iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Cin-025411

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

EAAA01000421

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCING00000006975.3	ENSCINT00000014360.3	ENSCINP00000014360.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.50e-60	205.0	327	824
UBD/Alpha-Helix/UBA	2.50e-18	65.4	696	730

Active Site

Position(s)	Description	Evidence
336	Nucleophile	{ECO:0000256\|PIRSR:PIRSR016308-1}
787	Proton acceptor	{ECO:0000256\|PIRSR:PIRSR016308-1}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw........kskkk........avsprel 73
           +Gl+N+gNtCYmNSv+Q+L++ipe++e + ++ +++++++   e++g+++ +l kl  +l+        +   +        +v+pr++
   Q: 327  VGLNNMGNTCYMNSVIQVLYSIPEFMERYTTEASNEIQNRV-LESSGDFSIQLCKLGLALTspdmlkhqD---StkqevtscSVTPRTM 411
           6******************************9999999875.8**************9997776665431...1345688889****** PP
   S: 74   lkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnv 162
           ++++++ ++efs+++qqD++Efl ++l+ +e++                            +k ++    ++F++ ++++i c++ ++v
   Q: 412  KRIVGRGHPEFSTNRQQDTHEFLLHVLSVIERSE---------------------------HKNGSVSPGEVFRFMVEDRIECQASKQV 473
           ********************************99...........................4566667789****************** PP
   S: 163  ssreepfldlslpvpgkeetkke............................slqdcLesftkeeelegenkyycekckkkqeaekklkl 223
             ++ + + l lp+p +   +k                               + c+e+f+  e +++   ++++  k+k ea+k++++
   Q: 474  RYTKRSDYALALPIPLEAAANKAavgeyqavveankkdvsvkvgevvrlsiPYTACIEAFAHDELIQD---FWSSAVKEKAEAKKRTRF 559
           ***************9998877799************************9999*************97...****************** PP
   S: 224  kklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts............................................. 267
            ++P++L++++k+f++ e  ++++k++ +ve+p+ L+l+                                                  
   Q: 560  VTFPDYLVVQMKKFTVGE-DWVPKKLDVSVEMPDILNLNDLRGGglqkdetllpdieppsappseplieideeaviaisqmgfplarcr 647
           **************8866.5*******************98888677777777777777777777777777766666666666666666 PP
   S: 268  .........................................................peekqke......................... 274
                                                                    +     e                         
   Q: 648  ealvatgnmgveaavmwlmenntpggvlkitepagaaaaqpsgasdgnvasivamgfT-----Egqakkalhatgnnleraadwifshl 731
           6666666666666666666666666666666666666666555555555555555550.....05555556666666666666666666 PP
   S: 275  ...................................kkkYeLiavvvHsG.slssGHYvayvknekgkWllfdDskVtevkeeevleetg 327
                                              + +YeL+a ++H+G s+ +GHYv+++k+ +g+W+ f+D+kV e+  e+  +   
   Q: 732  deldsievdtplepanqvaagdtpmdtsanhlkdgSGNYELFAFISHMGsSTMCGHYVCHIKK-DGRWVIFNDEKVAES--EQPPK--- 814
           66666667777777777777777777778888888****************************.9************99..78899... PP
   S: 328  staYvlfYkr 337
           + +Y++fYkr
   Q: 815  DLGYIYFYKR 824
           99******98 PP

UBD/Alpha-Helix/UBA

   S: 7    leqlveMGFdreealqaLraannnleaAveyLldg 41
           ++ +v+MGF++ +a++aL a++nnle+A+++++++
   Q: 696  VASIVAMGFTEGQAKKALHATGNNLERAADWIFSH 730
           7889*****************************97 PP

Organism

Ciona intestinalis

Protein Sequence
(Fasta)

IGRMPDTDLL VPLLPCVRVP GLGDNVYKEE CCFSFDTPKS DDGLYICLST FLGFNRKYVE 60
LFHETTGHKL FLHMKQIKKI LPKSEEASPV EKKKPKRLAI GIEGGFDAAN GEKIEYEDVN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATCAATAGGC AGGATGCCTG ATACTGACTT GTTGGTGCCA CTGCTGCCTT GTGTGAGGGT 60
TCCAGGGTTG GGAGACAATG TTTATAAAGA AGAATGCTGC TTCTCATTTG ATACACCGGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000394	Aegilops tauschii	40.13	3.00e-160	557.00
IUUC-Aml-002104	Ailuropoda melanoleuca	49.77	0.00e+00	847.00
IUUC-Atr-002580	Amborella trichopoda	46.35	1.00e-94	340.00
IUUC-Apl-003774	Anas platyrhynchos	50.12	0.00e+00	824.00
IUUC-Aca-005368	Anolis carolinensis	51.32	0.00e+00	875.00
IUUC-Aly-005727	Arabidopsis lyrata	42.32	4.00e-179	620.00
IUUC-Ath-006974	Arabidopsis thaliana	42.01	3.00e-179	620.00
IUUC-Ago-007890	Ashbya gossypii	27.29	5.00e-68	251.00
IUUC-Acl-008057	Aspergillus clavatus	32.10	1.00e-102	366.00
IUUC-Afl-008547	Aspergillus flavus	34.38	7.00e-100	356.00
IUUC-Afu-008805	Aspergillus fumigatus	31.31	1.00e-93	335.00
IUUC-Ani-009441	Aspergillus nidulans	30.90	1.00e-88	319.00
IUUC-Ang-009720	Aspergillus niger	32.34	2.00e-102	365.00
IUUC-Aor-010111	Aspergillus oryzae	32.97	3.00e-110	391.00
IUUC-Ate-010531	Aspergillus terreus	29.93	2.00e-83	301.00
IUUC-Ame-011470	Astyanax mexicanus	45.38	0.00e+00	743.00
IUUC-Bgr-012183	Blumeria graminis	30.91	4.00e-100	357.00
IUUC-Bta-013179	Bos taurus	50.12	0.00e+00	860.00
IUUC-Bci-013858	Botrytis cinerea	33.90	8.00e-113	399.00
IUUC-Bdi-014904	Brachypodium distachyon	42.93	0.00e+00	631.00
IUUC-Bol-015296	Brassica oleracea	42.55	0.00e+00	629.00
IUUC-Bra-017939	Brassica rapa	42.62	0.00e+00	632.00
IUUC-Cel-018625	Caenorhabditis elegans	34.81	2.00e-119	421.00
IUUC-Cja-019063	Callithrix jacchus	49.42	0.00e+00	841.00
IUUC-Cfa-020976	Canis familiaris	51.62	0.00e+00	862.00
IUUC-Cpo-022265	Cavia porcellus	51.61	0.00e+00	862.00
IUUC-Cre-022640	Chlamydomonas reinhardtii	39.76	2.00e-106	378.00
IUUC-Csa-024177	Chlorocebus sabaeus	47.83	0.00e+00	748.00
IUUC-Cho-024702	Choloepus hoffmanni	43.10	2.00e-131	461.00
IUUC-Csv-026347	Ciona savignyi	76.02	0.00e+00	1220.00
IUUC-Cgl-026667	Colletotrichum gloeosporioides	31.96	1.00e-92	333.00
IUUC-Cne-026831	Cryptococcus neoformans	35.13	2.00e-111	395.00
IUUC-Cme-027335	Cyanidioschyzon merolae	29.26	1.00e-41	164.00
IUUC-Dre-027982	Danio rerio	47.32	0.00e+00	753.00
IUUC-Dno-029034	Dasypus novemcinctus	49.88	0.00e+00	855.00
IUUC-Dor-030479	Dipodomys ordii	49.18	1.00e-102	366.00
IUUC-Dse-031467	Dothistroma septosporum	33.81	2.00e-107	382.00
IUUC-Dme-032075	Drosophila melanogaster	45.10	0.00e+00	681.00
IUUC-Ete-032865	Echinops telfairi	46.22	0.00e+00	758.00
IUUC-Eca-034059	Equus caballus	49.65	0.00e+00	847.00
IUUC-Eeu-035304	Erinaceus europaeus	47.73	0.00e+00	769.00
IUUC-Fca-035515	Felis catus	49.88	0.00e+00	852.00
IUUC-Fal-037271	Ficedula albicollis	51.00	0.00e+00	805.00
IUUC-Fox-037745	Fusarium oxysporum	35.02	5.00e-107	380.00
IUUC-Fso-038158	Fusarium solani	33.73	1.00e-103	369.00
IUUC-Gmo-039071	Gadus morhua	47.68	0.00e+00	764.00
IUUC-Ggr-040098	Gaeumannomyces graminis	32.13	2.00e-97	349.00
IUUC-Gga-040635	Gallus gallus	50.00	0.00e+00	867.00
IUUC-Gac-042528	Gasterosteus aculeatus	48.16	0.00e+00	781.00
IUUC-Gma-043614	Glycine max	41.23	7.00e-174	602.00
IUUC-Ggo-044602	Gorilla gorilla	49.53	0.00e+00	848.00
IUUC-Hsa-045959	Homo sapiens	49.53	0.00e+00	848.00
IUUC-Hvu-047563	Hordeum vulgare	44.12	6.00e-148	516.00
IUUC-Itr-048712	Ictidomys tridecemlineatus	50.00	0.00e+00	855.00
IUUC-Kpa-049156	Komagataella pastoris	30.59	9.00e-92	330.00
IUUC-Lch-049648	Latimeria chalumnae	52.47	0.00e+00	842.00
IUUC-Lpe-051523	Leersia perrieri	41.73	7.00e-180	622.00
IUUC-Loc-052072	Lepisosteus oculatus	44.05	0.00e+00	726.00
IUUC-Lma-053216	Leptosphaeria maculans	34.10	2.00e-100	359.00
IUUC-Laf-054327	Loxodonta africana	49.94	0.00e+00	851.00
IUUC-Mcc-055443	Macaca mulatta	49.47	0.00e+00	848.00
IUUC-Meu-056298	Macropus eugenii	51.63	4.00e-177	613.00
IUUC-Mor-057106	Magnaporthe oryzae	32.65	1.00e-105	376.00
IUUC-Mpo-057589	Magnaporthe poae	31.65	3.00e-98	351.00
IUUC-Mtr-058680	Medicago truncatula	43.15	5.00e-176	610.00
IUUC-Mla-058903	Melampsora laricipopulina	32.40	2.00e-99	355.00
IUUC-Mga-059669	Meleagris gallopavo	49.88	0.00e+00	818.00
IUUC-Mvi-060476	Microbotryum violaceum	33.45	4.00e-103	367.00
IUUC-Mmr-060575	Microcebus murinus	49.77	0.00e+00	850.00
IUUC-Mdo-062183	Monodelphis domestica	49.76	0.00e+00	847.00
IUUC-Mmu-063592	Mus musculus	49.83	0.00e+00	850.00
IUUC-Mac-065634	Musa acuminata	39.82	4.00e-173	600.00
IUUC-Mpu-066082	Mustela putorius furo	51.14	0.00e+00	857.00
IUUC-Mlu-067345	Myotis lucifugus	50.29	0.00e+00	852.00
IUUC-Nfi-068558	Neosartorya fischeri	33.33	1.00e-105	376.00
IUUC-Ncr-068960	Neurospora crassa	31.49	6.00e-94	337.00
IUUC-Nle-070173	Nomascus leucogenys	51.14	0.00e+00	857.00
IUUC-Opr-070556	Ochotona princeps	49.88	0.00e+00	852.00
IUUC-Ont-071502	Oreochromis niloticus	48.16	0.00e+00	767.00
IUUC-Oan-072959	Ornithorhynchus anatinus	54.09	3.00e-69	253.00
IUUC-Ocu-074861	Oryctolagus cuniculus	51.50	0.00e+00	865.00
IUUC-Oba-075109	Oryza barthii	42.70	0.00e+00	639.00
IUUC-Obr-076292	Oryza brachyantha	44.05	0.00e+00	655.00
IUUC-Ogl-077065	Oryza glaberrima	43.93	0.00e+00	668.00
IUUC-Ogu-078776	Oryza glumaepatula	42.46	0.00e+00	643.00
IUUC-Oin-080048	Oryza indica	43.69	0.00e+00	657.00
IUUC-Olo-080711	Oryza longistaminata	40.93	5.00e-166	576.00
IUUC-Ome-081506	Oryza meridionalis	42.07	2.00e-170	590.00
IUUC-Oni-082320	Oryza nivara	42.26	0.00e+00	634.00
IUUC-Opu-083801	Oryza punctata	43.27	0.00e+00	632.00
IUUC-Oru-085139	Oryza rufipogon	42.26	0.00e+00	637.00
IUUC-Osa-085713	Oryza sativa	43.93	0.00e+00	668.00
IUUC-Ola-086951	Oryzias latipes	48.07	0.00e+00	763.00
IUUC-Olu-087822	Ostreococcus lucimarinus	41.68	1.00e-167	582.00
IUUC-Oga-088625	Otolemur garnettii	49.47	0.00e+00	847.00
IUUC-Oar-089995	Ovis aries	49.88	0.00e+00	858.00
IUUC-Ptr-090640	Pan troglodytes	49.42	0.00e+00	847.00
IUUC-Pan-091974	Papio anubis	49.59	0.00e+00	845.00
IUUC-Psi-093957	Pelodiscus sinensis	50.12	0.00e+00	876.00
IUUC-Pma-094242	Petromyzon marinus	50.39	5.00e-114	402.00
IUUC-Pno-094835	Phaeosphaeria nodorum	33.25	3.00e-89	322.00
IUUC-Ppa-095901	Physcomitrella patens	43.63	0.00e+00	656.00
IUUC-Pfo-097148	Poecilia formosa	48.87	0.00e+00	776.00
IUUC-Pab-098068	Pongo abelii	44.12	0.00e+00	707.00
IUUC-Pop-098943	Populus trichocarpa	42.67	1.00e-178	618.00
IUUC-Pca-100738	Procavia capensis	47.54	2.00e-160	558.00
IUUC-Ppe-101315	Prunus persica	42.58	5.00e-175	606.00
IUUC-Pva-102154	Pteropus vampyrus	49.94	0.00e+00	844.00
IUUC-Pgr-103343	Puccinia graminis	30.90	7.00e-84	303.00
IUUC-Ptt-103928	Puccinia triticina	27.82	2.00e-82	298.00
IUUC-Pte-104306	Pyrenophora teres	33.25	9.00e-92	330.00
IUUC-Pyt-104696	Pyrenophora triticirepentis	33.45	2.00e-92	332.00
IUUC-Rno-105801	Rattus norvegicus	50.41	0.00e+00	856.00
IUUC-Sce-106304	Saccharomyces cerevisiae	28.33	3.00e-62	232.00
IUUC-Sha-107635	Sarcophilus harrisii	51.37	0.00e+00	858.00
IUUC-Sja-107678	Schizosaccharomyces japonicus	31.65	4.00e-94	337.00
IUUC-Spo-108144	Schizosaccharomyces pombe	31.31	1.00e-91	329.00
IUUC-Smo-108703	Selaginella moellendorffii	43.50	0.00e+00	637.00
IUUC-Sit-110728	Setaria italica	43.10	0.00e+00	665.00
IUUC-Sly-111523	Solanum lycopersicum	43.56	0.00e+00	659.00
IUUC-Sar-113733	Sorex araneus	41.26	5.00e-91	327.00
IUUC-Sbi-114419	Sorghum bicolor	43.24	0.00e+00	657.00
IUUC-Sre-115225	Sporisorium reilianum	32.16	2.00e-102	365.00
IUUC-Ssc-115686	Sus scrofa	49.77	0.00e+00	852.00
IUUC-Tgu-117346	Taeniopygia guttata	49.83	0.00e+00	848.00
IUUC-Tru-118350	Takifugu rubripes	46.99	0.00e+00	768.00
IUUC-Tsy-119278	Tarsius syrichta	41.10	1.00e-174	605.00
IUUC-Tni-120658	Tetraodon nigroviridis	47.49	0.00e+00	749.00
IUUC-Tca-121585	Theobroma cacao	42.86	4.00e-173	600.00
IUUC-Tre-122043	Trichoderma reesei	33.25	8.00e-104	370.00
IUUC-Tvi-122303	Trichoderma virens	31.98	3.00e-95	341.00
IUUC-Tae-125686	Triticum aestivum	43.22	0.00e+00	631.00
IUUC-Tur-126732	Triticum urartu	40.51	7.00e-170	589.00
IUUC-Tme-126909	Tuber melanosporum	33.25	4.00e-98	351.00
IUUC-Tbe-127261	Tupaia belangeri	43.68	1.00e-137	482.00
IUUC-Ttr-128295	Tursiops truncatus	42.00	1.00e-180	625.00
IUUC-Uma-129599	Ustilago maydis	31.69	2.00e-109	389.00
IUUC-Vda-129688	Verticillium dahliae	32.69	2.00e-100	358.00
IUUC-Vpa-130170	Vicugna pacos	38.96	5.00e-159	553.00
IUUC-Vvi-131116	Vitis vinifera	42.94	3.00e-175	607.00
IUUC-Xtr-131953	Xenopus tropicalis	50.18	0.00e+00	800.00
IUUC-Xma-133837	Xiphophorus maculatus	48.75	0.00e+00	774.00
IUUC-Yli-134510	Yarrowia lipolytica	34.06	1.00e-107	382.00
IUUC-Zma-135786	Zea mays	42.87	3.00e-180	624.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence