iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Bra-017522

Ensembl Protein ID

Bra009196.1-P

UniProt Accession

M4CY99; M4CY99_BRARP

Protein Name

Uncharacterized protein

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
Bra009196	Bra009196.1	Bra009196.1-P

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	1.50e-165	552.4	386	873

Active Site

Position(s)	Description	Evidence
567	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU10132}

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGv.....gsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvnve 91
           YD Qi ++G++ q+kl+ a+v++vGag+lGcE+lKnL+l+Gv     g++tv+D+d +e+snl+rqFLfr++++g+ K+ vaa a++ +n+  +++
   Q: 386  YDAQISVFGSTLQKKLEDARVFVVGAGALGCEFLKNLALMGVscgvqGKLTVTDDDVIEKSNLSRQFLFRDWNIGQAKSTVAATAAAGINSRLKID 481
           ************************************************************************************************ PP
   S: 92   aheesiteleeeiv...FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsddppqktiPfctlketpnaae 184
           a ++++ +++e+++   F ++++vVv+aldn+ ar++v+++c++ ++pl+esgtlG + +++ +i++lte y +s+dpp+k++P+ct+ ++p +++
   Q: 482  ALQNRVGPETENVFddsFWENLTVVVNALDNVTARLYVDSRCVYFQKPLLESGTLGAKCNTQMVIPHLTENYGASRDPPEKQAPMCTVHSFPHNID 577
           ************99********************************************************************************** PP
   S: 185  htiewa............vlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafakttinsikqllksfecdivtks 268
           h+++wa            + +n +l++ ++  +       ++ ++++ +v + l++e+ ++f+++i++a+  f+ ++ n +kql+  f+ d  t+ 
   Q: 578  HCLTWArsefegllektpAEVNAYLSNPDEYMKAMRTAGDAQARDTLGRVVECLEKEKCNSFQDCITWARLRFEDYFVNRVKQLIFTFPEDANTST 673
           ***************999888888888888888888888999999999999999****************************************** PP
   S: 269  kspfwv.........................................................sfcsnaealqvpekvekdeevvkasap..lyll 305
           ++pfw+                                                         +f++ ++a+ v +  +    + +++++  +  l
   Q: 674  GAPFWSapkrfprplkftstdlshtnfvmaaailraetfgiptpewaktptglaeavervtvpNFEPREDAKIVTDEKATTLSTASVDDAavINEL 769
           ***************************************************999999999999888888888777666666666666666688888 PP
   S: 306  lraler..fekkkgrkpgelsfekddds..avdlvtaaanlraeslgiepkldddlikeiagniipaiattnavvgGlaaqEviKvvsg..kfepl 395
           +++ler  ++ +++  ++ ++fekddd   ++d+++ +an+ra ++++++ +d+ + k iag+iipaiat +a+  G++++E++Kv++g  k e +
   Q: 770  IAKLERcrLSLQPEFRMKPIQFEKDDDTnyHMDMIAGLANMRARNYSVPE-VDKLKAKFIAGRIIPAIATSTAMATGFVCLELYKVLDGahKVEDY 864
           888886226789999***********************************.**************************************99999** PP
   S: 396  knfflfdae 404
           +n+f ++a+
   Q: 865  RNTFANLAL 873
           ****99875 PP

Organism

Brassica rapa

Protein Sequence
(Fasta)

MRRLFASNVL ISGIQGLGVE IAKNIILAGV KSVTLHDENV VELWDLSSNF VFTEEDVGKN 60
RALASVHKLQ ELNNAVAVSA LTGELTKEQL SGFQAVVFVD ASFEKATEFD DYCHSHQPPI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAGGAGGC TTTTCGCTTC CAACGTCCTC ATCTCAGGGA TCCAGGGCCT TGGTGTTGAG 60
ATTGGTAACC GCTTTTTTTT TTTTTTAAAT TTAGTTGTTA AATCAATCTT GCATGTCACA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0436--Ligase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR032420--E1_4HB
IPR032418--E1_FCCH
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
IPR018965--Ub-activating_enz_E1_C
IPR019572--UBA_E1_Cys
IPR018075--UBQ-activ_enz_E1
IPR018074--UBQ-activ_enz_E1_CS
IPR033127--UBQ-activ_enz_E1_Cys_AS
IPR000011--UBQ/SUMO-activ_enz_E1-like

PROSITE

PS00536--UBIQUITIN_ACTIVAT_1
PS00865--UBIQUITIN_ACTIVAT_2

Pfam

PF16191--E1_4HB
PF16190--E1_FCCH
PF09358--E1_UFD
PF00899--ThiF
PF10585--UBA_e1_thiolCys

PRINTS

PR01849--UBIQUITINACT

SMART

SM00985--UBA_e1_C

Gene Ontology

GO:0005829--C:cytosol
GO:0005524--F:ATP binding
GO:0008641--F:small protein activating enzyme activity
GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-004158	Anas platyrhynchos	39.40	0.00e+00	675.00
IUUC-Aca-004620	Anolis carolinensis	45.75	0.00e+00	863.00
IUUC-Aly-005515	Arabidopsis lyrata	92.84	0.00e+00	1910.00
IUUC-Ath-006891	Arabidopsis thaliana	93.14	0.00e+00	1922.00
IUUC-Bol-015665	Brassica oleracea	98.59	0.00e+00	1988.00
IUUC-Cja-019152	Callithrix jacchus	45.76	0.00e+00	880.00
IUUC-Cpo-022526	Cavia porcellus	45.86	0.00e+00	870.00
IUUC-Eeu-035323	Erinaceus europaeus	39.82	6.00e-146	511.00
IUUC-Fal-036848	Ficedula albicollis	39.60	0.00e+00	686.00
IUUC-Fox-038007	Fusarium oxysporum	46.18	7.00e-132	463.00
IUUC-Gga-040747	Gallus gallus	39.50	0.00e+00	679.00
IUUC-Meu-056258	Macropus eugenii	45.86	0.00e+00	866.00
IUUC-Mga-059721	Meleagris gallopavo	40.29	0.00e+00	655.00
IUUC-Mdo-062032	Monodelphis domestica	45.68	0.00e+00	855.00
IUUC-Mmu-063721	Mus musculus	45.79	0.00e+00	880.00
IUUC-Nle-070072	Nomascus leucogenys	44.82	0.00e+00	800.00
IUUC-Ptr-090609	Pan troglodytes	38.23	0.00e+00	669.00
IUUC-Psi-093489	Pelodiscus sinensis	38.31	0.00e+00	668.00
IUUC-Pca-100347	Procavia capensis	43.20	0.00e+00	714.00
IUUC-Sha-107142	Sarcophilus harrisii	46.49	0.00e+00	879.00
IUUC-Tgu-116565	Taeniopygia guttata	39.30	0.00e+00	677.00
IUUC-Tru-118742	Takifugu rubripes	46.25	0.00e+00	825.00
IUUC-Tsy-119436	Tarsius syrichta	33.37	3.00e-158	552.00
IUUC-Tni-120401	Tetraodon nigroviridis	45.75	0.00e+00	823.00
IUUC-Tbe-127714	Tupaia belangeri	33.71	9.00e-141	494.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence