iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Sha-107368

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEFK01082857

Gene Name

UBA7

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSHAG00000017846.1	ENSSHAT00000021215.1	ENSSHAP00000021045.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	2.60e-185	616.6	417	876

Active Site

Position(s)	Description	Evidence
599	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU10132}

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGv.....gsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkel 84
           YD+Qi+++G++ q+kl++++++lvGag++GcEllK ++++G+     g itv+Dmdtve+snlnrqFLfr +d +ksK+e+aa a++ +
   Q: 417  YDGQIAVFGDDFQKKLGKQRYFLVGAGAIGCELLKIFAMLGLgagegGGITVTDMDTVELSNLNRQFLFRSQDLQKSKSEAAALAVRSM 505
           ***************************************************************************************** PP
   S: 85   npdvnveaheesiteleeeiv...FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsd.dppqk 169
           np  +v+ h++++ +++e+ +   Ff+ +d+V++a+d+++ar++v ++c+++ +p++esgt G+ G ++++++ lte y+    d p++
   Q: 506  NPALSVTTHTSELGPDTEHLFgddFFSSLDGVASAVDSFQARNYVSKRCVHYLKPMLESGTQGTQGSASIFVPFLTEPYRVIAeDAPET 594
           *******************99***********************************************************999899*** PP
   S: 170  tiPfctlketpnaaehtiewa........vlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafaktti 250
            +P+ctl+++p+++eht++wa        +l +++++ + +e   lek+ + + ++ ++  + +  +  ++ + +++++a+  ++ +++
   Q: 595  AYPLCTLRSFPSTIEHTLQWArnefeglfRLTAETINRYLQEPGFLEKTGAPQVLDHLKMASTSFLT-PPQCWRDCVAWARGRWQHCFH 682
           *****************************88888888888888888888888888888888666555.69******************* PP
   S: 251  nsikqllksfecdivtkskspfwv................................................sfcsnaealqvp..... 286
            si+ ll++f++d+v+++++pfw+                                                +          +     
   Q: 683  DSITHLLQYFPPDKVSEEGVPFWSgtklcprplefdiggdthldyvlaaanlyaqthklpgsqdrdqvrailQ----------Dlptpa 761
           ************************************************9999998886666655555555551..........144444 PP
   S: 287  .......ekvekdeevvkasap.....lylllralerfekkkgrkpgelsfekddds..avdlvtaaanlraeslgiepkldddlikei 361
                  +  ++d+e ++asa      l+ l  +   +ek +g + + + fekddds  +vd++ aa+nlra ++gi+p +d+++ k+i
   Q: 762  fqgqahgPVFADDQELSQASARwdpthLQELCST---LEKWRGTPLEPQLFEKDDDSnfHVDFIVAASNLRANNYGIPP-ADRNKSKKI 846
           4444444677777777777766785555555555...555566666678******************************.********* PP
   S: 362  agniipaiattnavvgGlaaqEviKvvsgk 391
           +g+iipaiatt+avv+Gl+ +E++Kvv g+
   Q: 847  VGKIIPAIATTTAVVAGLVGLELYKVVMGH 876
           ***************************984 PP

Organism

Sarcophilus harrisii

Protein Sequence
(Fasta)

MGDLKTCLDV NEQLYSRQLY VLGRNAMRRL RGSSMLVSGM KGLGVEIAKN LVLAGVGNLA 60
LHDPRPTCWA DLASQFFLSE KDIGRKRAEA SLAPLAQLNS DVRITTHDGP LTEAVLRGFQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGAGTCCTG GGATGGAGGA CAAGGGAGCT TCCTGAATTG AGGCAGCAGT TTGGCTATGG 60
GACAGGCCTA GGGAAGGAAG TAGAAGGAGG CTTTCATCAC TGGGAGCTCA GGGCCCCACT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0436--Ligase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR032420--E1_4HB
IPR032418--E1_FCCH
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
IPR018965--Ub-activating_enz_E1_C
IPR019572--UBA_E1_Cys
IPR018075--UBQ-activ_enz_E1
IPR033127--UBQ-activ_enz_E1_Cys_AS
IPR000011--UBQ/SUMO-activ_enz_E1-like

PROSITE

PS00865--UBIQUITIN_ACTIVAT_2

Pfam

PF16191--E1_4HB
PF16190--E1_FCCH
PF09358--E1_UFD
PF00899--ThiF
PF10585--UBA_e1_thiolCys

PRINTS

PR01849--UBIQUITINACT

SMART

SM00985--UBA_e1_C

Gene Ontology

GO:0005524--F:ATP binding
GO:0019782--F:ISG15 activating enzyme activity
GO:0032020--P:ISG15-protein conjugation
GO:0019941--P:modification-dependent protein catabolic process

KEGG

shr:100934851

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001816	Ailuropoda melanoleuca	59.55	0.00e+00	1095.00
IUUC-Bta-012665	Bos taurus	57.42	0.00e+00	1016.00
IUUC-Cja-019047	Callithrix jacchus	58.37	0.00e+00	1067.00
IUUC-Cfa-021225	Canis familiaris	60.18	0.00e+00	1102.00
IUUC-Csa-023462	Chlorocebus sabaeus	60.02	0.00e+00	1051.00
IUUC-Dno-029347	Dasypus novemcinctus	61.35	0.00e+00	1147.00
IUUC-Dor-030997	Dipodomys ordii	56.10	0.00e+00	1024.00
IUUC-Ete-033124	Echinops telfairi	59.53	0.00e+00	779.00
IUUC-Eca-033929	Equus caballus	59.90	0.00e+00	1165.00
IUUC-Eeu-034717	Erinaceus europaeus	56.83	0.00e+00	786.00
IUUC-Fca-036564	Felis catus	60.26	0.00e+00	1109.00
IUUC-Ggo-044480	Gorilla gorilla	59.24	0.00e+00	1038.00
IUUC-Hsa-046498	Homo sapiens	59.53	0.00e+00	1032.00
IUUC-Itr-048657	Ictidomys tridecemlineatus	57.09	0.00e+00	1041.00
IUUC-Laf-054119	Loxodonta africana	60.53	0.00e+00	1164.00
IUUC-Mcc-055597	Macaca mulatta	58.42	0.00e+00	991.00
IUUC-Meu-056534	Macropus eugenii	64.52	0.00e+00	1238.00
IUUC-Mdo-063058	Monodelphis domestica	75.00	0.00e+00	1469.00
IUUC-Mmu-063578	Mus musculus	56.37	0.00e+00	1090.00
IUUC-Mpu-066255	Mustela putorius furo	59.96	0.00e+00	1111.00
IUUC-Mlu-067814	Myotis lucifugus	57.85	0.00e+00	985.00
IUUC-Nle-069193	Nomascus leucogenys	58.61	0.00e+00	1038.00
IUUC-Opr-070715	Ochotona princeps	53.91	0.00e+00	973.00
IUUC-Oan-073306	Ornithorhynchus anatinus	57.79	0.00e+00	843.00
IUUC-Ocu-074162	Oryctolagus cuniculus	58.05	0.00e+00	1051.00
IUUC-Oga-088895	Otolemur garnettii	57.94	0.00e+00	1031.00
IUUC-Oar-089579	Ovis aries	57.62	0.00e+00	1029.00
IUUC-Ptr-090581	Pan troglodytes	59.72	0.00e+00	1018.00
IUUC-Pan-092458	Papio anubis	59.82	0.00e+00	1036.00
IUUC-Pab-098653	Pongo abelii	56.02	0.00e+00	966.00
IUUC-Rno-106066	Rattus norvegicus	56.90	0.00e+00	1102.00
IUUC-Ssc-115743	Sus scrofa	60.33	0.00e+00	1105.00
IUUC-Tbe-127587	Tupaia belangeri	60.14	0.00e+00	801.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence