iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	circBase	microRNA	TRANSFAC
RepTar	miRNAMap	RAID2
Protein-protein Interaction
iRefIndex	Mentha
Drug and target
GRAC
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
Phospho.ELM	UniProt	PHOSIDA	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	8.70e-10	39.8	6	55

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCrs 53
           ++C vC+ +++ ++ ++eC+ C++wfH  C++ + eee p+ + + Cp+C++
   Q: 6    VYC-VCRLPYDVTRFMIECDACKDWFHGSCVGVE-EEEAPDIDIYHCPNCEK 55
           69*.******************************.*******99******86 PP

Organism

Mus musculus

Functional Description
(View)

Lysine demethylase that demethylates both histones and non-histone proteins. Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B. Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA (By similarity).

Protein Sequence
(Fasta)

MATVPVYCVC RLPYDVTRFM IECDACKDWF HGSCVGVEEE EAPDIDIYHC PNCEKTHGKS 60
TLKKKRTWHK HGPGPTPDVK PVQNGSQLFI KELRSRTFPS AEDVVSRVPG SQLTVGYMEE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCGTCCGCTC CGGCCGCGGC GCCCGCGCCC GCCGCCCCCG CCGCCCTCGC CGCGCGGCCC 60
CCGGCCCGGC CCGGCCCGAC CCGGGCAGCG CAGCGGCGGG GCGAGCGGCG GCGCGGCAAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0010--Activator
KW-0137--Centromere
KW-0156--Chromatin regulator
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0223--Dioxygenase
KW-0408--Iron
KW-0995--Kinetochore
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0560--Oxidoreductase
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR003347--JmjC_dom
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51184--JMJC
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2

Pfam

PF02373--JmjC
PF00628--PHD

SMART

SM00558--JmjC
SM00249--PHD

Gene Ontology

GO:0000777--C:condensed chromosome kinetochore
GO:0005829--C:cytosol
GO:0000776--C:kinetochore
GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:0051213--F:dioxygenase activity
GO:0032454--F:histone demethylase activity (H3-K9 specific)
GO:0005506--F:iron ion binding
GO:0035064--F:methylated histone binding
GO:0003713--F:transcription coactivator activity
GO:0008270--F:zinc ion binding
GO:0033169--P:histone H3-K9 demethylation
GO:0061188--P:negative regulation of chromatin silencing at rDNA
GO:0006482--P:protein demethylation
GO:0006351--P:transcription, DNA-templated

KEGG

mmu:18676

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Atr-002986	Amborella trichopoda	37.18	7.00e-12	63.90
IUUC-Aca-005043	Anolis carolinensis	90.44	0.00e+00	898.00
IUUC-Aly-005443	Arabidopsis lyrata	35.82	2.00e-11	62.40
IUUC-Ath-007631	Arabidopsis thaliana	46.00	3.00e-11	62.00
IUUC-Bdi-014153	Brachypodium distachyon	43.64	1.00e-12	66.20
IUUC-Bol-015887	Brassica oleracea	48.00	4.00e-12	64.70
IUUC-Dre-028285	Danio rerio	79.30	0.00e+00	764.00
IUUC-Fal-037017	Ficedula albicollis	89.13	0.00e+00	926.00
IUUC-Gga-040290	Gallus gallus	88.91	0.00e+00	924.00
IUUC-Gma-042998	Glycine max	36.76	1.00e-11	62.80
IUUC-Hsa-046760	Homo sapiens	92.43	0.00e+00	1607.00
IUUC-Hvu-047723	Hordeum vulgare	32.84	4.00e-10	58.20
IUUC-Lpe-051400	Leersia perrieri	45.45	2.00e-12	65.90
IUUC-Loc-051927	Lepisosteus oculatus	83.48	0.00e+00	845.00
IUUC-Mtr-057710	Medicago truncatula	38.46	2.00e-11	62.80
IUUC-Mmr-061132	Microcebus murinus	91.41	0.00e+00	1620.00
IUUC-Mac-065355	Musa acuminata	45.10	1.00e-11	63.20
IUUC-Ont-071935	Oreochromis niloticus	76.84	0.00e+00	740.00
IUUC-Oba-075188	Oryza barthii	45.45	5.00e-12	64.30
IUUC-Obr-076844	Oryza brachyantha	45.45	5.00e-12	64.30
IUUC-Ogl-077260	Oryza glaberrima	45.45	5.00e-12	64.30
IUUC-Ogu-078663	Oryza glumaepatula	45.45	2.00e-12	65.90
IUUC-Oin-079894	Oryza indica	45.45	2.00e-12	65.90
IUUC-Olo-080411	Oryza longistaminata	45.45	2.00e-12	65.50
IUUC-Ome-081623	Oryza meridionalis	45.45	3.00e-12	65.50
IUUC-Oni-082587	Oryza nivara	45.45	2.00e-12	65.90
IUUC-Opu-083591	Oryza punctata	43.64	4.00e-12	64.70
IUUC-Oru-084597	Oryza rufipogon	45.45	2.00e-12	65.90
IUUC-Osa-086057	Oryza sativa	45.45	2.00e-12	65.90
IUUC-Ola-087236	Oryzias latipes	77.83	0.00e+00	766.00
IUUC-Ptr-091328	Pan troglodytes	85.45	0.00e+00	1112.00
IUUC-Pfo-096227	Poecilia formosa	76.42	0.00e+00	763.00
IUUC-Pop-098853	Populus trichocarpa	44.00	2.00e-11	62.80
IUUC-Ppe-101818	Prunus persica	37.66	6.00e-12	64.30
IUUC-Spo-108120	Schizosaccharomyces pombe	35.91	3.00e-50	193.00
IUUC-Sit-110411	Setaria italica	47.46	6.00e-14	70.50
IUUC-Sly-110932	Solanum lycopersicum	35.06	5.00e-12	64.30
IUUC-Stu-112357	Solanum tuberosum	40.68	2.00e-11	62.40
IUUC-Sbi-114098	Sorghum bicolor	49.09	2.00e-13	69.30
IUUC-Tgu-117091	Taeniopygia guttata	89.13	0.00e+00	922.00
IUUC-Tru-118118	Takifugu rubripes	59.86	0.00e+00	1224.00
IUUC-Tni-120632	Tetraodon nigroviridis	78.95	0.00e+00	798.00
IUUC-Tca-121518	Theobroma cacao	48.00	5.00e-12	64.30
IUUC-Tae-125802	Triticum aestivum	43.64	1.00e-12	67.00
IUUC-Tur-126461	Triticum urartu	43.64	1.00e-12	66.20
IUUC-Ttr-128194	Tursiops truncatus	92.19	0.00e+00	1625.00
IUUC-Vvi-131614	Vitis vinifera	48.00	6.00e-12	64.30
IUUC-Xma-134037	Xiphophorus maculatus	76.42	0.00e+00	764.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence