iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aca-004663

UUCD1 version

UUC-AnC-00751

Ensembl Protein ID

ENSACAP00000012710.3

UniProt Accession

G1KN06; G1KN06_ANOCA

Protein Name

Uncharacterized protein

Gene Name

LOC100568112

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSACAG00000012928.3	ENSACAT00000012966.3	ENSACAP00000012710.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.80e-77	260.9	784	1105

Active Site

Position(s)	Description	Evidence
1074	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEe.gldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           +lk +l vef+gE    ++gGv +ef++ +++++ +pd+g+f+y   ++ +++  +++        + ++++G+l+g+a++++ +  
   Q: 784  SLKMQLLVEFEGEMsRFEAGGVLLEFFSHVFEDMVQPDYGMFMYPHPSSPMWFCTRKKVS-----KNKYYLFGILCGLAMFNRVIAY 865
           5788999*****98578***************************************9974.....4566688*************** PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
           +p++ + +k+ll+kk +l+dl+e+dp l +sl+ +++++ +diee  ++l f    +i+ +  +++L+p+G++i V+n+Nk+++v++
   Q: 866  VPFPLAAFKKLLDKKPTLDDLKELDPVLGRSLQAVLDYECDDIEEN-FQLCF----SIFWDDVKVDLIPNGNSIAVNNSNKKDFVNK 947
           **************************************66666664.55555....5899999999********************* PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           +v+y+++ +++e + +f++Gf++v+++ +++ F++ el  l  G++++d+e  +k++ y g y++++p+i++Fw+v++e+  +++k 
   Q: 948  YVDYIFNISVNEVFGEFKRGFYKVLDKCIIDFFEPPELMELAIGNANYDWELYEKNAVYWGIYSPTHPTIKMFWKVFHELPLTDKKS 1034
           *************************************************************************************** PP
   S: 264  fLqFvTgssrlPlgGfaelkprlfvirk..dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           fL Fv g++r+P+ G+++l+   ++i+   + s+d+ P+++ Cf++L LP++s+  +lkekL+ Aie+++gF++
   Q: 1035 FLLFVAGTDRVPPMGMNSLR---ITIHShrSLSEDHIPEAQICFHLLLLPPFSTIGKLKEKLQQAIENNRGFGK 1105
           ********************...66666568899**************************************96 PP

Organism

Anolis carolinensis

Protein Sequence
(Fasta)

MKLAASDVGR AAGRGGTPSG LVHEGPNGRP GGASLGGRRK GPAKEVQRGL DPGQERGAHL 60
RGERMLYCWG EGSAGQLGLG KGEGVSGPVP FRPGPRAPAD QAVVLVACGE RHTLLLRDDG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAAACTGG CAGCCTCCGA TGTGGGCAGG GCTGCTGGGA GGGGCGGTAC TCCCTCTGGG 60
CTTGTACATG AAGGCCCAAA TGGGAGGCCA GGGGGTGCTT CCTTAGGAGG AAGGAGGAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity
GO:0002244--P:hematopoietic progenitor cell differentiation

KEGG

acs:100568112

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001374	Ailuropoda melanoleuca	46.91	0.00e+00	810.00
IUUC-Bta-013080	Bos taurus	46.90	0.00e+00	873.00
IUUC-Cja-018891	Callithrix jacchus	45.75	0.00e+00	843.00
IUUC-Cfa-020763	Canis familiaris	46.69	0.00e+00	790.00
IUUC-Cpo-022346	Cavia porcellus	47.11	0.00e+00	860.00
IUUC-Csa-023049	Chlorocebus sabaeus	47.32	0.00e+00	918.00
IUUC-Dno-029093	Dasypus novemcinctus	47.58	0.00e+00	886.00
IUUC-Eca-034098	Equus caballus	47.14	0.00e+00	826.00
IUUC-Eeu-035028	Erinaceus europaeus	47.42	2.00e-97	350.00
IUUC-Fca-036283	Felis catus	45.81	0.00e+00	801.00
IUUC-Ggo-045553	Gorilla gorilla	45.82	0.00e+00	854.00
IUUC-Hsa-046396	Homo sapiens	47.17	0.00e+00	888.00
IUUC-Loc-052700	Lepisosteus oculatus	41.65	0.00e+00	798.00
IUUC-Laf-054433	Loxodonta africana	47.08	0.00e+00	910.00
IUUC-Mcc-055014	Macaca mulatta	45.04	0.00e+00	857.00
IUUC-Mdo-061839	Monodelphis domestica	46.43	0.00e+00	805.00
IUUC-Mmu-064378	Mus musculus	46.06	0.00e+00	827.00
IUUC-Mpu-066293	Mustela putorius furo	46.77	0.00e+00	781.00
IUUC-Mlu-067407	Myotis lucifugus	47.29	0.00e+00	867.00
IUUC-Nle-069978	Nomascus leucogenys	47.66	0.00e+00	926.00
IUUC-Oga-088780	Otolemur garnettii	44.47	0.00e+00	822.00
IUUC-Oar-090307	Ovis aries	48.47	0.00e+00	873.00
IUUC-Ptr-091567	Pan troglodytes	47.17	0.00e+00	894.00
IUUC-Pan-091802	Papio anubis	43.76	0.00e+00	833.00
IUUC-Pca-100320	Procavia capensis	38.80	0.00e+00	669.00
IUUC-Pva-102382	Pteropus vampyrus	43.92	0.00e+00	803.00
IUUC-Rno-105768	Rattus norvegicus	43.83	0.00e+00	800.00
IUUC-Sha-106525	Sarcophilus harrisii	45.09	0.00e+00	843.00
IUUC-Sar-113014	Sorex araneus	46.17	6.00e-112	398.00
IUUC-Vpa-130214	Vicugna pacos	44.13	0.00e+00	732.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence