iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000028514.15	ENSMUST00000094933.4	ENSMUSP00000092538.4
ENSMUSG00000028514.15	ENSMUST00000165709.7	ENSMUSP00000133095.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	microRNA	TRANSFAC	RAID2
Protein-protein Interaction
IID	HINT
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
UniProt	PHOSIDA	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/UBA	UBA	24286619

Classification

Family	E-value	Score	Start	End
DUB/USP	2.20e-78	265.0	1686	2038
UBD/Alpha-Helix/UBA	2.60e-05	25.3	4	41

Active Site

Position(s)	Description	Evidence
1695	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
1967	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgy 87
           +Gl+N g+tCYmN+v Q+L++ p l e ll+     ++++  ++p+ ++  ++q+lf +l++sk +++ p++++k++k++++e+   
   Q: 1686 VGLRNGGATCYMNAVFQQLYMQPGLPESLLS-----VDDD-TDNPDDSVFYQVQSLFGHLMESKLQYYVPENFWKIFKMWNKELYVR 1766
           6******************************.....5444.468999**************************************** PP
   S: 88   eqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlsl 174
           eqqDa Ef++ l+dq++e+l                          kk+  +++ +++Fqg +++q +c++c ++++ree f+ l+l
   Q: 1767 EQQDAYEFFTSLIDQMDEYL--------------------------KKMGREQIFKNTFQGIYSDQKICKDCPHRYEREEAFMALNL 1827
           ********************..........................789999*********************************** PP
   S: 175  pvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdl 261
            v + +     sl+ +L++f++ e leg+n+yycekck+k+ ++k++ +k+lP vL++hL+Rf f+ e ++++k ++++ fp +L++
   Q: 1828 GVTSCQ-----SLEISLDQFVRGEVLEGSNAYYCEKCKEKRITVKRTCIKSLPSVLVIHLMRFGFDWESGRSIKYDEQIRFPWMLNM 1909
           ******.....9*************************************************************************** PP
   S: 262  spfcts.....peekqke.........................kkkYeLiavvvHsGslssGHYvayvkn....ekgkWllfdDskV 314
           +p+++      +     +                         +++YeL++v+vHsG+++ GHY++++k+     kgkW++f+D+ +
   Q: 1910 EPYTVAgmarqD-----SssevgengrnmdqggggsprkkvalTENYELVGVIVHSGQAHAGHYYSFIKDrrgcGKGKWYKFNDTVI 1991
           ****99566550.....34445555566666666666666666***************************55555666********* PP
   S: 315  tevk.eeevleetg.......................staYvlfYkr 337
           +e +  +e le +                        ++aY+lfY+r
   Q: 1992 EEFDlNDETLEYECfggeyrpkvydqtnpytdvrrryWNAYMLFYQR 2038
           ***844666664449******************************98 PP

UBD/Alpha-Helix/UBA

   S: 2    ededkleqlveMGF.dreealqaLraannnleaAveyL 38
           e+e+ +  l  MGF d+ ++++aLr a n++++Av++L
   Q: 4    EEEQHMTTLLCMGFsDPATIRKALRLAKNDINEAVALL 41
           6788889999**************************98 PP

Organism

Mus musculus

Functional Description
(View)

Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Deubiquitinates DDB2, preventing its proteasomal degradation (By similarity).

Protein Sequence
(Fasta)

MESEEEQHMT TLLCMGFSDP ATIRKALRLA KNDINEAVAL LTNERPGLDY GGYEPMDSGG 60
PSPGPGGGPR GDSGSDGSGP SRGGSTGGGG GFDPPPAYHE VVDAEKNDEN GNCSGEGIEF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAAGAGGAGG AGCAGGCCAA CATGGCGGCG CGCAGGGCTG GGCCGGCCGG CCGCGCCTGA 60
GCGCCCCACC ACCCCAGCTC GGCTCGCTGC GCCCACGCGC GCACCTAACC CTGGCCCGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR029071--Ubiquitin-rel_dom
IPR033382--USP24
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

mmu:329908

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002266	Ailuropoda melanoleuca	98.10	0.00e+00	4812.00
IUUC-Apl-003203	Anas platyrhynchos	74.33	0.00e+00	3498.00
IUUC-Aca-004396	Anolis carolinensis	89.26	0.00e+00	4493.00
IUUC-Ame-011886	Astyanax mexicanus	84.24	0.00e+00	1769.00
IUUC-Bta-013381	Bos taurus	97.13	0.00e+00	4874.00
IUUC-Cel-018352	Caenorhabditis elegans	30.13	3.00e-63	238.00
IUUC-Cja-018955	Callithrix jacchus	97.63	0.00e+00	4404.00
IUUC-Cfa-020720	Canis familiaris	97.89	0.00e+00	4801.00
IUUC-Cpo-022430	Cavia porcellus	95.48	0.00e+00	3433.00
IUUC-Csa-024180	Chlorocebus sabaeus	97.87	0.00e+00	4626.00
IUUC-Cho-025074	Choloepus hoffmanni	91.74	0.00e+00	1832.00
IUUC-Dre-027696	Danio rerio	80.05	0.00e+00	4085.00
IUUC-Dno-029307	Dasypus novemcinctus	94.56	0.00e+00	4756.00
IUUC-Dor-030889	Dipodomys ordii	94.59	0.00e+00	4605.00
IUUC-Ete-032294	Echinops telfairi	92.33	0.00e+00	2317.00
IUUC-Eca-033823	Equus caballus	92.52	0.00e+00	4509.00
IUUC-Eeu-035178	Erinaceus europaeus	88.46	0.00e+00	2124.00
IUUC-Fca-035444	Felis catus	97.89	0.00e+00	4744.00
IUUC-Fal-037555	Ficedula albicollis	92.19	0.00e+00	4516.00
IUUC-Gmo-038587	Gadus morhua	80.12	0.00e+00	2494.00
IUUC-Gga-041231	Gallus gallus	91.56	0.00e+00	4616.00
IUUC-Gac-041584	Gasterosteus aculeatus	79.94	0.00e+00	2457.00
IUUC-Ggo-044502	Gorilla gorilla	96.60	0.00e+00	4858.00
IUUC-Hsa-045851	Homo sapiens	96.76	0.00e+00	4873.00
IUUC-Itr-048746	Ictidomys tridecemlineatus	97.47	0.00e+00	1573.00
IUUC-Lch-049999	Latimeria chalumnae	79.57	0.00e+00	3927.00
IUUC-Loc-051767	Lepisosteus oculatus	82.07	0.00e+00	4118.00
IUUC-Laf-054139	Loxodonta africana	96.56	0.00e+00	4867.00
IUUC-Mcc-055217	Macaca mulatta	96.83	0.00e+00	4873.00
IUUC-Meu-056659	Macropus eugenii	81.33	0.00e+00	2249.00
IUUC-Mga-059267	Meleagris gallopavo	92.36	0.00e+00	4546.00
IUUC-Mmr-060971	Microcebus murinus	95.78	0.00e+00	4819.00
IUUC-Mdo-061925	Monodelphis domestica	93.77	0.00e+00	4626.00
IUUC-Mpu-066652	Mustela putorius furo	96.91	0.00e+00	4911.00
IUUC-Mlu-067518	Myotis lucifugus	97.57	0.00e+00	4733.00
IUUC-Nle-069763	Nomascus leucogenys	97.77	0.00e+00	4749.00
IUUC-Opr-071031	Ochotona princeps	91.24	0.00e+00	4400.00
IUUC-Ont-072136	Oreochromis niloticus	78.27	0.00e+00	3992.00
IUUC-Oan-072908	Ornithorhynchus anatinus	85.13	0.00e+00	968.00
IUUC-Ocu-073880	Oryctolagus cuniculus	96.37	0.00e+00	4870.00
IUUC-Ola-086544	Oryzias latipes	77.46	0.00e+00	3853.00
IUUC-Oga-088695	Otolemur garnettii	97.44	0.00e+00	4931.00
IUUC-Oar-089401	Ovis aries	97.29	0.00e+00	4730.00
IUUC-Ptr-091657	Pan troglodytes	97.89	0.00e+00	4771.00
IUUC-Pan-092394	Papio anubis	96.87	0.00e+00	4875.00
IUUC-Psi-093813	Pelodiscus sinensis	92.41	0.00e+00	4522.00
IUUC-Pma-094698	Petromyzon marinus	53.33	4.00e-140	491.00
IUUC-Pfo-096811	Poecilia formosa	78.93	0.00e+00	3992.00
IUUC-Pab-097814	Pongo abelii	96.79	0.00e+00	4872.00
IUUC-Pca-101135	Procavia capensis	92.23	0.00e+00	2216.00
IUUC-Pva-102334	Pteropus vampyrus	92.58	0.00e+00	4619.00
IUUC-Rno-105040	Rattus norvegicus	98.70	0.00e+00	4953.00
IUUC-Sha-106658	Sarcophilus harrisii	94.44	0.00e+00	4648.00
IUUC-Sar-113153	Sorex araneus	86.62	0.00e+00	2748.00
IUUC-Ssc-115641	Sus scrofa	95.98	0.00e+00	4576.00
IUUC-Tgu-117467	Taeniopygia guttata	92.90	0.00e+00	3303.00
IUUC-Tru-118074	Takifugu rubripes	72.28	0.00e+00	3451.00
IUUC-Tsy-119165	Tarsius syrichta	93.51	0.00e+00	4507.00
IUUC-Tni-119923	Tetraodon nigroviridis	68.66	0.00e+00	3219.00
IUUC-Tbe-127910	Tupaia belangeri	88.94	0.00e+00	1816.00
IUUC-Ttr-128218	Tursiops truncatus	96.42	0.00e+00	4737.00
IUUC-Vpa-130090	Vicugna pacos	98.39	0.00e+00	1735.00
IUUC-Xtr-131911	Xenopus tropicalis	86.39	0.00e+00	1717.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence