iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000031787.8	ENSMUST00000034239.8	ENSMUSP00000034239.7
ENSMUSG00000031787.8	ENSMUST00000212968.1	ENSMUSP00000148781.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	microRNA	TRANSFAC	RepTar
miRNAMap	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	3.70e-45	151.0	145	180
UBD/Beta-Prp	7.80e-60	203.7	15	258

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgv 34
           gH+  v+cl+f +d + l+s++dD+t+k+WDl+ g+
   Q: 145  GHSQAVRCLRFsPDgKWLASAADDHTVKLWDLTAGK 180
           8***********999*****************9997 PP

UBD/Beta-Prp

   S: 4    tlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkg 92
           ++ +h ++v + v  + +++llatg++d ++ +w++ +++++ sl gh+++v +v+++  ++++v gs+ + i+vwdl++ k+++tl g
   Q: 15   EIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMG 103
           67788888999888899************************************************************************ PP
   S: 93   hedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtd 181
           h+++++sl+f+p+g++++sGs+d  i++wd++ + c+    +gh+++v+c++++pdg+ l+s+++D tv+lWdl  gk++ ++ g ht+
   Q: 104  HKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVF-RYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPG-HTG 190
           *************************************9.9********************************************9.*** PP
   S: 182  svyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWd 250
           +v+ ++f++n   l+sgs d+t+++wdl++ ++v   +g   +v+sv f p++  l+sg +D s+r++ 
   Q: 191  PVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQD-SLRVYG 258
           ***********************************************************766.556544 PP

Organism

Mus musculus

Functional Description
(View)

Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.

Protein Sequence
(Fasta)

MATPVVTKTA WKLQEIVAHA SNVSSLVLGK ASGRLLATGG DDCRVNLWSI NKPNCIMSLT 60
GHTSPVESVR LNTPEELIVA GSQSGSIRVW DLEAAKILRT LMGHKANICS LDFHPYGEFV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGGCCGGAGG TTTTGTTGTG AGGGTCGGTT GTCAAGCAGC GACCAATCAG GGCAAAGGAT 60
GGAGGCAAGT GGGGGTCGCG CCTGGAGGGA AGCCTTGGCC TCCAGAGCTA CAGCTGCAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0493--Microtubule
KW-0498--Mitosis
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR003143--Cyt_cd1_C
IPR020472--G-protein_beta_WD-40_rep
IPR026962--Katanin_bsu1
IPR028021--Katanin_C-terminal
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF13925--Katanin_con80
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0030424--C:axon
GO:0005813--C:centrosome
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0030426--C:growth cone
GO:0008352--C:katanin complex
GO:0016020--C:membrane
GO:0005874--C:microtubule
GO:0015630--C:microtubule cytoskeleton
GO:0030496--C:midbody
GO:0043025--C:neuronal cell body
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0000922--C:spindle pole
GO:0070840--F:dynein complex binding
GO:0008568--F:microtubule-severing ATPase activity
GO:0046982--F:protein heterodimerization activity
GO:0051301--P:cell division
GO:0051013--P:microtubule severing
GO:0007067--P:mitotic nuclear division
GO:0007026--P:negative regulation of microtubule depolymerization
GO:0010942--P:positive regulation of cell death
GO:0031117--P:positive regulation of microtubule depolymerization
GO:0010976--P:positive regulation of neuron projection development

KEGG

mmu:74187

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000954	Aegilops tauschii	48.10	1.00e-84	308.00
IUUC-Aml-002187	Ailuropoda melanoleuca	87.41	0.00e+00	1065.00
IUUC-Atr-002899	Amborella trichopoda	54.33	2.00e-101	363.00
IUUC-Apl-003305	Anas platyrhynchos	77.29	0.00e+00	992.00
IUUC-Aca-004635	Anolis carolinensis	80.21	0.00e+00	951.00
IUUC-Aly-005711	Arabidopsis lyrata	51.68	9.00e-101	361.00
IUUC-Ath-007606	Arabidopsis thaliana	51.68	9.00e-101	361.00
IUUC-Ame-010870	Astyanax mexicanus	56.04	2.00e-94	339.00
IUUC-Bta-012527	Bos taurus	93.09	0.00e+00	1151.00
IUUC-Bdi-014652	Brachypodium distachyon	53.38	1.00e-102	367.00
IUUC-Bol-015242	Brassica oleracea	50.67	6.00e-99	355.00
IUUC-Bra-017390	Brassica rapa	51.01	2.00e-99	357.00
IUUC-Cja-019706	Callithrix jacchus	93.64	0.00e+00	1072.00
IUUC-Cfa-020139	Canis familiaris	78.53	0.00e+00	732.00
IUUC-Cpo-021710	Cavia porcellus	94.38	0.00e+00	1148.00
IUUC-Cre-022746	Chlamydomonas reinhardtii	41.55	1.00e-68	254.00
IUUC-Csa-023546	Chlorocebus sabaeus	95.14	0.00e+00	1053.00
IUUC-Cin-025156	Ciona intestinalis	42.02	5.00e-157	548.00
IUUC-Csv-025962	Ciona savignyi	49.66	9.00e-90	323.00
IUUC-Dre-028215	Danio rerio	61.64	0.00e+00	833.00
IUUC-Dno-029314	Dasypus novemcinctus	93.16	0.00e+00	1090.00
IUUC-Dor-030482	Dipodomys ordii	95.14	0.00e+00	1194.00
IUUC-Dme-032188	Drosophila melanogaster	40.69	6.00e-59	222.00
IUUC-Eca-034143	Equus caballus	93.31	0.00e+00	1150.00
IUUC-Fca-035924	Felis catus	94.22	0.00e+00	1129.00
IUUC-Fal-037387	Ficedula albicollis	79.00	0.00e+00	987.00
IUUC-Gmo-038692	Gadus morhua	64.82	5.00e-152	531.00
IUUC-Gga-040597	Gallus gallus	78.82	0.00e+00	1031.00
IUUC-Gac-042004	Gasterosteus aculeatus	61.84	0.00e+00	817.00
IUUC-Gma-044134	Glycine max	32.11	1.00e-103	370.00
IUUC-Ggo-044761	Gorilla gorilla	95.29	0.00e+00	1073.00
IUUC-Hsa-045698	Homo sapiens	95.14	0.00e+00	1093.00
IUUC-Hvu-047649	Hordeum vulgare	53.38	1.00e-102	367.00
IUUC-Itr-048697	Ictidomys tridecemlineatus	94.38	0.00e+00	1124.00
IUUC-Lch-049674	Latimeria chalumnae	67.74	0.00e+00	914.00
IUUC-Lpe-051554	Leersia perrieri	54.39	7.00e-105	375.00
IUUC-Loc-052623	Lepisosteus oculatus	66.09	0.00e+00	888.00
IUUC-Laf-054587	Loxodonta africana	94.38	0.00e+00	1148.00
IUUC-Mcc-055851	Macaca mulatta	95.14	0.00e+00	1073.00
IUUC-Meu-056704	Macropus eugenii	88.91	0.00e+00	1148.00
IUUC-Mtr-058053	Medicago truncatula	52.68	2.00e-103	370.00
IUUC-Mga-059608	Meleagris gallopavo	78.42	0.00e+00	1016.00
IUUC-Mmr-061154	Microcebus murinus	92.87	0.00e+00	1092.00
IUUC-Mdo-062365	Monodelphis domestica	85.37	0.00e+00	1082.00
IUUC-Mac-064667	Musa acuminata	52.76	2.00e-99	356.00
IUUC-Mpu-066245	Mustela putorius furo	94.07	0.00e+00	1085.00
IUUC-Mlu-067692	Myotis lucifugus	94.47	0.00e+00	1120.00
IUUC-Nle-070051	Nomascus leucogenys	92.55	0.00e+00	1056.00
IUUC-Opr-070855	Ochotona princeps	94.22	0.00e+00	1139.00
IUUC-Ont-071883	Oreochromis niloticus	59.21	0.00e+00	811.00
IUUC-Oan-073293	Ornithorhynchus anatinus	89.11	0.00e+00	1006.00
IUUC-Ocu-074644	Oryctolagus cuniculus	94.98	0.00e+00	1153.00
IUUC-Oba-075448	Oryza barthii	54.73	3.00e-105	376.00
IUUC-Obr-076385	Oryza brachyantha	53.72	3.00e-104	373.00
IUUC-Ogl-077427	Oryza glaberrima	54.73	1.00e-105	378.00
IUUC-Ogu-079022	Oryza glumaepatula	49.35	2.00e-97	350.00
IUUC-Oin-079811	Oryza indica	52.27	2.00e-102	367.00
IUUC-Olo-080245	Oryza longistaminata	52.27	2.00e-102	367.00
IUUC-Ome-081239	Oryza meridionalis	54.14	6.00e-102	365.00
IUUC-Oni-082640	Oryza nivara	54.73	3.00e-105	376.00
IUUC-Opu-083748	Oryza punctata	54.39	8.00e-105	375.00
IUUC-Oru-084609	Oryza rufipogon	54.73	3.00e-105	376.00
IUUC-Osa-086267	Oryza sativa	49.35	1.00e-97	350.00
IUUC-Ola-087483	Oryzias latipes	56.28	0.00e+00	630.00
IUUC-Oga-087964	Otolemur garnettii	94.53	0.00e+00	1160.00
IUUC-Oar-089483	Ovis aries	91.59	0.00e+00	1103.00
IUUC-Ptr-091387	Pan troglodytes	95.29	0.00e+00	1095.00
IUUC-Pan-092623	Papio anubis	95.14	0.00e+00	1073.00
IUUC-Psi-093830	Pelodiscus sinensis	80.87	0.00e+00	1039.00
IUUC-Pma-094135	Petromyzon marinus	44.06	4.00e-37	147.00
IUUC-Ppa-095379	Physcomitrella patens	54.67	1.00e-96	347.00
IUUC-Pfo-096755	Poecilia formosa	57.45	0.00e+00	785.00
IUUC-Pab-097564	Pongo abelii	93.86	0.00e+00	944.00
IUUC-Pop-099149	Populus trichocarpa	52.68	5.00e-103	369.00
IUUC-Pca-100357	Procavia capensis	99.52	4.00e-126	445.00
IUUC-Ppe-101237	Prunus persica	52.68	8.00e-103	368.00
IUUC-Pva-102397	Pteropus vampyrus	89.97	0.00e+00	1052.00
IUUC-Rno-105349	Rattus norvegicus	97.87	0.00e+00	1214.00
IUUC-Smo-109409	Selaginella moellendorffii	53.98	7.00e-100	358.00
IUUC-Sit-110360	Setaria italica	54.73	4.00e-105	376.00
IUUC-Sly-111307	Solanum lycopersicum	53.02	1.00e-98	354.00
IUUC-Stu-112462	Solanum tuberosum	52.60	5.00e-95	342.00
IUUC-Sar-112953	Sorex araneus	82.02	5.00e-109	388.00
IUUC-Sbi-114389	Sorghum bicolor	47.46	4.00e-94	339.00
IUUC-Ssc-115949	Sus scrofa	90.27	0.00e+00	834.00
IUUC-Tgu-117461	Taeniopygia guttata	78.23	0.00e+00	1012.00
IUUC-Tru-117865	Takifugu rubripes	59.12	0.00e+00	778.00
IUUC-Tsy-119036	Tarsius syrichta	78.23	4.00e-75	275.00
IUUC-Tni-120903	Tetraodon nigroviridis	60.30	0.00e+00	767.00
IUUC-Tca-121185	Theobroma cacao	51.68	4.00e-100	359.00
IUUC-Tae-125263	Triticum aestivum	53.72	9.00e-103	368.00
IUUC-Tur-126181	Triticum urartu	48.45	4.00e-94	339.00
IUUC-Tbe-127518	Tupaia belangeri	79.56	2.00e-176	612.00
IUUC-Ttr-128172	Tursiops truncatus	93.62	0.00e+00	1111.00
IUUC-Vvi-131489	Vitis vinifera	53.36	2.00e-103	370.00
IUUC-Xtr-132915	Xenopus tropicalis	73.17	0.00e+00	954.00
IUUC-Xma-134133	Xiphophorus maculatus	57.31	0.00e+00	776.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence