iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Laf-053427

Ensembl Protein ID

ENSLAFP00000021235.1

UniProt Accession

G3U077; G3U077_LOXAF

Protein Name

Coronin

Gene Name

CORO1A

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000029519.1	ENSLAFT00000031546.1	ENSLAFP00000021235.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.50e-19	68.9	79	114

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf...sdtllvsGsdDgtikvWDlrtg 33
           gHt++v ++a+   +d+ ++sGs D+t++vW++ +g
   Q: 79   GHTAPVLDIAWcphNDNVIASGSEDCTVMVWEIPDG 114
           8***********9877****************8887 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

MSRQVVRSSK FRHVFGQPAK ADQCYEDVRV SQTTWDSGFC AVNPKFVALI CEASGGGAFL 60
VLPLGKTGRV DKNVPLVCGH TAPVLDIAWC PHNDNVIASG SEDCTVMVWE IPDGLMLPLR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAGCCGGC AGGTGGTCCG CTCCAGCAAG TTCCGCCATG TGTTCGGACA GCCAGCCAAG 60
GCCGACCAGT GCTATGAGGA TGTGCGGGTC TCACAGACCA CCTGGGACAG TGGCTTCTGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR029508--CORO1A
IPR015505--Coronin
IPR015048--DUF1899
IPR015049--Trimer_CC
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08953--DUF1899
PF08954--Trimer_CC
PF00400--WD40

SMART

SM01166--DUF1899
SM00320--WD40

Gene Ontology

GO:0005884--C:actin filament
GO:0030424--C:axon
GO:0005911--C:cell-cell junction
GO:0030864--C:cortical actin cytoskeleton
GO:0005829--C:cytosol
GO:0005769--C:early endosome
GO:0070062--C:extracellular exosome
GO:0001772--C:immunological synapse
GO:0030027--C:lamellipodium
GO:0001891--C:phagocytic cup
GO:0045335--C:phagocytic vesicle
GO:0043234--C:protein complex
GO:0003723--F:RNA binding
GO:0007015--P:actin filament organization
GO:0006816--P:calcium ion transport
GO:0031589--P:cell-substrate adhesion
GO:0071353--P:cellular response to interleukin-4
GO:0061502--P:early endosome to recycling endosome transport
GO:0048873--P:homeostasis of number of cells within a tissue
GO:0030595--P:leukocyte chemotaxis
GO:0043320--P:natural killer cell degranulation
GO:0051126--P:negative regulation of actin nucleation
GO:0043524--P:negative regulation of neuron apoptotic process
GO:0031339--P:negative regulation of vesicle fusion
GO:0038180--P:nerve growth factor signaling pathway
GO:0001845--P:phagolysosome assembly
GO:0050918--P:positive chemotaxis
GO:0030335--P:positive regulation of cell migration
GO:0042102--P:positive regulation of T cell proliferation
GO:0008360--P:regulation of cell shape
GO:0051279--P:regulation of release of sequestered calcium ion into cytosol
GO:0043029--P:T cell homeostasis
GO:0032796--P:uropod organization

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002012	Ailuropoda melanoleuca	96.75	0.00e+00	914.00
IUUC-Ago-007901	Ashbya gossypii	41.75	2.00e-90	327.00
IUUC-Acl-008280	Aspergillus clavatus	42.51	3.00e-98	352.00
IUUC-Ame-011101	Astyanax mexicanus	68.64	0.00e+00	671.00
IUUC-Bgr-011990	Blumeria graminis	41.48	6.00e-98	351.00
IUUC-Bta-013168	Bos taurus	95.66	0.00e+00	910.00
IUUC-Bci-013935	Botrytis cinerea	42.72	1.00e-100	360.00
IUUC-Cja-019660	Callithrix jacchus	96.53	0.00e+00	917.00
IUUC-Cfa-020938	Canis familiaris	96.53	0.00e+00	913.00
IUUC-Cpo-022056	Cavia porcellus	94.36	0.00e+00	902.00
IUUC-Csa-023193	Chlorocebus sabaeus	96.53	0.00e+00	914.00
IUUC-Cne-026773	Cryptococcus neoformans	39.66	6.00e-89	321.00
IUUC-Dre-028167	Danio rerio	68.86	0.00e+00	664.00
IUUC-Dno-029363	Dasypus novemcinctus	96.10	0.00e+00	907.00
IUUC-Dor-030426	Dipodomys ordii	95.23	0.00e+00	902.00
IUUC-Eca-034229	Equus caballus	95.66	0.00e+00	905.00
IUUC-Eeu-034499	Erinaceus europaeus	93.58	0.00e+00	773.00
IUUC-Fca-036472	Felis catus	95.23	0.00e+00	903.00
IUUC-Gac-042545	Gasterosteus aculeatus	68.34	0.00e+00	671.00
IUUC-Ggo-045162	Gorilla gorilla	96.53	0.00e+00	915.00
IUUC-Hsa-046874	Homo sapiens	96.53	0.00e+00	915.00
IUUC-Itr-048911	Ictidomys tridecemlineatus	96.31	0.00e+00	911.00
IUUC-Lch-050582	Latimeria chalumnae	67.16	0.00e+00	681.00
IUUC-Mcc-055750	Macaca mulatta	96.49	0.00e+00	849.00
IUUC-Meu-056083	Macropus eugenii	88.50	0.00e+00	841.00
IUUC-Mpo-057410	Magnaporthe poae	42.08	6.00e-91	328.00
IUUC-Mvi-060569	Microbotryum violaceum	40.25	4.00e-88	318.00
IUUC-Mmr-060858	Microcebus murinus	97.18	0.00e+00	919.00
IUUC-Mdo-062469	Monodelphis domestica	90.17	0.00e+00	845.00
IUUC-Mmu-063583	Mus musculus	94.79	0.00e+00	902.00
IUUC-Mpu-066451	Mustela putorius furo	96.61	0.00e+00	879.00
IUUC-Mlu-066978	Myotis lucifugus	95.66	0.00e+00	905.00
IUUC-Nfi-068476	Neosartorya fischeri	41.77	6.00e-97	348.00
IUUC-Ncr-068781	Neurospora crassa	40.05	7.00e-99	354.00
IUUC-Nle-069815	Nomascus leucogenys	96.75	0.00e+00	915.00
IUUC-Opr-070911	Ochotona princeps	93.28	0.00e+00	877.00
IUUC-Ont-072391	Oreochromis niloticus	68.83	0.00e+00	677.00
IUUC-Ocu-074429	Oryctolagus cuniculus	85.43	0.00e+00	780.00
IUUC-Oga-089072	Otolemur garnettii	95.68	0.00e+00	904.00
IUUC-Oar-089676	Ovis aries	95.44	0.00e+00	909.00
IUUC-Ptr-091647	Pan troglodytes	96.31	0.00e+00	913.00
IUUC-Pan-092672	Papio anubis	96.53	0.00e+00	914.00
IUUC-Pab-098348	Pongo abelii	91.11	0.00e+00	845.00
IUUC-Pva-102668	Pteropus vampyrus	96.10	0.00e+00	912.00
IUUC-Rno-105604	Rattus norvegicus	94.14	0.00e+00	894.00
IUUC-Sce-106378	Saccharomyces cerevisiae	41.45	2.00e-92	333.00
IUUC-Sha-107210	Sarcophilus harrisii	89.59	0.00e+00	865.00
IUUC-Sar-113292	Sorex araneus	95.14	0.00e+00	720.00
IUUC-Sre-114911	Sporisorium reilianum	40.00	1.00e-81	296.00
IUUC-Tme-126924	Tuber melanosporum	40.67	5.00e-94	338.00
IUUC-Tbe-128025	Tupaia belangeri	95.17	2.00e-148	517.00
IUUC-Ttr-128689	Tursiops truncatus	95.44	0.00e+00	908.00
IUUC-Uma-129489	Ustilago maydis	40.05	9.00e-87	314.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence