iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000037622.14	ENSMUST00000043305.13	ENSMUSP00000040647.7
ENSMUSG00000037622.14	ENSMUST00000105906.1	ENSMUSP00000101526.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	miRNAMap	RAID2
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
UniProt	PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.90e-27	95.3	45	76

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf..sdtllvsGsdDgtikvWDl 30
           gH++ v+cl++   ++ll+sGsdD    vWD+
   Q: 45   GHSGCVNCLEWneKGDLLASGSDDQHTIVWDP 76
           8**********65339***************6 PP

Organism

Mus musculus

Functional Description
(View)

May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

Protein Sequence
(Fasta)

MAKVNITRDL IRRQVKERGA LSFERRYHVT DPFIRRLGLE AELQGHSGCV NCLEWNEKGD 60
LLASGSDDQH TIVWDPLHHK KLLSMHTGHT ANIFSVKFLP HAGDRILITG AADSKVHVHD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGGCCTTGG GCAGGATCTG GGATTAGAAG TTAGCCTGGG CTGCATGGGA AGCTGGAGAC 60
CTATACCGAG ACTCTGTCTC GAAAAGGCAA ATCAAACCAG CGTGGTGGTG CATGCCTGAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0802--TPR repeat
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR013026--TPR-contain_dom
IPR011990--TPR-like_helical_dom
IPR019734--TPR_repeat
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50293--TPR_REGION
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

SMART

SM00028--TPR
SM00320--WD40

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0004857--F:enzyme inhibitor activity
GO:0042393--F:histone binding
GO:0042826--F:histone deacetylase binding
GO:0055082--P:cellular chemical homeostasis
GO:0032869--P:cellular response to insulin stimulus
GO:0006006--P:glucose metabolic process
GO:0001701--P:in utero embryonic development
GO:0035264--P:multicellular organism growth
GO:0045717--P:negative regulation of fatty acid biosynthetic process
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0016567--P:protein ubiquitination
GO:0008361--P:regulation of cell size

KEGG

mmu:230796

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000083	Aegilops tauschii	33.10	6.00e-31	129.00
IUUC-Aml-001699	Ailuropoda melanoleuca	96.76	0.00e+00	1323.00
IUUC-Atr-002509	Amborella trichopoda	31.65	4.00e-50	192.00
IUUC-Apl-003379	Anas platyrhynchos	91.59	0.00e+00	1262.00
IUUC-Aca-005202	Anolis carolinensis	89.10	0.00e+00	1233.00
IUUC-Aly-006475	Arabidopsis lyrata	32.08	1.00e-52	201.00
IUUC-Ath-007666	Arabidopsis thaliana	31.42	2.00e-52	200.00
IUUC-Afl-008592	Aspergillus flavus	28.25	9.00e-26	112.00
IUUC-Ani-009263	Aspergillus nidulans	27.90	1.00e-25	112.00
IUUC-Ang-009671	Aspergillus niger	27.61	3.00e-26	115.00
IUUC-Aor-010229	Aspergillus oryzae	27.97	6.00e-26	113.00
IUUC-Ame-010988	Astyanax mexicanus	80.87	0.00e+00	989.00
IUUC-Bdi-014100	Brachypodium distachyon	30.80	1.00e-50	194.00
IUUC-Bol-016409	Brassica oleracea	31.98	2.00e-51	197.00
IUUC-Bra-016979	Brassica rapa	32.62	6.00e-52	199.00
IUUC-Cel-018561	Caenorhabditis elegans	32.25	1.00e-33	137.00
IUUC-Cja-019212	Callithrix jacchus	94.84	0.00e+00	1279.00
IUUC-Cfa-020200	Canis familiaris	96.61	0.00e+00	1322.00
IUUC-Cpo-021739	Cavia porcellus	97.20	0.00e+00	1326.00
IUUC-Cre-022659	Chlamydomonas reinhardtii	33.46	6.00e-34	139.00
IUUC-Csa-023648	Chlorocebus sabaeus	96.76	0.00e+00	1321.00
IUUC-Cin-025155	Ciona intestinalis	44.22	4.00e-64	238.00
IUUC-Csv-026289	Ciona savignyi	46.34	4.00e-150	524.00
IUUC-Cme-027316	Cyanidioschyzon merolae	27.99	3.00e-27	117.00
IUUC-Dre-028745	Danio rerio	79.50	0.00e+00	1099.00
IUUC-Dno-029403	Dasypus novemcinctus	90.86	0.00e+00	1231.00
IUUC-Dor-030332	Dipodomys ordii	86.89	0.00e+00	1195.00
IUUC-Dme-031811	Drosophila melanogaster	37.28	5.00e-108	385.00
IUUC-Ete-032331	Echinops telfairi	90.26	5.00e-143	501.00
IUUC-Eca-033783	Equus caballus	96.32	0.00e+00	1324.00
IUUC-Eeu-034732	Erinaceus europaeus	94.69	0.00e+00	1281.00
IUUC-Fca-036543	Felis catus	96.76	0.00e+00	1323.00
IUUC-Fal-037245	Ficedula albicollis	91.08	0.00e+00	1273.00
IUUC-Gmo-039346	Gadus morhua	77.70	0.00e+00	1108.00
IUUC-Gga-041034	Gallus gallus	91.45	0.00e+00	1257.00
IUUC-Gac-041297	Gasterosteus aculeatus	78.50	0.00e+00	1094.00
IUUC-Gma-042727	Glycine max	31.41	3.00e-47	183.00
IUUC-Ggo-045309	Gorilla gorilla	96.76	0.00e+00	1321.00
IUUC-Hsa-046622	Homo sapiens	96.76	0.00e+00	1321.00
IUUC-Itr-049052	Ictidomys tridecemlineatus	95.97	0.00e+00	1150.00
IUUC-Lch-049810	Latimeria chalumnae	84.60	0.00e+00	1142.00
IUUC-Lpe-051600	Leersia perrieri	28.97	1.00e-67	251.00
IUUC-Loc-052088	Lepisosteus oculatus	84.37	0.00e+00	1169.00
IUUC-Laf-054097	Loxodonta africana	96.31	0.00e+00	1321.00
IUUC-Mcc-054848	Macaca mulatta	96.76	0.00e+00	1321.00
IUUC-Meu-056022	Macropus eugenii	71.78	0.00e+00	790.00
IUUC-Mtr-057735	Medicago truncatula	29.80	1.00e-45	178.00
IUUC-Mga-059622	Meleagris gallopavo	91.45	0.00e+00	1259.00
IUUC-Mmr-060709	Microcebus murinus	96.46	0.00e+00	1323.00
IUUC-Mdo-062401	Monodelphis domestica	93.95	0.00e+00	1281.00
IUUC-Mac-064840	Musa acuminata	30.26	2.00e-47	184.00
IUUC-Mpu-066268	Mustela putorius furo	96.61	0.00e+00	1321.00
IUUC-Mlu-067211	Myotis lucifugus	96.34	0.00e+00	840.00
IUUC-Nle-070019	Nomascus leucogenys	96.61	0.00e+00	1298.00
IUUC-Opr-071008	Ochotona princeps	96.31	0.00e+00	1324.00
IUUC-Ont-072123	Oreochromis niloticus	80.27	0.00e+00	1125.00
IUUC-Ocu-074166	Oryctolagus cuniculus	95.87	0.00e+00	1320.00
IUUC-Oba-075298	Oryza barthii	29.60	1.00e-42	168.00
IUUC-Obr-076849	Oryza brachyantha	28.54	2.00e-41	164.00
IUUC-Ogl-077515	Oryza glaberrima	29.60	1.00e-42	168.00
IUUC-Ogu-077968	Oryza glumaepatula	29.62	5.00e-39	155.00
IUUC-Oin-079231	Oryza indica	29.75	5.00e-38	152.00
IUUC-Olo-081045	Oryza longistaminata	29.75	6.00e-37	150.00
IUUC-Ome-081395	Oryza meridionalis	29.54	1.00e-36	148.00
IUUC-Oni-082801	Oryza nivara	29.60	9.00e-43	168.00
IUUC-Opu-083585	Oryza punctata	29.82	2.00e-42	167.00
IUUC-Oru-085163	Oryza rufipogon	28.85	6.00e-42	166.00
IUUC-Osa-085550	Oryza sativa	34.00	1.00e-28	120.00
IUUC-Ola-086925	Oryzias latipes	77.91	0.00e+00	1090.00
IUUC-Oga-088095	Otolemur garnettii	95.29	0.00e+00	1316.00
IUUC-Oar-090285	Ovis aries	95.13	0.00e+00	1287.00
IUUC-Ptr-091221	Pan troglodytes	96.76	0.00e+00	1321.00
IUUC-Pan-091771	Papio anubis	96.76	0.00e+00	1321.00
IUUC-Psi-093977	Pelodiscus sinensis	90.71	0.00e+00	1253.00
IUUC-Ppa-095373	Physcomitrella patens	30.95	9.00e-50	192.00
IUUC-Pfo-096640	Poecilia formosa	79.65	0.00e+00	1107.00
IUUC-Pab-098513	Pongo abelii	96.76	0.00e+00	1321.00
IUUC-Pop-098837	Populus trichocarpa	31.52	9.00e-45	175.00
IUUC-Pca-101095	Procavia capensis	87.46	0.00e+00	1168.00
IUUC-Ppe-101507	Prunus persica	30.15	3.00e-46	180.00
IUUC-Pva-102444	Pteropus vampyrus	97.05	0.00e+00	1326.00
IUUC-Rno-105952	Rattus norvegicus	98.82	0.00e+00	1350.00
IUUC-Sha-106614	Sarcophilus harrisii	94.40	0.00e+00	1295.00
IUUC-Smo-108844	Selaginella moellendorffii	32.50	7.00e-47	182.00
IUUC-Sit-110154	Setaria italica	33.44	2.00e-40	160.00
IUUC-Sly-111707	Solanum lycopersicum	31.43	3.00e-48	186.00
IUUC-Sar-113129	Sorex araneus	79.53	0.00e+00	1049.00
IUUC-Sbi-113858	Sorghum bicolor	27.91	2.00e-52	200.00
IUUC-Ssc-116275	Sus scrofa	97.35	0.00e+00	1328.00
IUUC-Tgu-117507	Taeniopygia guttata	91.45	0.00e+00	1262.00
IUUC-Tru-117969	Takifugu rubripes	77.47	0.00e+00	1108.00
IUUC-Tsy-119374	Tarsius syrichta	84.55	0.00e+00	839.00
IUUC-Tni-119887	Tetraodon nigroviridis	75.80	0.00e+00	1050.00
IUUC-Tca-121722	Theobroma cacao	32.53	3.00e-48	187.00
IUUC-Tae-124854	Triticum aestivum	34.84	2.00e-36	147.00
IUUC-Tur-125968	Triticum urartu	35.34	3.00e-32	135.00
IUUC-Tme-126910	Tuber melanosporum	34.26	3.00e-24	107.00
IUUC-Tbe-127511	Tupaia belangeri	90.53	2.00e-86	313.00
IUUC-Ttr-128390	Tursiops truncatus	93.67	0.00e+00	1249.00
IUUC-Uma-129509	Ustilago maydis	26.85	4.00e-13	70.10
IUUC-Vpa-130124	Vicugna pacos	57.84	4.00e-143	501.00
IUUC-Xtr-132290	Xenopus tropicalis	76.25	0.00e+00	1039.00
IUUC-Xma-134025	Xiphophorus maculatus	79.20	0.00e+00	1102.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence