iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
miRTarBase	microRNA	TRANSFAC	RepTar
RAID2
Protein-protein Interaction
IID	iRefIndex	Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
PHOSIDA	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 adaptor/Cullin RING/SCF/F-box	87.58	0.00e+00	1361.00	IUUC-Hsa-046682

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Mus musculus

Functional Description
(View)

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Required for muscle atrophy following denervation.

Protein Sequence
(Fasta)

MEEEVQQHSH CMNCVSRRCM TRPEPGVSCD LIGCPLVCGA VFHSCKADEH RLLCPFERVA 60
CLNRNFGCPF TLARNKVAEH LEMCPASVVC CTMEWNRWPV SYSDRKSYES LSRDVDEVAQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGTTGGAGGC CGAGGAGAAA AGGCGGCGGT CCGGGCAGGG CGGAGGCGCA GAGGATTGGG 60
ACGGGACGGG CCCCGTGCGT GGTCCGGTCC GGTGCGGGGA CGCTGCGGAG CCGCCGGGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001810--F-box_dom
IPR031890--Fbxo30/Fbxo40
IPR008974--TRAF-like
IPR013083--Znf_RING/FYVE/PHD
IPR001293--Znf_TRAF

PROSITE

PS50181--FBOX
PS50145--ZF_TRAF

Pfam

PF15966--F-box_4
PF15965--zf-TRAF_2

Gene Ontology

GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding

KEGG

mmu:71865

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001191	Ailuropoda melanoleuca	86.50	0.00e+00	1345.00
IUUC-Atr-002846	Amborella trichopoda	41.94	4.30e-01	27.30
IUUC-Apl-003279	Anas platyrhynchos	72.46	0.00e+00	1108.00
IUUC-Aca-004293	Anolis carolinensis	69.53	0.00e+00	1051.00
IUUC-Ani-009450	Aspergillus nidulans	40.38	7.00e-03	35.00
IUUC-Ame-011141	Astyanax mexicanus	58.42	0.00e+00	824.00
IUUC-Bta-013004	Bos taurus	86.36	0.00e+00	1324.00
IUUC-Cel-018506	Caenorhabditis elegans	31.34	1.00e-11	64.30
IUUC-Cja-019129	Callithrix jacchus	87.17	0.00e+00	1357.00
IUUC-Cfa-020617	Canis familiaris	85.96	0.00e+00	1321.00
IUUC-Cpo-021712	Cavia porcellus	86.50	0.00e+00	1329.00
IUUC-Cre-022576	Chlamydomonas reinhardtii	54.05	3.00e-03	37.00
IUUC-Csa-023463	Chlorocebus sabaeus	87.70	0.00e+00	1358.00
IUUC-Cho-024287	Choloepus hoffmanni	81.02	0.00e+00	1234.00
IUUC-Dre-028739	Danio rerio	80.40	6.00e-165	574.00
IUUC-Dno-029454	Dasypus novemcinctus	83.96	0.00e+00	1274.00
IUUC-Dor-031145	Dipodomys ordii	87.70	0.00e+00	1362.00
IUUC-Ete-033085	Echinops telfairi	83.26	0.00e+00	1163.00
IUUC-Eca-034171	Equus caballus	86.76	0.00e+00	1353.00
IUUC-Eeu-034630	Erinaceus europaeus	81.02	0.00e+00	1251.00
IUUC-Fca-035665	Felis catus	86.36	0.00e+00	1316.00
IUUC-Fal-036615	Ficedula albicollis	70.66	0.00e+00	1078.00
IUUC-Gmo-039277	Gadus morhua	58.59	0.00e+00	850.00
IUUC-Gga-040427	Gallus gallus	71.90	0.00e+00	1096.00
IUUC-Gac-041803	Gasterosteus aculeatus	58.29	0.00e+00	833.00
IUUC-Ggo-044649	Gorilla gorilla	87.72	0.00e+00	1363.00
IUUC-Hsa-046682	Homo sapiens	87.58	0.00e+00	1361.00
IUUC-Itr-048787	Ictidomys tridecemlineatus	88.10	0.00e+00	1370.00
IUUC-Lch-049910	Latimeria chalumnae	65.12	0.00e+00	980.00
IUUC-Loc-052516	Lepisosteus oculatus	63.43	0.00e+00	933.00
IUUC-Laf-054464	Loxodonta africana	85.03	0.00e+00	1264.00
IUUC-Mcc-054771	Macaca mulatta	87.83	0.00e+00	1363.00
IUUC-Meu-056672	Macropus eugenii	92.73	2.00e-155	543.00
IUUC-Mga-059844	Meleagris gallopavo	71.60	0.00e+00	1089.00
IUUC-Mmr-060619	Microcebus murinus	87.43	0.00e+00	1367.00
IUUC-Mdo-062500	Monodelphis domestica	77.17	0.00e+00	1142.00
IUUC-Mpu-066049	Mustela putorius furo	86.63	0.00e+00	1324.00
IUUC-Mlu-067541	Myotis lucifugus	86.50	0.00e+00	1331.00
IUUC-Nle-069653	Nomascus leucogenys	87.85	0.00e+00	1363.00
IUUC-Opr-070824	Ochotona princeps	95.54	0.00e+00	682.00
IUUC-Ont-072617	Oreochromis niloticus	59.66	0.00e+00	840.00
IUUC-Oan-073691	Ornithorhynchus anatinus	76.64	0.00e+00	1113.00
IUUC-Ocu-074793	Oryctolagus cuniculus	85.81	0.00e+00	1294.00
IUUC-Ola-087112	Oryzias latipes	61.69	3.00e-123	436.00
IUUC-Oga-088620	Otolemur garnettii	86.73	0.00e+00	1353.00
IUUC-Oar-090411	Ovis aries	86.76	0.00e+00	1301.00
IUUC-Ptr-091121	Pan troglodytes	87.45	0.00e+00	1358.00
IUUC-Pan-092257	Papio anubis	87.83	0.00e+00	1364.00
IUUC-Psi-094017	Pelodiscus sinensis	70.56	0.00e+00	957.00
IUUC-Pma-094673	Petromyzon marinus	50.34	2.00e-82	300.00
IUUC-Pfo-096058	Poecilia formosa	78.45	8.00e-163	567.00
IUUC-Pab-098470	Pongo abelii	83.04	0.00e+00	1266.00
IUUC-Pca-100432	Procavia capensis	84.09	0.00e+00	1277.00
IUUC-Ppe-101323	Prunus persica	41.03	3.80e-02	32.00
IUUC-Pva-103197	Pteropus vampyrus	87.03	0.00e+00	1355.00
IUUC-Rno-106018	Rattus norvegicus	93.57	0.00e+00	1453.00
IUUC-Sce-106328	Saccharomyces cerevisiae	38.46	4.10e+00	26.60
IUUC-Sha-106714	Sarcophilus harrisii	77.84	0.00e+00	1149.00
IUUC-Smo-109422	Selaginella moellendorffii	28.95	5.70e-02	32.70
IUUC-Sar-113544	Sorex araneus	84.09	0.00e+00	1288.00
IUUC-Ssc-115836	Sus scrofa	86.61	0.00e+00	1323.00
IUUC-Tgu-116548	Taeniopygia guttata	72.80	0.00e+00	1089.00
IUUC-Tru-118572	Takifugu rubripes	79.88	7.00e-164	570.00
IUUC-Tsy-119478	Tarsius syrichta	86.36	0.00e+00	1322.00
IUUC-Tni-120227	Tetraodon nigroviridis	58.86	2.00e-108	386.00
IUUC-Tbe-127566	Tupaia belangeri	85.47	0.00e+00	1034.00
IUUC-Vpa-130509	Vicugna pacos	86.76	0.00e+00	1330.00
IUUC-Xtr-132254	Xenopus tropicalis	63.17	0.00e+00	957.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence