iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000029364.15	ENSMUST00000031309.15	ENSMUSP00000031309.9
ENSMUSG00000029364.15	ENSMUST00000111959.1	ENSMUSP00000107590.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
microRNA	TRANSFAC	RepTar	RAID2
Protein-protein Interaction
HINT
Post-translational Modifications (PTMs)
CPLM	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	1.50e-14	54.7	358	405
E3 adaptor/Cullin RING/DCX/DWD	5.10e-33	112.8	153	186
UBD/Beta-Prp	6.10e-46	158.1	127	362

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 1    lsklwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyed 51
           ++++w++++   SL+hLCR+a r++l+++++    +LP+Pk++k++L y++
   Q: 358  HVQFWTAPRVLSSLKHLCRKALRSFLTTYQV---LALPIPKKMKEFLTYRT 405
           689****************************...***************86 PP

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf..sd.tllvsGsdDgtikvWDlr 31
           gH+d v++l+f  s+  +lvs+s+D+t+++WDl 
   Q: 153  GHQDVVRDLSFtpSGsLILVSASRDKTLRIWDLN 186
           8***********6556779*************85 PP

UBD/Beta-Prp

   S: 24   llatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgk.ilvtgseDrtikvwdls.tgkcvhtlkghedsvlslsfspsgdklv 110
           +latg  dg ik+w+v+tg ll  lsgh++ v++++f p+g+ ilv++s+D+t+++wdl+  gk++++l+gh + v+++s+sp+ + l 
   Q: 127  ILATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSlILVSASRDKTLRIWDLNkHGKQIQVLSGHLQWVYCCSISPDCSMLC 215
           699***************************************9****************9789********************99**** PP
   S: 111  sGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtl...........tgghtdsvyslsf 188
           s+   + + +w +++++ ++  l+gh+++v +  ++pd+ llv++s+D+ v +Wd  tg+ lr l           +  h +s +s+ f
   Q: 216  SAAGEKSVFLWSMRSYTLIR-KLEGHQSSVVSCDFSPDSALLVTASYDTSVIMWDPYTGERLRSLhhtqleptmddSDVHMSSLRSVCF 303
           ********************.****************************************999999999997777666777777777* PP
   S: 189  dsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriW 249
           +++g +l+++++d+ +++w l+ +       +  +n ++  f+p++ ++++g+ Dg +++W
   Q: 304  SPEGLYLATVADDRLLRIWALELK--APVAFAPMTNGLCCTFFPHGGIIATGTRDGHVQFW 362
           *********************888..5778999**************************** PP

Organism

Mus musculus

Protein Sequence
(Fasta)

MISPSPEEPL LLAELKPGRP HQFDWKSSCE TWSVAFSPDG SWFAWSQGHC VVKLVPWPLE 60
EQFIPKGFEA KSRSSKNDPK GRGSLKEKTL DCGQIVWGLA FSPWPSPPSR KLWARHHPQA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGGAAGCAG CTGATGGCCT CTGCGGGCGG CAGCGGCGGC GGCATTGGCG GCGGTGGTGG 60
CGGCGGCGGG CGCGGCCGCG GCGGGGCGGG CGCGGAATGA AGGCCCACGG CCCTGGGGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR020472--G-protein_beta_WD-40_rep
IPR027295--Quinoprotein_ADH-like_fam
IPR001496--SOCS_box
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50225--SOCS
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF07525--SOCS_box
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00253--SOCS
SM00969--SOCS_box
SM00320--WD40

Gene Ontology

GO:0005622--C:intracellular
GO:0035556--P:intracellular signal transduction
GO:0016567--P:protein ubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002221	Ailuropoda melanoleuca	95.57	0.00e+00	805.00
IUUC-Apl-004107	Anas platyrhynchos	69.03	2.00e-131	461.00
IUUC-Aca-004354	Anolis carolinensis	73.88	2.00e-169	588.00
IUUC-Bta-012627	Bos taurus	96.42	0.00e+00	763.00
IUUC-Cja-018897	Callithrix jacchus	94.60	0.00e+00	764.00
IUUC-Cfa-020122	Canis familiaris	95.81	0.00e+00	805.00
IUUC-Cpo-022540	Cavia porcellus	96.93	0.00e+00	787.00
IUUC-Csa-023719	Chlorocebus sabaeus	95.88	0.00e+00	776.00
IUUC-Cho-024367	Choloepus hoffmanni	96.64	5.00e-171	593.00
IUUC-Dno-029021	Dasypus novemcinctus	96.68	0.00e+00	785.00
IUUC-Dor-030321	Dipodomys ordii	96.91	0.00e+00	780.00
IUUC-Ete-032955	Echinops telfairi	96.74	0.00e+00	776.00
IUUC-Eca-033485	Equus caballus	96.68	0.00e+00	756.00
IUUC-Fca-035389	Felis catus	96.14	0.00e+00	778.00
IUUC-Fal-037184	Ficedula albicollis	84.81	1.00e-143	501.00
IUUC-Gga-041014	Gallus gallus	77.26	9.00e-178	616.00
IUUC-Ggo-045585	Gorilla gorilla	96.16	0.00e+00	785.00
IUUC-Hsa-046344	Homo sapiens	96.16	0.00e+00	784.00
IUUC-Itr-049085	Ictidomys tridecemlineatus	97.69	0.00e+00	787.00
IUUC-Lch-050131	Latimeria chalumnae	70.05	2.00e-167	581.00
IUUC-Loc-052807	Lepisosteus oculatus	50.93	2.00e-116	412.00
IUUC-Laf-053528	Loxodonta africana	96.93	0.00e+00	767.00
IUUC-Mcc-055665	Macaca mulatta	96.16	0.00e+00	784.00
IUUC-Meu-056054	Macropus eugenii	88.38	0.00e+00	697.00
IUUC-Mga-059326	Meleagris gallopavo	77.44	0.00e+00	630.00
IUUC-Mmr-060815	Microcebus murinus	93.86	0.00e+00	768.00
IUUC-Mdo-062000	Monodelphis domestica	91.52	0.00e+00	750.00
IUUC-Mpu-065726	Mustela putorius furo	94.86	0.00e+00	766.00
IUUC-Mlu-067527	Myotis lucifugus	96.19	2.00e-118	417.00
IUUC-Nle-069680	Nomascus leucogenys	95.65	0.00e+00	776.00
IUUC-Opr-070356	Ochotona princeps	96.49	0.00e+00	796.00
IUUC-Oan-073647	Ornithorhynchus anatinus	83.94	4.00e-136	478.00
IUUC-Ocu-073973	Oryctolagus cuniculus	97.19	0.00e+00	787.00
IUUC-Oga-088797	Otolemur garnettii	95.66	0.00e+00	775.00
IUUC-Oar-089187	Ovis aries	96.42	0.00e+00	763.00
IUUC-Ptr-091317	Pan troglodytes	96.16	0.00e+00	784.00
IUUC-Pan-092694	Papio anubis	88.31	0.00e+00	668.00
IUUC-Psi-093392	Pelodiscus sinensis	79.65	0.00e+00	642.00
IUUC-Pab-098145	Pongo abelii	95.88	0.00e+00	776.00
IUUC-Pca-100454	Procavia capensis	88.22	0.00e+00	714.00
IUUC-Pva-102986	Pteropus vampyrus	87.97	0.00e+00	716.00
IUUC-Rno-104931	Rattus norvegicus	97.16	0.00e+00	777.00
IUUC-Sha-106476	Sarcophilus harrisii	92.52	0.00e+00	748.00
IUUC-Ssc-115643	Sus scrofa	96.91	0.00e+00	779.00
IUUC-Tgu-117522	Taeniopygia guttata	64.04	6.00e-136	477.00
IUUC-Tsy-119301	Tarsius syrichta	96.24	0.00e+00	798.00
IUUC-Tni-120198	Tetraodon nigroviridis	49.88	7.00e-110	390.00
IUUC-Ttr-128683	Tursiops truncatus	96.91	0.00e+00	779.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence