iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFCAG00000009717.3	ENSFCAT00000009719.3	ENSFCAP00000009011.3
ENSFCAG00000009717.3	ENSFCAT00000027912.1	ENSFCAP00000023329.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/Cullin	3.30e-147	491.9	1024	1571

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/Cullin

   S: 70   nreWekfreqlkvlrkifayldrtyvkkskkvsevrkLaldlwrkeivedikkrllelllklieaeRkgeavdrrllsgvveslveL 156
            ++W+ freql++++++f      y+++           +++w+++i+ed +++ll+l+++l+ a+R+++++++r+l++++++    
   Q: 1024 PTFWPVFREQLCRHTRLF------YMVR-----------AQAWSQDIAED-RRSLLHLSSRLNGALRQEQNFADRFLPDDEAA---- 1088
           689***************......****...........***********.********************************.... PP
   S: 157  slnklaiykesFEakfleatqefykaesaeflqe.nevdeYlkkvearlneeeeraaryleestetkLlevvekeliakhlesllae 242
               +a++k+++Ea++++ +q++++++++ ++   + +d+Yl+++ea+ n+++++aa++++++++t+Ll++ve+++++       ++
   Q: 1089 ----QALGKTCWEALVSPLVQNITSPDEDGISPLgWLLDQYLECREAAHNPQSRAAAFSSRVRRLTHLLVHVEPCEAP-------PP 1164
           ....**************************************************************************.......** PP
   S: 243  lvallrdkktedlsrmykLlsrvln..gleellkeleshikeqgkaaltaeekekdpkkyVerllelknklqklvseaFnndakFlk 327
            va++r k++++ +++++L++r+l+  ++++l+++++++++eq++++lt+ +++ d   +V+r++e+++ lqk++se+F+++a+Fl 
   Q: 1165 AVATPRPKGRNRSHDWSSLATRGLPssIVRNLTRCWRAVVEEQVNNFLTSRWRDGD---FVPRYCEHFHNLQKSSSELFGPRAAFLL 1248
           ************************999*****************************...**************************** PP
   S: 328  aldkafetfvnknsvlkaakspEllAryiDqlLrks.skglteeeleaqldkvllvfkyisekdv...FekyYkkhLakRLlsgksa 410
           al+++++ +++k s+lkaa+++E++Ar+iDq++++s ++g++++e++ ql+++l+ + ++s++++   Fe+yY++++a+RLl   + 
   Q: 1249 ALQNGCAGALLKLSFLKAAHVSEQFARHIDQRIQGSrIGGARGMEMLVQLQRCLETVLIFSGLEIattFEHYYQHYMADRLLG--VG 1333
           ***********************************************************************************..** PP
   S: 411  sseaEesviekLkeecgaeftskL.erMfqdlkvSedlnrqFk............................................ 452
           ss++E++v+e++    g++f+++L ++M+++l++Se+l+rqF+                                            
   Q: 1334 SSWLEGAVLEQI----GPCFPNRLpQQMLRSLSMSEELQRQFHvyqlqrldqellkledtekkiqggheasdrehkrekaeeaegag 1416
           ************....*********************************************************************** PP
   S: 453  ................eekenteesesvelsvlvLsagaWpta..set..ekvsLPaelektiekfeefY........lekhsgRkL 511
                           e+++ ++e +++e+svlvLs+++Wpta  ++t  ++++LPa+l+ t++++++fY        le++++R+L
   Q: 1417 aaaatdvageeeedeeEDEDLYYEGAMPEVSVLVLSPRCWPTAsiCHTltPRTCLPAYLRGTLNRYSNFYnksqsypaLERGPQRRL 1503
           **************98889999*********************9988888************************************* PP
   S: 512  qWqhtlgraelkaelkkgkyelqVstfQmavLLafnnsekvsveelkkatelpeeeLrrtlqsLvssk..kqv 582
           qW++ lgrael++    g ++l+Vst+Qm++LL++n+ ++vsve+l + ++l++++L++++++L+ss+   ++
   Q: 1504 QWTW-LGRAELQF----GDQTLHVSTVQMWLLLYLNDLKAVSVESLLALSGLSPDMLNQAIGPLTSSRgpLDL 1571
           ****.********....*************************************************9944444 PP

Organism

Felis catus

Protein Sequence
(Fasta)

SSVPRRNASS RTLESSPSRG PGARMVGELR YREFRVPLGP GLHAYPDELI RQRVGHDGHP 60
EYQIRWLILR RGDDGEGGSS QVDCKAEHIL LWMSNDEIYA NCHKMLGEDG QVIGPSQEIA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGTTCAGTCC CGCGGAGAAA TGCGAGCAGC ACTAGCAACC CGGCATTAGA AGGGCTGGAA 60
GCAAACACTG GGGTAGTTCC TGAGTGGATT GTGCGTGTTG CAGTAAATGA TATAATGCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR004939--APC_su10/DOC_dom
IPR016024--ARM-type_fold
IPR021097--CPH_domain
IPR031223--CUL7
IPR016158--Cullin_homology
IPR001373--Cullin_N
IPR019559--Cullin_neddylation_domain
IPR008979--Galactose-bd-like
IPR014722--Rib_L2_dom2
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS50069--CULLIN_2
PS51284--DOC

Pfam

PF03256--ANAPC10
PF11515--Cul7
PF00888--Cullin
PF10557--Cullin_Nedd8

SMART

SM01337--APC10
SM00884--Cullin_Nedd8

Gene Ontology

GO:1990393--C:3M complex
GO:0005813--C:centrosome
GO:0031467--C:Cul7-RING ubiquitin ligase complex
GO:0005794--C:Golgi apparatus
GO:0048471--C:perinuclear region of cytoplasm
GO:0001837--P:epithelial to mesenchymal transition
GO:0000226--P:microtubule cytoskeleton organization
GO:0000281--P:mitotic cytokinesis
GO:0001890--P:placenta development
GO:0050775--P:positive regulation of dendrite morphogenesis
GO:0016567--P:protein ubiquitination
GO:0007088--P:regulation of mitotic nuclear division
GO:0006511--P:ubiquitin-dependent protein catabolic process
GO:0001570--P:vasculogenesis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002360	Ailuropoda melanoleuca	91.86	0.00e+00	2939.00
IUUC-Bta-013285	Bos taurus	88.35	0.00e+00	2848.00
IUUC-Cja-019033	Callithrix jacchus	82.06	0.00e+00	2667.00
IUUC-Cfa-020695	Canis familiaris	90.62	0.00e+00	1853.00
IUUC-Cpo-021513	Cavia porcellus	77.78	0.00e+00	2502.00
IUUC-Csa-023798	Chlorocebus sabaeus	85.45	0.00e+00	2790.00
IUUC-Dno-029587	Dasypus novemcinctus	83.12	0.00e+00	1518.00
IUUC-Dor-030234	Dipodomys ordii	83.30	0.00e+00	2794.00
IUUC-Ete-032612	Echinops telfairi	77.70	0.00e+00	925.00
IUUC-Eca-033408	Equus caballus	90.83	0.00e+00	2878.00
IUUC-Gmo-038795	Gadus morhua	44.08	0.00e+00	1009.00
IUUC-Gac-041628	Gasterosteus aculeatus	45.68	0.00e+00	1311.00
IUUC-Ggo-044721	Gorilla gorilla	86.55	0.00e+00	2751.00
IUUC-Hsa-046406	Homo sapiens	86.32	0.00e+00	2780.00
IUUC-Itr-048525	Ictidomys tridecemlineatus	86.78	0.00e+00	2779.00
IUUC-Lch-049956	Latimeria chalumnae	44.21	0.00e+00	1073.00
IUUC-Laf-054068	Loxodonta africana	85.98	0.00e+00	2828.00
IUUC-Mcc-055464	Macaca mulatta	85.68	0.00e+00	2767.00
IUUC-Meu-056198	Macropus eugenii	55.01	0.00e+00	1592.00
IUUC-Mmr-061464	Microcebus murinus	88.27	0.00e+00	2833.00
IUUC-Mdo-062018	Monodelphis domestica	58.62	0.00e+00	1390.00
IUUC-Mmu-063413	Mus musculus	76.13	0.00e+00	2412.00
IUUC-Mpu-066146	Mustela putorius furo	91.91	0.00e+00	2878.00
IUUC-Mlu-067036	Myotis lucifugus	87.58	0.00e+00	2867.00
IUUC-Opr-070670	Ochotona princeps	75.98	0.00e+00	2450.00
IUUC-Oan-073451	Ornithorhynchus anatinus	51.93	0.00e+00	1197.00
IUUC-Ocu-074155	Oryctolagus cuniculus	83.56	0.00e+00	2678.00
IUUC-Oga-089084	Otolemur garnettii	87.51	0.00e+00	2886.00
IUUC-Oar-090029	Ovis aries	88.20	0.00e+00	2853.00
IUUC-Ptr-091282	Pan troglodytes	87.32	0.00e+00	2860.00
IUUC-Pan-091883	Papio anubis	85.80	0.00e+00	2795.00
IUUC-Pab-098383	Pongo abelii	85.71	0.00e+00	2763.00
IUUC-Pca-100519	Procavia capensis	76.69	0.00e+00	850.00
IUUC-Pva-102417	Pteropus vampyrus	87.40	0.00e+00	2313.00
IUUC-Rno-105962	Rattus norvegicus	77.81	0.00e+00	2523.00
IUUC-Sar-113750	Sorex araneus	76.19	1.00e-170	594.00
IUUC-Ssc-115899	Sus scrofa	83.29	0.00e+00	2541.00
IUUC-Tsy-118860	Tarsius syrichta	84.04	0.00e+00	1135.00
IUUC-Tbe-127660	Tupaia belangeri	82.17	0.00e+00	1397.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence