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Tag Content
UUCD2 ID IUUC-Dre-028233
UUCD1 version UUC-DaR-01495
Ensembl Protein ID ENSDARP00000123913.1
UniProt Accession E7FEV5; E7FEV5_DANRE
Genbank Protein ID ENSDARP00000078684
Protein Name Cylindromatosis (turban tumor syndrome), a
Genbank Nucleotide ID CT030153
Gene Name cylda
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSDARG00000060058.7 ENSDART00000148905.3 ENSDARP00000123696.1
ENSDARG00000060058.7 ENSDART00000150229.2 ENSDARP00000123913.1
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/USP 6.10e-20 72.6 588 944
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   DUB/USP
   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgyeq 89
           G++ + N+CY++S+L cL++++++ + +l + ++k++ e +ke+++ l +++ + ++     + +k ++ r++l+++++++    ++e+
   Q: 588  GIQGHYNSCYLDSTLFCLFSFSSVLDTVLLRPRSKTDVEYYKETQELLRTEIVNPLRIHGyVCATKIMKLRRILEKVEAASGF--TSEE 674
           999***************************99999999999999999999999999877679***************988875..899* PP
   S: 90   qDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlk.sqik...clecdnvs.sreepfldls 173
           +D +Efl++l++++ +         ++  ++ +++   ++  +kk+k    + ++l+++++  s++k    ++c  ++  r+ + +++ 
   Q: 675  KDPEEFLNILFHHILRVD--PLLRLRSAGQKVQDCYFYQIFMDKKDKVMVPTSQQLLEWSFInSDLKfaeAPSCLIIQmPRFGKDFKMF 761
           **************9977..667777888888899999**********************9843444334899****999********* PP
   S: 174  lpvpgkeetkkeslqdcLesftkeeelegenk.yycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkve..fpleL 259
            ++  + e    +++d+L++  +e++++g  + y+c++c+++ + +   k+k+++e    +          + r+ki+++v+  +p+eL
   Q: 762  NKIFPSLEL---DITDLLDDTPRECRICGGLAlYECRECYEDYDITPG-KIKQFCEKCNTQVH-------LHPRRKIHRYVKlsVPKEL 839
           **9999988...****************99888**********86655.99999884433332.......2344555555551167777 PP
   S: 260  dlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk..WllfdD.............skVtevke.eevleetg..... 327
             s + + +      +++ eL+av++ +      HYva+vk  + +  Wl fd               +V+ ++e  e l++t      
   Q: 840  HESVWRQGSY----PHQQMELFAVLCIET----SHYVAFVKYGSADsaWLFFDSmadrdggqngfniPQVSRCPEvGEYLKMTPeelha 920
           7776665533....3899********999....9********65556688888888888888888886666665546666666566777 PP
   S: 328  ..............staYvlfYkr 337
                         ++aY+++Y++
   Q: 921  ldpkniqgyarrllCDAYMCMYQS 944
           77777777788***********85 PP
   
Organism Danio rerio
Protein Sequence
(Fasta)
MSSTLWSQEK PGGSFRDDWR FYIVVKECTV ERPGQKTLRI PRGSLGQACQ ERNSLGRTIP 60
ASKGKRSLRI LDQTNVVVSV DERDVMELEE KLAELLFPIT NCEERYSLLC NRSRLDRARD 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Dre-028233|DUB,USP|Danio rerio
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ACTGTAAATA ATACCCACAC TTATTAGAAA TTTAGCAACG ACCTCGGCTT TAACTAGTAT 60
TATCGGATTC TTCCCCCCGT GTTTTCGTCT TCGTCTCGAT CGAGATTAAT CCTAGCCTGT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Dre-028233|DUB,USP|Danio rerio
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-1185--Reference proteome
Interpro

IPR000938--CAP-Gly_domain
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
PROSITE

PS50245--CAP_GLY_2
PS00972--USP_1
PS50235--USP_3
Pfam

PF01302--CAP_GLY
PF00443--UCH
SMART

SM01052--CAP_GLY
Gene Ontology

GO:0005829--C:cytosol
GO:0061578--F:Lys63-specific deubiquitinase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0021551--P:central nervous system morphogenesis
GO:0070266--P:necroptotic process
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:2001238--P:positive regulation of extrinsic apoptotic signaling pathway
GO:1990108--P:protein linear deubiquitination
GO:2001242--P:regulation of intrinsic apoptotic signaling pathway
GO:0007346--P:regulation of mitotic cell cycle
GO:0006511--P:ubiquitin-dependent protein catabolic process
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001298 Ailuropoda melanoleuca 67.73 0.00e+00 1287.00
IUUC-Apl-003356 Anas platyrhynchos 69.52 0.00e+00 1285.00
IUUC-Aca-004402 Anolis carolinensis 64.45 0.00e+00 1142.00
IUUC-Ame-011581 Astyanax mexicanus 90.35 0.00e+00 1601.00
IUUC-Bta-012359 Bos taurus 67.56 0.00e+00 1283.00
IUUC-Cel-018528 Caenorhabditis elegans 35.51 3.00e-56 214.00
IUUC-Cja-018797 Callithrix jacchus 67.35 0.00e+00 1282.00
IUUC-Cfa-020264 Canis familiaris 67.42 0.00e+00 1281.00
IUUC-Cpo-022057 Cavia porcellus 67.93 0.00e+00 1291.00
IUUC-Csa-023093 Chlorocebus sabaeus 67.66 0.00e+00 1286.00
IUUC-Cho-024486 Choloepus hoffmanni 74.84 2.00e-134 473.00
IUUC-Cin-025179 Ciona intestinalis 45.34 3.00e-120 425.00
IUUC-Dno-029496 Dasypus novemcinctus 67.70 0.00e+00 1283.00
IUUC-Dor-030919 Dipodomys ordii 81.65 0.00e+00 823.00
IUUC-Dme-032159 Drosophila melanogaster 45.97 3.00e-123 436.00
IUUC-Ete-032734 Echinops telfairi 64.30 0.00e+00 1180.00
IUUC-Eca-033350 Equus caballus 67.56 0.00e+00 1286.00
IUUC-Eeu-034566 Erinaceus europaeus 77.96 3.00e-87 317.00
IUUC-Fca-035632 Felis catus 62.34 0.00e+00 806.00
IUUC-Fal-037313 Ficedula albicollis 73.08 0.00e+00 1032.00
IUUC-Gmo-039239 Gadus morhua 84.57 0.00e+00 1512.00
IUUC-Gga-040668 Gallus gallus 69.52 0.00e+00 1285.00
IUUC-Gac-042630 Gasterosteus aculeatus 84.60 0.00e+00 1477.00
IUUC-Ggo-044462 Gorilla gorilla 68.12 0.00e+00 1280.00
IUUC-Hsa-045846 Homo sapiens 68.12 0.00e+00 1280.00
IUUC-Itr-048894 Ictidomys tridecemlineatus 68.65 3.00e-168 584.00
IUUC-Lch-050303 Latimeria chalumnae 64.83 0.00e+00 1140.00
IUUC-Loc-052190 Lepisosteus oculatus 79.54 0.00e+00 1451.00
IUUC-Laf-054480 Loxodonta africana 77.19 0.00e+00 635.00
IUUC-Mcc-055849 Macaca mulatta 67.45 0.00e+00 1281.00
IUUC-Meu-056755 Macropus eugenii 54.89 3.00e-151 529.00
IUUC-Mga-059561 Meleagris gallopavo 69.09 0.00e+00 1278.00
IUUC-Mmr-060942 Microcebus murinus 67.62 0.00e+00 1273.00
IUUC-Mdo-062618 Monodelphis domestica 68.46 0.00e+00 1288.00
IUUC-Mmu-063843 Mus musculus 66.84 0.00e+00 1246.00
IUUC-Mpu-066919 Mustela putorius furo 67.83 0.00e+00 1290.00
IUUC-Mlu-066983 Myotis lucifugus 67.08 0.00e+00 1253.00
IUUC-Nle-069893 Nomascus leucogenys 68.22 0.00e+00 1281.00
IUUC-Opr-071181 Ochotona princeps 61.18 0.00e+00 1028.00
IUUC-Ont-071697 Oreochromis niloticus 86.62 0.00e+00 1504.00
IUUC-Oan-073658 Ornithorhynchus anatinus 68.68 0.00e+00 1274.00
IUUC-Ocu-074954 Oryctolagus cuniculus 67.90 0.00e+00 1283.00
IUUC-Ola-086523 Oryzias latipes 83.40 0.00e+00 1477.00
IUUC-Oga-089003 Otolemur garnettii 67.35 0.00e+00 1285.00
IUUC-Oar-090376 Ovis aries 67.28 0.00e+00 1282.00
IUUC-Ptr-090520 Pan troglodytes 66.67 0.00e+00 1234.00
IUUC-Pan-092281 Papio anubis 67.66 0.00e+00 1286.00
IUUC-Psi-093047 Pelodiscus sinensis 72.12 0.00e+00 1242.00
IUUC-Pma-094575 Petromyzon marinus 54.84 3.00e-66 244.00
IUUC-Pfo-096358 Poecilia formosa 83.63 0.00e+00 1414.00
IUUC-Pab-097740 Pongo abelii 68.02 0.00e+00 1279.00
IUUC-Pca-100461 Procavia capensis 61.39 0.00e+00 1013.00
IUUC-Pva-102134 Pteropus vampyrus 60.66 0.00e+00 1116.00
IUUC-Rno-105807 Rattus norvegicus 66.46 0.00e+00 1231.00
IUUC-Sha-107236 Sarcophilus harrisii 67.43 0.00e+00 1252.00
IUUC-Sar-113366 Sorex araneus 82.22 0.00e+00 787.00
IUUC-Tgu-117201 Taeniopygia guttata 66.53 0.00e+00 1208.00
IUUC-Tru-117953 Takifugu rubripes 84.74 0.00e+00 1494.00
IUUC-Tsy-119610 Tarsius syrichta 65.95 0.00e+00 1241.00
IUUC-Tni-120743 Tetraodon nigroviridis 40.31 2.00e-159 556.00
IUUC-Tbe-128155 Tupaia belangeri 57.64 2.00e-154 540.00
IUUC-Ttr-128942 Tursiops truncatus 62.62 0.00e+00 1162.00
IUUC-Vpa-130281 Vicugna pacos 60.75 0.00e+00 1082.00
IUUC-Xtr-132627 Xenopus tropicalis 63.21 0.00e+00 1108.00
Created Date 25-Jun-2017

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