iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Cpo-021805

Ensembl Protein ID

ENSCPOP00000008947.2

UniProt Accession

H0VFT6; H0VFT6_CAVPO

Genbank Protein ID

ENSCPOP00000008947

Protein Name

Non-specific serine/threonine protein kinase

Genbank Nucleotide ID

AAKN02049388

Gene Name

PRKAA2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCPOG00000009969.3	ENSCPOT00000010059.2	ENSCPOP00000008947.2

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/Alpha-Helix/UBA	48.07	3.00e-124	442.00	IUUC-Ath-007014
UBD/Alpha-Helix/UBA	41.29	7.00e-107	382.00	IUUC-Spo-108202

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Cavia porcellus

Protein Sequence
(Fasta)

MAEKQKHDGR VKIGHYVLGD TLGVGTFGKV KIGEHQLTGH KVAVKILNRQ KIRSLDVVGK 60
IKREIQNLKL FRHPHIIKLY QVISTPTDFF MVMEYVSGGE LFDYICKHGR VEEMEARRLF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCTGAGA AACAGAAGCA CGACGGGCGG GTGAAGATCG GGCACTATGT CCTGGGGGAC 60
ACGCTGGGCG TCGGCACCTT CGGCAAAGTG AAGAGTTGAG TGCGCGGCGG CCGGGACGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase

Interpro

IPR032270--AMPK_C
IPR028375--KA1/Ssp2_C
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR008271--Ser/Thr_kinase_AS

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST

Pfam

PF16579--AdenylateSensor
PF00069--Pkinase

SMART

SM00220--S_TKc

Gene Ontology

GO:0005794--C:Golgi apparatus
GO:0016607--C:nuclear speck
GO:0004679--F:AMP-activated protein kinase activity
GO:0005524--F:ATP binding
GO:0003682--F:chromatin binding
GO:0035174--F:histone serine kinase activity
GO:0004712--F:protein serine/threonine/tyrosine kinase activity
GO:0035690--P:cellular response to drug
GO:0042149--P:cellular response to glucose starvation
GO:0071380--P:cellular response to prostaglandin E stimulus
GO:0042593--P:glucose homeostasis
GO:0008610--P:lipid biosynthetic process
GO:0043066--P:negative regulation of apoptotic process
GO:0032007--P:negative regulation of TOR signaling
GO:0010508--P:positive regulation of autophagy
GO:0042752--P:regulation of circadian rhythm
GO:0010468--P:regulation of gene expression
GO:0016241--P:regulation of macroautophagy
GO:0014850--P:response to muscle activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000713	Aegilops tauschii	47.01	3.00e-122	432.00
IUUC-Aml-001907	Ailuropoda melanoleuca	74.68	0.00e+00	794.00
IUUC-Atr-002770	Amborella trichopoda	47.77	4.00e-125	441.00
IUUC-Apl-003395	Anas platyrhynchos	93.30	0.00e+00	1019.00
IUUC-Aca-004480	Anolis carolinensis	93.73	0.00e+00	1027.00
IUUC-Aly-006289	Arabidopsis lyrata	47.96	1.00e-125	443.00
IUUC-Ath-007014	Arabidopsis thaliana	48.07	5.00e-126	444.00
IUUC-Ago-007957	Ashbya gossypii	42.62	3.00e-115	409.00
IUUC-Acl-008103	Aspergillus clavatus	60.07	3.00e-101	363.00
IUUC-Afl-008555	Aspergillus flavus	59.71	6.00e-102	365.00
IUUC-Afu-008949	Aspergillus fumigatus	47.78	2.00e-101	363.00
IUUC-Ani-009408	Aspergillus nidulans	62.17	8.00e-102	364.00
IUUC-Ang-009551	Aspergillus niger	60.07	2.00e-101	363.00
IUUC-Aor-010176	Aspergillus oryzae	59.71	6.00e-102	365.00
IUUC-Ate-010287	Aspergillus terreus	60.07	3.00e-101	362.00
IUUC-Ame-011019	Astyanax mexicanus	86.45	0.00e+00	1013.00
IUUC-Bgr-012045	Blumeria graminis	61.42	6.00e-102	365.00
IUUC-Bta-012786	Bos taurus	75.77	0.00e+00	795.00
IUUC-Bci-013774	Botrytis cinerea	46.84	5.00e-104	372.00
IUUC-Bdi-014319	Brachypodium distachyon	47.14	4.00e-125	441.00
IUUC-Bol-016242	Brassica oleracea	48.35	3.00e-128	451.00
IUUC-Bra-016750	Brassica rapa	48.25	1.00e-128	452.00
IUUC-Cel-018518	Caenorhabditis elegans	58.70	0.00e+00	632.00
IUUC-Cja-019386	Callithrix jacchus	98.73	0.00e+00	1104.00
IUUC-Cfa-020177	Canis familiaris	73.28	0.00e+00	761.00
IUUC-Cre-022915	Chlamydomonas reinhardtii	54.83	7.00e-97	347.00
IUUC-Csa-024267	Chlorocebus sabaeus	98.91	0.00e+00	1090.00
IUUC-Cho-024859	Choloepus hoffmanni	71.51	0.00e+00	748.00
IUUC-Cin-025550	Ciona intestinalis	61.97	0.00e+00	676.00
IUUC-Csv-026139	Ciona savignyi	60.04	0.00e+00	675.00
IUUC-Cne-027044	Cryptococcus neoformans	51.15	1.00e-108	387.00
IUUC-Cme-027289	Cyanidioschyzon merolae	45.57	2.00e-111	395.00
IUUC-Dre-027749	Danio rerio	70.36	0.00e+00	792.00
IUUC-Dno-030006	Dasypus novemcinctus	74.50	0.00e+00	792.00
IUUC-Dor-030578	Dipodomys ordii	98.19	0.00e+00	1100.00
IUUC-Dse-031507	Dothistroma septosporum	63.06	2.00e-105	377.00
IUUC-Dme-031704	Drosophila melanogaster	60.34	0.00e+00	664.00
IUUC-Ete-033055	Echinops telfairi	72.98	0.00e+00	810.00
IUUC-Eca-034016	Equus caballus	98.27	0.00e+00	1035.00
IUUC-Fca-035754	Felis catus	72.84	0.00e+00	787.00
IUUC-Fal-037363	Ficedula albicollis	74.59	0.00e+00	786.00
IUUC-Fox-038073	Fusarium oxysporum	51.92	3.00e-105	375.00
IUUC-Fso-038236	Fusarium solani	51.24	1.00e-101	364.00
IUUC-Gmo-039633	Gadus morhua	70.51	0.00e+00	821.00
IUUC-Ggr-039987	Gaeumannomyces graminis	49.04	2.00e-102	366.00
IUUC-Gga-040546	Gallus gallus	91.86	0.00e+00	1053.00
IUUC-Gac-041822	Gasterosteus aculeatus	83.81	0.00e+00	950.00
IUUC-Gma-042712	Glycine max	47.07	3.00e-125	441.00
IUUC-Ggo-045303	Gorilla gorilla	99.09	0.00e+00	1108.00
IUUC-Hsa-045746	Homo sapiens	99.09	0.00e+00	1108.00
IUUC-Hvu-047406	Hordeum vulgare	46.94	3.00e-125	441.00
IUUC-Itr-048134	Ictidomys tridecemlineatus	99.28	0.00e+00	1110.00
IUUC-Kpa-049190	Komagataella pastoris	45.06	5.00e-123	434.00
IUUC-Lch-049623	Latimeria chalumnae	73.23	0.00e+00	786.00
IUUC-Lpe-051392	Leersia perrieri	46.73	4.00e-125	441.00
IUUC-Loc-052928	Lepisosteus oculatus	90.42	0.00e+00	1035.00
IUUC-Lma-053054	Leptosphaeria maculans	63.30	2.00e-106	380.00
IUUC-Laf-053459	Loxodonta africana	98.01	0.00e+00	1097.00
IUUC-Mcc-055862	Macaca mulatta	99.09	0.00e+00	1108.00
IUUC-Mor-057170	Magnaporthe oryzae	50.44	4.00e-100	359.00
IUUC-Mpo-057302	Magnaporthe poae	49.18	2.00e-102	366.00
IUUC-Mtr-058309	Medicago truncatula	48.12	4.00e-124	438.00
IUUC-Mla-059058	Melampsora laricipopulina	43.09	2.00e-104	372.00
IUUC-Mga-059206	Meleagris gallopavo	91.36	0.00e+00	993.00
IUUC-Mvi-060337	Microbotryum violaceum	41.84	2.00e-107	383.00
IUUC-Mmr-061619	Microcebus murinus	98.19	0.00e+00	1088.00
IUUC-Mdo-062160	Monodelphis domestica	93.48	0.00e+00	1069.00
IUUC-Mmu-063406	Mus musculus	97.46	0.00e+00	1089.00
IUUC-Mac-064518	Musa acuminata	45.54	9.00e-122	430.00
IUUC-Mpu-066326	Mustela putorius furo	98.27	0.00e+00	1038.00
IUUC-Mlu-067968	Myotis lucifugus	96.78	0.00e+00	1005.00
IUUC-Nfi-068493	Neosartorya fischeri	60.07	1.00e-101	363.00
IUUC-Ncr-068665	Neurospora crassa	40.98	4.00e-106	379.00
IUUC-Nle-070158	Nomascus leucogenys	98.91	0.00e+00	1107.00
IUUC-Opr-070272	Ochotona princeps	72.66	0.00e+00	785.00
IUUC-Ont-071395	Oreochromis niloticus	86.20	0.00e+00	992.00
IUUC-Oan-073322	Ornithorhynchus anatinus	68.78	0.00e+00	749.00
IUUC-Ocu-074188	Oryctolagus cuniculus	73.42	0.00e+00	786.00
IUUC-Oba-075436	Oryza barthii	47.24	7.00e-127	447.00
IUUC-Obr-076507	Oryza brachyantha	47.57	1.00e-126	446.00
IUUC-Ogl-077718	Oryza glaberrima	50.11	9.00e-124	437.00
IUUC-Ogu-078349	Oryza glumaepatula	46.91	5.00e-127	447.00
IUUC-Oin-079889	Oryza indica	45.81	3.00e-124	438.00
IUUC-Olo-080521	Oryza longistaminata	47.24	1.00e-126	446.00
IUUC-Ome-081630	Oryza meridionalis	47.03	2.00e-126	445.00
IUUC-Oni-082211	Oryza nivara	47.24	5.00e-127	448.00
IUUC-Opu-083617	Oryza punctata	46.94	2.00e-125	442.00
IUUC-Oru-084252	Oryza rufipogon	47.24	1.00e-126	446.00
IUUC-Osa-085548	Oryza sativa	47.24	1.00e-126	446.00
IUUC-Ola-087169	Oryzias latipes	84.41	0.00e+00	966.00
IUUC-Olu-087861	Ostreococcus lucimarinus	49.18	2.00e-116	412.00
IUUC-Oga-088003	Otolemur garnettii	74.68	0.00e+00	794.00
IUUC-Oar-089933	Ovis aries	75.77	0.00e+00	795.00
IUUC-Ptr-090741	Pan troglodytes	99.09	0.00e+00	1108.00
IUUC-Pan-092526	Papio anubis	74.86	0.00e+00	795.00
IUUC-Psi-094034	Pelodiscus sinensis	74.19	0.00e+00	785.00
IUUC-Pno-095030	Phaeosphaeria nodorum	63.30	9.00e-105	373.00
IUUC-Ppa-095615	Physcomitrella patens	45.28	3.00e-124	438.00
IUUC-Pfo-096295	Poecilia formosa	85.30	0.00e+00	979.00
IUUC-Pab-098023	Pongo abelii	99.09	0.00e+00	1108.00
IUUC-Pop-100042	Populus trichocarpa	47.98	2.00e-128	452.00
IUUC-Pca-101104	Procavia capensis	78.87	1.00e-174	606.00
IUUC-Ppe-101642	Prunus persica	48.95	1.00e-125	443.00
IUUC-Pva-102470	Pteropus vampyrus	97.83	0.00e+00	1090.00
IUUC-Pgr-103406	Puccinia graminis	61.36	6.00e-92	332.00
IUUC-Ptt-103713	Puccinia triticina	37.85	6.00e-79	288.00
IUUC-Pte-104259	Pyrenophora teres	62.55	3.00e-105	376.00
IUUC-Pyt-104752	Pyrenophora triticirepentis	62.92	6.00e-106	378.00
IUUC-Rno-104960	Rattus norvegicus	98.37	0.00e+00	1102.00
IUUC-Sce-106290	Saccharomyces cerevisiae	42.46	8.00e-116	410.00
IUUC-Sha-107603	Sarcophilus harrisii	74.50	0.00e+00	791.00
IUUC-Sja-107772	Schizosaccharomyces japonicus	40.53	2.00e-110	392.00
IUUC-Spo-108202	Schizosaccharomyces pombe	41.29	3.00e-107	382.00
IUUC-Ssl-108535	Sclerotinia sclerotiorum	46.34	5.00e-103	368.00
IUUC-Smo-109309	Selaginella moellendorffii	45.44	3.00e-122	431.00
IUUC-Sit-109745	Setaria italica	48.18	3.00e-127	448.00
IUUC-Sly-110890	Solanum lycopersicum	48.07	2.00e-126	446.00
IUUC-Stu-112144	Solanum tuberosum	46.23	3.00e-119	422.00
IUUC-Sar-113521	Sorex araneus	65.13	0.00e+00	635.00
IUUC-Sbi-114764	Sorghum bicolor	47.99	4.00e-128	451.00
IUUC-Sre-115141	Sporisorium reilianum	66.91	1.00e-114	407.00
IUUC-Ssc-115732	Sus scrofa	73.42	0.00e+00	759.00
IUUC-Tgu-117190	Taeniopygia guttata	74.77	0.00e+00	786.00
IUUC-Tru-118735	Takifugu rubripes	84.59	0.00e+00	978.00
IUUC-Tsy-119503	Tarsius syrichta	95.38	0.00e+00	984.00
IUUC-Tni-119880	Tetraodon nigroviridis	84.79	0.00e+00	979.00
IUUC-Tca-121386	Theobroma cacao	47.46	3.00e-127	448.00
IUUC-Tre-122070	Trichoderma reesei	40.90	8.00e-103	367.00
IUUC-Tvi-122305	Trichoderma virens	47.69	1.00e-101	363.00
IUUC-Tae-123515	Triticum aestivum	47.54	2.00e-126	446.00
IUUC-Tur-126416	Triticum urartu	46.85	1.00e-123	436.00
IUUC-Tbe-127791	Tupaia belangeri	85.65	8.00e-113	400.00
IUUC-Ttr-129224	Tursiops truncatus	72.84	0.00e+00	785.00
IUUC-Uma-129372	Ustilago maydis	66.91	4.00e-114	405.00
IUUC-Vda-129819	Verticillium dahliae	54.04	8.00e-87	315.00
IUUC-Vpa-130220	Vicugna pacos	98.65	0.00e+00	1036.00
IUUC-Vvi-131649	Vitis vinifera	47.97	7.00e-126	444.00
IUUC-Xtr-132954	Xenopus tropicalis	92.22	0.00e+00	1062.00
IUUC-Xma-134119	Xiphophorus maculatus	85.13	0.00e+00	977.00
IUUC-Yli-134422	Yarrowia lipolytica	45.58	2.00e-119	422.00
IUUC-Zma-135621	Zea mays	62.31	9.00e-121	427.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence