iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046299

UUCD1 version

UUC-HoS-00280

Ensembl Protein ID

ENSP00000355137.5

UniProt Accession

Q969K3; B7Z933; Q8NG47; Q9H6W8; RNF34_HUMAN

Genbank Protein ID

BAC11802.1; AAK51328.1; AAM29180.1; BAH14169.1; BAB15132.1; AAP35947.1; CAG33623.1; AAH07826.1

Protein Name

E3 ubiquitin-protein ligase RNF34; Caspase regulator CARP1; Caspases-8 and -10-associated RING finger protein 1; FYVE-RING finger protein Momo; Human RING finger homologous to inhibitor of apoptosis protein; RING finger protein 34; RING finger protein RIFF; RING-type E3 ubiquitin transferase RNF34

Genbank Nucleotide ID

AB084914; AF306709; AY098934; AK304366; AK025439; BT007283; CR457342; BC007826

Gene Name

RNF34

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000170633.16	ENST00000361234.9	ENSP00000355137.5
ENSG00000170633.16	ENST00000392465.7	ENSP00000376258.3
ENSG00000170633.16	ENST00000392464.3	ENSP00000376257.2
ENSG00000170633.16	ENST00000555076.1	ENSP00000452200.1
ENSG00000170633.16	ENST00000613529.4	ENSP00000477987.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	miRNAMap	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
GWASdb	OMIM
Drug and target
TTD
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	PHOSIDA
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	15069192

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	0.041	16.1	325	360

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvf.hadClqkwpglknssskefrCPlCr 46
           C iC++   d  ++l CgH+  +++C           ++   CP+Cr
   Q: 325  CRICMDAVID-CVLLECGHMVtCTKC----------GKRMSECPICR 360
           ********99.888*****888****..........777799****8 PP

Organism

Homo sapiens

Functional Description
(View)

E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis (PubMed:15069192). May mediate 'Lys-48'-linked polyubiquitination of RIPK1 and its subsequent proteasomal degradation thereby indirectly regulating the tumor necrosis factor-mediated signaling pathway (Ref.13). Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation (PubMed:17121812). Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN (PubMed:18382127). Mediates PPARGC1A proteasomal degradation probably through ubiquitination thereby indirectly regulating the metabolism of brown fat cells (PubMed:22064484). Possibly involved in innate immunity, through 'Lys-48'-linked polyubiquitination of NOD1 and its subsequent proteasomal degradation (PubMed:25012219).

Protein Sequence
(Fasta)

MKAGATSMWA SCCGLLNEVM GTGAVRGQQS AFAGATGPFR FTPNPEFSTY PPAATEGPNI 60
VCKACGLSFS VFRKKHVCCD CKKDFCSVCS VLQENLRRCS TCHLLQETAF QRPQLMRLKV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGCTTTTAC CGGGGCACGC GGCGAGCGTG ACCACGCCCC TTACGTCCGG ACGCTCGGTC 60
GCCTCCCGGG GCGCGGTAAT CACCGCCCAG AGGGAAGGAG GTCGGCAGTG TGAGGAGCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0472--Membrane
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR003034--SAP_dom
IPR011011--Znf_FYVE_PHD
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

SMART

SM00184--RING

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0012505--C:endomembrane system
GO:0016604--C:nuclear body
GO:0016607--C:nuclear speck
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0002039--F:p53 binding
GO:1901981--F:phosphatidylinositol phosphate binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0008270--F:zinc ion binding
GO:0006915--P:apoptotic process
GO:0070417--P:cellular response to cold
GO:2001271--P:negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis
GO:1902042--P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:1901797--P:negative regulation of signal transduction by p53 class mediator
GO:0035872--P:nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070936--P:protein K48-linked ubiquitination
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:2000374--P:regulation of oxygen metabolic process

KEGG

hsa:80196

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002341	Ailuropoda melanoleuca	90.40	6.00e-170	590.00
IUUC-Apl-003398	Anas platyrhynchos	74.40	4.00e-137	481.00
IUUC-Aca-005050	Anolis carolinensis	66.51	2.00e-78	285.00
IUUC-Bta-012886	Bos taurus	92.00	4.00e-175	607.00
IUUC-Cja-019045	Callithrix jacchus	96.51	0.00e+00	629.00
IUUC-Cfa-020037	Canis familiaris	88.76	6.00e-158	550.00
IUUC-Cpo-021618	Cavia porcellus	78.76	1.00e-141	496.00
IUUC-Csa-023303	Chlorocebus sabaeus	95.73	0.00e+00	640.00
IUUC-Cho-024671	Choloepus hoffmanni	84.10	6.00e-171	593.00
IUUC-Dre-027887	Danio rerio	60.57	1.00e-101	363.00
IUUC-Dno-029136	Dasypus novemcinctus	91.94	0.00e+00	638.00
IUUC-Dor-030596	Dipodomys ordii	85.44	3.00e-154	537.00
IUUC-Ete-032684	Echinops telfairi	87.30	5.00e-149	520.00
IUUC-Eca-033598	Equus caballus	92.33	6.00e-178	616.00
IUUC-Eeu-034878	Erinaceus europaeus	90.84	4.00e-172	597.00
IUUC-Fca-036370	Felis catus	89.79	2.00e-173	601.00
IUUC-Fal-036937	Ficedula albicollis	75.54	8.00e-133	466.00
IUUC-Gga-040411	Gallus gallus	74.18	1.00e-129	456.00
IUUC-Gac-042281	Gasterosteus aculeatus	61.14	2.00e-110	392.00
IUUC-Ggo-044752	Gorilla gorilla	99.73	0.00e+00	650.00
IUUC-Itr-047907	Ictidomys tridecemlineatus	90.45	5.00e-173	600.00
IUUC-Lch-049616	Latimeria chalumnae	65.37	5.00e-107	381.00
IUUC-Loc-052099	Lepisosteus oculatus	60.75	4.00e-118	417.00
IUUC-Laf-054103	Loxodonta africana	85.37	5.00e-164	570.00
IUUC-Mcc-055295	Macaca mulatta	96.28	0.00e+00	643.00
IUUC-Mga-059584	Meleagris gallopavo	73.64	5.00e-129	454.00
IUUC-Mmr-061766	Microcebus murinus	92.37	0.00e+00	634.00
IUUC-Mdo-062738	Monodelphis domestica	75.32	3.00e-135	474.00
IUUC-Mmu-064403	Mus musculus	87.77	1.00e-158	552.00
IUUC-Mpu-066021	Mustela putorius furo	90.13	2.00e-176	611.00
IUUC-Mlu-067144	Myotis lucifugus	90.35	1.00e-165	575.00
IUUC-Nle-070133	Nomascus leucogenys	98.86	7.00e-174	603.00
IUUC-Opr-070683	Ochotona princeps	82.70	1.00e-162	566.00
IUUC-Ont-072065	Oreochromis niloticus	60.50	4.00e-107	381.00
IUUC-Oan-073504	Ornithorhynchus anatinus	80.74	6.00e-147	513.00
IUUC-Ocu-074382	Oryctolagus cuniculus	88.20	7.00e-173	599.00
IUUC-Ola-087022	Oryzias latipes	60.00	3.00e-111	394.00
IUUC-Oga-087963	Otolemur garnettii	91.34	0.00e+00	643.00
IUUC-Oar-089439	Ovis aries	91.20	3.00e-173	601.00
IUUC-Ptr-091616	Pan troglodytes	99.46	0.00e+00	640.00
IUUC-Pan-092754	Papio anubis	96.26	0.00e+00	641.00
IUUC-Psi-093217	Pelodiscus sinensis	69.86	1.00e-119	422.00
IUUC-Pab-098124	Pongo abelii	98.92	0.00e+00	644.00
IUUC-Pca-100954	Procavia capensis	89.36	9.00e-179	619.00
IUUC-Pva-102588	Pteropus vampyrus	90.11	3.00e-171	594.00
IUUC-Pte-104027	Pyrenophora teres	31.51	2.00e-08	55.50
IUUC-Rno-105481	Rattus norvegicus	85.83	1.00e-160	559.00
IUUC-Sha-106640	Sarcophilus harrisii	80.91	9.00e-145	506.00
IUUC-Sit-110649	Setaria italica	39.66	2.00e-08	52.00
IUUC-Sar-113331	Sorex araneus	92.18	4.00e-176	610.00
IUUC-Tgu-117252	Taeniopygia guttata	73.60	2.00e-130	458.00
IUUC-Tru-118556	Takifugu rubripes	59.57	2.00e-111	395.00
IUUC-Tsy-118891	Tarsius syrichta	65.88	1.00e-66	246.00
IUUC-Tni-119741	Tetraodon nigroviridis	58.12	1.00e-106	379.00
IUUC-Tbe-127380	Tupaia belangeri	92.43	0.00e+00	633.00
IUUC-Ttr-128999	Tursiops truncatus	90.62	6.00e-175	606.00
IUUC-Vpa-130168	Vicugna pacos	77.73	8.00e-89	319.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence