iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
microRNA	TRANSFAC	RepTar	miRNAMap
RAID2
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	Phospho.ELM
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.60e-10	42.0	264	292

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 7    tclaf.sd.tllvsGsdDgtikvWDlrtg 33
            cl++ +d +++v+G+ D  + vW++ ++
   Q: 264  LCLCWsPDgKYIVTGGEDDLVTVWSFLDC 292
           6*****999***************97665 PP

Organism

Mus musculus

Functional Description
(View)

Regulator of deubiquitinating complexes. Activates deubiquitinating activity of complexes containing USP12.

Protein Sequence
(Fasta)

MATEGRGKET NEIKTHFTTR EGLYRLLPHS EYSRPNRVPF NSQGSNPVRV SFVNLNDQTG 60
NGNRLCFSVG RELYVYIYKG VRKAADLSKP IDKRIYKGTQ PTCHDFNHLT ATAESVSLLV 120

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Nucleotide Sequence
(Fasta)

GGAACCTAAC TTGGGTCCTT TGCAAGAATA GCACGCACTC TTAACTGCTG AGACATCTCT 60
TCAGCCCCAT TTCTCCAAAA TGTTTCTTAA AGCCCCTACA TTTACAGATA TCTACAAAAA 120

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Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0016579--P:protein deubiquitination

KEGG

mmu:70948

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Atr-002459	Amborella trichopoda	38.64	2.00e-55	210.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence