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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045871
Ensembl Protein ID ENSP00000349205.3
UniProt Accession Q99570; Q2TBF4; PI3R4_HUMAN
Genbank Protein ID CAA70176.1; AAI10319.1; AAI27107.1
Protein Name Phosphoinositide 3-kinase regulatory subunit 4; PI3-kinase p150 subunit; Phosphoinositide 3-kinase adaptor protein
Genbank Nucleotide ID Y08991; BC110318; BC127106
Gene Name PIK3R4; VPS15
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000196455.7 ENST00000356763.7 ENSP00000349205.3
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbcircBasecircRNADbCircNet
miRTarBasemicroRNATRANSFACmiRWalk
TargetScanRepTarmiRNAMapSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Variation
OMIM
Drug and target
GRAC
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
MethyCancerTCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.20e-16 61.8 992 1021
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWD 29
           H++ v+ ++  ++  l++++s+Dgt+k+W+
   Q: 992  HKSAVNRIRVsDEhSLFATCSNDGTVKIWN 1021
           9999999999544788*************9 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123).
 Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123).
Protein Sequence
(Fasta)
MGNQLAGIAP SQILSVESYF SDIHDFEYDK SLGSTRFFKV ARAKHREGLV VVKVFAIQDP 60
TLPLTSYKQE LEELKIRLNS AQNCLPFQKA SEKASEKAAM LFRQYVRDNL YDRISTRPFL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045871|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GAGGTCAGAC CGGTTGCTTT CCCGGGAGTT CGGCGTTTGC TGGGGCTGCA GCAGCTGAAG 60
TGTAGTGTTT TCTTGGGACT GGCGGTCTGC ACTTCTCTCC CGGGTTCCAT CTCCCCCCGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045871|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0968--Cytoplasmic vesicle
KW-0903--Direct protein sequencing
KW-0967--Endosome
KW-0418--Kinase
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0519--Myristate
KW-0547--Nucleotide-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase
KW-0853--WD repeat
Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR021133--HEAT_type_2
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR008271--Ser/Thr_kinase_AS
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS50077--HEAT_REPEAT
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00069--Pkinase
PF00400--WD40
SMART

SM00220--S_TKc
SM00320--WD40
Gene Ontology

GO:0005776--C:autophagosome
GO:0005930--C:axoneme
GO:0005829--C:cytosol
GO:0043231--C:intracellular membrane-bounded organelle
GO:0005770--C:late endosome
GO:0016020--C:membrane
GO:0015630--C:microtubule cytoskeleton
GO:0005643--C:nuclear pore
GO:0071561--C:nucleus-vacuole junction
GO:0030670--C:phagocytic vesicle membrane
GO:0035032--C:phosphatidylinositol 3-kinase complex, class III
GO:0034271--C:phosphatidylinositol 3-kinase complex, class III, type I
GO:0034272--C:phosphatidylinositol 3-kinase complex, class III, type II
GO:0016303--F:1-phosphatidylinositol-3-kinase activity
GO:0005524--F:ATP binding
GO:0004672--F:protein kinase activity
GO:0004674--F:protein serine/threonine kinase activity
GO:0042149--P:cellular response to glucose starvation
GO:0045324--P:late endosome to vacuole transport
GO:0016236--P:macroautophagy
GO:0030242--P:pexophagy
GO:0006661--P:phosphatidylinositol biosynthetic process
GO:0043552--P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0006468--P:protein phosphorylation
GO:0006623--P:protein targeting to vacuole
GO:0032801--P:receptor catabolic process
GO:0032465--P:regulation of cytokinesis
GO:0034162--P:toll-like receptor 9 signaling pathway
KEGG hsa:30849
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000213 Aegilops tauschii 31.87 4.00e-43 171.00
IUUC-Aml-001659 Ailuropoda melanoleuca 97.94 0.00e+00 2711.00
IUUC-Atr-002968 Amborella trichopoda 40.06 1.00e-47 186.00
IUUC-Apl-003418 Anas platyrhynchos 91.72 0.00e+00 2600.00
IUUC-Aca-004344 Anolis carolinensis 90.80 0.00e+00 2312.00
IUUC-Aly-006107 Arabidopsis lyrata 46.67 4.00e-71 264.00
IUUC-Ath-007260 Arabidopsis thaliana 46.97 8.00e-72 266.00
IUUC-Ago-007721 Ashbya gossypii 39.05 9.00e-57 216.00
IUUC-Acl-008378 Aspergillus clavatus 37.33 8.00e-149 522.00
IUUC-Afl-008632 Aspergillus flavus 36.05 2.00e-142 501.00
IUUC-Afu-009020 Aspergillus fumigatus 36.45 3.00e-142 500.00
IUUC-Ani-009204 Aspergillus nidulans 35.51 4.00e-132 466.00
IUUC-Ang-009811 Aspergillus niger 35.30 3.00e-140 493.00
IUUC-Aor-010168 Aspergillus oryzae 36.05 2.00e-142 501.00
IUUC-Ate-010556 Aspergillus terreus 35.54 3.00e-140 493.00
IUUC-Ame-011955 Astyanax mexicanus 81.02 0.00e+00 1825.00
IUUC-Bgr-012050 Blumeria graminis 36.53 1.00e-140 495.00
IUUC-Bta-012432 Bos taurus 96.61 0.00e+00 2719.00
IUUC-Bci-013846 Botrytis cinerea 34.60 2.00e-142 500.00
IUUC-Bdi-015072 Brachypodium distachyon 42.98 1.00e-66 249.00
IUUC-Bol-015314 Brassica oleracea 46.97 6.00e-72 266.00
IUUC-Bra-017476 Brassica rapa 46.97 7.00e-72 266.00
IUUC-Cel-018550 Caenorhabditis elegans 31.98 9.00e-85 309.00
IUUC-Cja-019538 Callithrix jacchus 98.75 0.00e+00 2769.00
IUUC-Cfa-020483 Canis familiaris 97.79 0.00e+00 2720.00
IUUC-Cpo-021392 Cavia porcellus 97.28 0.00e+00 2729.00
IUUC-Csa-024112 Chlorocebus sabaeus 99.63 0.00e+00 2790.00
IUUC-Cho-025015 Choloepus hoffmanni 90.34 0.00e+00 947.00
IUUC-Cin-025209 Ciona intestinalis 41.52 0.00e+00 1084.00
IUUC-Csv-026334 Ciona savignyi 41.86 0.00e+00 894.00
IUUC-Cgl-026447 Colletotrichum gloeosporioides 35.92 4.00e-144 506.00
IUUC-Cne-026999 Cryptococcus neoformans 39.83 1.00e-116 415.00
IUUC-Dre-028662 Danio rerio 81.58 0.00e+00 2316.00
IUUC-Dno-029545 Dasypus novemcinctus 95.58 0.00e+00 2666.00
IUUC-Dor-030941 Dipodomys ordii 66.44 0.00e+00 717.00
IUUC-Dse-031455 Dothistroma septosporum 36.53 1.00e-137 484.00
IUUC-Dme-031726 Drosophila melanogaster 40.72 0.00e+00 1001.00
IUUC-Ete-033147 Echinops telfairi 94.88 0.00e+00 1016.00
IUUC-Eca-034025 Equus caballus 98.16 0.00e+00 2747.00
IUUC-Eeu-034480 Erinaceus europaeus 90.17 0.00e+00 1522.00
IUUC-Fca-035741 Felis catus 97.28 0.00e+00 2711.00
IUUC-Fal-037666 Ficedula albicollis 90.68 0.00e+00 2575.00
IUUC-Fox-037818 Fusarium oxysporum 33.98 2.00e-127 451.00
IUUC-Fso-038086 Fusarium solani 34.26 3.00e-130 460.00
IUUC-Gmo-038804 Gadus morhua 81.18 0.00e+00 742.00
IUUC-Ggr-039800 Gaeumannomyces graminis 35.83 1.00e-134 475.00
IUUC-Gga-041251 Gallus gallus 90.37 0.00e+00 2020.00
IUUC-Gac-042376 Gasterosteus aculeatus 79.23 0.00e+00 2247.00
IUUC-Gma-044095 Glycine max 45.86 7.00e-74 273.00
IUUC-Ggo-044506 Gorilla gorilla 99.26 0.00e+00 2778.00
IUUC-Hvu-047648 Hordeum vulgare 31.01 1.00e-44 175.00
IUUC-Itr-048082 Ictidomys tridecemlineatus 98.67 0.00e+00 1215.00
IUUC-Kpa-049390 Komagataella pastoris 32.68 2.00e-127 451.00
IUUC-Lch-050284 Latimeria chalumnae 85.74 0.00e+00 2353.00
IUUC-Lpe-050880 Leersia perrieri 41.76 3.00e-64 241.00
IUUC-Loc-052815 Lepisosteus oculatus 82.19 0.00e+00 2325.00
IUUC-Lma-053324 Leptosphaeria maculans 36.62 1.00e-146 515.00
IUUC-Laf-054204 Loxodonta africana 86.03 0.00e+00 2324.00
IUUC-Mcc-054612 Macaca mulatta 99.56 0.00e+00 2784.00
IUUC-Meu-056227 Macropus eugenii 85.91 0.00e+00 851.00
IUUC-Mor-057094 Magnaporthe oryzae 36.51 5.00e-135 476.00
IUUC-Mtr-058550 Medicago truncatula 43.92 7.00e-73 270.00
IUUC-Mla-058893 Melampsora laricipopulina 34.93 3.00e-130 460.00
IUUC-Mga-059474 Meleagris gallopavo 90.60 0.00e+00 2439.00
IUUC-Mvi-060227 Microbotryum violaceum 45.01 5.00e-85 310.00
IUUC-Mmr-061543 Microcebus murinus 90.43 0.00e+00 2447.00
IUUC-Mdo-062129 Monodelphis domestica 93.82 0.00e+00 2556.00
IUUC-Mmu-064381 Mus musculus 95.88 0.00e+00 2693.00
IUUC-Mac-064455 Musa acuminata 38.36 2.00e-123 437.00
IUUC-Mpu-066151 Mustela putorius furo 98.55 0.00e+00 988.00
IUUC-Mlu-067824 Myotis lucifugus 98.01 0.00e+00 2738.00
IUUC-Nfi-068241 Neosartorya fischeri 37.63 1.00e-145 511.00
IUUC-Ncr-068964 Neurospora crassa 36.32 3.00e-140 493.00
IUUC-Nle-069152 Nomascus leucogenys 99.63 0.00e+00 2784.00
IUUC-Opr-070870 Ochotona princeps 85.55 0.00e+00 1450.00
IUUC-Ont-071293 Oreochromis niloticus 80.66 0.00e+00 2293.00
IUUC-Oan-072852 Ornithorhynchus anatinus 88.13 0.00e+00 2446.00
IUUC-Ocu-074727 Oryctolagus cuniculus 97.86 0.00e+00 2708.00
IUUC-Oba-075932 Oryza barthii 39.69 4.00e-64 240.00
IUUC-Obr-076424 Oryza brachyantha 46.64 3.00e-61 231.00
IUUC-Ogl-077491 Oryza glaberrima 39.69 4.00e-64 240.00
IUUC-Ogu-078933 Oryza glumaepatula 33.87 1.00e-98 355.00
IUUC-Oin-079604 Oryza indica 44.13 1.00e-69 258.00
IUUC-Olo-080850 Oryza longistaminata 36.07 6.00e-116 412.00
IUUC-Ome-081860 Oryza meridionalis 44.13 1.00e-69 258.00
IUUC-Oni-082895 Oryza nivara 39.69 8.00e-64 239.00
IUUC-Opu-083741 Oryza punctata 43.84 4.00e-68 254.00
IUUC-Oru-084616 Oryza rufipogon 39.39 2.00e-63 238.00
IUUC-Osa-085941 Oryza sativa 28.74 2.00e-36 146.00
IUUC-Ola-087357 Oryzias latipes 86.22 7.00e-160 556.00
IUUC-Olu-087659 Ostreococcus lucimarinus 30.59 9.00e-89 322.00
IUUC-Oga-088555 Otolemur garnettii 98.31 0.00e+00 2726.00
IUUC-Oar-089304 Ovis aries 96.02 0.00e+00 1324.00
IUUC-Ptr-091140 Pan troglodytes 99.93 0.00e+00 2796.00
IUUC-Pan-092413 Papio anubis 99.24 0.00e+00 2674.00
IUUC-Psi-093210 Pelodiscus sinensis 91.55 0.00e+00 2597.00
IUUC-Pma-094674 Petromyzon marinus 56.18 0.00e+00 735.00
IUUC-Pno-094969 Phaeosphaeria nodorum 31.51 9.00e-146 511.00
IUUC-Ppa-096017 Physcomitrella patens 46.42 5.00e-77 283.00
IUUC-Pfo-096077 Poecilia formosa 80.56 0.00e+00 2246.00
IUUC-Pab-098269 Pongo abelii 98.90 0.00e+00 2773.00
IUUC-Pop-100052 Populus trichocarpa 44.20 1.00e-64 242.00
IUUC-Pca-100377 Procavia capensis 92.02 0.00e+00 2468.00
IUUC-Ppe-101445 Prunus persica 46.69 4.00e-73 270.00
IUUC-Pva-102198 Pteropus vampyrus 98.13 0.00e+00 1806.00
IUUC-Pgr-103544 Puccinia graminis 47.80 1.00e-81 299.00
IUUC-Ptt-103964 Puccinia triticina 47.48 1.00e-78 288.00
IUUC-Pte-104196 Pyrenophora teres 36.94 9.00e-139 488.00
IUUC-Pyt-104544 Pyrenophora triticirepentis 37.50 2.00e-137 484.00
IUUC-Rno-105256 Rattus norvegicus 95.73 0.00e+00 2689.00
IUUC-Sce-106295 Saccharomyces cerevisiae 33.50 2.00e-114 408.00
IUUC-Sha-107597 Sarcophilus harrisii 92.88 0.00e+00 2587.00
IUUC-Sja-107781 Schizosaccharomyces japonicus 34.23 1.00e-105 379.00
IUUC-Spo-108031 Schizosaccharomyces pombe 44.14 5.00e-73 270.00
IUUC-Ssl-108579 Sclerotinia sclerotiorum 35.64 1.00e-136 481.00
IUUC-Smo-108679 Selaginella moellendorffii 44.85 2.00e-79 291.00
IUUC-Sit-110765 Setaria italica 41.55 8.00e-64 239.00
IUUC-Sly-111527 Solanum lycopersicum 44.20 1.00e-73 272.00
IUUC-Stu-112899 Solanum tuberosum 44.20 1.00e-73 272.00
IUUC-Sar-112986 Sorex araneus 96.91 0.00e+00 2709.00
IUUC-Sbi-114604 Sorghum bicolor 41.02 9.00e-67 249.00
IUUC-Sre-115191 Sporisorium reilianum 44.00 4.00e-67 250.00
IUUC-Ssc-115440 Sus scrofa 96.03 0.00e+00 2687.00
IUUC-Tgu-116633 Taeniopygia guttata 90.83 0.00e+00 2578.00
IUUC-Tru-118439 Takifugu rubripes 78.73 0.00e+00 2250.00
IUUC-Tsy-119472 Tarsius syrichta 90.47 0.00e+00 1443.00
IUUC-Tni-119808 Tetraodon nigroviridis 74.73 0.00e+00 2053.00
IUUC-Tca-121648 Theobroma cacao 47.59 1.00e-74 275.00
IUUC-Tre-122161 Trichoderma reesei 34.35 4.00e-123 436.00
IUUC-Tvi-122575 Trichoderma virens 33.26 1.00e-114 408.00
IUUC-Tae-123381 Triticum aestivum 46.62 6.00e-67 249.00
IUUC-Tur-126291 Triticum urartu 44.13 1.00e-67 252.00
IUUC-Tme-126979 Tuber melanosporum 37.47 2.00e-150 527.00
IUUC-Tbe-127576 Tupaia belangeri 81.57 0.00e+00 941.00
IUUC-Ttr-129106 Tursiops truncatus 98.33 0.00e+00 1323.00
IUUC-Uma-129633 Ustilago maydis 43.17 1.00e-75 279.00
IUUC-Vda-130001 Verticillium dahliae 34.78 7.00e-130 459.00
IUUC-Vpa-130733 Vicugna pacos 89.48 0.00e+00 1312.00
IUUC-Vvi-131318 Vitis vinifera 44.60 3.00e-71 264.00
IUUC-Xtr-131908 Xenopus tropicalis 86.16 0.00e+00 2462.00
IUUC-Xma-133331 Xiphophorus maculatus 80.41 0.00e+00 2260.00
IUUC-Yli-134651 Yarrowia lipolytica 37.21 1.00e-121 431.00
IUUC-Zma-135850 Zea mays 40.75 8.00e-68 253.00
Created Date 25-Jun-2017

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