iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fal-036995

Ensembl Protein ID

ENSFALP00000003358.1

UniProt Accession

U3JKQ4; U3JKQ4_FICAL

Genbank Protein ID

ENSFALP00000003358

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGTO01000121

Gene Name

CUL4A

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFALG00000003226.1	ENSFALT00000003371.1	ENSFALP00000003358.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/Cullin	3.90e-217	722.4	126	721

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/Cullin

   S: 1    klreavkkilrqesvkkeyeelytavynlclskvgaklYkklkevleefi.kqvkkkveesedeq.lLktynreWekfreqlkvlrkif 87
           kl+eav +i+++ s+k+++eely+av+nlc++kv+a lYk+l++v+ee++ +q+ + +e+s d+  +Lk++n++W+++++q+ ++r+if
   Q: 126  KLHEAVGAIQNSISIKYNLEELYQAVENLCSYKVSATLYKQLRQVCEEHVkAQILQFREDSLDSLlFLKKINKCWQDHCRQMIMIRSIF 214
           5899**********************************************99************************************* PP
   S: 88   ayldrtyvkkskkvsevrkLaldlwrkeived..ikkrllelllklieaeRkgeavdrrllsgvveslveLslnklaiykesFEakfle 174
           ++ldrtyv +++ + ++++++l+l+r++i++d  +++++++ +l lie+eR+geavdr+ll+++ ++l++L     ++ykesFE++fle
   Q: 215  LFLDRTYVLQNSVLPSIWDMGLELFRNHIISDkqVQTKTIDGILLLIERERNGEAVDRSLLRSLLSMLSDL-----QVYKESFEQRFLE 298
           **********9999******************99*********************************9998.....9************ PP
   S: 175  atqefykaesaeflqenevdeYlkkvearlneeeeraaryleestetkLlevvekeliakhlesll.aelvallrdkktedlsrmykLl 262
           +t+ +y+ae ++++qe+ev eYl++v+ rl+ee +r+ +yl++st+++L+++vek+l+ +hl ++l ++l++ll++++  dl++ y+L+
   Q: 299  ETNCLYAAEGQRLMQEREVPEYLHHVNRRLEEEGDRVITYLDHSTQKPLIACVEKQLLGEHLSAILqKGLDSLLDENRIPDLTQTYQLF 387
           ****************************************************************9989********************* PP
   S: 263  srvlngleellkeleshikeqgkaaltaeekekdpkkyVerllelknklqklvseaFnndakFlkaldkafetfvnknsvlkaaksp.E 350
           srv+ g + ll++++++ik+ g+++++++ek+kd   +V++ll++k+k++++++ +F++++kF++ ++++fetf+nk+     +++p E
   Q: 388  SRVKGGQQILLQHWSEYIKNFGTTIVVNPEKDKD---MVQELLDFKDKVDHIIEVCFQKNEKFINLMKESFETFINKR-----PNKPaE 468
           **********************************...*****************************************.....66666* PP
   S: 351  llAryiDqlLrksskglteeeleaqldkvllvfkyisekdvFekyYkkhLakRLlsgksasseaEesviekLkeecgaeftskLerMfq 439
           l+A+y+D++Lr+++k++t+eele++ldk++++f++i++kdvFe++Ykk+LakRLl+gksas +aE+s+++kLk+ecga+ftskLe+Mf+
   Q: 469  LIAKYVDSKLRAGNKEATDEELERILDKIMIIFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFK 557
           ***************************************************************************************** PP
   S: 440  dlkvSedlnrqFkeekenteesesvelsvlvLsagaWptasetekvsLPaelektiekfeefYlekhsgRkLqWqhtlgraelkaelkk 528
           d+++S+d++ qFk+ ++n+++  +++l+v++L++g+Wpt++ +e v+L +e+ k++e f++fYl khsgRkLqWq+tlg+a lkae+k+
   Q: 558  DMELSKDVMVQFKQYMQNQSDPGNIDLTVNILTMGYWPTYTPME-VHLNSEMIKLQEVFKTFYLGKHSGRKLQWQTTLGHAVLKAEFKE 645
           ****************************************9999.******************************************** PP
   S: 529  gkyelqVstfQmavLLafnnsekvsveelkkatelpeeeLrrtlqsLvsskkqvlkkepeskeieeedlfsvNqef 604
           gk+e+qVs fQ++vLL+fn+ +++s+ee+k+at+++++eLrrtlqsL+++k++vl k+p++k++e++d+f++N +f
   Q: 646  GKKEFQVSLFQTLVLLMFNEGDEFSFEEIKMATGIEDSELRRTLQSLACGKARVLIKNPKGKDVEDGDKFIFNGDF 721
           *************************************************************************998 PP

Organism

Ficedula albicollis

Protein Sequence
(Fasta)

MCETRTRSVL LHAGLGGVWG VPVSRARGPL GLVVAGCSLP FVPYPSAGTS EQSQGKRGTP 60
GGCCPREAAP AREPSCERGP PPPASLAATR STGGGGATAS SKKLVIKNFR ERPKLPDNYT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCCAATGGGA GGGAGCGGTG GGCTGGCAGC CAATGGGAAG GAGCGATGGG CGGGGCAGAG 60
GGCGCGCGTC AGGGTGTACC GCGTGCGCCG GGGCGCGGCG CGCGATCGTG GGTGGCGGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR016157--Cullin_CS
IPR016158--Cullin_homology
IPR001373--Cullin_N
IPR019559--Cullin_neddylation_domain
IPR016159--Cullin_repeat-like_dom
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS01256--CULLIN_1
PS50069--CULLIN_2

Pfam

PF00888--Cullin
PF10557--Cullin_Nedd8

SMART

SM00182--CULLIN
SM00884--Cullin_Nedd8

Gene Ontology

GO:0031464--C:Cul4A-RING E3 ubiquitin ligase complex
GO:0030097--P:hemopoiesis
GO:0030853--P:negative regulation of granulocyte differentiation
GO:0008284--P:positive regulation of cell proliferation
GO:1900087--P:positive regulation of G1/S transition of mitotic cell cycle
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:2000001--P:regulation of DNA damage checkpoint
GO:2000819--P:regulation of nucleotide-excision repair
GO:0051246--P:regulation of protein metabolic process
GO:0035019--P:somatic stem cell population maintenance

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001592	Ailuropoda melanoleuca	90.73	0.00e+00	1333.00
IUUC-Apl-003269	Anas platyrhynchos	97.75	0.00e+00	1397.00
IUUC-Bta-012355	Bos taurus	90.28	0.00e+00	1327.00
IUUC-Cja-019861	Callithrix jacchus	91.20	0.00e+00	1333.00
IUUC-Cfa-021009	Canis familiaris	93.58	0.00e+00	1366.00
IUUC-Cpo-021867	Cavia porcellus	88.10	0.00e+00	1343.00
IUUC-Csa-024139	Chlorocebus sabaeus	91.62	0.00e+00	1339.00
IUUC-Cho-024899	Choloepus hoffmanni	96.43	0.00e+00	1005.00
IUUC-Cme-027355	Cyanidioschyzon merolae	32.53	4.00e-111	395.00
IUUC-Dno-028879	Dasypus novemcinctus	86.38	0.00e+00	1274.00
IUUC-Dor-030698	Dipodomys ordii	91.39	0.00e+00	1326.00
IUUC-Ete-033101	Echinops telfairi	88.90	0.00e+00	1255.00
IUUC-Eca-033696	Equus caballus	91.70	0.00e+00	1341.00
IUUC-Fca-036333	Felis catus	91.98	0.00e+00	1334.00
IUUC-Gga-040358	Gallus gallus	93.10	0.00e+00	1422.00
IUUC-Hsa-045679	Homo sapiens	91.90	0.00e+00	1340.00
IUUC-Lch-050417	Latimeria chalumnae	91.83	0.00e+00	1344.00
IUUC-Loc-051804	Lepisosteus oculatus	86.75	0.00e+00	1290.00
IUUC-Laf-054100	Loxodonta africana	92.64	0.00e+00	1343.00
IUUC-Meu-056492	Macropus eugenii	76.98	2.00e-165	575.00
IUUC-Mga-059866	Meleagris gallopavo	97.61	0.00e+00	1397.00
IUUC-Mmr-061551	Microcebus murinus	91.35	0.00e+00	1332.00
IUUC-Mdo-062215	Monodelphis domestica	93.83	0.00e+00	1397.00
IUUC-Mmu-063402	Mus musculus	91.67	0.00e+00	1344.00
IUUC-Mpu-066383	Mustela putorius furo	91.87	0.00e+00	1333.00
IUUC-Nle-069606	Nomascus leucogenys	91.76	0.00e+00	1340.00
IUUC-Opr-070671	Ochotona princeps	80.93	2.00e-111	396.00
IUUC-Oan-073299	Ornithorhynchus anatinus	91.62	0.00e+00	1337.00
IUUC-Ocu-074731	Oryctolagus cuniculus	92.36	0.00e+00	1355.00
IUUC-Oar-089346	Ovis aries	89.97	0.00e+00	1319.00
IUUC-Ptr-091177	Pan troglodytes	91.90	0.00e+00	1340.00
IUUC-Pan-092191	Papio anubis	90.96	0.00e+00	1326.00
IUUC-Pab-097622	Pongo abelii	91.48	0.00e+00	1337.00
IUUC-Pca-100391	Procavia capensis	84.79	0.00e+00	996.00
IUUC-Rno-105829	Rattus norvegicus	88.62	0.00e+00	1356.00
IUUC-Sha-106762	Sarcophilus harrisii	95.42	0.00e+00	1340.00
IUUC-Sre-114943	Sporisorium reilianum	39.28	9.00e-130	457.00
IUUC-Ssc-116133	Sus scrofa	87.83	0.00e+00	1316.00
IUUC-Tgu-116961	Taeniopygia guttata	98.75	0.00e+00	1429.00
IUUC-Tre-121907	Trichoderma reesei	39.56	1.00e-126	446.00
IUUC-Ttr-128326	Tursiops truncatus	85.84	0.00e+00	1139.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence