation
GO:0008285--P:negative regulation of cell proliferation
GO:0045926--P:negative regulation of growth
GO:0043065--P:positive regulation of apoptotic process
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0006473--P:protein acetylation
GO:1901796--P:regulation of signal transduction by p53 class mediator
GO:0006351--P:transcription, DNA-templated

KEGG

hsa:84289

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002381	Ailuropoda melanoleuca	98.25	2.00e-112	398.00
IUUC-Atr-002906	Amborella trichopoda	33.06	7.00e-34	137.00
IUUC-Apl-003516	Anas platyrhynchos	89.22	2.00e-94	338.00
IUUC-Aca-005009	Anolis carolinensis	86.13	3.00e-108	384.00
IUUC-Ame-011879	Astyanax mexicanus	76.76	9.00e-102	362.00
IUUC-Bta-012590	Bos taurus	96.48	2.00e-114	404.00
IUUC-Cja-019518	Callithrix jacchus	98.75	2.00e-125	441.00
IUUC-Cfa-020620	Canis familiaris	98.33	6.00e-128	449.00
IUUC-Cpo-022085	Cavia porcellus	97.88	3.00e-118	417.00
IUUC-Csa-023421	Chlorocebus sabaeus	100.00	2.00e-122	431.00
IUUC-Dre-027588	Danio rerio	75.62	9.00e-102	362.00
IUUC-Eca-033493	Equus caballus	95.59	1.00e-115	408.00
IUUC-Fca-035635	Felis catus	95.45	1.00e-55	209.00
IUUC-Fal-036998	Ficedula albicollis	89.13	3.00e-109	387.00
IUUC-Fox-037925	Fusarium oxysporum	59.62	2.00e-19	90.10
IUUC-Gmo-039035	Gadus morhua	76.35	5.00e-98	350.00
IUUC-Gga-040578	Gallus gallus	90.42	3.00e-118	417.00
IUUC-Gac-042172	Gasterosteus aculeatus	74.69	1.00e-100	358.00
IUUC-Loc-052725	Lepisosteus oculatus	82.08	1.00e-99	355.00
IUUC-Mcc-055455	Macaca mulatta	99.13	2.00e-114	404.00
IUUC-Mtr-058089	Medicago truncatula	32.51	2.00e-35	142.00
IUUC-Mga-059312	Meleagris gallopavo	89.11	6.00e-95	339.00
IUUC-Mmr-061351	Microcebus murinus	97.36	2.00e-110	392.00
IUUC-Mdo-062282	Monodelphis domestica	96.25	1.00e-116	412.00
IUUC-Mmu-063201	Mus musculus	94.58	1.00e-119	421.00
IUUC-Mac-064625	Musa acuminata	34.29	2.00e-37	149.00
IUUC-Mpu-066302	Mustela putorius furo	98.33	8.00e-121	426.00
IUUC-Mlu-068192	Myotis lucifugus	97.08	1.00e-120	425.00
IUUC-Ont-072055	Oreochromis niloticus	76.25	5.00e-97	347.00
IUUC-Oan-073652	Ornithorhynchus anatinus	96.05	1.00e-113	401.00
IUUC-Ocu-073871	Oryctolagus cuniculus	96.27	2.00e-121	427.00
IUUC-Ola-087103	Oryzias latipes	75.62	8.00e-94	336.00
IUUC-Oga-088066	Otolemur garnettii	87.35	3.00e-102	364.00
IUUC-Ptr-091665	Pan troglodytes	100.00	2.00e-122	431.00
IUUC-Pan-091875	Papio anubis	100.00	2.00e-122	431.00
IUUC-Psi-093904	Pelodiscus sinensis	93.43	8.00e-102	362.00
IUUC-Pfo-096981	Poecilia formosa	76.35	2.00e-97	348.00
IUUC-Pva-102282	Pteropus vampyrus	90.00	3.00e-121	427.00
IUUC-Rno-105646	Rattus norvegicus	94.17	4.00e-119	420.00
IUUC-Sha-107031	Sarcophilus harrisii	95.22	2.00e-109	388.00
IUUC-Smo-109441	Selaginella moellendorffii	35.08	9.00e-41	159.00
IUUC-Tgu-116837	Taeniopygia guttata	87.88	1.00e-108	385.00
IUUC-Tru-117974	Takifugu rubripes	75.62	8.00e-94	336.00
IUUC-Tni-120024	Tetraodon nigroviridis	75.93	2.00e-87	315.00
IUUC-Vvi-131487	Vitis vinifera	33.76	6.00e-34	137.00
IUUC-Xtr-132189	Xenopus tropicalis	83.26	5.00e-108	383.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence