iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	RAID2
Protein-protein Interaction
IID
Protein 3D Structure
PDB
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
DUB/OTU	33.09	3.00e-37	150.00	IUUC-Sce-106323
ULD/UDP/UFD/UBX	33.09	3.00e-37	150.00	IUUC-Sce-106323

Active Site

Position(s)	Description	Evidence
152	N/A	{ECO:0000250\|UniProtKB:Q96FW1}
155	Nucleophile	{ECO:0000250\|UniProtKB:Q5VVQ6}
262		{ECO:0000250\|UniProtKB:Q5VVQ6}
337		{ECO:0000250\|UniProtKB:Q96FW1}

Organism

Mus musculus

Functional Description
(View)

Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains. Cleaves both polyubiquitin and di-ubiquitin (By similarity).

Protein Sequence
(Fasta)

MFGGAKGGHF GVPPAGYSGA VPQSEAGTKA GPAGGRPADT MWRVRCKAKG GTHLLQGLSS 60
RTRLRELQGQ IAAITGIAPG SQRILVGYPP ECLDLSDRDI TLGDLPIQSG DMLIVEEDQT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACCGGAGCGC TCGGGAGAGC CGGCCGACCC CCAACCCTCA CCCGCGGCCG CCCTTGCCAC 60
TTTAAGAGCC CGCGCCGTTT TTGGAAGGAC CGAGGCCGAG TCCCCCCCAC CCCCCACCGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0834--Unfolded protein response
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR003323--OTU_dom
IPR029071--Ubiquitin-rel_dom
IPR013087--Znf_C2H2_type

PROSITE

PS50802--OTU
PS00028--ZINC_FINGER_C2H2_1

Pfam

PF02338--OTU

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0046872--F:metal ion binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0031625--F:ubiquitin protein ligase binding
GO:1904265--F:ubiquitin-specific protease activity involved in negative regulation of retrograde protein transport, ER to cytosol
GO:0030968--P:endoplasmic reticulum unfolded protein response
GO:0016579--P:protein deubiquitination
GO:0035871--P:protein K11-linked deubiquitination
GO:1990167--P:protein K27-linked deubiquitination
GO:0035523--P:protein K29-linked deubiquitination
GO:1990168--P:protein K33-linked deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0030433--P:ubiquitin-dependent ERAD pathway

KEGG

mmu:226418

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000271	Aegilops tauschii	48.15	1.00e-44	172.00
IUUC-Aml-001860	Ailuropoda melanoleuca	88.22	3.00e-180	624.00
IUUC-Atr-002548	Amborella trichopoda	49.51	3.00e-50	191.00
IUUC-Apl-004025	Anas platyrhynchos	79.17	2.00e-104	371.00
IUUC-Aca-004505	Anolis carolinensis	73.62	1.00e-135	475.00
IUUC-Aly-005999	Arabidopsis lyrata	44.66	1.00e-46	179.00
IUUC-Ath-006774	Arabidopsis thaliana	45.63	3.00e-47	181.00
IUUC-Ago-007741	Ashbya gossypii	38.89	5.00e-38	151.00
IUUC-Acl-008278	Aspergillus clavatus	41.58	2.00e-41	162.00
IUUC-Afl-008710	Aspergillus flavus	44.06	8.00e-43	167.00
IUUC-Afu-009009	Aspergillus fumigatus	34.38	3.00e-43	169.00
IUUC-Ani-009430	Aspergillus nidulans	31.33	3.00e-39	155.00
IUUC-Ang-009508	Aspergillus niger	32.86	7.00e-36	144.00
IUUC-Aor-009992	Aspergillus oryzae	34.94	2.00e-43	169.00
IUUC-Ate-010440	Aspergillus terreus	34.51	5.00e-45	174.00
IUUC-Ame-011038	Astyanax mexicanus	68.98	3.00e-125	441.00
IUUC-Bgr-012262	Blumeria graminis	34.47	3.00e-34	139.00
IUUC-Bta-012864	Bos taurus	86.49	2.00e-176	611.00
IUUC-Bci-013986	Botrytis cinerea	34.93	2.00e-35	142.00
IUUC-Bdi-014194	Brachypodium distachyon	48.78	1.00e-50	192.00
IUUC-Bol-016166	Brassica oleracea	46.12	5.00e-48	183.00
IUUC-Bra-017783	Brassica rapa	46.60	2.00e-48	185.00
IUUC-Cja-019488	Callithrix jacchus	85.92	2.00e-175	608.00
IUUC-Cpo-021728	Cavia porcellus	86.21	8.00e-178	615.00
IUUC-Cre-022819	Chlamydomonas reinhardtii	45.59	3.00e-42	164.00
IUUC-Csa-024237	Chlorocebus sabaeus	91.42	7.00e-165	572.00
IUUC-Cho-024544	Choloepus hoffmanni	85.34	2.00e-175	607.00
IUUC-Cin-025549	Ciona intestinalis	44.26	5.00e-72	264.00
IUUC-Cgl-026552	Colletotrichum gloeosporioides	29.64	1.00e-32	134.00
IUUC-Cne-027022	Cryptococcus neoformans	44.06	7.00e-44	171.00
IUUC-Cme-027196	Cyanidioschyzon merolae	36.84	4.00e-46	178.00
IUUC-Dre-027799	Danio rerio	68.98	8.00e-120	423.00
IUUC-Dno-029863	Dasypus novemcinctus	84.48	1.00e-173	602.00
IUUC-Dor-030804	Dipodomys ordii	80.80	6.00e-159	553.00
IUUC-Dse-031494	Dothistroma septosporum	39.71	4.00e-39	155.00
IUUC-Dme-032065	Drosophila melanogaster	41.50	7.00e-68	250.00
IUUC-Ete-033193	Echinops telfairi	86.21	2.00e-172	598.00
IUUC-Eca-033993	Equus caballus	88.51	3.00e-180	624.00
IUUC-Fca-035949	Felis catus	88.22	2.00e-180	624.00
IUUC-Fal-037473	Ficedula albicollis	76.27	2.00e-100	357.00
IUUC-Fox-037779	Fusarium oxysporum	31.37	5.00e-28	118.00
IUUC-Fso-038370	Fusarium solani	35.56	2.00e-27	116.00
IUUC-Gmo-038778	Gadus morhua	56.91	7.00e-90	323.00
IUUC-Ggr-039940	Gaeumannomyces graminis	33.13	2.00e-35	143.00
IUUC-Gga-041102	Gallus gallus	71.71	1.00e-124	439.00
IUUC-Gac-041954	Gasterosteus aculeatus	68.83	2.00e-123	435.00
IUUC-Gma-043608	Glycine max	47.09	2.00e-48	185.00
IUUC-Ggo-044753	Gorilla gorilla	86.78	2.00e-176	611.00
IUUC-Hsa-045714	Homo sapiens	87.54	8.00e-157	546.00
IUUC-Hvu-047600	Hordeum vulgare	48.78	4.00e-51	194.00
IUUC-Itr-048026	Ictidomys tridecemlineatus	88.22	0.00e+00	626.00
IUUC-Kpa-049360	Komagataella pastoris	31.23	1.00e-38	153.00
IUUC-Lch-049900	Latimeria chalumnae	73.68	2.00e-124	438.00
IUUC-Lpe-050984	Leersia perrieri	40.20	1.00e-32	132.00
IUUC-Loc-052567	Lepisosteus oculatus	71.15	8.00e-130	456.00
IUUC-Lma-053247	Leptosphaeria maculans	30.28	7.00e-39	154.00
IUUC-Laf-053361	Loxodonta africana	86.49	5.00e-169	587.00
IUUC-Meu-056137	Macropus eugenii	73.41	6.00e-144	503.00
IUUC-Mor-057191	Magnaporthe oryzae	29.50	2.00e-26	113.00
IUUC-Mpo-057565	Magnaporthe poae	38.27	3.00e-31	128.00
IUUC-Mtr-058196	Medicago truncatula	46.60	9.00e-49	186.00
IUUC-Mla-059096	Melampsora laricipopulina	32.82	2.00e-39	155.00
IUUC-Mga-059489	Meleagris gallopavo	79.66	3.00e-111	394.00
IUUC-Mvi-060300	Microbotryum violaceum	36.73	2.00e-41	162.00
IUUC-Mmr-061618	Microcebus murinus	90.24	7.00e-160	556.00
IUUC-Mdo-061909	Monodelphis domestica	84.29	1.00e-157	549.00
IUUC-Mac-064676	Musa acuminata	48.54	2.00e-50	192.00
IUUC-Mpu-066733	Mustela putorius furo	87.93	7.00e-180	622.00
IUUC-Mlu-066990	Myotis lucifugus	83.57	4.00e-171	593.00
IUUC-Nfi-068249	Neosartorya fischeri	42.57	1.00e-42	166.00
IUUC-Ncr-068764	Neurospora crassa	39.13	1.00e-34	140.00
IUUC-Nle-069094	Nomascus leucogenys	87.07	5.00e-176	610.00
IUUC-Oan-073585	Ornithorhynchus anatinus	84.87	3.00e-155	540.00
IUUC-Oba-075949	Oryza barthii	49.03	2.00e-49	188.00
IUUC-Obr-076096	Oryza brachyantha	49.03	3.00e-50	191.00
IUUC-Ogl-077106	Oryza glaberrima	48.54	4.00e-49	187.00
IUUC-Ogu-078024	Oryza glumaepatula	49.03	2.00e-49	188.00
IUUC-Oin-079635	Oryza indica	48.06	2.00e-49	188.00
IUUC-Olo-080299	Oryza longistaminata	49.03	3.00e-49	187.00
IUUC-Ome-081359	Oryza meridionalis	49.03	2.00e-49	188.00
IUUC-Oni-082459	Oryza nivara	48.54	4.00e-49	187.00
IUUC-Opu-083167	Oryza punctata	50.00	7.00e-51	193.00
IUUC-Oru-084577	Oryza rufipogon	48.06	2.00e-49	188.00
IUUC-Osa-085746	Oryza sativa	52.94	1.00e-12	63.90
IUUC-Ola-086890	Oryzias latipes	69.51	7.00e-126	443.00
IUUC-Olu-087585	Ostreococcus lucimarinus	41.79	1.00e-42	165.00
IUUC-Oga-088190	Otolemur garnettii	88.46	1.00e-162	565.00
IUUC-Oar-089631	Ovis aries	87.36	4.00e-178	617.00
IUUC-Pan-091892	Papio anubis	87.36	5.00e-176	610.00
IUUC-Pma-094491	Petromyzon marinus	56.51	2.00e-87	315.00
IUUC-Pno-094993	Phaeosphaeria nodorum	31.80	3.00e-40	159.00
IUUC-Ppa-095791	Physcomitrella patens	50.49	5.00e-52	197.00
IUUC-Pfo-096301	Poecilia formosa	69.31	5.00e-126	443.00
IUUC-Pab-097873	Pongo abelii	87.36	2.00e-177	615.00
IUUC-Pop-099482	Populus trichocarpa	46.60	2.00e-49	188.00
IUUC-Pca-100817	Procavia capensis	87.54	1.00e-158	552.00
IUUC-Ppe-101624	Prunus persica	49.27	9.00e-52	196.00
IUUC-Pva-102120	Pteropus vampyrus	85.06	8.00e-173	599.00
IUUC-Pgr-103368	Puccinia graminis	31.38	6.00e-43	168.00
IUUC-Ptt-103923	Puccinia triticina	39.36	1.00e-42	167.00
IUUC-Pte-104199	Pyrenophora teres	39.20	1.00e-39	156.00
IUUC-Pyt-104502	Pyrenophora triticirepentis	38.38	5.00e-40	157.00
IUUC-Rno-105605	Rattus norvegicus	96.50	0.00e+00	654.00
IUUC-Sce-106323	Saccharomyces cerevisiae	33.09	2.00e-33	135.00
IUUC-Sha-107176	Sarcophilus harrisii	85.17	8.00e-135	472.00
IUUC-Sja-107812	Schizosaccharomyces japonicus	35.71	7.00e-37	147.00
IUUC-Spo-108085	Schizosaccharomyces pombe	29.94	7.00e-38	150.00
IUUC-Smo-109050	Selaginella moellendorffii	48.06	2.00e-49	188.00
IUUC-Sit-110056	Setaria italica	47.80	6.00e-50	190.00
IUUC-Sly-111869	Solanum lycopersicum	49.71	1.00e-43	169.00
IUUC-Stu-112452	Solanum tuberosum	48.29	6.00e-50	190.00
IUUC-Sar-113629	Sorex araneus	81.97	4.00e-56	211.00
IUUC-Sbi-114422	Sorghum bicolor	48.54	2.00e-50	191.00
IUUC-Sre-115105	Sporisorium reilianum	41.50	2.00e-31	129.00
IUUC-Ssc-115553	Sus scrofa	87.93	1.00e-179	622.00
IUUC-Tgu-116921	Taeniopygia guttata	77.37	3.00e-101	360.00
IUUC-Tru-117830	Takifugu rubripes	67.55	3.00e-123	434.00
IUUC-Tsy-119320	Tarsius syrichta	87.07	2.00e-176	611.00
IUUC-Tni-119706	Tetraodon nigroviridis	66.34	3.00e-117	414.00
IUUC-Tca-121238	Theobroma cacao	48.06	5.00e-50	190.00
IUUC-Tae-124711	Triticum aestivum	49.03	9.00e-51	193.00
IUUC-Tme-126966	Tuber melanosporum	35.12	8.00e-50	190.00
IUUC-Tbe-127712	Tupaia belangeri	93.43	4.00e-108	383.00
IUUC-Ttr-129168	Tursiops truncatus	85.63	1.00e-176	612.00
IUUC-Uma-129461	Ustilago maydis	40.00	2.00e-37	149.00
IUUC-Vda-129890	Verticillium dahliae	35.00	4.00e-25	108.00
IUUC-Vpa-130616	Vicugna pacos	87.64	3.00e-180	624.00
IUUC-Vvi-131250	Vitis vinifera	48.54	3.00e-50	191.00
IUUC-Xtr-132126	Xenopus tropicalis	70.72	6.00e-130	456.00
IUUC-Xma-133596	Xiphophorus maculatus	68.85	2.00e-125	441.00
IUUC-Yli-134562	Yarrowia lipolytica	31.16	7.00e-32	131.00
IUUC-Zma-135205	Zea mays	48.06	1.00e-49	189.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence