iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mlu-067376

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAPE02037824

Gene Name

HECTD4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMLUG00000008345.2	ENSMLUT00000008363.2	ENSMLUP00000007630.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	5.90e-77	259.3	3629	3989

Active Site

Position(s)	Description	Evidence
3963	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglf.......lysendketlqpnpdsglknpehlklFeflGrllgkalq 83
           d ++ ++++f+gEe++++  ++r+fl++++kelq+++l+l+       ++++++k+ l+p+p ++     +++l +flG+llg+a++
   Q: 3629 DPTYAFNIRFTGEEVHGTICSFRHFLWQVCKELQSSSLSLLllcpssaVNKNKGKYILTPSPITY----GEEQLLHFLGQLLGIAIR 3711
           5667788*********************************9999999888888***********9....789*************** PP
   S: 84   dgrlldlplsksfyklllgkklsl.edleevdpelykslkeik.enaesdieelgldltfs..vseei...............lget 151
            + +l+l+l +sf+k+l+g++l+  +dl+e d  +y+++k+ +  n+e ++e+l+++++++  +  ++                 + 
   Q: 3712 ADVPLPLDLLPSFWKTLVGEPLDPdQDLQEADILTYNYVKKFEsINDEIELEALCAEIASQhlA--TEspdspnkpccrftylTMTG 3796
           **************************************66666155555777777777776432..225689999*****9655555 PP
   S: 152  keeeLkpgGenipVtneNkeeYvklvveyrlke.gikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykg 237
           +e+eL+++G++ipV++eNk+ Y  ++ ++rl+e + +e+ +a+r+G+ +++pl+ll+ +++ e+el +cG ++i++e lk++t+y+ 
   Q: 3797 EEVELCSRGRHIPVAWENKDIYAAAIRSLRLRElQNDECATAVRAGLGSIVPLQLLTTLSPLEMELRTCGLPYINLEFLKAHTMYQV 3883
           6667*****************************9***************************************************** PP
   S: 238  gytedspaiqwFwevleefsseerkafLqFvTgssrlPl......gGfaelk....prlfvirk...dasddrlPssnTCfnyLkLP 311
           g++e++++i++Fw +le+f +ee ++f++F+++++r+P+      gG ++ +    p+++  ++    + d+r+++++TC++++kLP
   Q: 3884 GLMETDQHIEFFWGALEMFAQEELCKFIKFACNQERIPFtcpckdGGPDTAHvppyPMKIAPPDgtaGSPDSRYIRVETCMFMIKLP 3970
           *********************************************99999999988888888889955555**************** PP
   S: 312  eYsskeilkekLlyAieet 330
           +Yss ei+ ekL++Ai+++
   Q: 3971 QYSSLEIMLEKLRCAIHYR 3989
           ****************986 PP

Organism

Myotis lucifugus

Protein Sequence
(Fasta)

MPANHLPVGS TMSTVHLSSD GTYFYWIWSP ASLNEKTPKG HSVFMDIFEL VVENGVYVAS 60
PLQERTILMR KEGESAKSIN EMLLSRLSRY RASPSATLAA LTGSTISNTL KEDQAANTSC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCCAGCTA ATCATCTCCC TGTTGGCAGC ACTATGAGCA CCGTGCACCT TTCTTCAGAT 60
GGTACTTACT TCTATTGGAT CTGGTCTCCT GCCAGCCTGA ATGAGAAAAC ACCTAAGGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom

PROSITE

PS50237--HECT

Pfam

PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002256	Ailuropoda melanoleuca	97.45	0.00e+00	7232.00
IUUC-Apl-004161	Anas platyrhynchos	92.13	0.00e+00	5130.00
IUUC-Aca-005341	Anolis carolinensis	89.24	0.00e+00	6608.00
IUUC-Ame-011574	Astyanax mexicanus	80.77	0.00e+00	4486.00
IUUC-Bta-012514	Bos taurus	97.07	0.00e+00	1912.00
IUUC-Cja-019148	Callithrix jacchus	96.22	0.00e+00	5240.00
IUUC-Cfa-020499	Canis familiaris	96.18	0.00e+00	7172.00
IUUC-Cpo-021894	Cavia porcellus	96.97	0.00e+00	2769.00
IUUC-Csa-023079	Chlorocebus sabaeus	96.06	0.00e+00	7195.00
IUUC-Cho-024415	Choloepus hoffmanni	93.42	0.00e+00	5063.00
IUUC-Dre-027452	Danio rerio	79.10	0.00e+00	4482.00
IUUC-Dno-029595	Dasypus novemcinctus	95.40	0.00e+00	7165.00
IUUC-Dor-030849	Dipodomys ordii	95.96	0.00e+00	1779.00
IUUC-Ete-032563	Echinops telfairi	90.51	0.00e+00	1155.00
IUUC-Eca-034202	Equus caballus	97.53	0.00e+00	7152.00
IUUC-Eeu-035175	Erinaceus europaeus	96.38	0.00e+00	1068.00
IUUC-Fca-036295	Felis catus	95.69	0.00e+00	6964.00
IUUC-Fal-037003	Ficedula albicollis	91.28	0.00e+00	6160.00
IUUC-Gmo-038579	Gadus morhua	84.93	0.00e+00	2859.00
IUUC-Gga-040961	Gallus gallus	91.36	0.00e+00	6932.00
IUUC-Gac-041899	Gasterosteus aculeatus	85.05	0.00e+00	2898.00
IUUC-Ggo-045099	Gorilla gorilla	97.24	0.00e+00	6364.00
IUUC-Hsa-046331	Homo sapiens	96.33	0.00e+00	7261.00
IUUC-Itr-048190	Ictidomys tridecemlineatus	96.15	0.00e+00	2120.00
IUUC-Lch-049923	Latimeria chalumnae	86.28	0.00e+00	2663.00
IUUC-Loc-052630	Lepisosteus oculatus	83.77	0.00e+00	4028.00
IUUC-Laf-053394	Loxodonta africana	95.52	0.00e+00	7228.00
IUUC-Mcc-055763	Macaca mulatta	96.01	0.00e+00	7184.00
IUUC-Meu-056039	Macropus eugenii	88.79	0.00e+00	5030.00
IUUC-Mga-059500	Meleagris gallopavo	92.01	0.00e+00	6931.00
IUUC-Mmr-060868	Microcebus murinus	92.33	0.00e+00	6922.00
IUUC-Mdo-062772	Monodelphis domestica	92.64	0.00e+00	7034.00
IUUC-Mmu-063606	Mus musculus	94.92	0.00e+00	7149.00
IUUC-Mpu-065860	Mustela putorius furo	95.53	0.00e+00	7107.00
IUUC-Nle-069693	Nomascus leucogenys	95.98	0.00e+00	7152.00
IUUC-Opr-071065	Ochotona princeps	94.41	0.00e+00	1210.00
IUUC-Ont-072470	Oreochromis niloticus	83.58	0.00e+00	4650.00
IUUC-Oan-073693	Ornithorhynchus anatinus	94.69	0.00e+00	3394.00
IUUC-Ocu-074032	Oryctolagus cuniculus	94.54	0.00e+00	7149.00
IUUC-Ola-087433	Oryzias latipes	83.62	0.00e+00	1582.00
IUUC-Oga-088546	Otolemur garnettii	97.18	0.00e+00	6907.00
IUUC-Oar-089643	Ovis aries	90.66	0.00e+00	754.00
IUUC-Ptr-090504	Pan troglodytes	97.42	0.00e+00	7283.00
IUUC-Pan-092543	Papio anubis	96.16	0.00e+00	7187.00
IUUC-Psi-093952	Pelodiscus sinensis	90.15	0.00e+00	6832.00
IUUC-Pfo-096356	Poecilia formosa	82.41	0.00e+00	4603.00
IUUC-Pab-098240	Pongo abelii	96.04	0.00e+00	7185.00
IUUC-Pca-100994	Procavia capensis	96.57	0.00e+00	2980.00
IUUC-Pva-102263	Pteropus vampyrus	96.57	0.00e+00	7144.00
IUUC-Rno-104888	Rattus norvegicus	94.85	0.00e+00	7111.00
IUUC-Sha-106944	Sarcophilus harrisii	93.38	0.00e+00	7080.00
IUUC-Sar-113556	Sorex araneus	85.90	0.00e+00	954.00
IUUC-Ssc-116187	Sus scrofa	97.77	0.00e+00	5158.00
IUUC-Tgu-116655	Taeniopygia guttata	91.96	0.00e+00	5091.00
IUUC-Tru-118093	Takifugu rubripes	83.73	0.00e+00	3000.00
IUUC-Tni-119739	Tetraodon nigroviridis	83.33	0.00e+00	1610.00
IUUC-Tbe-127962	Tupaia belangeri	91.16	0.00e+00	1183.00
IUUC-Ttr-128819	Tursiops truncatus	92.59	0.00e+00	2840.00
IUUC-Vpa-130482	Vicugna pacos	95.03	0.00e+00	4445.00
IUUC-Xtr-132222	Xenopus tropicalis	87.16	0.00e+00	6592.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence