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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045704
UUCD1 version UUC-HoS-00153
Ensembl Protein ID ENSP00000347548.2
UniProt Accession Q5VTB9; B3KPJ3; B4DLZ9; E9PCS1; Q4KMX2; Q9NVP6; RN220_HUMAN
Genbank Protein ID BAA91704.1; BAG51705.1; BAG59711.1; CAH72320.1; CAH72320.1; CAH72320.1; CAI16124.1; CAI16124.1; CAI16124.1; CAI22343.1; CAI22343.1; CAI22343.1; AAH34221.1; AAH98266.1; AAH98300.1
Protein Name E3 ubiquitin-protein ligase RNF220; RING finger protein 220; RING-type E3 ubiquitin transferase RNF220
Genbank Nucleotide ID AK001459; AK056424; AK297228; AL596225; AL122004; AL359373; AL359373; AL122004; AL596225; AL122004; AL359373; AL596225; BC034221; BC098266; BC098300
Gene Name RNF220; C1orf164
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000187147.17 ENST00000355387.6 ENSP00000347548.2
ENSG00000187147.17 ENST00000453863.5 ENSP00000411541.1
ENSG00000187147.17 ENST00000335497.11 ENSP00000335580.7
ENSG00000187147.17 ENST00000440132.2 ENSP00000388533.2
ENSG00000187147.17 ENST00000488865.2 ENSP00000475383.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
RepTarmiRNAMapSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
ClinVarGWASdbGWAS CentralOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtBioGRID
mUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 20170641
Classification
Family E-value Score Start End
E3 activity/RING/RING 0.2 13.8 514 553
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iC+++++ ++ + +C Hv +++C+ +          + +CP C+
   Q: 514  CLICMDSYSMPLTSIQCWHVHCEECWLRT------LGAKKLCPQCN 553
           ********99788899*********9777......899999****7 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of SIN3B (By similarity). Independently of its E3 ligase activity, acts as a CTNNB1 stabilizer through USP7-mediated deubiquitination of CTNNB1 promoting Wnt signaling (PubMed:25266658).
 E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of SIN3B (By similarity). Independently of its E3 ligase activity, acts as a CTNNB1 stabilizer through USP7-mediated deubiquitination of CTNNB1 promoting Wnt signaling (PubMed:25266658).
Protein Sequence
(Fasta)
MDLHRAAFKM ENSSYLPNPL ASPALMVLAS TAEASRDASI PCQQPRPFGV PVSVDKDVHI 60
PFTNGSYTFA SMYHRQGGVP GTFANRDFPP SLLHLHPQFA PPNLDCTPIS MLNHSGVGAF 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045704|E3,RING|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TGCGTGCGTG TGTGTGTGCG CGCGTGTGTG TGTCTCCGAG TCCCTGGGAG AGTGGAGGCT 60
CATTCACTGA TTAGATCCAG CGCTGAGAGG CAGCACTGCT CCTTCTCTCA CGCCAACTGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045704|E3,RING|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR031824--RNF220_mid
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50089--ZF_RING_2
Pfam

PF15926--RNF220
Gene Ontology

GO:0005737--C:cytoplasm
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0090263--P:positive regulation of canonical Wnt signaling pathway
GO:0051865--P:protein autoubiquitination
GO:0016567--P:protein ubiquitination
KEGG hsa:55182
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002101 Ailuropoda melanoleuca 96.30 0.00e+00 1065.00
IUUC-Apl-003248 Anas platyrhynchos 92.61 0.00e+00 1036.00
IUUC-Aca-004242 Anolis carolinensis 72.95 3.00e-127 447.00
IUUC-Ame-010840 Astyanax mexicanus 77.82 0.00e+00 875.00
IUUC-Bta-013469 Bos taurus 99.29 0.00e+00 1108.00
IUUC-Cja-019668 Callithrix jacchus 95.28 0.00e+00 627.00
IUUC-Cfa-020783 Canis familiaris 99.29 0.00e+00 1108.00
IUUC-Cpo-022329 Cavia porcellus 99.29 0.00e+00 1109.00
IUUC-Csa-024183 Chlorocebus sabaeus 99.25 2.00e-151 527.00
IUUC-Cho-024989 Choloepus hoffmanni 94.93 0.00e+00 696.00
IUUC-Cin-025335 Ciona intestinalis 33.73 3.00e-21 95.10
IUUC-Csv-025998 Ciona savignyi 34.94 4.00e-21 93.60
IUUC-Dre-027666 Danio rerio 79.38 0.00e+00 880.00
IUUC-Dno-029877 Dasypus novemcinctus 89.38 1.00e-144 506.00
IUUC-Dor-030123 Dipodomys ordii 90.12 0.00e+00 954.00
IUUC-Dme-031847 Drosophila melanogaster 41.55 6.00e-35 141.00
IUUC-Ete-032907 Echinops telfairi 90.72 0.00e+00 807.00
IUUC-Eca-033571 Equus caballus 97.54 0.00e+00 1068.00
IUUC-Eeu-034827 Erinaceus europaeus 79.50 0.00e+00 724.00
IUUC-Fca-036595 Felis catus 97.88 0.00e+00 1068.00
IUUC-Fal-036741 Ficedula albicollis 93.47 0.00e+00 1057.00
IUUC-Gmo-038853 Gadus morhua 68.98 2.00e-164 572.00
IUUC-Gga-040915 Gallus gallus 90.03 0.00e+00 1049.00
IUUC-Gac-041804 Gasterosteus aculeatus 76.24 0.00e+00 844.00
IUUC-Ggo-045244 Gorilla gorilla 96.13 0.00e+00 644.00
IUUC-Itr-048567 Ictidomys tridecemlineatus 97.20 0.00e+00 1083.00
IUUC-Lch-049680 Latimeria chalumnae 93.81 2.00e-118 417.00
IUUC-Loc-052023 Lepisosteus oculatus 84.20 0.00e+00 969.00
IUUC-Laf-053349 Loxodonta africana 98.59 0.00e+00 1100.00
IUUC-Mcc-054596 Macaca mulatta 99.82 0.00e+00 1113.00
IUUC-Meu-056519 Macropus eugenii 87.15 0.00e+00 982.00
IUUC-Mga-059955 Meleagris gallopavo 90.72 0.00e+00 1013.00
IUUC-Mmr-061479 Microcebus murinus 99.16 0.00e+00 673.00
IUUC-Mdo-061811 Monodelphis domestica 94.37 0.00e+00 1060.00
IUUC-Mmu-064344 Mus musculus 97.88 0.00e+00 1095.00
IUUC-Mpu-066890 Mustela putorius furo 94.73 0.00e+00 1042.00
IUUC-Mlu-067364 Myotis lucifugus 91.22 0.00e+00 632.00
IUUC-Nle-070000 Nomascus leucogenys 99.12 0.00e+00 1103.00
IUUC-Opr-071140 Ochotona princeps 73.54 0.00e+00 801.00
IUUC-Ont-072377 Oreochromis niloticus 76.47 0.00e+00 830.00
IUUC-Oan-072918 Ornithorhynchus anatinus 96.17 6.00e-120 422.00
IUUC-Ocu-074560 Oryctolagus cuniculus 97.17 0.00e+00 1082.00
IUUC-Ola-086788 Oryzias latipes 57.87 9.00e-161 560.00
IUUC-Oga-088709 Otolemur garnettii 99.65 0.00e+00 1111.00
IUUC-Oar-089330 Ovis aries 91.78 0.00e+00 634.00
IUUC-Ptr-091304 Pan troglodytes 100.00 0.00e+00 678.00
IUUC-Pan-091776 Papio anubis 99.72 0.00e+00 675.00
IUUC-Psi-093769 Pelodiscus sinensis 84.99 3.00e-162 564.00
IUUC-Pma-094615 Petromyzon marinus 52.52 1.00e-36 144.00
IUUC-Pfo-096349 Poecilia formosa 73.55 0.00e+00 828.00
IUUC-Pab-098557 Pongo abelii 95.41 0.00e+00 1041.00
IUUC-Pca-100758 Procavia capensis 98.24 0.00e+00 1095.00
IUUC-Pva-102552 Pteropus vampyrus 98.77 0.00e+00 1095.00
IUUC-Rno-105430 Rattus norvegicus 91.38 0.00e+00 652.00
IUUC-Sha-107584 Sarcophilus harrisii 87.32 1.00e-165 575.00
IUUC-Sar-113640 Sorex araneus 97.30 0.00e+00 758.00
IUUC-Ssc-116017 Sus scrofa 89.12 2.00e-145 508.00
IUUC-Tgu-116450 Taeniopygia guttata 93.99 0.00e+00 1063.00
IUUC-Tru-117573 Takifugu rubripes 73.52 0.00e+00 771.00
IUUC-Tsy-118997 Tarsius syrichta 98.03 0.00e+00 759.00
IUUC-Tni-120609 Tetraodon nigroviridis 76.40 0.00e+00 823.00
IUUC-Tbe-127547 Tupaia belangeri 79.13 0.00e+00 653.00
IUUC-Ttr-128945 Tursiops truncatus 93.12 0.00e+00 1022.00
IUUC-Vpa-130219 Vicugna pacos 89.56 0.00e+00 964.00
IUUC-Xtr-132389 Xenopus tropicalis 89.40 0.00e+00 1036.00
Created Date 25-Jun-2017

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