iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ggo-045585

UUCD1 version

UUC-GoG-00104

Ensembl Protein ID

ENSGGOP00000002541.2

UniProt Accession

G3QJE7; G3QJE7_GORGO

Protein Name

Uncharacterized protein

Gene Name

WSB2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGGOG00000002578.2	ENSGGOT00000002594.2	ENSGGOP00000002541.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	9.50e-15	54.6	373	420
E3 adaptor/Cullin RING/DCX/DWD	5.10e-32	109.0	168	201
UBD/Beta-Prp	6.40e-46	157.3	142	377

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 1    lsklwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyed 51
           ++++w++++   SL+hLCR+a r++l+++++    +LP+Pk++k++L y++
   Q: 373  HVQFWTAPRVLSSLKHLCRKALRSFLTTYQV---LALPIPKKMKEFLTYRT 420
           689****************************...***************86 PP

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf..sd.tllvsGsdDgtikvWDlr 31
           gH+d v++l+f  s+  +lvs+s+D+t+++WDl 
   Q: 168  GHQDVVRDLSFtpSGsLILVSASRDKTLRIWDLN 201
           8***********6556779*************85 PP

UBD/Beta-Prp

   S: 24   llatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgk.ilvtgseDrtikvwdls.tgkcvhtlkghedsvlslsfspsgdklv 110
           +latg  dg ik+w+v+tg ll  lsgh++ v++++f p+g+ ilv++s+D+t+++wdl+  gk++++l+gh + v+++s+sp+ + l 
   Q: 142  VLATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSlILVSASRDKTLRIWDLNkHGKQIQVLSGHLQWVYCCSISPDCSMLC 230
           79****************************************9****************9789********************99**** PP
   S: 111  sGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtl...........tgghtdsvyslsf 188
           s+   + + +w +++++ ++  l+gh+++v +  ++pd+ llv++s+D+ v +Wd  tg+ lr l           +  h +s +s+ f
   Q: 231  SAAGEKSVFLWSMRSYTLIR-KLEGHQSSVVSCDFSPDSALLVTASYDTNVIMWDPYTGERLRSLhhtqvdpamddSDVHISSLRSVCF 318
           ********************.********************************************99999999888777888888888* PP
   S: 189  dsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriW 249
           +++g +l+++++d+ +++w l+ ++   +  +  +n ++  f+p++  +++g+ Dg +++W
   Q: 319  SPEGLYLATVADDRLLRIWALELKT--PIAFAPMTNGLCCTFFPHGGVIATGTRDGHVQFW 377
           *********************9885..7899****************************** PP

Organism

Gorilla gorilla

Protein Sequence
(Fasta)

MQVDRESRFL RGTGTGEAVA VEEPLLLAEL KPGRPHQFDW KSSCETWSVA FSPDGSWFAW 60
SQGHCIVKLI PWPLEEQFIP KGFEAKSRSS KNETKGRGSP KEKTLDCGQI VWGLAFSPWP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCAGGTAG ACAGGGAGAG CAGGTTTCTC AGGGGGACGG GGACAGGCGA GGCTGTCGCA 60
GTAGGTAGTT AAGGGGACAG TCTTCTTCCG AATCGCTCCT GCCCCGTTTT TTATCTCGTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR020472--G-protein_beta_WD-40_rep
IPR001496--SOCS_box
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50225--SOCS
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF07525--SOCS_box
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00253--SOCS
SM00969--SOCS_box
SM00320--WD40

Gene Ontology

GO:0005622--C:intracellular
GO:0035556--P:intracellular signal transduction
GO:0016567--P:protein ubiquitination

KEGG

ggo:101148393

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002221	Ailuropoda melanoleuca	98.25	0.00e+00	815.00
IUUC-Apl-004107	Anas platyrhynchos	69.29	7.00e-132	463.00
IUUC-Aca-004354	Anolis carolinensis	73.63	4.00e-169	587.00
IUUC-Bta-012627	Bos taurus	98.72	0.00e+00	780.00
IUUC-Cja-018897	Callithrix jacchus	97.15	0.00e+00	802.00
IUUC-Cfa-020122	Canis familiaris	98.50	0.00e+00	815.00
IUUC-Cpo-022540	Cavia porcellus	97.44	0.00e+00	792.00
IUUC-Csa-023719	Chlorocebus sabaeus	99.74	0.00e+00	799.00
IUUC-Cho-024367	Choloepus hoffmanni	97.32	2.00e-172	597.00
IUUC-Dno-029021	Dasypus novemcinctus	98.21	0.00e+00	796.00
IUUC-Dor-030321	Dipodomys ordii	97.68	0.00e+00	788.00
IUUC-Ete-032955	Echinops telfairi	97.24	0.00e+00	781.00
IUUC-Eca-033485	Equus caballus	98.47	0.00e+00	771.00
IUUC-Fca-035389	Felis catus	98.20	0.00e+00	793.00
IUUC-Fal-037184	Ficedula albicollis	84.45	5.00e-143	499.00
IUUC-Gga-041014	Gallus gallus	77.34	1.00e-176	612.00
IUUC-Hsa-046344	Homo sapiens	100.00	0.00e+00	807.00
IUUC-Itr-049085	Ictidomys tridecemlineatus	97.94	0.00e+00	795.00
IUUC-Lch-050131	Latimeria chalumnae	70.54	1.00e-167	582.00
IUUC-Loc-052807	Lepisosteus oculatus	54.33	8.00e-117	413.00
IUUC-Laf-053528	Loxodonta africana	98.21	0.00e+00	776.00
IUUC-Mcc-055665	Macaca mulatta	100.00	0.00e+00	807.00
IUUC-Meu-056054	Macropus eugenii	87.88	0.00e+00	701.00
IUUC-Mga-059326	Meleagris gallopavo	77.25	0.00e+00	631.00
IUUC-Mmr-060815	Microcebus murinus	96.93	0.00e+00	788.00
IUUC-Mdo-062000	Monodelphis domestica	90.17	0.00e+00	751.00
IUUC-Mmu-063927	Mus musculus	96.14	0.00e+00	782.00
IUUC-Mpu-065726	Mustela putorius furo	96.40	0.00e+00	777.00
IUUC-Mlu-067527	Myotis lucifugus	97.14	5.00e-120	422.00
IUUC-Nle-069680	Nomascus leucogenys	99.49	0.00e+00	799.00
IUUC-Opr-070356	Ochotona princeps	97.74	0.00e+00	804.00
IUUC-Oan-073647	Ornithorhynchus anatinus	83.94	2.00e-136	478.00
IUUC-Ocu-073973	Oryctolagus cuniculus	97.19	0.00e+00	786.00
IUUC-Oga-088797	Otolemur garnettii	98.98	0.00e+00	796.00
IUUC-Oar-089187	Ovis aries	98.72	0.00e+00	780.00
IUUC-Ptr-091317	Pan troglodytes	100.00	0.00e+00	806.00
IUUC-Pan-092694	Papio anubis	91.95	0.00e+00	688.00
IUUC-Psi-093392	Pelodiscus sinensis	79.40	0.00e+00	643.00
IUUC-Pab-098145	Pongo abelii	99.74	0.00e+00	798.00
IUUC-Pca-100454	Procavia capensis	88.72	0.00e+00	721.00
IUUC-Pva-102986	Pteropus vampyrus	89.97	0.00e+00	730.00
IUUC-Rno-104931	Rattus norvegicus	94.85	0.00e+00	769.00
IUUC-Sha-106476	Sarcophilus harrisii	91.77	0.00e+00	748.00
IUUC-Ssc-115643	Sus scrofa	98.71	0.00e+00	792.00
IUUC-Tgu-117522	Taeniopygia guttata	64.44	7.00e-137	480.00
IUUC-Tsy-119301	Tarsius syrichta	99.50	0.00e+00	820.00
IUUC-Ttr-128683	Tursiops truncatus	98.71	0.00e+00	792.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence