iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000044072.14	ENSMUST00000058902.5	ENSMUSP00000051080.5
ENSMUSG00000044072.14	ENSMUST00000137689.2	ENSMUSP00000116197.2
ENSMUSG00000044072.14	ENSMUST00000109452.2	ENSMUSP00000105078.2

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RAID2
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.70e-61	202.5	105	144
UBD/Beta-Prp	1.80e-134	448.8	725	944

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdD..gtikvWDlrtgvllk 37
           Ht +v claf sd  +l+s + D  +t+ +WD+r+g+ll 
   Q: 105  HTHGVACLAFdSDgQHLASVGLDakNTVCIWDWRKGKLLA 144
           99*********999*******9999***********9875 PP

UBD/Beta-Prp

   S: 7    ghhksvitcvkfspdksllatg..srdgtikvwdvttgkllrslsg.heaevtavkfspdgkilvtgseD..rtikvwdlstgkcvhtl 90
           gh+++ ++ ++++p k+++atg  +rd+ + vwd++t k+l+ l+g h+ +v a++fs dgk lv+++ D  + +  wd ++g+ + t 
   Q: 725  GHDDDILS-LTIHPVKDYVATGqvGRDAAVHVWDTQTLKCLSLLKGhHQRGVCALDFSADGKCLVSVGLDdfHSVVFWDWKKGEKIATT 812
           45555555.999*********95569******************6615779*******************65566669*********** PP
   S: 91   kghedsvlslsfspsg.dklvsGshdrtirvwdletgqclee....tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrt 174
           +gh+d++  ++ +p+  dklv+ +  + i+ w+   g   ++      +g+ ++ +cv++   ++l++sG++ + + +W  k   ll+t
   Q: 813  RGHKDKIFVVKCNPQHaDKLVTVG-IKHIKFWQQAGGGFTSKrgsfGSAGKLETMMCVSYGRMEDLVFSGAATGDIFIW--KDVLLLKT 898
           **************7757777776.9******98888888779999999******************************..8899**** PP
   S: 175  ltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtd 223
            +  h+++v  +   +  k +v+g++dg v+lwd   ++c++t+   ++
   Q: 899  VKA-HDGPVFAMYALD--KGFVTGGKDGIVELWDDMFERCLKTYAIKRT 944
           *98.*******99888..57**********************9976664 PP

Organism

Mus musculus

Functional Description
(View)

May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.

Protein Sequence
(Fasta)

MADRTAPRCQ LRLEWVYGYR GHQCRNNLYY TAGKEVVYFV AGVGVVYNTR EHSQKFFLGH 60
NDDIISLALH PDKTLIATGQ VGKEPYICIW NSYNVHTVSI LKDVHTHGVA CLAFDSDGQH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCCCCTGGAG CCAGGGAAGG AGGAAGAGCT GGTCCCCAGA TCCCCGGTGA CGAAACCTAA 60
CCCGGGAGCG CGGGGAGGGA GGGAGGGCAG GCAGAGGATT TCGCTGGCTG GTGCGAGATC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0493--Microtubule
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR024977--Apc4_WD40_dom
IPR005108--HELP
IPR011047--Quinoprotein_ADH-like_supfam
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12894--ANAPC4_WD40
PF03451--HELP
PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005874--C:microtubule
GO:0015630--C:microtubule cytoskeleton
GO:0008017--F:microtubule binding

KEGG

mmu:237711

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001387	Ailuropoda melanoleuca	96.78	0.00e+00	3820.00
IUUC-Apl-003604	Anas platyrhynchos	93.23	0.00e+00	3671.00
IUUC-Aca-004572	Anolis carolinensis	89.30	0.00e+00	3572.00
IUUC-Ame-010713	Astyanax mexicanus	79.98	0.00e+00	3208.00
IUUC-Bta-012812	Bos taurus	96.53	0.00e+00	3809.00
IUUC-Cja-019191	Callithrix jacchus	96.44	0.00e+00	3783.00
IUUC-Cfa-020041	Canis familiaris	96.89	0.00e+00	3548.00
IUUC-Cre-022931	Chlamydomonas reinhardtii	34.47	5.00e-100	361.00
IUUC-Csa-023689	Chlorocebus sabaeus	95.87	0.00e+00	3690.00
IUUC-Cho-025038	Choloepus hoffmanni	95.56	0.00e+00	1470.00
IUUC-Cin-025205	Ciona intestinalis	61.72	0.00e+00	2576.00
IUUC-Csv-026014	Ciona savignyi	63.09	0.00e+00	2598.00
IUUC-Dno-029982	Dasypus novemcinctus	94.86	0.00e+00	3638.00
IUUC-Eca-034161	Equus caballus	95.32	0.00e+00	3648.00
IUUC-Fca-036307	Felis catus	96.88	0.00e+00	3817.00
IUUC-Fal-037332	Ficedula albicollis	91.62	0.00e+00	3585.00
IUUC-Gmo-039057	Gadus morhua	74.83	0.00e+00	2989.00
IUUC-Gac-042555	Gasterosteus aculeatus	80.14	0.00e+00	3229.00
IUUC-Ggo-045107	Gorilla gorilla	97.14	0.00e+00	3831.00
IUUC-Hsa-046482	Homo sapiens	97.09	0.00e+00	3830.00
IUUC-Itr-049023	Ictidomys tridecemlineatus	95.32	0.00e+00	3696.00
IUUC-Loc-052642	Lepisosteus oculatus	87.63	0.00e+00	3464.00
IUUC-Laf-053649	Loxodonta africana	94.85	0.00e+00	3704.00
IUUC-Mcc-055361	Macaca mulatta	96.79	0.00e+00	3352.00
IUUC-Meu-056618	Macropus eugenii	77.62	0.00e+00	1784.00
IUUC-Mga-059202	Meleagris gallopavo	92.10	0.00e+00	3554.00
IUUC-Mmr-060729	Microcebus murinus	94.56	0.00e+00	3788.00
IUUC-Mdo-062462	Monodelphis domestica	94.51	0.00e+00	3645.00
IUUC-Mpu-066724	Mustela putorius furo	97.09	0.00e+00	3826.00
IUUC-Mlu-067816	Myotis lucifugus	96.49	0.00e+00	3820.00
IUUC-Opr-070213	Ochotona princeps	93.76	0.00e+00	1986.00
IUUC-Ont-071928	Oreochromis niloticus	78.93	0.00e+00	3231.00
IUUC-Oan-073563	Ornithorhynchus anatinus	94.09	0.00e+00	3724.00
IUUC-Ocu-074531	Oryctolagus cuniculus	96.83	0.00e+00	3815.00
IUUC-Ola-086943	Oryzias latipes	78.28	0.00e+00	3130.00
IUUC-Olu-087860	Ostreococcus lucimarinus	39.27	2.00e-116	412.00
IUUC-Oga-088665	Otolemur garnettii	95.80	0.00e+00	3669.00
IUUC-Oar-090429	Ovis aries	96.78	0.00e+00	3818.00
IUUC-Ptr-091168	Pan troglodytes	88.29	0.00e+00	3410.00
IUUC-Pan-092788	Papio anubis	96.67	0.00e+00	3034.00
IUUC-Psi-093281	Pelodiscus sinensis	91.45	0.00e+00	3631.00
IUUC-Pma-094424	Petromyzon marinus	72.46	3.00e-125	441.00
IUUC-Pab-098561	Pongo abelii	95.95	0.00e+00	3317.00
IUUC-Pca-100107	Procavia capensis	61.68	0.00e+00	1963.00
IUUC-Rno-105002	Rattus norvegicus	97.75	0.00e+00	3875.00
IUUC-Sha-107105	Sarcophilus harrisii	91.94	0.00e+00	3522.00
IUUC-Sar-113401	Sorex araneus	65.09	0.00e+00	1430.00
IUUC-Ssc-116282	Sus scrofa	96.83	0.00e+00	3715.00
IUUC-Tgu-116807	Taeniopygia guttata	92.95	0.00e+00	3663.00
IUUC-Tru-118040	Takifugu rubripes	78.47	0.00e+00	3165.00
IUUC-Tni-120118	Tetraodon nigroviridis	76.14	0.00e+00	3144.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence