iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Eca-033953

Ensembl Protein ID

ENSECAP00000005860.1

UniProt Accession

F7CEL8; F7CEL8_HORSE

Protein Name

Uncharacterized protein

Gene Name

BRWD3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000007187.1	ENSECAT00000007913.1	ENSECAP00000005860.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.10e-30	103.6	7	44
UBD/Beta-Prp	1.00e-52	179.4	109	368

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf..sdtllvsGsdDgtikvWDlrtgvll 36
           gH +sv+c+af  s++++ +GsdD+ +k+W +++g+ll
   Q: 7    GHLSSVYCVAFdrSGRRIFTGSDDCLVKIWATDDGRLL 44
           8**********96669******************9987 PP

UBD/Beta-Prp

   S: 22   ksllatgsrdgtikvwdvttgkl........lrslsgheae..vtavkfspdgkilvtgseDrtikvw..dlstgkcvhtlkghedsvl 98
           +++l+++++dgti  w+++ +++        + + s    +  +++ +fs+ g ++ tgs+D++i+++    + ++ +  l+ h+d+v+
   Q: 109  TRYLTSTGADGTICFWQWHVKTMkfrdrpvkFTERSRP--GvqISCSSFSSGGMFITTGSTDHVIRIYylGSEIPEKIAELESHTDKVV 195
           689*************9998777667776433333333..35599***********************7777899************** PP
   S: 99   slsfspsg..dklvsGshdrtirvwdletgqclee................tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktg 169
           +++f+ +g   ++vsGs+d t+r+w+ +++++ +                  +++++  v++v+++  +  +v++ ++  +++W++ tg
   Q: 196  AVQFCNNGdsLRFVSGSRDGTARIWQYQQQEWKSIvldmatkmtgnnlpsgEDKVTKLKVTMVAWDRYDTTVVTAVNNFLLKVWNSITG 284
           ******8832468*******************999************999888888899****************************** PP
   S: 170  kllrtltgghtdsvysls...fdsngkelvsgsldgtvklwdlqtgecvrtlnght.....dnvksvrfspnderlvsgssDgsiri 248
           +ll+tl+g h+d v  l+   fd+  + ++s+++dg + +wdl +g+ +r + +         v + +fsp++++++++ s+g + +
   Q: 285  QLLHTLSG-HDDEVFVLEahpFDQ--RIILSAGHDGNIFIWDLDRGTKIRNYFNMIegqghGAVFDCKFSPDGNHFACTDSHGHLLL 368
           *******9.*********555555..99********************98887755455567788899999***9999999988766 PP

Organism

Equus caballus

Protein Sequence
(Fasta)

MHKRILGHLS SVYCVAFDRS GRRIFTGSDD CLVKIWATDD GRLLATLRGH SAEISDMAVN 60
YENTLIAAGS CDKVVRVWCL RTCAPVAVLQ GHSASITSIQ FCPSTKGTTR YLTSTGADGT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGTGGCAGCC AATGCACACA TTCCTCCAGA CTACCTCCTT AAAATTTGTG AGCGGATTGG 60
TCCCTTACTA GATAAGGAGA TCCCTCAGAG CGTTCCTGGG GTGCAGACAT TGCTAGGTGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR001487--Bromodomain
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50014--BROMODOMAIN_2
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00439--Bromodomain
PF00400--WD40

PRINTS

PR00503--BROMODOMAIN

SMART

SM00297--BROMO
SM00320--WD40

Gene Ontology

GO:0005634--C:nucleus
GO:0007010--P:cytoskeleton organization
GO:0008360--P:regulation of cell shape
GO:0006357--P:regulation of transcription from RNA polymerase II promoter

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001881	Ailuropoda melanoleuca	98.04	0.00e+00	2850.00
IUUC-Apl-004016	Anas platyrhynchos	82.77	0.00e+00	2154.00
IUUC-Aca-004722	Anolis carolinensis	78.76	0.00e+00	2234.00
IUUC-Bta-013198	Bos taurus	96.93	0.00e+00	2836.00
IUUC-Cfa-020963	Canis familiaris	98.16	0.00e+00	2836.00
IUUC-Cpo-022448	Cavia porcellus	87.67	0.00e+00	2505.00
IUUC-Csa-023166	Chlorocebus sabaeus	96.98	0.00e+00	2683.00
IUUC-Cin-025553	Ciona intestinalis	39.27	4.00e-114	405.00
IUUC-Dre-028508	Danio rerio	66.29	0.00e+00	1659.00
IUUC-Dno-030070	Dasypus novemcinctus	95.89	0.00e+00	2749.00
IUUC-Dor-031052	Dipodomys ordii	87.42	0.00e+00	1364.00
IUUC-Ete-032650	Echinops telfairi	89.95	0.00e+00	1658.00
IUUC-Eeu-034871	Erinaceus europaeus	80.78	0.00e+00	1056.00
IUUC-Fca-036099	Felis catus	97.48	0.00e+00	2857.00
IUUC-Fal-037246	Ficedula albicollis	81.87	0.00e+00	2268.00
IUUC-Gga-041097	Gallus gallus	83.31	0.00e+00	2317.00
IUUC-Gac-042435	Gasterosteus aculeatus	65.66	0.00e+00	1646.00
IUUC-Hsa-045666	Homo sapiens	96.98	0.00e+00	2683.00
IUUC-Loc-051802	Lepisosteus oculatus	70.44	0.00e+00	1862.00
IUUC-Laf-053942	Loxodonta africana	96.84	0.00e+00	2686.00
IUUC-Mcc-054645	Macaca mulatta	97.11	0.00e+00	2688.00
IUUC-Meu-056321	Macropus eugenii	74.63	0.00e+00	885.00
IUUC-Mga-060063	Meleagris gallopavo	84.04	0.00e+00	2309.00
IUUC-Mmr-061262	Microcebus murinus	97.58	0.00e+00	2697.00
IUUC-Mdo-062320	Monodelphis domestica	75.27	0.00e+00	2034.00
IUUC-Mmu-063163	Mus musculus	94.85	0.00e+00	2733.00
IUUC-Mpu-066628	Mustela putorius furo	97.42	0.00e+00	2828.00
IUUC-Mlu-068082	Myotis lucifugus	97.72	0.00e+00	2676.00
IUUC-Nle-069609	Nomascus leucogenys	96.98	0.00e+00	2698.00
IUUC-Ont-071589	Oreochromis niloticus	66.80	0.00e+00	1643.00
IUUC-Ocu-074122	Oryctolagus cuniculus	95.50	0.00e+00	2156.00
IUUC-Ola-086580	Oryzias latipes	67.24	0.00e+00	1674.00
IUUC-Oga-089053	Otolemur garnettii	96.13	0.00e+00	2806.00
IUUC-Oar-090042	Ovis aries	97.30	0.00e+00	2849.00
IUUC-Ptr-091268	Pan troglodytes	97.18	0.00e+00	2687.00
IUUC-Pan-092376	Papio anubis	97.11	0.00e+00	2689.00
IUUC-Psi-093408	Pelodiscus sinensis	82.66	0.00e+00	2355.00
IUUC-Pfo-096515	Poecilia formosa	65.28	0.00e+00	1590.00
IUUC-Pab-097672	Pongo abelii	96.98	0.00e+00	2691.00
IUUC-Pva-102512	Pteropus vampyrus	98.54	0.00e+00	2054.00
IUUC-Rno-105797	Rattus norvegicus	94.42	0.00e+00	2613.00
IUUC-Sha-107061	Sarcophilus harrisii	77.79	0.00e+00	2159.00
IUUC-Sar-113004	Sorex araneus	85.48	0.00e+00	1688.00
IUUC-Tgu-117254	Taeniopygia guttata	82.78	0.00e+00	2262.00
IUUC-Tru-118186	Takifugu rubripes	66.61	0.00e+00	1665.00
IUUC-Tsy-119003	Tarsius syrichta	91.57	0.00e+00	2466.00
IUUC-Tni-120110	Tetraodon nigroviridis	66.41	0.00e+00	1628.00
IUUC-Tbe-127813	Tupaia belangeri	78.79	0.00e+00	935.00
IUUC-Ttr-129265	Tursiops truncatus	95.90	0.00e+00	2635.00
IUUC-Vpa-130736	Vicugna pacos	91.71	0.00e+00	1516.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence