iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Tru-117922

Ensembl Protein ID

ENSTRUP00000031120.1

UniProt Accession

H2U2F9; H2U2F9_TAKRU

Protein Name

Histone-lysine N-methyltransferase

Gene Name

KMT2D

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTRUG00000012286.1	ENSTRUT00000031238.1	ENSTRUP00000031120.1
ENSTRUG00000012286.1	ENSTRUT00000031239.1	ENSTRUP00000031121.1
ENSTRUG00000012286.1	ENSTRUT00000031240.1	ENSTRUP00000031122.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	6.30e-32	110.8	259	309

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 1    ekvClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCrsk 54
           +kvC  C+++ged+ ++++C+ C++ +H  Cl+++  ++lp++ +w C++Cr +
   Q: 259  CKVCQTCRKPGEDS-KMLVCDACDKGYHTFCLQPA-MDSLPTD-PWKCKRCRVC 309
           579*********87.6*******************.*******.6******965 PP

Organism

Takifugu rubripes

Protein Sequence
(Fasta)

MDEQKSNCEE NDSEPTADDN ASSKQLEEDS KTCTAAEDVS GSTVASSSTH IESVQVCALC 60
NCVEWSLHGQ RELRYFGPFS EWRTLQPSST PLPQPGNDDL SSIGFSVLPC LAALLDDSGG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGACGAGC AGAAATCAAA CTGCGAAGAG AATGACTCTG AACCAACAGG TACTTTTCCA 60
CGCCTCATCA TCAAATCCAA TGATCACAAA GATCTGTTTC TTGTTGCTTT AAAAGTGAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR034732--EPHD
IPR003889--FYrich_C
IPR003888--FYrich_N
IPR009071--HMG_box_dom
IPR003616--Post-SET_dom
IPR001214--SET_dom
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51805--EPHD
PS51543--FYRC
PS51542--FYRN
PS50868--POST_SET
PS50280--SET
PS50016--ZF_PHD_2
PS50089--ZF_RING_2

Pfam

PF05965--FYRC
PF05964--FYRN
PF00628--PHD
PF00856--SET

SMART

SM00542--FYRC
SM00541--FYRN
SM00398--HMG
SM00249--PHD
SM00508--PostSET
SM00184--RING
SM00317--SET

Gene Ontology

GO:0005634--C:nucleus
GO:0018024--F:histone-lysine N-methyltransferase activity
GO:0008270--F:zinc ion binding

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001054	Aegilops tauschii	35.05	2.00e-14	74.30
IUUC-Aml-001806	Ailuropoda melanoleuca	80.32	0.00e+00	986.00
IUUC-Aca-005364	Anolis carolinensis	79.86	0.00e+00	955.00
IUUC-Ame-010612	Astyanax mexicanus	58.28	0.00e+00	1704.00
IUUC-Bta-013011	Bos taurus	80.04	0.00e+00	988.00
IUUC-Cja-019841	Callithrix jacchus	80.39	0.00e+00	989.00
IUUC-Cfa-021131	Canis familiaris	80.39	0.00e+00	989.00
IUUC-Cpo-021957	Cavia porcellus	80.21	0.00e+00	988.00
IUUC-Csa-023722	Chlorocebus sabaeus	80.57	0.00e+00	990.00
IUUC-Dno-029932	Dasypus novemcinctus	80.39	0.00e+00	989.00
IUUC-Ete-032572	Echinops telfairi	81.30	0.00e+00	822.00
IUUC-Eeu-034848	Erinaceus europaeus	53.96	0.00e+00	706.00
IUUC-Fca-035424	Felis catus	80.04	0.00e+00	986.00
IUUC-Fal-037179	Ficedula albicollis	80.04	0.00e+00	962.00
IUUC-Gmo-038719	Gadus morhua	69.18	0.00e+00	1872.00
IUUC-Gga-040815	Gallus gallus	57.95	2.00e-151	532.00
IUUC-Gac-042436	Gasterosteus aculeatus	73.79	0.00e+00	3570.00
IUUC-Ggo-044711	Gorilla gorilla	80.39	0.00e+00	989.00
IUUC-Hsa-046567	Homo sapiens	80.39	0.00e+00	990.00
IUUC-Itr-048510	Ictidomys tridecemlineatus	80.39	0.00e+00	989.00
IUUC-Loc-051979	Lepisosteus oculatus	88.63	0.00e+00	1088.00
IUUC-Laf-054377	Loxodonta africana	80.21	0.00e+00	988.00
IUUC-Mcc-055577	Macaca mulatta	74.69	0.00e+00	897.00
IUUC-Meu-055992	Macropus eugenii	81.03	0.00e+00	942.00
IUUC-Mmr-061772	Microcebus murinus	80.39	0.00e+00	989.00
IUUC-Mdo-062876	Monodelphis domestica	61.95	7.00e-127	449.00
IUUC-Mmu-063903	Mus musculus	80.50	0.00e+00	986.00
IUUC-Mpu-066700	Mustela putorius furo	80.57	0.00e+00	989.00
IUUC-Mlu-068180	Myotis lucifugus	80.39	0.00e+00	989.00
IUUC-Opr-070304	Ochotona princeps	69.88	0.00e+00	792.00
IUUC-Ont-071881	Oreochromis niloticus	69.71	0.00e+00	2046.00
IUUC-Ocu-074053	Oryctolagus cuniculus	80.39	0.00e+00	988.00
IUUC-Ola-086384	Oryzias latipes	68.51	0.00e+00	3282.00
IUUC-Oga-088450	Otolemur garnettii	80.57	0.00e+00	991.00
IUUC-Oar-089975	Ovis aries	79.86	0.00e+00	978.00
IUUC-Pan-092871	Papio anubis	80.57	0.00e+00	992.00
IUUC-Pfo-097525	Poecilia formosa	65.06	0.00e+00	2214.00
IUUC-Pab-097679	Pongo abelii	80.39	0.00e+00	990.00
IUUC-Pca-100499	Procavia capensis	80.04	0.00e+00	987.00
IUUC-Pva-102898	Pteropus vampyrus	79.86	0.00e+00	976.00
IUUC-Rno-105660	Rattus norvegicus	79.40	0.00e+00	910.00
IUUC-Sha-107431	Sarcophilus harrisii	81.03	0.00e+00	953.00
IUUC-Sbi-114711	Sorghum bicolor	34.65	1.00e-05	42.70
IUUC-Ssc-115678	Sus scrofa	80.25	0.00e+00	982.00
IUUC-Tbe-127625	Tupaia belangeri	65.86	8.00e-103	370.00
IUUC-Ttr-129162	Tursiops truncatus	79.86	0.00e+00	989.00
IUUC-Xtr-132455	Xenopus tropicalis	78.94	0.00e+00	937.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence