iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
UniProt	PHOSIDA	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	6.40e-27	93.6	141	173

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf...sdtllvsGsdDgtikvWDlr 31
           H+d v++l+    +d++++s+sdDg + +WD+r
   Q: 141  HEDAVYGLSVspvNDNIFASSSDDGRVLIWDIR 173
           9*******9999999****************87 PP

Organism

Mus musculus

Functional Description
(View)

May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

Protein Sequence
(Fasta)

MKRRAGLGGS MRSVVGFLSQ RGLHGDPLLT QDFQRRRLRG CRNLYKKDLL GHFGCVNAIE 60
FSNNGGQWLV SGGDDRRVLL WHMEQAIHSR VKPIQLKGEH HSNIFCLAFN SGNTKVFSGG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGGGACGCG ACCGTGAGGA AGCCGCGAAC GCCGCCGACC GACCGTCTGC ACACCTCGCT 60
CCGTCTGCCA TGGCTGGTTA AAGAAGCCTC CGGCTCGCTG CGCGCGGGGA GGGACGGGAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0080008--C:Cul4-RING E3 ubiquitin ligase complex
GO:0005739--C:mitochondrion
GO:0016567--P:protein ubiquitination

KEGG

mmu:320808

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001497	Ailuropoda melanoleuca	89.97	0.00e+00	1507.00
IUUC-Apl-003432	Anas platyrhynchos	70.54	0.00e+00	1080.00
IUUC-Aca-005069	Anolis carolinensis	67.96	0.00e+00	1037.00
IUUC-Ame-011063	Astyanax mexicanus	86.04	0.00e+00	750.00
IUUC-Bta-013013	Bos taurus	89.16	0.00e+00	1468.00
IUUC-Cel-018265	Caenorhabditis elegans	31.22	2.00e-33	137.00
IUUC-Cja-018816	Callithrix jacchus	90.81	0.00e+00	1651.00
IUUC-Cfa-020397	Canis familiaris	90.81	0.00e+00	1589.00
IUUC-Cpo-021999	Cavia porcellus	88.26	0.00e+00	1432.00
IUUC-Csa-024256	Chlorocebus sabaeus	91.02	0.00e+00	1653.00
IUUC-Cho-024707	Choloepus hoffmanni	84.34	0.00e+00	1335.00
IUUC-Cin-025728	Ciona intestinalis	46.67	5.00e-53	200.00
IUUC-Dre-027683	Danio rerio	87.27	0.00e+00	761.00
IUUC-Dno-029603	Dasypus novemcinctus	90.71	0.00e+00	1595.00
IUUC-Dme-031660	Drosophila melanogaster	45.09	5.00e-92	332.00
IUUC-Ete-032701	Echinops telfairi	83.11	0.00e+00	1327.00
IUUC-Eca-033345	Equus caballus	90.29	0.00e+00	1486.00
IUUC-Eeu-034973	Erinaceus europaeus	81.92	0.00e+00	855.00
IUUC-Fca-036007	Felis catus	91.24	0.00e+00	1610.00
IUUC-Fal-036759	Ficedula albicollis	70.08	0.00e+00	1071.00
IUUC-Gmo-039095	Gadus morhua	85.12	0.00e+00	763.00
IUUC-Gga-040850	Gallus gallus	96.42	2.00e-159	555.00
IUUC-Gac-041422	Gasterosteus aculeatus	84.84	0.00e+00	764.00
IUUC-Ggo-045451	Gorilla gorilla	90.71	0.00e+00	1620.00
IUUC-Hsa-046752	Homo sapiens	90.81	0.00e+00	1578.00
IUUC-Itr-048562	Ictidomys tridecemlineatus	85.29	0.00e+00	990.00
IUUC-Lch-049676	Latimeria chalumnae	59.40	0.00e+00	977.00
IUUC-Loc-052200	Lepisosteus oculatus	86.13	0.00e+00	755.00
IUUC-Laf-053783	Loxodonta africana	89.42	0.00e+00	1450.00
IUUC-Mcc-055495	Macaca mulatta	91.02	0.00e+00	1654.00
IUUC-Meu-056044	Macropus eugenii	78.17	0.00e+00	1219.00
IUUC-Mga-059650	Meleagris gallopavo	69.32	0.00e+00	920.00
IUUC-Mvi-060289	Microbotryum violaceum	26.72	4.00e-13	69.30
IUUC-Mdo-063059	Monodelphis domestica	82.28	0.00e+00	1394.00
IUUC-Mpu-066563	Mustela putorius furo	88.67	0.00e+00	1345.00
IUUC-Mlu-067408	Myotis lucifugus	89.27	0.00e+00	1431.00
IUUC-Nle-069574	Nomascus leucogenys	90.92	0.00e+00	1651.00
IUUC-Opr-070491	Ochotona princeps	78.10	0.00e+00	1334.00
IUUC-Ont-071270	Oreochromis niloticus	85.01	0.00e+00	775.00
IUUC-Oan-073632	Ornithorhynchus anatinus	77.65	0.00e+00	843.00
IUUC-Ocu-074329	Oryctolagus cuniculus	89.86	0.00e+00	1597.00
IUUC-Ola-087017	Oryzias latipes	84.62	3.00e-143	500.00
IUUC-Oga-088295	Otolemur garnettii	85.70	0.00e+00	1533.00
IUUC-Oar-089609	Ovis aries	85.74	0.00e+00	1437.00
IUUC-Ptr-090891	Pan troglodytes	90.71	0.00e+00	1573.00
IUUC-Pan-092220	Papio anubis	90.86	0.00e+00	1618.00
IUUC-Psi-093097	Pelodiscus sinensis	58.15	2.00e-157	549.00
IUUC-Pfo-096844	Poecilia formosa	83.20	0.00e+00	630.00
IUUC-Pab-098512	Pongo abelii	91.02	0.00e+00	1655.00
IUUC-Pca-100999	Procavia capensis	83.46	0.00e+00	1357.00
IUUC-Pva-102524	Pteropus vampyrus	90.18	0.00e+00	1578.00
IUUC-Pgr-103528	Puccinia graminis	24.78	8.00e-30	125.00
IUUC-Rno-104861	Rattus norvegicus	95.45	0.00e+00	1692.00
IUUC-Sha-106554	Sarcophilus harrisii	95.98	2.00e-128	451.00
IUUC-Sar-113644	Sorex araneus	84.07	2.00e-166	580.00
IUUC-Sre-114948	Sporisorium reilianum	27.12	3.00e-22	100.00
IUUC-Ssc-115431	Sus scrofa	100.00	9.00e-79	284.00
IUUC-Tgu-117355	Taeniopygia guttata	72.86	0.00e+00	1174.00
IUUC-Tru-118672	Takifugu rubripes	81.92	0.00e+00	750.00
IUUC-Tni-120215	Tetraodon nigroviridis	74.72	0.00e+00	672.00
IUUC-Ttr-128965	Tursiops truncatus	94.39	0.00e+00	1026.00
IUUC-Vpa-130586	Vicugna pacos	86.16	0.00e+00	1365.00
IUUC-Xtr-132611	Xenopus tropicalis	59.52	0.00e+00	930.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence