iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Aml-002299

Ensembl Protein ID

ENSAMEP00000013622.1

UniProt Accession

G1M2R1; G1M2R1_AILME

Genbank Protein ID

ENSAMEP00000013622

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ACTA01011855

Gene Name

PHIP

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMEG00000012897.1	ENSAMET00000014190.1	ENSAMEP00000013622.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	8.70e-35	117.4	143	180
UBD/Beta-Prp	2.70e-52	177.9	242	503

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvll 36
           gH +sv+c+ f  + +++ +GsdD+ +k+W +++g+ll
   Q: 143  GHLSSVYCVTFdRTgRRIFTGSDDCLVKIWATDDGRLL 180
           8**********955599*****************9987 PP

UBD/Beta-Prp

   S: 19   spdksllatgsrdgtikvwdvttgkl.....lrsl.sgheaevtavk..fspdgkilvtgseDrtikvw..dlstgkcvhtlkghedsv 97
           s +k++l ++++dgti  w ++ g+l      +++ +   ++v+ ++  fs  g +l+tgs+D++i+v+     +++ ++ l+ h+d+v
   Q: 242  SGSKRYLSSTGADGTICFWLWDAGTLkinprPAKFtERPRPGVQMICssFSAGGMFLATGSTDHIIRVYffGSGQPEKISELEFHTDKV 330
           67899***********999999999988988555547777888765522777888**************777779999*********** PP
   S: 98   lslsfspsgdklvsGshdrtirvwdletgqclee................tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgk 170
            s++fs +++++vsGs+d t+r+w+ + +++ +                  +++++  v++v+++  +n ++++ ++ t+++W++ tg+
   Q: 331  DSIQFSNTSNRFVSGSRDGTARIWQFKRREWKSIlldmatrpagqnlqgiEDKITKMKVTMVAWDRHDNTVITAVNNMTLKVWNSYTGQ 419
           ********************************99***************888899999******************************* PP
   S: 171  llrtltgghtdsvysls...fdsngkelvsgsldgtvklwdlqtgecvrtlnght.....dnvksvrfspnderlvsgssDgsiriW 249
           l++ l g h+d v  l+   fd+  + l s+++dg v++wdl +g  +r++ +         v + + sp++++++++ s+g + i+
   Q: 420  LIHVLMG-HEDEVFVLEphpFDP--RVLFSAGHDGNVIVWDLARGVKIRSYFNMIegqghGAVFDCKCSPDGQHFACTDSHGHLLIF 503
           ******9.*********999999..89******************999998875544445566667777999999999999988887 PP

Organism

Ailuropoda melanoleuca

Protein Sequence
(Fasta)

VLSPQLLPRR TDWTGKEHPR TYQNLVKYYR HLAPDHLLQI CHRLGPLLEQ EIPQSVPGVQ 60
TLLGAGRQSL LRTNKSCKHV VWKGSALAAL HCGRPPESPI NYGSPPSIAD TLFSRKLNGK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTCCTGTCCC CACAGCTGCT GCCCCGCCGC ACCGACTGGA CCGGGAAGGA GCATCCCAGG 60
ACCTACCAGA ATCTGGTGAG ACATTCACGT CGCGGAGCAA AGAAACTTTT CCCCGAGTCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR001487--Bromodomain
IPR018359--Bromodomain_CS
IPR028738--PHIP
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00633--BROMODOMAIN_1
PS50014--BROMODOMAIN_2
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00439--Bromodomain
PF00400--WD40

PRINTS

PR00503--BROMODOMAIN

SMART

SM00297--BROMO
SM00320--WD40

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0007010--P:cytoskeleton organization
GO:0008286--P:insulin receptor signaling pathway
GO:2001237--P:negative regulation of extrinsic apoptotic signaling pathway
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0022604--P:regulation of cell morphogenesis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003700	Anas platyrhynchos	86.48	0.00e+00	2879.00
IUUC-Aca-004474	Anolis carolinensis	81.96	0.00e+00	2779.00
IUUC-Aly-006406	Arabidopsis lyrata	31.92	1.00e-65	245.00
IUUC-Ath-006801	Arabidopsis thaliana	31.76	1.00e-66	249.00
IUUC-Bta-013125	Bos taurus	96.42	0.00e+00	3142.00
IUUC-Bdi-014797	Brachypodium distachyon	30.88	5.00e-56	213.00
IUUC-Bol-015737	Brassica oleracea	32.24	6.00e-70	259.00
IUUC-Bra-017961	Brassica rapa	32.87	3.00e-69	258.00
IUUC-Cja-018868	Callithrix jacchus	93.77	0.00e+00	3229.00
IUUC-Cfa-021179	Canis familiaris	98.14	0.00e+00	3171.00
IUUC-Cpo-022077	Cavia porcellus	90.08	0.00e+00	3063.00
IUUC-Csa-023618	Chlorocebus sabaeus	96.07	0.00e+00	3264.00
IUUC-Cho-024794	Choloepus hoffmanni	90.54	0.00e+00	872.00
IUUC-Dre-028029	Danio rerio	80.99	0.00e+00	1293.00
IUUC-Dno-030048	Dasypus novemcinctus	96.41	0.00e+00	3208.00
IUUC-Dor-030195	Dipodomys ordii	89.83	0.00e+00	1459.00
IUUC-Ete-032748	Echinops telfairi	84.50	0.00e+00	1169.00
IUUC-Eca-034274	Equus caballus	97.67	0.00e+00	3200.00
IUUC-Eeu-034688	Erinaceus europaeus	85.90	0.00e+00	1429.00
IUUC-Fca-035451	Felis catus	97.66	0.00e+00	3122.00
IUUC-Fal-037465	Ficedula albicollis	85.88	0.00e+00	2878.00
IUUC-Gmo-039451	Gadus morhua	68.38	0.00e+00	723.00
IUUC-Gga-040798	Gallus gallus	85.93	0.00e+00	2914.00
IUUC-Gma-043340	Glycine max	34.65	2.00e-66	248.00
IUUC-Hsa-046757	Homo sapiens	96.30	0.00e+00	3239.00
IUUC-Hvu-047706	Hordeum vulgare	31.84	1.00e-37	150.00
IUUC-Itr-048843	Ictidomys tridecemlineatus	92.33	0.00e+00	1172.00
IUUC-Laf-054140	Loxodonta africana	96.14	0.00e+00	3231.00
IUUC-Mcc-055061	Macaca mulatta	96.47	0.00e+00	3279.00
IUUC-Mmr-060837	Microcebus murinus	95.83	0.00e+00	3221.00
IUUC-Mdo-061903	Monodelphis domestica	91.39	0.00e+00	3126.00
IUUC-Mmu-063772	Mus musculus	94.00	0.00e+00	3190.00
IUUC-Mac-065343	Musa acuminata	30.33	1.00e-68	255.00
IUUC-Mpu-066359	Mustela putorius furo	98.42	0.00e+00	3016.00
IUUC-Mlu-067928	Myotis lucifugus	95.68	0.00e+00	3244.00
IUUC-Nle-070094	Nomascus leucogenys	96.41	0.00e+00	3242.00
IUUC-Opr-070971	Ochotona princeps	74.38	0.00e+00	954.00
IUUC-Ont-072221	Oreochromis niloticus	76.77	0.00e+00	1278.00
IUUC-Oan-073185	Ornithorhynchus anatinus	87.68	0.00e+00	2916.00
IUUC-Ocu-074033	Oryctolagus cuniculus	94.05	0.00e+00	2853.00
IUUC-Ogu-078641	Oryza glumaepatula	24.28	9.00e-30	126.00
IUUC-Oin-079669	Oryza indica	31.13	3.00e-52	200.00
IUUC-Olo-080755	Oryza longistaminata	31.65	4.00e-54	207.00
IUUC-Oni-082991	Oryza nivara	27.78	2.00e-39	159.00
IUUC-Oga-088578	Otolemur garnettii	96.19	0.00e+00	3174.00
IUUC-Oar-090247	Ovis aries	96.42	0.00e+00	3138.00
IUUC-Ptr-091266	Pan troglodytes	96.34	0.00e+00	3219.00
IUUC-Pan-092734	Papio anubis	96.30	0.00e+00	3269.00
IUUC-Pab-098402	Pongo abelii	96.41	0.00e+00	3240.00
IUUC-Pca-101128	Procavia capensis	86.29	0.00e+00	2861.00
IUUC-Ppe-101849	Prunus persica	31.19	2.00e-68	255.00
IUUC-Pva-103058	Pteropus vampyrus	95.91	0.00e+00	1592.00
IUUC-Rno-106013	Rattus norvegicus	93.06	0.00e+00	3137.00
IUUC-Sha-107496	Sarcophilus harrisii	91.99	0.00e+00	3136.00
IUUC-Sar-113520	Sorex araneus	91.36	0.00e+00	1543.00
IUUC-Ssc-115461	Sus scrofa	93.20	0.00e+00	3094.00
IUUC-Tgu-116821	Taeniopygia guttata	85.72	0.00e+00	2878.00
IUUC-Tsy-119132	Tarsius syrichta	84.41	0.00e+00	2585.00
IUUC-Tae-122854	Triticum aestivum	30.33	2.00e-64	241.00
IUUC-Tbe-127479	Tupaia belangeri	91.43	0.00e+00	1447.00
IUUC-Ttr-128427	Tursiops truncatus	92.47	0.00e+00	3057.00
IUUC-Vpa-130160	Vicugna pacos	93.54	0.00e+00	3058.00
IUUC-Xtr-132717	Xenopus tropicalis	74.82	0.00e+00	2514.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence