iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
Post-translational Modifications (PTMs)
dbPAF	dbPTM	Phospho.ELM	UniProt
PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/Alpha-Helix/UBA	53.05	1.00e-122	437.00	IUUC-Ath-007014

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Caenorhabditis elegans

Functional Description
(View)

Acts as a sensor that couples lifespan to information about energy levels and insulin-like signals (PubMed:15574588). Role in motility and response to oxidative stress (PubMed:18408008, PubMed:24763318). Involved in the establishment of germline stem cell (GSC) quiescence during dauer development (PubMed:15574588, PubMed:20110331). Plays a role in axon regrowth after axotomy in PLM neurons (PubMed:24431434). Plays a role in the maintenance of glycogen stores which are necessary for resistance to hyperosmotic stress (PubMed:26439621).

Protein Sequence
(Fasta)

MFSHQDRDRD RKEDGGGDGT EMKSKSRSQP SGLNRVKNLS RKLSAKSRKE RKDRDSTDNS 60
SKMSSPGGET STKQQQELKA QIKIGHYILK ETLGVGTFGK VKVGIHETTQ YKVAVKILNR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAATGTTTTC TCATCAAGAT CGAGACCGCG ATAGGAAGGA GGACGGTGGT GGAGACGGTA 60
CTGAGATGAA ATCCAAGAGT CGGAGTCAGC CAAGTGGACT TAATCGCGTG AAAAATCTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0346--Stress response
KW-0808--Transferase

Interpro

IPR032270--AMPK_C
IPR028375--KA1/Ssp2_C
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR008271--Ser/Thr_kinase_AS

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST

Pfam

PF16579--AdenylateSensor
PF00069--Pkinase

SMART

SM00220--S_TKc

Gene Ontology

GO:0030424--C:axon
GO:0005737--C:cytoplasm
GO:0043025--C:neuronal cell body
GO:0031588--C:nucleotide-activated protein kinase complex
GO:0005634--C:nucleus
GO:0004679--F:AMP-activated protein kinase activity
GO:0005524--F:ATP binding
GO:0035174--F:histone serine kinase activity
GO:0042149--P:cellular response to glucose starvation
GO:0008340--P:determination of adult lifespan
GO:0035262--P:gonad morphogenesis
GO:0035556--P:intracellular signal transduction
GO:0032007--P:negative regulation of TOR signaling
GO:0018105--P:peptidyl-serine phosphorylation
GO:0061066--P:positive regulation of dauer larval development

KEGG

cel:CELE_T01C8.1

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000713	Aegilops tauschii	47.61	2.00e-120	424.00
IUUC-Aml-001907	Ailuropoda melanoleuca	57.32	9.00e-165	572.00
IUUC-Atr-002770	Amborella trichopoda	47.84	6.00e-124	436.00
IUUC-Apl-003395	Anas platyrhynchos	57.88	6.00e-172	595.00
IUUC-Aca-004480	Anolis carolinensis	64.23	8.00e-179	618.00
IUUC-Aly-006289	Arabidopsis lyrata	48.97	5.00e-125	439.00
IUUC-Ath-007014	Arabidopsis thaliana	52.66	3.00e-125	441.00
IUUC-Ago-007957	Ashbya gossypii	42.51	1.00e-110	392.00
IUUC-Acl-008103	Aspergillus clavatus	57.48	5.00e-101	360.00
IUUC-Afl-008555	Aspergillus flavus	55.73	1.00e-103	369.00
IUUC-Afu-008949	Aspergillus fumigatus	60.43	1.00e-100	359.00
IUUC-Ani-009408	Aspergillus nidulans	53.94	2.00e-102	365.00
IUUC-Ang-009551	Aspergillus niger	58.16	2.00e-101	362.00
IUUC-Aor-010176	Aspergillus oryzae	55.73	1.00e-103	369.00
IUUC-Ate-010287	Aspergillus terreus	57.82	3.00e-101	361.00
IUUC-Ame-011019	Astyanax mexicanus	57.24	0.00e+00	627.00
IUUC-Bgr-012045	Blumeria graminis	58.04	8.00e-108	383.00
IUUC-Bta-012786	Bos taurus	57.77	1.00e-165	575.00
IUUC-Bci-013774	Botrytis cinerea	57.69	1.00e-106	379.00
IUUC-Bdi-014319	Brachypodium distachyon	46.41	6.00e-121	426.00
IUUC-Bol-016242	Brassica oleracea	49.16	8.00e-127	446.00
IUUC-Bra-016750	Brassica rapa	49.37	2.00e-127	447.00
IUUC-Cja-019386	Callithrix jacchus	57.62	0.00e+00	632.00
IUUC-Cfa-020177	Canis familiaris	57.12	1.00e-160	558.00
IUUC-Cpo-021805	Cavia porcellus	58.35	0.00e+00	639.00
IUUC-Cre-022915	Chlamydomonas reinhardtii	59.33	1.00e-87	314.00
IUUC-Csa-024267	Chlorocebus sabaeus	57.82	0.00e+00	628.00
IUUC-Cho-024859	Choloepus hoffmanni	55.98	1.00e-156	545.00
IUUC-Cin-025550	Ciona intestinalis	54.77	6.00e-172	595.00
IUUC-Csv-026139	Ciona savignyi	54.61	7.00e-175	605.00
IUUC-Cne-027044	Cryptococcus neoformans	46.95	2.00e-101	362.00
IUUC-Cme-027289	Cyanidioschyzon merolae	46.03	5.00e-112	397.00
IUUC-Dre-027749	Danio rerio	54.64	1.00e-167	581.00
IUUC-Dno-030006	Dasypus novemcinctus	57.42	6.00e-165	572.00
IUUC-Dor-030578	Dipodomys ordii	57.29	1.00e-180	625.00
IUUC-Dse-031507	Dothistroma septosporum	58.17	3.00e-106	378.00
IUUC-Dme-031704	Drosophila melanogaster	74.85	4.00e-147	513.00
IUUC-Ete-033055	Echinops telfairi	56.05	1.00e-167	582.00
IUUC-Eca-034016	Equus caballus	58.33	7.00e-173	598.00
IUUC-Fca-035754	Felis catus	56.51	9.00e-163	565.00
IUUC-Fal-037363	Ficedula albicollis	57.77	2.00e-165	574.00
IUUC-Fox-038073	Fusarium oxysporum	60.26	5.00e-108	384.00
IUUC-Fso-038236	Fusarium solani	61.89	3.00e-105	374.00
IUUC-Gmo-039633	Gadus morhua	54.31	3.00e-175	607.00
IUUC-Ggr-039987	Gaeumannomyces graminis	60.58	2.00e-103	368.00
IUUC-Gga-040546	Gallus gallus	58.30	0.00e+00	638.00
IUUC-Gac-041822	Gasterosteus aculeatus	57.32	3.00e-176	610.00
IUUC-Gma-042712	Glycine max	48.25	3.00e-124	437.00
IUUC-Ggo-045303	Gorilla gorilla	57.82	0.00e+00	633.00
IUUC-Hsa-045746	Homo sapiens	57.82	0.00e+00	633.00
IUUC-Hvu-047406	Hordeum vulgare	47.23	6.00e-124	436.00
IUUC-Itr-048134	Ictidomys tridecemlineatus	58.00	0.00e+00	635.00
IUUC-Kpa-049190	Komagataella pastoris	44.74	1.00e-115	408.00
IUUC-Lch-049623	Latimeria chalumnae	57.19	1.00e-164	571.00
IUUC-Lpe-051392	Leersia perrieri	46.54	5.00e-121	426.00
IUUC-Loc-052928	Lepisosteus oculatus	59.23	0.00e+00	640.00
IUUC-Lma-053054	Leptosphaeria maculans	57.06	2.00e-108	385.00
IUUC-Laf-053459	Loxodonta africana	58.00	0.00e+00	632.00
IUUC-Mcc-055862	Macaca mulatta	57.82	0.00e+00	633.00
IUUC-Mor-057170	Magnaporthe oryzae	49.34	2.00e-102	365.00
IUUC-Mpo-057302	Magnaporthe poae	59.30	4.00e-105	374.00
IUUC-Mtr-058309	Medicago truncatula	50.32	9.00e-123	432.00
IUUC-Mla-059058	Melampsora laricipopulina	56.99	2.00e-94	338.00
IUUC-Mga-059206	Meleagris gallopavo	58.85	2.00e-172	597.00
IUUC-Mvi-060337	Microbotryum violaceum	50.41	2.00e-101	361.00
IUUC-Mmr-061619	Microcebus murinus	58.17	0.00e+00	630.00
IUUC-Mdo-062160	Monodelphis domestica	57.65	2.00e-180	624.00
IUUC-Mmu-063406	Mus musculus	57.64	0.00e+00	629.00
IUUC-Mac-064518	Musa acuminata	44.96	1.00e-115	408.00
IUUC-Mpu-066326	Mustela putorius furo	57.96	2.00e-172	597.00
IUUC-Mlu-067968	Myotis lucifugus	57.14	2.00e-169	587.00
IUUC-Nfi-068493	Neosartorya fischeri	60.43	8.00e-101	360.00
IUUC-Ncr-068665	Neurospora crassa	49.75	2.00e-107	382.00
IUUC-Nle-070158	Nomascus leucogenys	57.82	0.00e+00	632.00
IUUC-Opr-070272	Ochotona princeps	56.16	1.00e-162	565.00
IUUC-Ont-071395	Oreochromis niloticus	57.82	0.00e+00	634.00
IUUC-Oan-073322	Ornithorhynchus anatinus	55.76	4.00e-158	550.00
IUUC-Ocu-074188	Oryctolagus cuniculus	56.92	4.00e-162	563.00
IUUC-Oba-075436	Oryza barthii	47.05	5.00e-123	433.00
IUUC-Obr-076507	Oryza brachyantha	47.36	2.00e-123	434.00
IUUC-Ogl-077718	Oryza glaberrima	49.77	2.00e-119	421.00
IUUC-Ogu-078349	Oryza glumaepatula	47.05	6.00e-123	433.00
IUUC-Oin-079889	Oryza indica	46.44	1.00e-119	422.00
IUUC-Olo-080521	Oryza longistaminata	47.05	8.00e-123	432.00
IUUC-Ome-081630	Oryza meridionalis	46.84	2.00e-122	431.00
IUUC-Oni-082211	Oryza nivara	47.05	2.00e-123	434.00
IUUC-Opu-083617	Oryza punctata	46.56	5.00e-122	429.00
IUUC-Oru-084252	Oryza rufipogon	47.05	5.00e-123	432.00
IUUC-Osa-085548	Oryza sativa	47.05	5.00e-123	432.00
IUUC-Ola-087169	Oryzias latipes	56.53	0.00e+00	631.00
IUUC-Olu-087861	Ostreococcus lucimarinus	49.65	4.00e-114	403.00
IUUC-Oga-088003	Otolemur garnettii	57.69	3.00e-165	573.00
IUUC-Oar-089933	Ovis aries	57.77	1.00e-165	575.00
IUUC-Ptr-090741	Pan troglodytes	57.82	0.00e+00	633.00
IUUC-Pan-092526	Papio anubis	57.87	2.00e-165	574.00
IUUC-Psi-094034	Pelodiscus sinensis	57.12	2.00e-163	567.00
IUUC-Pno-095030	Phaeosphaeria nodorum	57.70	1.00e-106	378.00
IUUC-Ppa-095615	Physcomitrella patens	51.26	3.00e-121	427.00
IUUC-Pfo-096295	Poecilia formosa	58.10	0.00e+00	630.00
IUUC-Pab-098023	Pongo abelii	57.82	0.00e+00	633.00
IUUC-Pop-100042	Populus trichocarpa	47.45	1.00e-124	438.00
IUUC-Pca-101104	Procavia capensis	63.01	4.00e-128	450.00
IUUC-Ppe-101642	Prunus persica	52.78	3.00e-122	430.00
IUUC-Pva-102470	Pteropus vampyrus	57.64	6.00e-180	622.00
IUUC-Pgr-103406	Puccinia graminis	56.51	1.00e-91	329.00
IUUC-Ptt-103713	Puccinia triticina	34.55	7.00e-78	283.00
IUUC-Pte-104259	Pyrenophora teres	55.84	5.00e-107	380.00
IUUC-Pyt-104752	Pyrenophora triticirepentis	56.47	4.00e-108	384.00
IUUC-Rno-104960	Rattus norvegicus	58.00	0.00e+00	634.00
IUUC-Sce-106290	Saccharomyces cerevisiae	40.93	1.00e-109	389.00
IUUC-Sha-107603	Sarcophilus harrisii	57.77	1.00e-164	571.00
IUUC-Sja-107772	Schizosaccharomyces japonicus	41.39	6.00e-109	386.00
IUUC-Spo-108202	Schizosaccharomyces pombe	42.47	5.00e-111	393.00
IUUC-Ssl-108535	Sclerotinia sclerotiorum	57.74	3.00e-109	388.00
IUUC-Smo-109309	Selaginella moellendorffii	48.78	1.00e-122	432.00
IUUC-Sit-109745	Setaria italica	47.30	1.00e-119	421.00
IUUC-Sly-110890	Solanum lycopersicum	48.87	6.00e-127	446.00
IUUC-Stu-112144	Solanum tuberosum	44.83	3.00e-114	404.00
IUUC-Sar-113521	Sorex araneus	48.98	3.00e-123	434.00
IUUC-Sbi-114764	Sorghum bicolor	47.10	3.00e-120	424.00
IUUC-Sre-115141	Sporisorium reilianum	62.76	5.00e-113	400.00
IUUC-Ssc-115732	Sus scrofa	57.22	6.00e-160	555.00
IUUC-Tgu-117190	Taeniopygia guttata	57.59	6.00e-165	572.00
IUUC-Tru-118735	Takifugu rubripes	57.42	0.00e+00	630.00
IUUC-Tsy-119503	Tarsius syrichta	56.40	5.00e-163	566.00
IUUC-Tni-119880	Tetraodon nigroviridis	58.27	0.00e+00	636.00
IUUC-Tca-121386	Theobroma cacao	49.18	1.00e-123	435.00
IUUC-Tre-122070	Trichoderma reesei	62.24	1.00e-107	382.00
IUUC-Tvi-122305	Trichoderma virens	61.32	4.00e-107	380.00
IUUC-Tae-123515	Triticum aestivum	47.00	3.00e-121	427.00
IUUC-Tur-126416	Triticum urartu	47.34	6.00e-122	429.00
IUUC-Tbe-127791	Tupaia belangeri	67.83	9.00e-92	328.00
IUUC-Ttr-129224	Tursiops truncatus	56.12	7.00e-164	569.00
IUUC-Uma-129372	Ustilago maydis	62.11	9.00e-112	396.00
IUUC-Vda-129819	Verticillium dahliae	54.90	9.00e-89	320.00
IUUC-Vpa-130220	Vicugna pacos	58.26	3.00e-172	596.00
IUUC-Vvi-131649	Vitis vinifera	48.06	1.00e-123	435.00
IUUC-Xtr-132954	Xenopus tropicalis	57.89	0.00e+00	631.00
IUUC-Xma-134119	Xiphophorus maculatus	58.10	0.00e+00	630.00
IUUC-Yli-134422	Yarrowia lipolytica	44.78	2.00e-112	398.00
IUUC-Zma-135621	Zea mays	58.77	1.00e-112	399.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence