iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB	7.20e-22	78.7	63	130
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box	1.50e-11	43.4	162	193

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgkldene 69
           +Dv+lvvg +++ ah+++L+a+S++F+a+f++el es+ + +v+i+d++  +++ l++F Yt++++ +e
   Q: 63   CDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESR-QTEVVIRDIDERAMELLIDFAYTSQITVEE 130
           9*************************************.*************************98765 PP

E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box

   S: 1    leNclgilrfAdlydcpdLkdaaldfilkhFk 32
           ++Nclgi++fAd+++c++L   a++f++++F+
   Q: 162  PSNCLGIRAFADTHSCRELLRIADKFTQHNFQ 193
           89*****************************6 PP

Organism

Mus musculus

Functional Description
(View)

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. The BCR(KLHL20) E3 ubiquitin ligase complex mediates the ubiquitination of DAPK1, leading to its degradation by the proteasome, thereby acting as a negative regulator of apoptosis. The BCR(KLHL20) E3 ubiquitin ligase complex also specifically mediates 'Lys-33'-linked ubiquitination. Involved in anterograde Golgi to endosome transport by mediating 'Lys-33'-linked ubiquitination of CORO7, promoting interaction between CORO7 and EPS15, thereby facilitating actin polymerization and post-Golgi trafficking. Also acts as a regulator of endothelial migration during angiogenesis by controlling the activation of Rho GTPases. The BCR(KLHL20) E3 ubiquitin ligase complex acts as a regulator of neurite outgrowth by mediating ubiquitination and degradation of PDZ-RhoGEF/ARHGEF11 (By similarity).

Protein Sequence
(Fasta)

MRRCTNIRPG ETGMDVTSRC TLGDPNKLPE GVPQPARMPY ISDKHPRQTL EVINLLRKHR 60
ELCDVVLVVG AKKIYAHRVI LSACSPYFRA MFTGELAESR QTEVVIRDID ERAMELLIDF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACCGCTTCCT GTTTCTGGAT CTGGGCGGGT GCAGGGAAAG GAAATCGCTG CAGGAGCCGC 60
ATCCTGCCTG CGCTAGCGGC TCCAGAGGTG GAGGCAGAGA GGGCGGAGAA GGCAGAGAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0009--Actin-binding
KW-0966--Cell projection
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0333--Golgi apparatus
KW-0880--Kelch repeat
KW-0539--Nucleus
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0833--Ubl conjugation pathway

Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR011043--Gal_Oxase/kelch_b-propeller
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR011333--SKP1/BTB/POZ

PROSITE

PS50097--BTB

Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1

SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch

Gene Ontology

GO:0030424--C:axon
GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0030425--C:dendrite
GO:0005794--C:Golgi apparatus
GO:0048471--C:perinuclear region of cytoplasm
GO:0016605--C:PML body
GO:0005802--C:trans-Golgi network
GO:0019964--F:interferon-gamma binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006895--P:Golgi to endosome transport
GO:0043066--P:negative regulation of apoptotic process
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:1990390--P:protein K33-linked ubiquitination
GO:0015031--P:protein transport
GO:0016567--P:protein ubiquitination
GO:0035455--P:response to interferon-alpha

KEGG

mmu:226541

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001974	Ailuropoda melanoleuca	99.67	0.00e+00	1252.00
IUUC-Apl-003481	Anas platyrhynchos	99.50	0.00e+00	1248.00
IUUC-Aca-004877	Anolis carolinensis	99.34	0.00e+00	1245.00
IUUC-Aly-005957	Arabidopsis lyrata	36.30	6.00e-40	159.00
IUUC-Aor-010180	Aspergillus oryzae	24.65	1.00e-09	57.00
IUUC-Ame-011440	Astyanax mexicanus	98.82	0.00e+00	1220.00
IUUC-Bta-012603	Bos taurus	100.00	0.00e+00	1254.00
IUUC-Bol-016130	Brassica oleracea	27.14	8.00e-16	79.30
IUUC-Bra-016881	Brassica rapa	27.27	6.00e-17	83.20
IUUC-Cel-018464	Caenorhabditis elegans	59.51	0.00e+00	716.00
IUUC-Cja-019119	Callithrix jacchus	100.00	0.00e+00	1254.00
IUUC-Cfa-020169	Canis familiaris	100.00	0.00e+00	1254.00
IUUC-Cpo-021519	Cavia porcellus	99.83	0.00e+00	1251.00
IUUC-Csa-024173	Chlorocebus sabaeus	100.00	0.00e+00	1254.00
IUUC-Cho-024820	Choloepus hoffmanni	95.78	0.00e+00	786.00
IUUC-Cin-025270	Ciona intestinalis	75.43	0.00e+00	890.00
IUUC-Csv-026308	Ciona savignyi	75.43	0.00e+00	898.00
IUUC-Dre-027423	Danio rerio	98.98	0.00e+00	1220.00
IUUC-Dno-029350	Dasypus novemcinctus	99.67	0.00e+00	1249.00
IUUC-Dor-031011	Dipodomys ordii	100.00	4.00e-165	574.00
IUUC-Dme-032170	Drosophila melanogaster	80.94	0.00e+00	959.00
IUUC-Ete-033187	Echinops telfairi	99.77	0.00e+00	876.00
IUUC-Eca-033751	Equus caballus	100.00	0.00e+00	1252.00
IUUC-Eeu-034901	Erinaceus europaeus	99.67	0.00e+00	1251.00
IUUC-Fca-035752	Felis catus	98.91	0.00e+00	1123.00
IUUC-Fal-037630	Ficedula albicollis	99.34	0.00e+00	1244.00
IUUC-Gmo-039481	Gadus morhua	97.35	0.00e+00	1229.00
IUUC-Gga-040971	Gallus gallus	99.50	0.00e+00	1249.00
IUUC-Gac-042602	Gasterosteus aculeatus	97.68	0.00e+00	1231.00
IUUC-Ggo-044588	Gorilla gorilla	100.00	0.00e+00	1251.00
IUUC-Hsa-046641	Homo sapiens	100.00	0.00e+00	1254.00
IUUC-Itr-048394	Ictidomys tridecemlineatus	100.00	0.00e+00	1255.00
IUUC-Lch-049968	Latimeria chalumnae	99.01	0.00e+00	1246.00
IUUC-Loc-052720	Lepisosteus oculatus	98.01	0.00e+00	1237.00
IUUC-Lma-053201	Leptosphaeria maculans	27.21	3.00e-09	56.20
IUUC-Laf-054156	Loxodonta africana	100.00	0.00e+00	1253.00
IUUC-Mcc-054629	Macaca mulatta	100.00	0.00e+00	1254.00
IUUC-Meu-056605	Macropus eugenii	99.36	0.00e+00	645.00
IUUC-Mga-060014	Meleagris gallopavo	98.84	0.00e+00	1229.00
IUUC-Mmr-060814	Microcebus murinus	99.83	0.00e+00	1250.00
IUUC-Mdo-062242	Monodelphis domestica	99.50	0.00e+00	1248.00
IUUC-Mpu-066587	Mustela putorius furo	100.00	0.00e+00	1254.00
IUUC-Mlu-066958	Myotis lucifugus	96.54	0.00e+00	1203.00
IUUC-Nle-069059	Nomascus leucogenys	98.51	0.00e+00	1229.00
IUUC-Ont-072129	Oreochromis niloticus	97.68	0.00e+00	1233.00
IUUC-Oan-073073	Ornithorhynchus anatinus	99.34	0.00e+00	1242.00
IUUC-Ocu-073909	Oryctolagus cuniculus	99.01	0.00e+00	1241.00
IUUC-Ola-086392	Oryzias latipes	97.03	0.00e+00	1223.00
IUUC-Oga-088693	Otolemur garnettii	99.50	0.00e+00	1251.00
IUUC-Oar-089905	Ovis aries	99.83	0.00e+00	1252.00
IUUC-Ptr-091059	Pan troglodytes	100.00	0.00e+00	1254.00
IUUC-Pan-091833	Papio anubis	94.87	0.00e+00	790.00
IUUC-Psi-093499	Pelodiscus sinensis	99.50	0.00e+00	1242.00
IUUC-Pma-094404	Petromyzon marinus	80.33	0.00e+00	946.00
IUUC-Ppa-095249	Physcomitrella patens	31.13	1.00e-14	74.70
IUUC-Pfo-096891	Poecilia formosa	98.01	0.00e+00	1234.00
IUUC-Pab-097715	Pongo abelii	95.53	0.00e+00	1185.00
IUUC-Pva-102944	Pteropus vampyrus	83.61	0.00e+00	1018.00
IUUC-Rno-104878	Rattus norvegicus	100.00	0.00e+00	1254.00
IUUC-Sha-107444	Sarcophilus harrisii	99.50	0.00e+00	1249.00
IUUC-Ssc-115565	Sus scrofa	100.00	0.00e+00	1251.00
IUUC-Tgu-116902	Taeniopygia guttata	99.34	0.00e+00	1247.00
IUUC-Tru-118692	Takifugu rubripes	97.85	0.00e+00	1233.00
IUUC-Tsy-119031	Tarsius syrichta	92.38	0.00e+00	1133.00
IUUC-Tbe-127517	Tupaia belangeri	93.84	0.00e+00	1158.00
IUUC-Ttr-128366	Tursiops truncatus	100.00	0.00e+00	1254.00
IUUC-Vpa-130465	Vicugna pacos	99.67	0.00e+00	1249.00
IUUC-Vvi-131673	Vitis vinifera	34.33	3.00e-42	166.00
IUUC-Xtr-132243	Xenopus tropicalis	98.68	0.00e+00	1240.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence