iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Cfa-020761

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AAEX03006844

Gene Name

USP20

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000019975.3	ENSCAFT00000031793.3	ENSCAFP00000029601.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.80e-109	366.3	145	685

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgye 88
           tG+kNlgN+CYmN++LQ+Lsn+p+l++++le     +    ++++k +l+ks+qkl++e+w  ++ ++v p++l + +k ++++f+gy+
   Q: 145  TGMKNLGNSCYMNAALQALSNCPPLTQFFLE-----CGGLVRTDKKPALCKSYQKLVSEVWhRRRPSYVVPTSLSHGIKLVNPMFRGYA 228
           7******************************.....999999*******************889999********************** PP
   S: 89   qqDaqEflaflldqleeelkk..............eknkpkeeeeeedkselsde.................................. 129
           qqD+qEfl++l+dql+eelk+              +++++++e++e d+s ++de                                  
   Q: 229  QQDTQEFLCCLMDQLHEELKEpvvaaaaalvetrdSDSSDTDEKREGDRSPSEDEflscdsssdrgegdgqgrggggsqaeaellipde 317
           *******************998886666666655555555555555555555555********************************** PP
   S: 130  ......................................................................................... 129
                                                                                                    
   Q: 318  agraisekermkdrkfswgqqrtsseqvdedadvdtamaalddqpseaqppslqspspcrtpepdneahmwstsrpcspvhhheghtkl 406
           ***************************************************************************************** PP
   S: 130  ...........................aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke...... 185
                                      ++++k+++++s+isd+F+g++ s ++cl+cd+vs++ e+f+dlslp+pgke+ + +      
   Q: 407  assppraspvrmgpsyvlkkaqvlsagSRRRKEQRYRSVISDIFDGSILSLVQCLTCDRVSTTVETFQDLSLPIPGKEDLARLhsaiyq 495
           ******************************************************************************98888****** PP
   S: 186  ...........................................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLi 231
                                                      +l+dcL++f+ ++el+g+n+y+ce+ckk+++ +k +k+ +lPe+L 
   Q: 496  napakpgacgdsyaaqgwlafimeyirrflvsctpswfwgpvvTLEDCLAAFFVADELKGDNMYSCERCKKLRNGVKYCKVLRLPEILY 584
           ***************************************************************************************** PP
   S: 232  lhLkRfsfseeqksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvkn.ekgkWllfdDskVtevk 318
           +hLkRf  ++e + + ki+++v+fple Ldl+pf+++++++q   ++Y+L++v++H+G+++sGHY+ay++n  +g+W++fdD++Vtev+
   Q: 585  IHLKRF--RHEVMYSFKISSHVSFPLEgLDLRPFLAKECTSQ--ITTYDLLSVICHHGTAGSGHYIAYCQNvINGQWYEFDDQYVTEVH 669
           ******..9999***************************999..9**************************78999************* PP
   S: 319  eeevleetgstaYvlfYkr 337
           e+ v++   ++aYvlfY++
   Q: 670  ETVVQS---AEAYVLFYRK 685
           ******...********98 PP

Organism

Canis familiaris

Protein Sequence
(Fasta)

MGDSRDFCPH LDSIGEVTKE DLLFKSKGAC QSCGVTGPNL WACLQVACPY VGCGESFADH 60
STIHAQAKKH NLTVNLTTFR VWCYACEKEV FLEQRLAAHP AGPSPRFSEQ DSPLPSHPLK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGATGGTGT TCAGTTGCTG CTCACAATAG CTGATACCCC AGGATTTGGA GATACAGCCC 60
ATAATGTAAT TGCTGGCAGC CTGTTTTTGA CCACATTGCT AGTAAATTTG AAGACTAAGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS51283--DUSP
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF06337--DUSP
PF00443--UCH
PF02148--zf-UBP

SMART

SM00695--DUSP
SM00290--ZnF_UBP

Gene Ontology

GO:0005813--C:centrosome
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0008277--P:regulation of G-protein coupled receptor protein signaling pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

cfa:480696

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002209	Ailuropoda melanoleuca	95.19	0.00e+00	1708.00
IUUC-Apl-003351	Anas platyrhynchos	84.67	0.00e+00	1563.00
IUUC-Aca-005077	Anolis carolinensis	75.20	0.00e+00	1102.00
IUUC-Ame-011777	Astyanax mexicanus	74.92	0.00e+00	1328.00
IUUC-Bta-013063	Bos taurus	93.88	0.00e+00	1662.00
IUUC-Cja-019868	Callithrix jacchus	92.47	0.00e+00	1696.00
IUUC-Cpo-022267	Cavia porcellus	84.95	0.00e+00	1528.00
IUUC-Csa-024251	Chlorocebus sabaeus	93.66	0.00e+00	1710.00
IUUC-Cho-024483	Choloepus hoffmanni	95.75	2.00e-122	432.00
IUUC-Csv-025889	Ciona savignyi	43.75	2.00e-35	141.00
IUUC-Dre-028061	Danio rerio	73.82	0.00e+00	1203.00
IUUC-Dno-029423	Dasypus novemcinctus	94.10	0.00e+00	1693.00
IUUC-Dor-030877	Dipodomys ordii	90.00	0.00e+00	1078.00
IUUC-Dme-031837	Drosophila melanogaster	49.45	6.00e-137	481.00
IUUC-Ete-032802	Echinops telfairi	80.34	4.00e-136	478.00
IUUC-Eca-034283	Equus caballus	93.55	0.00e+00	1687.00
IUUC-Eeu-034620	Erinaceus europaeus	90.79	0.00e+00	1181.00
IUUC-Fca-036357	Felis catus	95.74	0.00e+00	1697.00
IUUC-Fal-037411	Ficedula albicollis	85.42	0.00e+00	1563.00
IUUC-Gga-041101	Gallus gallus	84.70	0.00e+00	1540.00
IUUC-Gac-041315	Gasterosteus aculeatus	73.45	0.00e+00	1310.00
IUUC-Ggo-045600	Gorilla gorilla	93.37	0.00e+00	1662.00
IUUC-Hsa-045825	Homo sapiens	93.99	0.00e+00	1675.00
IUUC-Itr-048549	Ictidomys tridecemlineatus	80.53	0.00e+00	1388.00
IUUC-Lch-050002	Latimeria chalumnae	74.49	0.00e+00	1307.00
IUUC-Loc-052574	Lepisosteus oculatus	77.04	0.00e+00	1400.00
IUUC-Laf-054428	Loxodonta africana	92.15	0.00e+00	1656.00
IUUC-Mcc-055736	Macaca mulatta	93.66	0.00e+00	1707.00
IUUC-Mga-059781	Meleagris gallopavo	84.16	0.00e+00	1541.00
IUUC-Mdo-063048	Monodelphis domestica	87.69	0.00e+00	1528.00
IUUC-Mmu-064079	Mus musculus	90.72	0.00e+00	1630.00
IUUC-Mpu-066616	Mustela putorius furo	94.00	0.00e+00	1743.00
IUUC-Mlu-067294	Myotis lucifugus	92.46	0.00e+00	1609.00
IUUC-Nle-070015	Nomascus leucogenys	93.44	0.00e+00	1634.00
IUUC-Opr-070328	Ochotona princeps	92.15	0.00e+00	1664.00
IUUC-Ont-071464	Oreochromis niloticus	73.88	0.00e+00	1299.00
IUUC-Oan-073259	Ornithorhynchus anatinus	78.79	0.00e+00	1310.00
IUUC-Ocu-074630	Oryctolagus cuniculus	89.73	0.00e+00	1585.00
IUUC-Ola-087240	Oryzias latipes	73.35	0.00e+00	1283.00
IUUC-Oga-088761	Otolemur garnettii	92.24	0.00e+00	1682.00
IUUC-Oar-089490	Ovis aries	88.74	0.00e+00	1506.00
IUUC-Ptr-091662	Pan troglodytes	94.10	0.00e+00	1675.00
IUUC-Pan-092199	Papio anubis	93.24	0.00e+00	1699.00
IUUC-Psi-093726	Pelodiscus sinensis	85.61	0.00e+00	1557.00
IUUC-Pma-094389	Petromyzon marinus	63.76	3.00e-98	351.00
IUUC-Pab-098632	Pongo abelii	93.77	0.00e+00	1667.00
IUUC-Pca-100614	Procavia capensis	85.38	0.00e+00	1285.00
IUUC-Pva-102922	Pteropus vampyrus	91.05	0.00e+00	970.00
IUUC-Rno-105215	Rattus norvegicus	90.38	0.00e+00	1626.00
IUUC-Sce-106176	Saccharomyces cerevisiae	32.97	6.00e-26	112.00
IUUC-Sha-106601	Sarcophilus harrisii	85.62	0.00e+00	1508.00
IUUC-Ssc-115533	Sus scrofa	91.90	0.00e+00	1635.00
IUUC-Tgu-117364	Taeniopygia guttata	85.26	0.00e+00	1525.00
IUUC-Tru-117770	Takifugu rubripes	71.31	0.00e+00	1275.00
IUUC-Tni-120001	Tetraodon nigroviridis	72.64	0.00e+00	1252.00
IUUC-Ttr-128732	Tursiops truncatus	94.32	0.00e+00	1682.00
IUUC-Xtr-132157	Xenopus tropicalis	76.04	0.00e+00	1354.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence