iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Nle-069193

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ADFV01173182

Gene Name

UBA7

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSNLEG00000006908.1	ENSNLET00000008813.1	ENSNLEP00000008418.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	6.60e-209	694.2	410	883

Active Site

Position(s)	Description	Evidence
594	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU10132}

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGv.....gsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkel 84
           YD+Qi+++G+  qekl+ +++llvGag++GcEllK ++l+G+     g +tvvDmd++e snl+rqFLfr +dvg++KAevaa+a++ l
   Q: 410  YDGQIAVFGAGFQEKLSHQHYLLVGAGAIGCELLKVFALVGLgagnsGGLTVVDMDHIERSNLSRQFLFRSQDVGRPKAEVAAAAAQGL 498
           ***************************************************************************************** PP
   S: 85   npdvnveaheesiteleeeiv...FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsd...dpp 167
           npd +v + ++++++++e+i+   Ff+++d+V++ald+++ar +v+ +c+++ +pl+e+gt G++G ++v+++++te+y+++     ++
   Q: 499  NPDLQVIPLTYPLDPTTEHIYgdnFFSRVDGVAAALDSFQARHYVAARCTHYLKPLLEAGTSGTWGSATVFMPHVTEAYRAPAsaaASE 587
           ************************************************************************************999** PP
   S: 168  qktiPfctlketpnaaehtiewa........vlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafakt 248
           +  +P+ct++ +p++aeht++wa        +l ++++++++++++ l+++d  ++++ +++v   l+  +++n+++++++a+ +++ +
   Q: 588  DAPYPVCTVRYFPSTAEHTLQWArhefeglfRLSAETINHHQQAHTSLADMDGPQTLTLLKPVLGVLRV-RPQNWQDCVAWALGHWKLC 675
           ***************************************************************888777.6****************** PP
   S: 249  tinsikqllksfecdivtkskspfwv................................................sfcsnaealqvpekv 289
           ++++i+ l + f++++    +++fw+                                                ++ ++ + +q+ +  
   Q: 676  FHYGIQLLRH-FPPNK-VCGGNSFWSgpkqcpqplefdtnqdthllyvlaaanlyaqmhglpgsqdwtalrellKLLPQPDPQQMAPIF 762
           ****976655.56656.68899******************************************************************* PP
   S: 290  ekdeevvkasap.....lylllralerfekkkgrkpgelsfekddds..avdlvtaaanlraeslgiepkldddlikeiagniipaiat 371
           +++ e  +asa+     ++ l +al+ ++  + +kp  l+fekddds  +vd+v+aaa+lr++++gi+p +++ + k+i+g+iipaiat
   Q: 763  ASNLELASASAEfgpeqQKELNKALQVWSVGPPLKP--LMFEKDDDSnfHVDFVAAAASLRCQNYGIPP-VNRAQSKRIVGQIIPAIAT 848
           ***********9***********************9..*******************************.******************* PP
   S: 372  tnavvgGlaaqEviKvvsg..kfeplknfflfdae 404
           t+a+v+Gl+ +E++Kvv g  + +++++ +l++ae
   Q: 849  TTAAVAGLLGLELYKVVGGprPRSAFRHSYLHLAE 883
           *******************7777789988888765 PP

Organism

Nomascus leucogenys

Protein Sequence
(Fasta)

MDALDTSKLL DEELYSRQLY VLGSPAMQRI QGARVLVSGL QGGAEVAKNL VLMGVGSLTL 60
HDPHPTCWSD LAAQFLLSEQ DLERSRAEAS QELLAQLNRA VQVVVHTGDI TEDLLLDFQV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCAGGAAGAG AGCTGTGACC AGCAGCGTCC CTTATTCCCT TGGCCTTGGT TCCTGTTTGC 60
ACTGGCTACA GCAGGGCACT GGCCCCTACT GTCACTGCCT CCTACACTAA GACCCTATCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0436--Ligase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR032420--E1_4HB
IPR032418--E1_FCCH
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
IPR018965--Ub-activating_enz_E1_C
IPR019572--UBA_E1_Cys
IPR018075--UBQ-activ_enz_E1
IPR033127--UBQ-activ_enz_E1_Cys_AS
IPR000011--UBQ/SUMO-activ_enz_E1-like

PROSITE

PS00865--UBIQUITIN_ACTIVAT_2

Pfam

PF16191--E1_4HB
PF16190--E1_FCCH
PF09358--E1_UFD
PF00899--ThiF
PF10585--UBA_e1_thiolCys

PRINTS

PR01849--UBIQUITINACT

SMART

SM00985--UBA_e1_C

Gene Ontology

GO:0005524--F:ATP binding
GO:0019782--F:ISG15 activating enzyme activity
GO:0032020--P:ISG15-protein conjugation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001816	Ailuropoda melanoleuca	79.19	0.00e+00	1454.00
IUUC-Bta-012665	Bos taurus	75.49	0.00e+00	1338.00
IUUC-Cja-019047	Callithrix jacchus	89.33	0.00e+00	1692.00
IUUC-Cfa-021225	Canis familiaris	81.25	0.00e+00	1538.00
IUUC-Cpo-022336	Cavia porcellus	71.50	0.00e+00	1312.00
IUUC-Csa-023462	Chlorocebus sabaeus	95.26	0.00e+00	1735.00
IUUC-Cho-024436	Choloepus hoffmanni	75.53	3.00e-95	343.00
IUUC-Dno-029347	Dasypus novemcinctus	78.95	0.00e+00	1458.00
IUUC-Dor-030997	Dipodomys ordii	75.40	0.00e+00	1366.00
IUUC-Ete-033124	Echinops telfairi	74.41	0.00e+00	950.00
IUUC-Eca-033929	Equus caballus	81.62	0.00e+00	1554.00
IUUC-Eeu-034717	Erinaceus europaeus	68.52	0.00e+00	949.00
IUUC-Fca-036564	Felis catus	81.36	0.00e+00	1497.00
IUUC-Ggo-044480	Gorilla gorilla	96.51	0.00e+00	1769.00
IUUC-Hsa-046498	Homo sapiens	95.36	0.00e+00	1748.00
IUUC-Itr-048657	Ictidomys tridecemlineatus	78.45	0.00e+00	1434.00
IUUC-Laf-054119	Loxodonta africana	78.97	0.00e+00	1498.00
IUUC-Mcc-055597	Macaca mulatta	93.58	0.00e+00	1686.00
IUUC-Meu-056534	Macropus eugenii	54.13	0.00e+00	820.00
IUUC-Mdo-063058	Monodelphis domestica	55.86	0.00e+00	993.00
IUUC-Mmu-063578	Mus musculus	73.60	0.00e+00	1395.00
IUUC-Mpu-066255	Mustela putorius furo	79.49	0.00e+00	1496.00
IUUC-Mlu-067814	Myotis lucifugus	76.02	0.00e+00	1347.00
IUUC-Opr-070715	Ochotona princeps	72.92	0.00e+00	1361.00
IUUC-Ocu-074162	Oryctolagus cuniculus	77.00	0.00e+00	1427.00
IUUC-Oga-088895	Otolemur garnettii	80.66	0.00e+00	1479.00
IUUC-Oar-089579	Ovis aries	75.20	0.00e+00	1332.00
IUUC-Ptr-090581	Pan troglodytes	95.57	0.00e+00	1711.00
IUUC-Pan-092458	Papio anubis	95.36	0.00e+00	1733.00
IUUC-Pma-094214	Petromyzon marinus	55.21	2.00e-43	168.00
IUUC-Pab-098653	Pongo abelii	90.41	0.00e+00	1649.00
IUUC-Pca-100578	Procavia capensis	75.39	0.00e+00	852.00
IUUC-Pva-102914	Pteropus vampyrus	78.35	0.00e+00	1181.00
IUUC-Rno-106066	Rattus norvegicus	73.20	0.00e+00	1402.00
IUUC-Sha-107368	Sarcophilus harrisii	58.71	0.00e+00	1089.00
IUUC-Ssc-115743	Sus scrofa	80.93	0.00e+00	1489.00
IUUC-Tbe-127587	Tupaia belangeri	74.03	0.00e+00	1201.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence