iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Nle-070062

Ensembl Protein ID

ENSNLEP00000018934.2

UniProt Accession

G1S0A6; G1S0A6_NOMLE

Genbank Protein ID

ENSNLEP00000018934

Protein Name

Tyrosine-protein kinase

Genbank Nucleotide ID

ADFV01184956

Gene Name

ABL2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSNLEG00000015604.2	ENSNLET00000019886.2	ENSNLEP00000018934.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.80e-12	47.0	109	166

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
            +++ +lyd+ a+ d++L+++kG++++v+  ++q+++W +     ++ +G +P+n+++ ++
   Q: 109  PNLFVALYDFVASGDNTLSITKGEKLRVL-GYNQNGEWSEV--RSKNGQGWVPSNYITPVN 166
           67899************************.*********98..788899*********997 PP

Organism

Nomascus leucogenys

Protein Sequence
(Fasta)

MGQQVGRVGE APGLQQPQPR GIRGSSAARP SGRRRDPAGR TTETGFNIFT QHDHFASCVE 60
DGFEGDKTGG SSPEALHRPY GCDVEPQALN EAVRWSSKEN LLGATESDPN LFVALYDFVA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGGCAGC AGGTGGGCCG CGTCGGGGAA GCTCCGGGGC TCCAGCAGCC TCAGCCCCGC 60
GGGATCCGGG GCAGCAGTGC AGCCAGGCCC TCCGGCCGCA GGCGGGACCC GGCGGGGCGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR015015--F-actin_binding
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF08919--F_actin_bind
PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00109--TYRKINASE

SMART

SM00808--FABD
SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0005623--C:cell
GO:0005524--F:ATP binding
GO:0000287--F:magnesium ion binding
GO:0030145--F:manganese ion binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0071300--P:cellular response to retinoic acid
GO:0007204--P:positive regulation of cytosolic calcium ion concentration
GO:0010976--P:positive regulation of neuron projection development
GO:0051353--P:positive regulation of oxidoreductase activity
GO:0010863--P:positive regulation of phospholipase C activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002263	Ailuropoda melanoleuca	99.02	0.00e+00	1253.00
IUUC-Atr-002778	Amborella trichopoda	32.49	9.00e-23	102.00
IUUC-Apl-003389	Anas platyrhynchos	80.43	0.00e+00	1565.00
IUUC-Bta-013370	Bos taurus	97.67	0.00e+00	1325.00
IUUC-Cja-018894	Callithrix jacchus	96.59	0.00e+00	1257.00
IUUC-Cfa-020398	Canis familiaris	97.27	0.00e+00	1897.00
IUUC-Cpo-022367	Cavia porcellus	96.91	0.00e+00	1224.00
IUUC-Csa-023386	Chlorocebus sabaeus	99.67	0.00e+00	1261.00
IUUC-Cho-024714	Choloepus hoffmanni	98.21	0.00e+00	1212.00
IUUC-Dre-027741	Danio rerio	80.71	0.00e+00	1070.00
IUUC-Dno-029246	Dasypus novemcinctus	95.34	0.00e+00	1284.00
IUUC-Dor-030416	Dipodomys ordii	88.65	0.00e+00	1174.00
IUUC-Dme-032098	Drosophila melanogaster	72.13	0.00e+00	736.00
IUUC-Ete-032899	Echinops telfairi	90.31	1.00e-146	514.00
IUUC-Eca-033387	Equus caballus	97.99	0.00e+00	1299.00
IUUC-Eeu-035058	Erinaceus europaeus	85.44	0.00e+00	1135.00
IUUC-Fca-036578	Felis catus	98.19	0.00e+00	1192.00
IUUC-Fal-037491	Ficedula albicollis	96.74	0.00e+00	1224.00
IUUC-Gmo-038509	Gadus morhua	87.11	0.00e+00	1048.00
IUUC-Gga-040638	Gallus gallus	92.06	0.00e+00	1213.00
IUUC-Gac-042550	Gasterosteus aculeatus	86.95	0.00e+00	1067.00
IUUC-Gma-043854	Glycine max	33.50	5.00e-21	96.70
IUUC-Ggo-044487	Gorilla gorilla	99.85	0.00e+00	1367.00
IUUC-Hsa-046636	Homo sapiens	99.85	0.00e+00	1367.00
IUUC-Itr-048685	Ictidomys tridecemlineatus	98.43	0.00e+00	1290.00
IUUC-Lch-049530	Latimeria chalumnae	84.68	0.00e+00	1187.00
IUUC-Lpe-051291	Leersia perrieri	31.05	4.00e-22	100.00
IUUC-Loc-051933	Lepisosteus oculatus	85.40	0.00e+00	1134.00
IUUC-Laf-053802	Loxodonta africana	97.10	0.00e+00	1408.00
IUUC-Mcc-054836	Macaca mulatta	99.71	0.00e+00	1364.00
IUUC-Meu-056488	Macropus eugenii	60.38	0.00e+00	725.00
IUUC-Mga-059277	Meleagris gallopavo	96.25	0.00e+00	1222.00
IUUC-Mmr-061206	Microcebus murinus	97.53	0.00e+00	1350.00
IUUC-Mdo-062281	Monodelphis domestica	89.62	0.00e+00	1813.00
IUUC-Mmu-063847	Mus musculus	95.49	0.00e+00	1262.00
IUUC-Mac-065156	Musa acuminata	27.72	1.00e-22	101.00
IUUC-Mpu-066309	Mustela putorius furo	96.76	0.00e+00	1934.00
IUUC-Mlu-068070	Myotis lucifugus	98.05	0.00e+00	1231.00
IUUC-Opr-070327	Ochotona princeps	68.89	0.00e+00	795.00
IUUC-Ont-072440	Oreochromis niloticus	79.00	0.00e+00	1068.00
IUUC-Oan-073526	Ornithorhynchus anatinus	96.25	0.00e+00	1222.00
IUUC-Ocu-074051	Oryctolagus cuniculus	97.24	0.00e+00	1224.00
IUUC-Oga-088767	Otolemur garnettii	88.17	0.00e+00	1087.00
IUUC-Oar-089800	Ovis aries	98.54	0.00e+00	1223.00
IUUC-Ptr-090857	Pan troglodytes	99.26	0.00e+00	2007.00
IUUC-Pan-092279	Papio anubis	96.65	0.00e+00	1308.00
IUUC-Psi-093573	Pelodiscus sinensis	95.95	0.00e+00	1220.00
IUUC-Pma-094420	Petromyzon marinus	76.11	0.00e+00	870.00
IUUC-Pfo-096543	Poecilia formosa	76.08	0.00e+00	1043.00
IUUC-Pab-097949	Pongo abelii	96.65	0.00e+00	1306.00
IUUC-Pca-100370	Procavia capensis	99.18	0.00e+00	766.00
IUUC-Pva-103220	Pteropus vampyrus	86.46	0.00e+00	1184.00
IUUC-Rno-105924	Rattus norvegicus	93.45	0.00e+00	1236.00
IUUC-Sha-107114	Sarcophilus harrisii	94.96	0.00e+00	1174.00
IUUC-Sit-110219	Setaria italica	30.30	5.00e-20	93.20
IUUC-Ssc-115968	Sus scrofa	98.54	0.00e+00	1356.00
IUUC-Tgu-117301	Taeniopygia guttata	96.27	0.00e+00	1222.00
IUUC-Tru-118410	Takifugu rubripes	79.02	0.00e+00	1112.00
IUUC-Tni-119991	Tetraodon nigroviridis	78.92	0.00e+00	1107.00
IUUC-Tca-121389	Theobroma cacao	33.85	1.00e-23	105.00
IUUC-Tae-124468	Triticum aestivum	29.13	7.00e-20	92.80
IUUC-Tbe-127362	Tupaia belangeri	98.84	0.00e+00	1313.00
IUUC-Ttr-129291	Tursiops truncatus	98.86	0.00e+00	1247.00
IUUC-Vpa-130800	Vicugna pacos	95.92	0.00e+00	1241.00
IUUC-Xtr-132965	Xenopus tropicalis	86.41	0.00e+00	1178.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence