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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063349
UUCD1 version UUC-MuM-00052
Ensembl Protein ID ENSMUSP00000028761.4
UniProt Accession Q925F4; RNF37_MOUSE
Genbank Protein ID AAK51467.1; AAH25068.1
Protein Name RING finger protein 37; RING-type E3 ubiquitin transferase RNF37; U-box domain-containing protein 5; UbcM4-interacting protein 5
Genbank Nucleotide ID AF360997; BC025068
Gene Name Ubox5; Rnf37; Uip5
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000027300.9 ENSMUST00000028761.4 ENSMUSP00000028761.4
ENSMUSG00000027300.9 ENSMUST00000140581.1 ENSMUSP00000114878.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
microRNATRANSFACRepTarRAID2
Protein-protein Interaction
IIDMentha
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 17050664
E3 activity/RING/U-box U-box 17050664
Classification
Family E-value Score Start End
E3 activity/RING/U-box 2.00e-18 67.3 258 337
E3 activity/RING/RING 0.00087 20.9 481 526
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/U-box
   S: 1    evpeeflCpIslelMrdPvvlpsGitydrssIekwlasggk.....tcPvtrqplteedl.vPnltlrrliqawceenss 74
           +vpeefl+pI+le+M +P+ lpsG ++d+s++ek+  s        ++P+t+  +t++++  P+ +l++ i++++ ++s+
   Q: 258  DVPEEFLDPITLEIMPCPMLLPSGKVIDQSTLEKCNLSEAAwgrvpSDPFTGLAFTPQSQpLPHPSLKARIDRFLLQHSI 337
           69*********************************877777999***********999999****************987 PP
   

   E3 activity/RING/RING
   S: 1    CaiCledf.....kdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           Ca C++ f      ++++ lpCgH+ ++ Cl +k        s+  +C  Cr
   Q: 481  CASCKQAFssystNEPVYQLPCGHLLCRPCLsEKQ------RSQPMMCTACR 526
           9***999998998778999***********94444......899999*9998 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     May have a ubiquitin-protein ligase activity acting as an E3 ubiquitin-protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates.
 May have a ubiquitin-protein ligase activity acting as an E3 ubiquitin-protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates.
Protein Sequence
(Fasta)
MVVNLCLPQF RPRIHCNKVS ADGYEVENLI SEDLIKRSHG FRTEYFIRPP IYVTVSFPFN 60
VEICRVNIDL TTGGYQNVSG LELYTSALSS RVSQDAQDCW TTGPVETSVP DKEAFTLVGK 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063349|E3,RING;E3,U-box|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AAGCGGAAGG TGAGGGCCGC TGGCCGGAAG TGGGTTGTGG AGCGGTTGAT GCAGGAGTCT 60
GTGCATTGAC TTACCCGGGG CGGCCCGGGA CTGGAGTTAG GGAGCTGCCT TCGCGGGCTT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063349|E3,RING;E3,U-box|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR008979--Galactose-bd-like
IPR003613--Ubox_domain
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS51698--U_BOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF04564--U-box
PF14634--zf-RING_5
SMART

SM00504--Ubox
Gene Ontology

GO:0005925--C:focal adhesion
GO:0016604--C:nuclear body
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0034450--F:ubiquitin-ubiquitin ligase activity
GO:0008270--F:zinc ion binding
GO:0000209--P:protein polyubiquitination
KEGG mmu:140629
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001702 Ailuropoda melanoleuca 80.96 0.00e+00 869.00
IUUC-Apl-003809 Anas platyrhynchos 58.32 1.00e-179 622.00
IUUC-Ame-011326 Astyanax mexicanus 40.11 5.00e-64 238.00
IUUC-Bta-012836 Bos taurus 73.20 0.00e+00 740.00
IUUC-Cja-018735 Callithrix jacchus 78.56 0.00e+00 849.00
IUUC-Cfa-020914 Canis familiaris 79.85 0.00e+00 848.00
IUUC-Cpo-022397 Cavia porcellus 75.60 0.00e+00 822.00
IUUC-Csa-023033 Chlorocebus sabaeus 79.87 0.00e+00 760.00
IUUC-Cho-025050 Choloepus hoffmanni 75.75 1.00e-130 459.00
IUUC-Cin-025271 Ciona intestinalis 26.74 1.00e-22 99.80
IUUC-Csv-025960 Ciona savignyi 28.77 1.00e-25 109.00
IUUC-Dre-028494 Danio rerio 35.27 1.00e-64 240.00
IUUC-Dno-029134 Dasypus novemcinctus 68.11 2.00e-151 529.00
IUUC-Dme-032212 Drosophila melanogaster 41.61 7.00e-26 111.00
IUUC-Eca-033535 Equus caballus 79.48 0.00e+00 845.00
IUUC-Fca-036298 Felis catus 80.51 0.00e+00 864.00
IUUC-Fal-037385 Ficedula albicollis 59.19 1.00e-172 599.00
IUUC-Gmo-039572 Gadus morhua 63.01 6.00e-22 98.60
IUUC-Gga-040207 Gallus gallus 57.93 4.00e-180 624.00
IUUC-Gac-042339 Gasterosteus aculeatus 40.06 3.00e-54 206.00
IUUC-Ggo-044710 Gorilla gorilla 79.67 0.00e+00 876.00
IUUC-Hsa-045766 Homo sapiens 79.30 0.00e+00 873.00
IUUC-Itr-048280 Ictidomys tridecemlineatus 80.04 0.00e+00 885.00
IUUC-Lch-050587 Latimeria chalumnae 46.68 8.00e-128 450.00
IUUC-Laf-053430 Loxodonta africana 73.38 0.00e+00 760.00
IUUC-Mcc-055661 Macaca mulatta 79.48 0.00e+00 875.00
IUUC-Meu-055959 Macropus eugenii 56.69 9.00e-163 566.00
IUUC-Mga-059505 Meleagris gallopavo 58.04 1.00e-179 622.00
IUUC-Mmr-061218 Microcebus murinus 80.59 0.00e+00 836.00
IUUC-Mdo-062113 Monodelphis domestica 62.86 0.00e+00 663.00
IUUC-Mpu-066189 Mustela putorius furo 74.31 0.00e+00 741.00
IUUC-Mlu-067083 Myotis lucifugus 78.19 0.00e+00 858.00
IUUC-Nle-069481 Nomascus leucogenys 82.52 2.00e-117 415.00
IUUC-Opr-070674 Ochotona princeps 73.96 0.00e+00 785.00
IUUC-Ont-071995 Oreochromis niloticus 36.64 3.00e-77 282.00
IUUC-Oan-073003 Ornithorhynchus anatinus 59.12 4.00e-164 571.00
IUUC-Ocu-073834 Oryctolagus cuniculus 79.30 0.00e+00 834.00
IUUC-Ola-086469 Oryzias latipes 36.33 1.00e-74 273.00
IUUC-Oga-088316 Otolemur garnettii 78.39 0.00e+00 733.00
IUUC-Oar-089563 Ovis aries 77.02 0.00e+00 838.00
IUUC-Ptr-091293 Pan troglodytes 79.11 0.00e+00 872.00
IUUC-Pan-092705 Papio anubis 79.23 0.00e+00 868.00
IUUC-Psi-093111 Pelodiscus sinensis 59.70 0.00e+00 637.00
IUUC-Pfo-096603 Poecilia formosa 30.09 2.00e-34 140.00
IUUC-Pab-098636 Pongo abelii 78.14 0.00e+00 765.00
IUUC-Pca-100109 Procavia capensis 67.79 8.00e-154 536.00
IUUC-Pva-103028 Pteropus vampyrus 80.78 0.00e+00 837.00
IUUC-Ptt-103949 Puccinia triticina 37.84 4.20e-02 33.10
IUUC-Rno-104883 Rattus norvegicus 92.39 0.00e+00 980.00
IUUC-Sha-107133 Sarcophilus harrisii 54.40 2.00e-167 582.00
IUUC-Ssc-116252 Sus scrofa 73.43 0.00e+00 766.00
IUUC-Tgu-117163 Taeniopygia guttata 58.64 3.00e-172 598.00
IUUC-Tru-118541 Takifugu rubripes 35.69 5.00e-73 268.00
IUUC-Tsy-119281 Tarsius syrichta 72.90 2.00e-155 542.00
IUUC-Tni-120789 Tetraodon nigroviridis 37.23 2.00e-72 266.00
IUUC-Ttr-128555 Tursiops truncatus 80.04 0.00e+00 851.00
IUUC-Xtr-132303 Xenopus tropicalis 52.38 2.00e-153 535.00
Created Date 25-Jun-2017

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