iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Rno-105541

Ensembl Protein ID

ENSRNOP00000074531.1

UniProt Accession

A0A0G2K8A5; A0A0G2K8A5_RAT

Genbank Protein ID

ENSRNOP00000074531

Protein Name

Ubiquitin-activating enzyme, Chr Y

Genbank Nucleotide ID

AC239817

Gene Name

Uba1y

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSRNOG00000052326.2	ENSRNOT00000092178.2	ENSRNOP00000074531.1

Annotation

mRNA Expression
GEO
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	7.00e-227	753.8	450	930

Active Site

Position(s)	Description	Evidence
631	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU10132}

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGv.....gsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkel 84
           YD+Q++++G++ qekl+++k++lvGag++GcEllKn++++G+     g+itv+Dmdt+e+snlnrqFLfr++dv k K+e+aa+a++++
   Q: 450  YDGQVAVFGSDLQEKLGKQKYFLVGAGAIGCELLKNFAMIGLgcgegGEITVTDMDTIEKSNLNRQFLFRPWDVTKLKSETAAAAVRDI 538
           ***************************************************************************************** PP
   S: 85   npdvnveaheesiteleeeiv...FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsddppqkt 170
           np+++v +h++++ +++e+++   Ff+++d+V++aldn++ar++++r+c+++r+pl+esgtlG++G+v+v+++ lte+ys+s+dpp+k+
   Q: 539  NPHIRVCSHQNRVGPETEHVYdddFFQNLDGVANALDNVDARLYMDRRCVYYRKPLLESGTLGTKGNVQVVVPFLTESYSSSQDPPEKS 627
           ***************************************************************************************** PP
   S: 171  iPfctlketpnaaehtiewa............vlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafak 247
           iP+ctlk++pna+eht++wa            + +n++l  ++++ e++ +l+ ++++e++++++ +l+ ++++++++++++a +++++
   Q: 628  IPICTLKNFPNAIEHTLQWArdefeglfkqsaENVNQYL-MDPKFMERTLQLAGTQPLEVLEAIQCSLVLQRPQTWADCVTWAYQHWHT 715
           ***************************************.5666666667799************************************ PP
   S: 248  ttinsikqllksfecdivtkskspfwv.......................................................sfcsnae 281
           +++++i+qll++f++d++t+s++ fw+                                                         ++   
   Q: 716  QYSHNIQQLLHNFPPDQLTSSGVLFWSgpkrcphpltfdtnnplhldyvmaaanlfaqtyglegsqdcaavttllqslpapkFAPKSGI 804
           **************************************************************999777766666655555532222222 PP
   S: 282  alqvpekvekdeevvkasaplylllralerfekkkgrkpgelsfekddds..avdlvtaaanlraeslgiepkldddlikeiagniipa 368
           ++ v e  ++++ +  +++ l+ l+++l + +k  g k+  ++fekddds  ++d++ aa+nlrae+++i+p +d+++ k iag+iipa
   Q: 805  RIHVSEQELQSTSATVDDSHLEELKTSLPTPDKMLGFKMHPIDFEKDDDSnfHMDFIVAASNLRAENYDIPP-ADRHKSKLIAGKIIPA 892
           333444444444444444449***************************************************.**************** PP
   S: 369  iattnavvgGlaaqEviKvvsg..kfeplknfflfdae 404
           iatt+++v Gl+++E++Kvv+g  + + +kn f+++a+
   Q: 893  IATTTSAVVGLVCLELYKVVQGhqQLDSFKNSFINLAL 930
           **********************9999********9875 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MSSSVLSKKR RVSGPDSEVD SSWPSTHSVM FGAPPGPNSG MSKNKEMDID ESLYSRQLYV 60
LGHEAMKHLQ TSSVLISGLQ GLGVEIAKNI ILGGVKAVTL HDQGTAQWAD LSSQFYLHEE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATCTTGTTCC TCGTGTGAGG ACGCGGACGC GCCTTTTGTG GAAGGAGTTT CTGAAAAAAC 60
TGGTCAGGGA CCTGAAGGTG GAGGCTGCAC CATCCTGGGA CCACGTCTTC GAGGAAGAGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0436--Ligase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR032420--E1_4HB
IPR032418--E1_FCCH
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
IPR018965--Ub-activating_enz_E1_C
IPR019572--UBA_E1_Cys
IPR018075--UBQ-activ_enz_E1
IPR018074--UBQ-activ_enz_E1_CS
IPR033127--UBQ-activ_enz_E1_Cys_AS
IPR000011--UBQ/SUMO-activ_enz_E1-like

PROSITE

PS00536--UBIQUITIN_ACTIVAT_1
PS00865--UBIQUITIN_ACTIVAT_2

Pfam

PF16191--E1_4HB
PF16190--E1_FCCH
PF09358--E1_UFD
PF00899--ThiF
PF10585--UBA_e1_thiolCys

PRINTS

PR01849--UBIQUITINACT

SMART

SM00985--UBA_e1_C

Gene Ontology

GO:0005524--F:ATP binding
GO:0004839--F:ubiquitin activating enzyme activity
GO:0007283--P:spermatogenesis
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

rno:25225

Orthology

iUUCD ID

Species

Identity

E-value

Score

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence