iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mdo-062215

UUCD1 version

UUC-MoD-00710

Ensembl Protein ID

ENSMODP00000037084.1

UniProt Accession

F7G925; F7G925_MONDO

Protein Name

Uncharacterized protein

Gene Name

CUL4A

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMODG00000003915.3	ENSMODT00000038683.2	ENSMODP00000037084.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/Cullin	1.60e-218	727.5	71	666

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/Cullin

   S: 1    klreavkkilrqesvkkeyeelytavynlclskvgaklYkklkevleefi.kqvkkkveesedeq.lLktynreWekfreqlkvlrkif 87
           kl+eav++i++++s+k+++eely+av+nlc++kv+  lYk+l++v+e+++ +q+ +   +s d+  +Lk++n++W+++++q+ ++r+if
   Q: 71   KLHEAVRAIQSSTSIKYNLEELYQAVENLCSYKVSPTLYKQLRQVCEDHVkAQILQCCTDSLDSVlFLKKINKCWQDHCRQMIMIRSIF 159
           5899**********************************************99************************************* PP
   S: 88   ayldrtyvkkskkvsevrkLaldlwrkeived..ikkrllelllklieaeRkgeavdrrllsgvveslveLslnklaiykesFEakfle 174
           ++ldrtyv +++++ ++++++l+l+r+++++d  +++++++ +l lie+eR+geavdr+ll+++ ++l++L     ++yk+sFE+kfle
   Q: 160  LFLDRTYVLQNSMLPSIWDMGLELFRNHVISDklVQSKTIDGILLLIERERNGEAVDRSLLRSLLSMLSDL-----QVYKDSFEQKFLE 243
           *******************************************************************9998.....9************ PP
   S: 175  atqefykaesaeflqenevdeYlkkvearlneeeeraaryleestetkLlevvekeliakhlesll.aelvallrdkktedlsrmykLl 262
           +t+ +y+ae ++++qe+ev eYl++v++rl+ee +r+ +yl++st+++L+++vek+l+ +hl+++l ++l++ll++++  dl++my+L+
   Q: 244  ETNCLYAAEGQRLMQEREVPEYLNHVNKRLEEEGDRVITYLDHSTQKPLIACVEKQLLGEHLTAILqKGLDNLLDENRVPDLTQMYQLF 332
           ****************************************************************9989********************* PP
   S: 263  srvlngleellkeleshikeqgkaaltaeekekdpkkyVerllelknklqklvseaFnndakFlkaldkafetfvnknsvlkaaksp.E 350
           srv+ g + ll++++++ik+ g+++++++ek+kd   +V++ll++k+k++++++ +F++++kF++ ++++fetf+nk+     +++p E
   Q: 333  SRVKGGQQILLQHWSEYIKTFGTTIVVNPEKDKD---MVQELLDFKDKVDHIIEICFQKNEKFINLMKESFETFINKR-----PNKPaE 413
           **********************************...*****************************************.....66666* PP
   S: 351  llAryiDqlLrksskglteeeleaqldkvllvfkyisekdvFekyYkkhLakRLlsgksasseaEesviekLkeecgaeftskLerMfq 439
           l+A+++D++Lr+++k++t+eele++ldk++++f++i++kdvFe++Ykk+LakRLl+gksas +aE+s+++kLk+ecga+ftskLe+Mf+
   Q: 414  LIAKHVDSKLRAGNKEATDEELERILDKIMIIFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFK 502
           ***************************************************************************************** PP
   S: 440  dlkvSedlnrqFkeekenteesesvelsvlvLsagaWptasetekvsLPaelektiekfeefYlekhsgRkLqWqhtlgraelkaelkk 528
           d+++S+d+++qFk+ ++n+++  +++l+v++L++g+Wpt++ +e v+L++e+ k++e f++fYl khsgRkLqWq+tlg+a lkae+k+
   Q: 503  DMELSKDIMIQFKQYMQNQSDPGNIDLTVNILTMGYWPTYTPME-VHLTPEMVKLQEVFKTFYLGKHSGRKLQWQTTLGHAVLKAEFKE 590
           ****************************************9999.******************************************** PP
   S: 529  gkyelqVstfQmavLLafnnsekvsveelkkatelpeeeLrrtlqsLvsskkqvlkkepeskeieeedlfsvNqef 604
           gk+e+qVs fQ++vLL+fn+ +++s+ee+k+at+++++eLrrtlqsL+++k++vl k+p++k+++++d+f++N +f
   Q: 591  GKKEFQVSLFQTLVLLMFNEGDEFSFEEIKMATGVEDSELRRTLQSLACGKARVLIKSPKGKDVDDGDKFIFNGDF 666
           *************************************************************************998 PP

Organism

Monodelphis domestica

Protein Sequence
(Fasta)

MAEETPKKGN FSALVGHTNG LTKPASLAAA AVATKPGGGG GSGGSSKKLV IKNFRDRPKL 60
PDNYTQDTWQ KLHEAVRAIQ SSTSIKYNLE ELYQAVENLC SYKVSPTLYK QLRQVCEDHV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGACGAGGA GCCCCGGGTC TGGTCGGGCT GTGTAGACAC AGAGGGCGAG CTACCAGTCG 60
GGTTCTCAGT CTTGTAGCGG AGGTGTAGTA GCACCGATCA CTTGAATCAT CTAGTGAGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR016157--Cullin_CS
IPR016158--Cullin_homology
IPR001373--Cullin_N
IPR019559--Cullin_neddylation_domain
IPR016159--Cullin_repeat-like_dom
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS01256--CULLIN_1
PS50069--CULLIN_2

Pfam

PF00888--Cullin
PF10557--Cullin_Nedd8

SMART

SM00182--CULLIN
SM00884--Cullin_Nedd8

Gene Ontology

GO:0031464--C:Cul4A-RING E3 ubiquitin ligase complex
GO:0031625--F:ubiquitin protein ligase binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0030097--P:hemopoiesis
GO:0001701--P:in utero embryonic development
GO:0030853--P:negative regulation of granulocyte differentiation
GO:0008284--P:positive regulation of cell proliferation
GO:1900087--P:positive regulation of G1/S transition of mitotic cell cycle
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:2000001--P:regulation of DNA damage checkpoint
GO:2000819--P:regulation of nucleotide-excision repair
GO:0051246--P:regulation of protein metabolic process
GO:0035019--P:somatic stem cell population maintenance

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001592	Ailuropoda melanoleuca	93.87	0.00e+00	1376.00
IUUC-Apl-003269	Anas platyrhynchos	95.49	0.00e+00	1369.00
IUUC-Afu-008833	Aspergillus fumigatus	37.61	5.00e-129	455.00
IUUC-Ani-009373	Aspergillus nidulans	39.76	5.00e-135	475.00
IUUC-Ang-009622	Aspergillus niger	39.01	8.00e-133	468.00
IUUC-Aor-010241	Aspergillus oryzae	37.63	2.00e-129	456.00
IUUC-Ate-010251	Aspergillus terreus	38.87	1.00e-136	480.00
IUUC-Bta-012355	Bos taurus	91.81	0.00e+00	1359.00
IUUC-Cja-019861	Callithrix jacchus	92.88	0.00e+00	1361.00
IUUC-Cfa-021009	Canis familiaris	93.99	0.00e+00	1421.00
IUUC-Cpo-021867	Cavia porcellus	90.46	0.00e+00	1395.00
IUUC-Csa-024139	Chlorocebus sabaeus	91.37	0.00e+00	1383.00
IUUC-Cho-024899	Choloepus hoffmanni	97.62	0.00e+00	1023.00
IUUC-Cin-025727	Ciona intestinalis	62.87	0.00e+00	767.00
IUUC-Cme-027355	Cyanidioschyzon merolae	32.62	3.00e-113	402.00
IUUC-Dno-028879	Dasypus novemcinctus	89.02	0.00e+00	1338.00
IUUC-Dor-030698	Dipodomys ordii	90.59	0.00e+00	1365.00
IUUC-Ete-033101	Echinops telfairi	90.03	0.00e+00	1275.00
IUUC-Eca-033696	Equus caballus	93.64	0.00e+00	1371.00
IUUC-Fca-036333	Felis catus	94.94	0.00e+00	1382.00
IUUC-Fal-036995	Ficedula albicollis	95.41	0.00e+00	1387.00
IUUC-Gga-040358	Gallus gallus	92.11	0.00e+00	1419.00
IUUC-Hsa-045679	Homo sapiens	91.37	0.00e+00	1384.00
IUUC-Lch-050417	Latimeria chalumnae	90.59	0.00e+00	1384.00
IUUC-Loc-051804	Lepisosteus oculatus	84.88	0.00e+00	1295.00
IUUC-Laf-054100	Loxodonta africana	94.31	0.00e+00	1371.00
IUUC-Meu-056492	Macropus eugenii	79.33	0.00e+00	627.00
IUUC-Mga-059866	Meleagris gallopavo	96.07	0.00e+00	1387.00
IUUC-Mmr-061551	Microcebus murinus	91.11	0.00e+00	1391.00
IUUC-Mmu-063402	Mus musculus	90.72	0.00e+00	1382.00
IUUC-Mpu-066383	Mustela putorius furo	94.67	0.00e+00	1381.00
IUUC-Mlu-067450	Myotis lucifugus	90.89	0.00e+00	1363.00
IUUC-Nfi-068363	Neosartorya fischeri	37.91	7.00e-131	461.00
IUUC-Nle-069606	Nomascus leucogenys	91.24	0.00e+00	1384.00
IUUC-Opr-070671	Ochotona princeps	82.49	3.00e-113	402.00
IUUC-Ont-071562	Oreochromis niloticus	80.31	0.00e+00	1240.00
IUUC-Oan-073299	Ornithorhynchus anatinus	91.76	0.00e+00	1392.00
IUUC-Ocu-074731	Oryctolagus cuniculus	91.24	0.00e+00	1402.00
IUUC-Oar-089346	Ovis aries	91.50	0.00e+00	1352.00
IUUC-Ptr-091177	Pan troglodytes	91.37	0.00e+00	1384.00
IUUC-Pan-092191	Papio anubis	91.28	0.00e+00	1385.00
IUUC-Pab-097622	Pongo abelii	90.98	0.00e+00	1381.00
IUUC-Pca-100391	Procavia capensis	85.29	0.00e+00	1010.00
IUUC-Ptt-103903	Puccinia triticina	40.94	7.00e-96	345.00
IUUC-Rno-105829	Rattus norvegicus	91.37	0.00e+00	1398.00
IUUC-Sha-106762	Sarcophilus harrisii	98.89	0.00e+00	1377.00
IUUC-Sre-114943	Sporisorium reilianum	37.50	9.00e-131	461.00
IUUC-Ssc-116133	Sus scrofa	91.76	0.00e+00	1382.00
IUUC-Tgu-116961	Taeniopygia guttata	95.84	0.00e+00	1397.00
IUUC-Tre-121907	Trichoderma reesei	39.33	2.00e-126	446.00
IUUC-Tvi-122568	Trichoderma virens	39.15	2.00e-127	450.00
IUUC-Tme-127162	Tuber melanosporum	40.85	9.00e-138	484.00
IUUC-Ttr-128326	Tursiops truncatus	87.02	0.00e+00	1165.00
IUUC-Uma-129531	Ustilago maydis	38.40	2.00e-109	390.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence